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High Grade Breast Mucoepidermoid Carcinoma

MedGen UID:
234346
•Concept ID:
C1334006
•
Neoplastic Process
Synonyms: High Grade Mucoepidermoid Breast Carcinoma; High-Grade Mucoepidermoid Carcinoma of Breast; High-Grade Mucoepidermoid Carcinoma of the Breast

Definition

An aggressive mucoepidermoid carcinoma characterized by the presence of focal necrosis and high mitotic activity. Lymph node and distant metastases are common. The prognosis is usually poor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHigh Grade Breast Mucoepidermoid Carcinoma

Professional guidelines

PubMed

Clinical outcomes of bulky parotid gland cancers: need for self-examination and screening program for early diagnosis of parotid tumors.
Choi SY, Lee E, Kim E, Chung MK, Son YI, Baek CH, Jeong HS
BMC Cancer 2021 Feb 18;21(1):178. doi: 10.1186/s12885-021-07902-9. PMID: 33602169Free PMC Article
The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas.
Skálová A, Stenman G, Simpson RHW, Hellquist H, Slouka D, Svoboda T, Bishop JA, Hunt JL, Nibu KI, Rinaldo A, Vander Poorten V, Devaney KO, Steiner P, Ferlito A
Am J Surg Pathol 2018 Feb;42(2):e11-e27. doi: 10.1097/PAS.0000000000000980. PMID: 29076877

Recent clinical studies

Etiology

The molecular landscape of breast mucoepidermoid carcinoma.
Venetis K, Sajjadi E, Ivanova M, Andaloro S, Pessina S, Zanetti C, Ranghiero A, Citelli G, Rossi C, Lucioni M, Malapelle U, Pagni F, Barberis M, Guerini-Rocco E, Viale G, Fusco N
Cancer Med 2023 May;12(9):10725-10737. Epub 2023 Mar 14 doi: 10.1002/cam4.5754. PMID: 36916425Free PMC Article
The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas.
Skálová A, Stenman G, Simpson RHW, Hellquist H, Slouka D, Svoboda T, Bishop JA, Hunt JL, Nibu KI, Rinaldo A, Vander Poorten V, Devaney KO, Steiner P, Ferlito A
Am J Surg Pathol 2018 Feb;42(2):e11-e27. doi: 10.1097/PAS.0000000000000980. PMID: 29076877
Salivary gland-like tumours of the breast: surgical and molecular pathology.
Pia-Foschini M, Reis-Filho JS, Eusebi V, Lakhani SR
J Clin Pathol 2003 Jul;56(7):497-506. doi: 10.1136/jcp.56.7.497. PMID: 12835294Free PMC Article
Low and high grade mucoepidermoid carcinomas of the breast.
Tjalma WA, Verslegers IO, De Loecker PA, Van Marck EA
Eur J Gynaecol Oncol 2002;23(5):423-5. PMID: 12440816
Histopathology of malignant salivary gland tumours.
Seifert G
Eur J Cancer B Oral Oncol 1992 Jul;28B(1):49-56. doi: 10.1016/0964-1955(92)90013-q. PMID: 1330147

Diagnosis

The molecular landscape of breast mucoepidermoid carcinoma.
Venetis K, Sajjadi E, Ivanova M, Andaloro S, Pessina S, Zanetti C, Ranghiero A, Citelli G, Rossi C, Lucioni M, Malapelle U, Pagni F, Barberis M, Guerini-Rocco E, Viale G, Fusco N
Cancer Med 2023 May;12(9):10725-10737. Epub 2023 Mar 14 doi: 10.1002/cam4.5754. PMID: 36916425Free PMC Article
The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas.
Skálová A, Stenman G, Simpson RHW, Hellquist H, Slouka D, Svoboda T, Bishop JA, Hunt JL, Nibu KI, Rinaldo A, Vander Poorten V, Devaney KO, Steiner P, Ferlito A
Am J Surg Pathol 2018 Feb;42(2):e11-e27. doi: 10.1097/PAS.0000000000000980. PMID: 29076877
Mucoepidermoid carcinoma of the breast: Four case reports and review of the literature.
Cheng M, Geng C, Tang T, Song Z
Medicine (Baltimore) 2017 Dec;96(51):e9385. doi: 10.1097/MD.0000000000009385. PMID: 29390541Free PMC Article
Mucoepidermoid carcinoma of the breast.
Markopoulos C, Gogas H, Livaditou A, Floros D
Eur J Gynaecol Oncol 1998;19(3):291-3. PMID: 9641234
Mucoepidermoid and squamous cell carcinomas of breast with reference to squamous metaplasia and giant cell tumors.
Fisher ER, Palekar AS, Gregorio RM, Paulson JD
Am J Surg Pathol 1983 Jan;7(1):15-27. doi: 10.1097/00000478-198301000-00002. PMID: 6829846

