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Pineal parenchymal tumor of intermediate differentiation

MedGen UID:
234566
•Concept ID:
C1367859
•
Neoplastic Process
Synonyms: Pineal Parenchymal Tumor of Intermediate Differentiation; pineal parenchymal tumor of intermediate differentiation; pineal parenchymal tumor of intermediate differentiation (morphologic abnormality); pineal parenchymal tumors of intermediate differentiation; pineal parenchymal tumour of intermediate differentiation (morphologic abnormality); pineal parenchymal tumours of intermediate differentiation; PPTID
SNOMED CT: Pineal parenchymal tumor of intermediate differentiation (397379005); Pineal parenchymal tumor of intermediate differentiation (715904005)
 
Monarch Initiative: MONDO:0006369

Definition

A WHO grade 2 or 3 pineal parenchymal neoplasm of intermediate-grade malignancy, affecting all ages. It is composed of diffuse sheets or large lobules of uniform cells with mild to moderate nuclear atypia and low to moderate level mitotic activity. (Adapted from WHO) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPineal parenchymal tumor of intermediate differentiation

Professional guidelines

PubMed

Pineal parenchymal tumor of intermediate differentiation: a systematic review and contemporary management of 389 cases reported during the last two decades.
Takase H, Tanoshima R, Singla N, Nakamura Y, Yamamoto T
Neurosurg Rev 2022 Apr;45(2):1135-1155. Epub 2021 Oct 20 doi: 10.1007/s10143-021-01674-3. PMID: 34668090

Recent clinical studies

Etiology

Pineal Parenchymal Tumor of Intermediate Differentiation and DICER1 Syndrome: A Case Report.
Gupte A, Sood S, Kupsky WJ, Altinok D, Miller S, Roy S, Bhambhani K
J Pediatr Hematol Oncol 2023 Apr 1;45(3):e406-e409. Epub 2022 Aug 30 doi: 10.1097/MPH.0000000000002518. PMID: 36044309
Histopathology and molecular pathology of pediatric pineal parenchymal tumors.
Vasiljevic A
Childs Nerv Syst 2023 Sep;39(9):2273-2284. Epub 2022 Aug 16 doi: 10.1007/s00381-022-05637-x. PMID: 35972537
Clinical experience and outcomes in patients with pineal parenchymal tumor of intermediate differentiation (PPTID): a single-institution analysis.
Webb M, Johnson DR, Mahajan A, Brown P, Neth B, Kizilbash SH, Sener U
J Neurooncol 2022 Nov;160(2):527-534. Epub 2022 Oct 27 doi: 10.1007/s11060-022-04174-6. PMID: 36301435
Pineal parenchymal tumor of intermediate differentiation: a systematic review and contemporary management of 389 cases reported during the last two decades.
Takase H, Tanoshima R, Singla N, Nakamura Y, Yamamoto T
Neurosurg Rev 2022 Apr;45(2):1135-1155. Epub 2021 Oct 20 doi: 10.1007/s10143-021-01674-3. PMID: 34668090
Pineal Parenchymal Tumor of Intermediate Differentiation (PPTID) and Papillary Tumor of Pineal Region (PTPR): A Review.
Sadashiva N, Deora H, Arumalla K, Rao S, Saini J, Shukla D, Santosh V
Neurol India 2021 Sep-Oct;69(5):1153-1164. doi: 10.4103/0028-3886.329550. PMID: 34747779

Diagnosis

Clinical experience and outcomes in patients with pineal parenchymal tumor of intermediate differentiation (PPTID): a single-institution analysis.
Webb M, Johnson DR, Mahajan A, Brown P, Neth B, Kizilbash SH, Sener U
J Neurooncol 2022 Nov;160(2):527-534. Epub 2022 Oct 27 doi: 10.1007/s11060-022-04174-6. PMID: 36301435
Pineal parenchymal tumor of intermediate differentiation: a systematic review and contemporary management of 389 cases reported during the last two decades.
Takase H, Tanoshima R, Singla N, Nakamura Y, Yamamoto T
Neurosurg Rev 2022 Apr;45(2):1135-1155. Epub 2021 Oct 20 doi: 10.1007/s10143-021-01674-3. PMID: 34668090
Pathologic Prognostic Factors of Pineal Parenchymal Tumor of Intermediate Differentiation.
Chatterjee D, Lath K, Singla N, Kumar N, Radotra BD
Appl Immunohistochem Mol Morphol 2019 Mar;27(3):210-215. doi: 10.1097/PAI.0000000000000565. PMID: 28800009
Pineal parenchymal tumor of intermediate differentiation.
Patil M, Karandikar M
Indian J Pathol Microbiol 2015 Oct-Dec;58(4):540-2. doi: 10.4103/0377-4929.168854. PMID: 26549088
Imagery of pineal tumors.
Deiana G, Mottolese C, Hermier M, Louis-Tisserand G, Berthezene Y
Neurochirurgie 2015 Apr-Jun;61(2-3):113-22. Epub 2015 Feb 9 doi: 10.1016/j.neuchi.2014.10.111. PMID: 25676911

