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Adult central nervous system germinoma

MedGen UID:
234581
•Concept ID:
C1370504
•
Neoplastic Process
Synonyms: Adult Central Nervous System Germinoma; adult central nervous system germinoma; Adult CNS Germinoma; adult CNS germinoma; central nervous system germinoma of adults; Germinoma of Adult Central Nervous System; germinoma of adult central nervous system; Germinoma of Adult CNS; germinoma of adult CNS; Germinoma of the Adult Central Nervous System; germinoma of the adult central nervous system; Germinoma of the Adult CNS; germinoma of the adult CNS
 
Monarch Initiative: MONDO:0004383

Definition

A central nervous system germinoma that occurs in an adult. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult central nervous system germinoma

Professional guidelines

PubMed

Primary central nervous system germ cell tumors in children and young adults: A review of controversies in diagnostic and treatment approach.
Yeo KK, Nagabushan S, Dhall G, Abdelbaki MS
Neoplasia 2023 Feb;36:100860. Epub 2022 Dec 13 doi: 10.1016/j.neo.2022.100860. PMID: 36521378Free PMC Article
Management trends and outcomes of pineal germinoma in a multi-institutional Australian cohort.
Stephens S, Kuchel A, Cheuk R, Alexander H, Robertson T, Rajah T, Tran Q, Inglis PL
J Clin Neurosci 2021 Aug;90:1-7. Epub 2021 May 21 doi: 10.1016/j.jocn.2021.05.006. PMID: 34275531
Germination of Germinoma Treatment.
McClelland S 3rd, Jaboin JJ
Int J Radiat Oncol Biol Phys 2019 Aug 1;104(5):967-968. doi: 10.1016/j.ijrobp.2018.03.040. PMID: 31327425

Recent clinical studies

Etiology

Primary central nervous system germ cell tumors in children and young adults: A review of controversies in diagnostic and treatment approach.
Yeo KK, Nagabushan S, Dhall G, Abdelbaki MS
Neoplasia 2023 Feb;36:100860. Epub 2022 Dec 13 doi: 10.1016/j.neo.2022.100860. PMID: 36521378Free PMC Article
Phase II trial of response-based radiation therapy for patients with localized germinoma: a Children's Oncology Group study.
Bartels U, Onar-Thomas A, Patel SK, Shaw D, Fangusaro J, Dhall G, Souweidane M, Bhatia A, Embry L, Trask CL, Murphy ES, MacDonald S, Wu S, Boyett JM, Leary S, Fouladi M, Gajjar A, Khatua S
Neuro Oncol 2022 Jun 1;24(6):974-983. doi: 10.1093/neuonc/noab270. PMID: 34850169Free PMC Article
Central Nervous System Germinomas Express Programmed Death Ligand 1.
Wildeman ME, Shepard MJ, Oldfield EH, Lopes MBS
J Neuropathol Exp Neurol 2018 Apr 1;77(4):312-316. doi: 10.1093/jnen/nly008. PMID: 29415126
Teratomas in central nervous system: a clinico-morphological study with review of literature.
Agrawal M, Uppin MS, Patibandla MR, Bhattacharjee S, Panigrahi MK, Saradhi V, Rani JY, Purohit AK, Challa S
Neurol India 2010 Nov-Dec;58(6):841-6. doi: 10.4103/0028-3886.73740. PMID: 21150046
Central nervous system tumours in adolescents.
Capra M, Hargrave D, Bartels U, Hyder D, Huang A, Bouffet E
Eur J Cancer 2003 Dec;39(18):2643-50. doi: 10.1016/j.ejca.2003.09.003. PMID: 14642926

Diagnosis

Pupillary Light-Near Dissociation.
La Corte E, Martinoni M
N Engl J Med 2021 Dec 23;385(26):e94. doi: 10.1056/NEJMicm2031597. PMID: 34936742
Stalking the Diagnosis.
Minter DJ, Richie M, Kumthekar P, Hollander H
N Engl J Med 2021 Apr 1;384(13):1262-1267. doi: 10.1056/NEJMcps2028560. PMID: 33789016
Ectopic intracranial germinoma.
Shankar S, Wu X, Kalra VB, Huttner AJ, Malhotra A
J Clin Neurosci 2016 Sep;31:192-5. Epub 2016 Apr 2 doi: 10.1016/j.jocn.2016.02.013. PMID: 27050919
Central nervous system germ cell tumors: an update.
Dufour C, Guerrini-Rousseau L, Grill J
Curr Opin Oncol 2014 Nov;26(6):622-6. doi: 10.1097/CCO.0000000000000140. PMID: 25233069
Central nervous system germ cell tumors: classification, clinical features, and treatment with a historical overview.
Fujimaki T
J Child Neurol 2009 Nov;24(11):1439-45. doi: 10.1177/0883073809342127. PMID: 19841431

Therapy

Phase II trial of response-based radiation therapy for patients with localized germinoma: a Children's Oncology Group study.
Bartels U, Onar-Thomas A, Patel SK, Shaw D, Fangusaro J, Dhall G, Souweidane M, Bhatia A, Embry L, Trask CL, Murphy ES, MacDonald S, Wu S, Boyett JM, Leary S, Fouladi M, Gajjar A, Khatua S
Neuro Oncol 2022 Jun 1;24(6):974-983. doi: 10.1093/neuonc/noab270. PMID: 34850169Free PMC Article
Germination of Germinoma Treatment.
McClelland S 3rd, Jaboin JJ
Int J Radiat Oncol Biol Phys 2019 Aug 1;104(5):967-968. doi: 10.1016/j.ijrobp.2018.03.040. PMID: 31327425
Craniospinal irradiation using helical tomotherapy for central nervous system tumors.
Schiopu SR, Habl G, Häfner M, Katayama S, Herfarth K, Debus J, Sterzing F
J Radiat Res 2017 Mar 1;58(2):238-246. doi: 10.1093/jrr/rrw095. PMID: 28096196Free PMC Article
Proton Therapy in Children: A Systematic Review of Clinical Effectiveness in 15 Pediatric Cancers.
Leroy R, Benahmed N, Hulstaert F, Van Damme N, De Ruysscher D
Int J Radiat Oncol Biol Phys 2016 May 1;95(1):267-278. Epub 2015 Oct 17 doi: 10.1016/j.ijrobp.2015.10.025. PMID: 27084646
Germ cell tumours of the central nervous system in children-controversies in radiotherapy.
Borg M
Med Pediatr Oncol 2003 Jun;40(6):367-74. doi: 10.1002/mpo.10285. PMID: 12692804

