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Uterine corpus choriocarcinoma

MedGen UID:
234466
•Concept ID:
C1336904
•
Neoplastic Process
Synonym: Gestational uterine corpus choriocarcinoma
 
Monarch Initiative: MONDO:0004491

Definition

An aggressive malignant tumor arising from trophoblastic cells in the uterus during pregnancy. Approximately half of the cases develop from a complete hydatidiform mole. There is often marked elevation of human chorionic gonadotropin (hCG) in the blood. Choriocarcinomas disseminate rapidly through the hematogenous route; the lungs are most frequently affected. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUterine corpus choriocarcinoma

Recent clinical studies

Etiology

Epidemiology of gynecological cancers in Kamrup Urban District cancer registry.
Barman D, Sharma JD, Barmon D, Kataki AC, Sharma A, Kalita M
Indian J Cancer 2017 Jan-Mar;54(1):388-391. doi: 10.4103/0019-509X.219590. PMID: 29199729
Rate of second primary tumors following diagnosed choriocarcinoma: a SEER analysis (1973-2010).
Sisti G, Kanninen TT, Asciutti S, Sorbi F, Fambrini M
Gynecol Oncol 2014 Jul;134(1):90-5. Epub 2014 May 14 doi: 10.1016/j.ygyno.2014.05.004. PMID: 24836277
New discoveries on the biology and detection of human chorionic gonadotropin.
Cole LA
Reprod Biol Endocrinol 2009 Jan 26;7:8. doi: 10.1186/1477-7827-7-8. PMID: 19171054Free PMC Article
Gynecologic cancers: factors affecting survival after pulmonary metastasectomy.
Clavero JM, Deschamps C, Cassivi SD, Allen MS, Nichols FC 3rd, Barrette BA, Larson DR, Pairolero PC
Ann Thorac Surg 2006 Jun;81(6):2004-7. doi: 10.1016/j.athoracsur.2006.01.068. PMID: 16731120
Uterine choriocarcinoma in a postmenopausal woman.
Mukherjee U, Thakur V, Katiyar D, Goyal HK, Pendharkar D
Med Oncol 2006;23(2):301-3. doi: 10.1385/MO:23:2:301. PMID: 16720931

Diagnosis

Epidemiology of gynecological cancers in Kamrup Urban District cancer registry.
Barman D, Sharma JD, Barmon D, Kataki AC, Sharma A, Kalita M
Indian J Cancer 2017 Jan-Mar;54(1):388-391. doi: 10.4103/0019-509X.219590. PMID: 29199729
Caesarean scar choriocarcinoma: a case report and review of the literature.
Qian ZD, Zhu XM
Eur J Med Res 2014 May 14;19(1):25. doi: 10.1186/2047-783X-19-25. PMID: 24887563Free PMC Article
New discoveries on the biology and detection of human chorionic gonadotropin.
Cole LA
Reprod Biol Endocrinol 2009 Jan 26;7:8. doi: 10.1186/1477-7827-7-8. PMID: 19171054Free PMC Article
The quagmire of hCG and hCG testing in gynecologic oncology.
Muller CY, Cole LA
Gynecol Oncol 2009 Mar;112(3):663-72. Epub 2008 Nov 12 doi: 10.1016/j.ygyno.2008.09.030. PMID: 19007977
Transvaginal color Doppler in early pregnancy: rational and clinical potential.
Kurjak A, Zalud I, Predanic M
J Perinat Med 1994;22(6):475-82. PMID: 7674101

