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Adult central nervous system germinoma

MedGen UID:
234581
•Concept ID:
C1370504
•
Neoplastic Process
Synonyms: Adult Central Nervous System Germinoma; adult central nervous system germinoma; Adult CNS Germinoma; adult CNS germinoma; central nervous system germinoma of adults; Germinoma of Adult Central Nervous System; germinoma of adult central nervous system; Germinoma of Adult CNS; germinoma of adult CNS; Germinoma of the Adult Central Nervous System; germinoma of the adult central nervous system; Germinoma of the Adult CNS; germinoma of the adult CNS
 
Monarch Initiative: MONDO:0004383

Definition

A central nervous system germinoma that occurs in an adult. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult central nervous system germinoma

Professional guidelines

PubMed

Management trends and outcomes of pineal germinoma in a multi-institutional Australian cohort.
Stephens S, Kuchel A, Cheuk R, Alexander H, Robertson T, Rajah T, Tran Q, Inglis PL
J Clin Neurosci 2021 Aug;90:1-7. Epub 2021 May 21 doi: 10.1016/j.jocn.2021.05.006. PMID: 34275531
Germination of Germinoma Treatment.
McClelland S 3rd, Jaboin JJ
Int J Radiat Oncol Biol Phys 2019 Aug 1;104(5):967-968. doi: 10.1016/j.ijrobp.2018.03.040. PMID: 31327425
Central nervous system germ cell tumors: classification, clinical features, and treatment with a historical overview.
Fujimaki T
J Child Neurol 2009 Nov;24(11):1439-45. doi: 10.1177/0883073809342127. PMID: 19841431

Recent clinical studies

Etiology

Primary central nervous system germ cell tumors in children and young adults: A review of controversies in diagnostic and treatment approach.
Yeo KK, Nagabushan S, Dhall G, Abdelbaki MS
Neoplasia 2023 Feb;36:100860. Epub 2022 Dec 13 doi: 10.1016/j.neo.2022.100860. PMID: 36521378Free PMC Article
Multimodality treatment for Central Nervous System Germ Cell Tumors: Disease spectrum and management strategies - A tertiary care center experience from India.
Kumar N, Madan R, Dracham CB, Khosla D, Das N, Dey T, Elangovan A, Tripathi M, Gupta K, Ahuja CK, Kapoor R
Clin Neurol Neurosurg 2021 Mar;202:106481. Epub 2021 Jan 13 doi: 10.1016/j.clineuro.2021.106481. PMID: 33508649
Central Nervous System Germinomas Express Programmed Death Ligand 1.
Wildeman ME, Shepard MJ, Oldfield EH, Lopes MBS
J Neuropathol Exp Neurol 2018 Apr 1;77(4):312-316. doi: 10.1093/jnen/nly008. PMID: 29415126
Teratomas in central nervous system: a clinico-morphological study with review of literature.
Agrawal M, Uppin MS, Patibandla MR, Bhattacharjee S, Panigrahi MK, Saradhi V, Rani JY, Purohit AK, Challa S
Neurol India 2010 Nov-Dec;58(6):841-6. doi: 10.4103/0028-3886.73740. PMID: 21150046
Central nervous system tumours in adolescents.
Capra M, Hargrave D, Bartels U, Hyder D, Huang A, Bouffet E
Eur J Cancer 2003 Dec;39(18):2643-50. doi: 10.1016/j.ejca.2003.09.003. PMID: 14642926