Therapy

CD138 Is Expressed in Different Entities of Salivary Gland Cancer and Their Lymph Node Metastases and Therefore Represents a Potential Therapeutic Target.
Mayer M, Nachtsheim L, Hoffmann F, von Eggeling F, Guntinas-Lichius O, Prinz J, Klußmann JP, Quaas A, Arolt C, Wolber P
Int J Mol Sci 2022 Aug 12;23(16) doi: 10.3390/ijms23169037. PMID: 36012301Free PMC Article
Spontaneous infarction of pleomorphic adenoma: report of a case simulating malignancy on fine-needle cytology sample.
Fulciniti F, Losito NS, Botti G, Manola M, Ionna F
Diagn Cytopathol 2010 Jun;38(6):430-4. doi: 10.1002/dc.21229. PMID: 19894261
Mucoepidermoid carcinoma of the breast.
Hornychová H, Ryska A, Betlach J, Bohác R, Cízek T, Tomsová M, Obermannová R
Neoplasma 2007;54(2):168-72. PMID: 17319792
Second malignant neoplasms in long-term survivors of osteosarcoma: Memorial Sloan-Kettering Cancer Center Experience.
Aung L, Gorlick RG, Shi W, Thaler H, Shorter NA, Healey JH, Huvos AG, Meyers PA
Cancer 2002 Oct 15;95(8):1728-34. doi: 10.1002/cncr.10861. PMID: 12365021
High-grade mucoepidermoid carcinoma of the breast.
Hastrup N, Sehested M
Histopathology 1985 Aug;9(8):887-92. doi: 10.1111/j.1365-2559.1985.tb02873.x. PMID: 4054847

Prognosis

The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas.
Skálová A, Stenman G, Simpson RHW, Hellquist H, Slouka D, Svoboda T, Bishop JA, Hunt JL, Nibu KI, Rinaldo A, Vander Poorten V, Devaney KO, Steiner P, Ferlito A
Am J Surg Pathol 2018 Feb;42(2):e11-e27. doi: 10.1097/PAS.0000000000000980. PMID: 29076877
Mucoepidermoid carcinoma of the breast.
Di Tommaso L, Foschini MP, Ragazzini T, Magrini E, Fornelli A, Ellis IO, Eusebi V
Virchows Arch 2004 Jan;444(1):13-9. Epub 2003 Nov 21 doi: 10.1007/s00428-003-0923-y. PMID: 14634807
Low and high grade mucoepidermoid carcinomas of the breast.
Tjalma WA, Verslegers IO, De Loecker PA, Van Marck EA
Eur J Gynaecol Oncol 2002;23(5):423-5. PMID: 12440816
Histopathology of malignant salivary gland tumours.
Seifert G
Eur J Cancer B Oral Oncol 1992 Jul;28B(1):49-56. doi: 10.1016/0964-1955(92)90013-q. PMID: 1330147
Mucoepidermoid and squamous cell carcinomas of breast with reference to squamous metaplasia and giant cell tumors.
Fisher ER, Palekar AS, Gregorio RM, Paulson JD
Am J Surg Pathol 1983 Jan;7(1):15-27. doi: 10.1097/00000478-198301000-00002. PMID: 6829846

Clinical prediction guides

The molecular landscape of breast mucoepidermoid carcinoma.
Venetis K, Sajjadi E, Ivanova M, Andaloro S, Pessina S, Zanetti C, Ranghiero A, Citelli G, Rossi C, Lucioni M, Malapelle U, Pagni F, Barberis M, Guerini-Rocco E, Viale G, Fusco N
Cancer Med 2023 May;12(9):10725-10737. Epub 2023 Mar 14 doi: 10.1002/cam4.5754. PMID: 36916425Free PMC Article
The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas.
Skálová A, Stenman G, Simpson RHW, Hellquist H, Slouka D, Svoboda T, Bishop JA, Hunt JL, Nibu KI, Rinaldo A, Vander Poorten V, Devaney KO, Steiner P, Ferlito A
Am J Surg Pathol 2018 Feb;42(2):e11-e27. doi: 10.1097/PAS.0000000000000980. PMID: 29076877
Early results of real-time qualitative sonoelastography in the evaluation of parotid gland masses: a study with histopathological correlation.
Celebi I, Mahmutoglu AS
Acta Radiol 2013 Feb 1;54(1):35-41. Epub 2012 Oct 22 doi: 10.1258/ar.2012.120405. PMID: 23091238
Mammary analog secretory carcinoma of salivary gland origin with the ETV6 gene rearrangement by FISH: expanded morphologic and immunohistochemical spectrum of a recently described entity.
Connor A, Perez-Ordoñez B, Shago M, Skálová A, Weinreb I
Am J Surg Pathol 2012 Jan;36(1):27-34. doi: 10.1097/PAS.0b013e318231542a. PMID: 21989350
Mucoepidermoid carcinoma of the breast: high grade variant.
Leong AS, Williams JA
Pathology 1985 Jul;17(3):516-21. doi: 10.3109/00313028509105513. PMID: 4069771

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