Therapy

Post molar choriocarcinoma with solitary renal metastasis in the absence of primary uterine tumor: a case report and review of the literature.
Geravandi M, Hajihashemi A, Adibi A, Habibi Tirtashi R
J Med Case Rep 2024 Mar 30;18(1):132. doi: 10.1186/s13256-024-04464-9. PMID: 38553733Free PMC Article
Caesarean scar choriocarcinoma: a case report and review of the literature.
Qian ZD, Zhu XM
Eur J Med Res 2014 May 14;19(1):25. doi: 10.1186/2047-783X-19-25. PMID: 24887563Free PMC Article
Uterine choriocarcinoma in a postmenopausal woman.
Mukherjee U, Thakur V, Katiyar D, Goyal HK, Pendharkar D
Med Oncol 2006;23(2):301-3. doi: 10.1385/MO:23:2:301. PMID: 16720931
Female reproductive organs and breast cancer mortality in New Jersey counties and the relationship with certain environmental variables.
Najem GR, Greer TW
Prev Med 1985 Sep;14(5):620-35. doi: 10.1016/0091-7435(85)90082-9. PMID: 3840894
Cervical choriocarcinoma associated with an intrauterine contraceptive device: a case report.
Martin BR 3rd, Orr JW Jr, Austin JM Jr
Am J Obstet Gynecol 1983 Oct 1;147(3):343-4. doi: 10.1016/0002-9378(83)91127-4. PMID: 6684883

Prognosis

Post molar choriocarcinoma with solitary renal metastasis in the absence of primary uterine tumor: a case report and review of the literature.
Geravandi M, Hajihashemi A, Adibi A, Habibi Tirtashi R
J Med Case Rep 2024 Mar 30;18(1):132. doi: 10.1186/s13256-024-04464-9. PMID: 38553733Free PMC Article
Caesarean scar choriocarcinoma: a case report and review of the literature.
Qian ZD, Zhu XM
Eur J Med Res 2014 May 14;19(1):25. doi: 10.1186/2047-783X-19-25. PMID: 24887563Free PMC Article
Biological functions of hCG and hCG-related molecules.
Cole LA
Reprod Biol Endocrinol 2010 Aug 24;8:102. doi: 10.1186/1477-7827-8-102. PMID: 20735820Free PMC Article
New discoveries on the biology and detection of human chorionic gonadotropin.
Cole LA
Reprod Biol Endocrinol 2009 Jan 26;7:8. doi: 10.1186/1477-7827-7-8. PMID: 19171054Free PMC Article
The quagmire of hCG and hCG testing in gynecologic oncology.
Muller CY, Cole LA
Gynecol Oncol 2009 Mar;112(3):663-72. Epub 2008 Nov 12 doi: 10.1016/j.ygyno.2008.09.030. PMID: 19007977

Clinical prediction guides

Rate of second primary tumors following diagnosed choriocarcinoma: a SEER analysis (1973-2010).
Sisti G, Kanninen TT, Asciutti S, Sorbi F, Fambrini M
Gynecol Oncol 2014 Jul;134(1):90-5. Epub 2014 May 14 doi: 10.1016/j.ygyno.2014.05.004. PMID: 24836277
New discoveries on the biology and detection of human chorionic gonadotropin.
Cole LA
Reprod Biol Endocrinol 2009 Jan 26;7:8. doi: 10.1186/1477-7827-7-8. PMID: 19171054Free PMC Article
Impact of p53 immunostaining in predicting advanced or recurrent placental site trophoblastic tumors: a study of 12 cases.
Nagai Y, Kamoi S, Matsuoka T, Hata A, Jobo T, Ogasawara T, Aoki Y, Ohira S, Okamoto T, Nakamoto T, Kanda K, Matsui H
Gynecol Oncol 2007 Sep;106(3):446-52. Epub 2007 Jun 4 doi: 10.1016/j.ygyno.2007.04.025. PMID: 17544490
The heterogeneity of human chorionic gonadotropin (hCG). III. The occurrence and biological and immunological activities of nicked hCG.
Cole LA, Kardana A, Andrade-Gordon P, Gawinowicz MA, Morris JC, Bergert ER, O'Connor J, Birken S
Endocrinology 1991 Sep;129(3):1559-67. doi: 10.1210/endo-129-3-1559. PMID: 1714836
Serum relaxin in patients with invasive mole, choriocarcinoma and persistent trophoblastic disease.
Seki K, Uesato T, Kato K
Endocrinol Jpn 1986 Oct;33(5):727-33. doi: 10.1507/endocrj1954.33.727. PMID: 3030714

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