Diagnosis

Neuropathology of Pituitary Adenomas and Sellar Lesions.
Kobalka PJ, Huntoon K, Becker AP
Neurosurgery 2021 Apr 15;88(5):900-918. doi: 10.1093/neuros/nyaa548. PMID: 33476394
Central nervous system germ cell tumors: an update.
Dufour C, Guerrini-Rousseau L, Grill J
Curr Opin Oncol 2014 Nov;26(6):622-6. doi: 10.1097/CCO.0000000000000140. PMID: 25233069
Teratomas in central nervous system: a clinico-morphological study with review of literature.
Agrawal M, Uppin MS, Patibandla MR, Bhattacharjee S, Panigrahi MK, Saradhi V, Rani JY, Purohit AK, Challa S
Neurol India 2010 Nov-Dec;58(6):841-6. doi: 10.4103/0028-3886.73740. PMID: 21150046
Central nervous system germ cell tumors: classification, clinical features, and treatment with a historical overview.
Fujimaki T
J Child Neurol 2009 Nov;24(11):1439-45. doi: 10.1177/0883073809342127. PMID: 19841431
Germ cell tumours of the central nervous system in children-controversies in radiotherapy.
Borg M
Med Pediatr Oncol 2003 Jun;40(6):367-74. doi: 10.1002/mpo.10285. PMID: 12692804

Therapy

The role of neoadjuvant chemotherapy in the management of metastatic central nervous system germinoma: A meta-analysis.
Abu-Arja MH, Shatara MS, Okcu MF, McGovern SL, Su JM, Abdelbaki MS
Pediatr Blood Cancer 2023 Oct;70(10):e30601. Epub 2023 Jul 27 doi: 10.1002/pbc.30601. PMID: 37501569
Germination of Germinoma Treatment.
McClelland S 3rd, Jaboin JJ
Int J Radiat Oncol Biol Phys 2019 Aug 1;104(5):967-968. doi: 10.1016/j.ijrobp.2018.03.040. PMID: 31327425
Craniospinal irradiation using helical tomotherapy for central nervous system tumors.
Schiopu SR, Habl G, Häfner M, Katayama S, Herfarth K, Debus J, Sterzing F
J Radiat Res 2017 Mar 1;58(2):238-246. doi: 10.1093/jrr/rrw095. PMID: 28096196Free PMC Article
Proton Therapy in Children: A Systematic Review of Clinical Effectiveness in 15 Pediatric Cancers.
Leroy R, Benahmed N, Hulstaert F, Van Damme N, De Ruysscher D
Int J Radiat Oncol Biol Phys 2016 May 1;95(1):267-278. Epub 2015 Oct 17 doi: 10.1016/j.ijrobp.2015.10.025. PMID: 27084646
Germ cell tumours of the central nervous system in children-controversies in radiotherapy.
Borg M
Med Pediatr Oncol 2003 Jun;40(6):367-74. doi: 10.1002/mpo.10285. PMID: 12692804

Prognosis

12p gain is predominantly observed in non-germinomatous germ cell tumors and identifies an unfavorable subgroup of central nervous system germ cell tumors.
Satomi K, Takami H, Fukushima S, Yamashita S, Matsushita Y, Nakazato Y, Suzuki T, Tanaka S, Mukasa A, Saito N, Kanamori M, Kumabe T, Tominaga T, Kobayashi K, Nagane M, Iuchi T, Yoshimoto K, Tamura K, Maehara T, Sakai K, Sugiyama K, Yokogami K, Takeshima H, Nonaka M, Asai A, Ushijima T, Matsutani M, Nishikawa R, Ichimura K
Neuro Oncol 2022 May 4;24(5):834-846. doi: 10.1093/neuonc/noab246. PMID: 34698864Free PMC Article
Central nervous system germ cell tumors: an update.
Dufour C, Guerrini-Rousseau L, Grill J
Curr Opin Oncol 2014 Nov;26(6):622-6. doi: 10.1097/CCO.0000000000000140. PMID: 25233069
Teratomas in central nervous system: a clinico-morphological study with review of literature.
Agrawal M, Uppin MS, Patibandla MR, Bhattacharjee S, Panigrahi MK, Saradhi V, Rani JY, Purohit AK, Challa S
Neurol India 2010 Nov-Dec;58(6):841-6. doi: 10.4103/0028-3886.73740. PMID: 21150046
Update on current standard treatments in central nervous system germ cell tumors.
Kamoshima Y, Sawamura Y
Curr Opin Neurol 2010 Dec;23(6):571-5. doi: 10.1097/WCO.0b013e32833ff522. PMID: 20885323
Germ cell tumours of the central nervous system in children-controversies in radiotherapy.
Borg M
Med Pediatr Oncol 2003 Jun;40(6):367-74. doi: 10.1002/mpo.10285. PMID: 12692804