Prognosis

Brain and Spinal Tumors Originating from the Germ Line Cells.
Wong TT, Tsai ML, Chang H, Hsieh KL, Ho DM, Lin SC, Yen HJ, Chen YW, Lee HL, Yang TF
Adv Exp Med Biol 2023;1405:421-455. doi: 10.1007/978-3-031-23705-8_16. PMID: 37452948
Primary suprasellar germinoma: A series of 15 cases.
Xue K, Han G, Wang Z, Zhang X
J Clin Neurosci 2023 May;111:71-77. Epub 2023 Mar 22 doi: 10.1016/j.jocn.2023.03.007. PMID: 36963125
Central nervous system germ cell tumors: an update.
Dufour C, Guerrini-Rousseau L, Grill J
Curr Opin Oncol 2014 Nov;26(6):622-6. doi: 10.1097/CCO.0000000000000140. PMID: 25233069
Teratomas in central nervous system: a clinico-morphological study with review of literature.
Agrawal M, Uppin MS, Patibandla MR, Bhattacharjee S, Panigrahi MK, Saradhi V, Rani JY, Purohit AK, Challa S
Neurol India 2010 Nov-Dec;58(6):841-6. doi: 10.4103/0028-3886.73740. PMID: 21150046
Germ cell tumours of the central nervous system in children-controversies in radiotherapy.
Borg M
Med Pediatr Oncol 2003 Jun;40(6):367-74. doi: 10.1002/mpo.10285. PMID: 12692804

Clinical prediction guides

Phase II trial of response-based radiation therapy for patients with localized germinoma: a Children's Oncology Group study.
Bartels U, Onar-Thomas A, Patel SK, Shaw D, Fangusaro J, Dhall G, Souweidane M, Bhatia A, Embry L, Trask CL, Murphy ES, MacDonald S, Wu S, Boyett JM, Leary S, Fouladi M, Gajjar A, Khatua S
Neuro Oncol 2022 Jun 1;24(6):974-983. doi: 10.1093/neuonc/noab270. PMID: 34850169Free PMC Article
Multimodality treatment for Central Nervous System Germ Cell Tumors: Disease spectrum and management strategies - A tertiary care center experience from India.
Kumar N, Madan R, Dracham CB, Khosla D, Das N, Dey T, Elangovan A, Tripathi M, Gupta K, Ahuja CK, Kapoor R
Clin Neurol Neurosurg 2021 Mar;202:106481. Epub 2021 Jan 13 doi: 10.1016/j.clineuro.2021.106481. PMID: 33508649
Central Nervous System Germinomas Express Programmed Death Ligand 1.
Wildeman ME, Shepard MJ, Oldfield EH, Lopes MBS
J Neuropathol Exp Neurol 2018 Apr 1;77(4):312-316. doi: 10.1093/jnen/nly008. PMID: 29415126
Clinical use of (11)C-methionine and (18)F-FDG-PET for germinoma in central nervous system.
Okochi Y, Nihashi T, Fujii M, Kato K, Okada Y, Ando Y, Maesawa S, Takebayashi S, Wakabayashi T, Naganawa S
Ann Nucl Med 2014 Feb;28(2):94-102. Epub 2013 Nov 24 doi: 10.1007/s12149-013-0787-4. PMID: 24272066Free PMC Article
Pineal region tumors.
Portillo ML, de González CM, Sangines JB, Zapata GS
Int Surg 1982 Oct-Dec;67(4):329-33. PMID: 7160992

Recent systematic reviews

Radiation-induced cavernoma in pediatric CNS tumors: a systematic review and treatment paradigm.
Vacek A, Kaliaperumal C
Childs Nerv Syst 2024 Nov;40(11):3527-3536. Epub 2024 Jul 19 doi: 10.1007/s00381-024-06543-0. PMID: 39028348Free PMC Article
Basal Ganglia Germ Cell Tumors With or Without Sellar Involvement: A Long-Term Follow-Up in a Single Medical Center and a Systematic Literature Review.
Zhang Y, Wang L, Ma W, Pan H, Wang R, Zhu H, Yao Y
Front Endocrinol (Lausanne) 2021;12:763609. Epub 2021 Nov 10 doi: 10.3389/fendo.2021.763609. PMID: 34858336Free PMC Article
Proton Therapy in Children: A Systematic Review of Clinical Effectiveness in 15 Pediatric Cancers.
Leroy R, Benahmed N, Hulstaert F, Van Damme N, De Ruysscher D
Int J Radiat Oncol Biol Phys 2016 May 1;95(1):267-278. Epub 2015 Oct 17 doi: 10.1016/j.ijrobp.2015.10.025. PMID: 27084646
Postradiation lower motor neuron syndrome: case series and literature review.
Abraham A, Drory VE
J Neurol 2013 Jul;260(7):1802-6. Epub 2013 Mar 5 doi: 10.1007/s00415-013-6881-7. PMID: 23463367

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