Prognosis

Histopathology and molecular pathology of pediatric pineal parenchymal tumors.
Vasiljevic A
Childs Nerv Syst 2023 Sep;39(9):2273-2284. Epub 2022 Aug 16 doi: 10.1007/s00381-022-05637-x. PMID: 35972537
Clinical experience and outcomes in patients with pineal parenchymal tumor of intermediate differentiation (PPTID): a single-institution analysis.
Webb M, Johnson DR, Mahajan A, Brown P, Neth B, Kizilbash SH, Sener U
J Neurooncol 2022 Nov;160(2):527-534. Epub 2022 Oct 27 doi: 10.1007/s11060-022-04174-6. PMID: 36301435
Pineal Parenchymal Tumor of Intermediate Differentiation (PPTID) and Papillary Tumor of Pineal Region (PTPR): A Review.
Sadashiva N, Deora H, Arumalla K, Rao S, Saini J, Shukla D, Santosh V
Neurol India 2021 Sep-Oct;69(5):1153-1164. doi: 10.4103/0028-3886.329550. PMID: 34747779
Pathologic Prognostic Factors of Pineal Parenchymal Tumor of Intermediate Differentiation.
Chatterjee D, Lath K, Singla N, Kumar N, Radotra BD
Appl Immunohistochem Mol Morphol 2019 Mar;27(3):210-215. doi: 10.1097/PAI.0000000000000565. PMID: 28800009
Pineal region glioblastomas display features of diffuse midline and non-midline gliomas.
D'Amico RS, Zanazzi G, Wu P, Canoll P, Bruce JN
J Neurooncol 2018 Oct;140(1):63-73. Epub 2018 Jul 10 doi: 10.1007/s11060-018-2931-4. PMID: 29992434Free PMC Article

Clinical prediction guides

A case of a pineal parenchymal tumor of intermediate differentiation with bifocal lesions differentiated by negative placental alkaline phosphatase in the spinal fluid.
Ito K, Aihara Y, Chiba K, Oda Y, Kawamata T
Childs Nerv Syst 2024 Sep;40(9):2935-2939. Epub 2024 May 7 doi: 10.1007/s00381-024-06429-1. PMID: 38713206
Pathologic Prognostic Factors of Pineal Parenchymal Tumor of Intermediate Differentiation.
Chatterjee D, Lath K, Singla N, Kumar N, Radotra BD
Appl Immunohistochem Mol Morphol 2019 Mar;27(3):210-215. doi: 10.1097/PAI.0000000000000565. PMID: 28800009
Quantitative imaging values of CT, MR, and FDG-PET to differentiate pineal parenchymal tumors and germinomas: are they useful?
Kakigi T, Okada T, Kanagaki M, Yamamoto A, Fushimi Y, Sakamoto R, Arakawa Y, Mikami Y, Shimono T, Takahashi JC, Togashi K
Neuroradiology 2014 Apr;56(4):297-303. Epub 2014 Feb 9 doi: 10.1007/s00234-014-1334-2. PMID: 24510202
Expression of hydroxyindole-O-methyltransferase enzyme in the human central nervous system and in pineal parenchymal cell tumors.
Fukuda T, Akiyama N, Ikegami M, Takahashi H, Sasaki A, Oka H, Komori T, Tanaka Y, Nakazato Y, Akimoto J, Tanaka M, Okada Y, Saito S
J Neuropathol Exp Neurol 2010 May;69(5):498-510. doi: 10.1097/NEN.0b013e3181db7d3c. PMID: 20418777
Comparative genomic hybridization in pineal parenchymal tumors.
Rickert CH, Simon R, Bergmann M, Dockhorn-Dworniczak B, Paulus W
Genes Chromosomes Cancer 2001 Jan;30(1):99-104. doi: 10.1002/1098-2264(2000)9999:9999<::aid-gcc1067>3.0.co;2-c. PMID: 11107183

Recent systematic reviews

Pineal parenchymal tumor of intermediate differentiation: a systematic review and contemporary management of 389 cases reported during the last two decades.
Takase H, Tanoshima R, Singla N, Nakamura Y, Yamamoto T
Neurosurg Rev 2022 Apr;45(2):1135-1155. Epub 2021 Oct 20 doi: 10.1007/s10143-021-01674-3. PMID: 34668090

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