Clinical prediction guides

12p gain is predominantly observed in non-germinomatous germ cell tumors and identifies an unfavorable subgroup of central nervous system germ cell tumors.
Satomi K, Takami H, Fukushima S, Yamashita S, Matsushita Y, Nakazato Y, Suzuki T, Tanaka S, Mukasa A, Saito N, Kanamori M, Kumabe T, Tominaga T, Kobayashi K, Nagane M, Iuchi T, Yoshimoto K, Tamura K, Maehara T, Sakai K, Sugiyama K, Yokogami K, Takeshima H, Nonaka M, Asai A, Ushijima T, Matsutani M, Nishikawa R, Ichimura K
Neuro Oncol 2022 May 4;24(5):834-846. doi: 10.1093/neuonc/noab246. PMID: 34698864Free PMC Article
Multimodality treatment for Central Nervous System Germ Cell Tumors: Disease spectrum and management strategies - A tertiary care center experience from India.
Kumar N, Madan R, Dracham CB, Khosla D, Das N, Dey T, Elangovan A, Tripathi M, Gupta K, Ahuja CK, Kapoor R
Clin Neurol Neurosurg 2021 Mar;202:106481. Epub 2021 Jan 13 doi: 10.1016/j.clineuro.2021.106481. PMID: 33508649
Central Nervous System Germinomas Express Programmed Death Ligand 1.
Wildeman ME, Shepard MJ, Oldfield EH, Lopes MBS
J Neuropathol Exp Neurol 2018 Apr 1;77(4):312-316. doi: 10.1093/jnen/nly008. PMID: 29415126
Clinical use of (11)C-methionine and (18)F-FDG-PET for germinoma in central nervous system.
Okochi Y, Nihashi T, Fujii M, Kato K, Okada Y, Ando Y, Maesawa S, Takebayashi S, Wakabayashi T, Naganawa S
Ann Nucl Med 2014 Feb;28(2):94-102. Epub 2013 Nov 24 doi: 10.1007/s12149-013-0787-4. PMID: 24272066Free PMC Article
New immunohistochemical markers in the evaluation of central nervous system tumors: a review of 7 selected adult and pediatric brain tumors.
Takei H, Bhattacharjee MB, Rivera A, Dancer Y, Powell SZ
Arch Pathol Lab Med 2007 Feb;131(2):234-41. doi: 10.5858/2007-131-234-NIMITE. PMID: 17284108

Recent systematic reviews

Basal Ganglia Germ Cell Tumors With or Without Sellar Involvement: A Long-Term Follow-Up in a Single Medical Center and a Systematic Literature Review.
Zhang Y, Wang L, Ma W, Pan H, Wang R, Zhu H, Yao Y
Front Endocrinol (Lausanne) 2021;12:763609. Epub 2021 Nov 10 doi: 10.3389/fendo.2021.763609. PMID: 34858336Free PMC Article
Proton Therapy in Children: A Systematic Review of Clinical Effectiveness in 15 Pediatric Cancers.
Leroy R, Benahmed N, Hulstaert F, Van Damme N, De Ruysscher D
Int J Radiat Oncol Biol Phys 2016 May 1;95(1):267-278. Epub 2015 Oct 17 doi: 10.1016/j.ijrobp.2015.10.025. PMID: 27084646
Postradiation lower motor neuron syndrome: case series and literature review.
Abraham A, Drory VE
J Neurol 2013 Jul;260(7):1802-6. Epub 2013 Mar 5 doi: 10.1007/s00415-013-6881-7. PMID: 23463367

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