Format

Send to:

Choose Destination

Neoplasm of the central nervous system

MedGen UID:
88335
Concept ID:
C0085136
Neoplastic Process
Synonym: Central nervous system neoplasm
SNOMED CT: Neoplasm of central nervous system (126951006)
 
HPO: HP:0100006
Monarch Initiative: MONDO:0006130

Definition

A neoplasm of the central nervous system. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Neoplasm of the central nervous system

Conditions with this feature

Prostate cancer/brain cancer susceptibility
MedGen UID:
400334
Concept ID:
C1863600
Finding
Prostate cancer is a common disease that affects men, usually in middle age or later. In this disorder, certain cells in the prostate become abnormal, multiply without control or order, and form a tumor. The prostate is a gland that surrounds the male urethra and helps produce semen, the fluid that carries sperm.\n\nEarly prostate cancer usually does not cause pain, and most affected men exhibit no noticeable symptoms. Men are often diagnosed as the result of health screenings, such as a blood test for a substance called prostate specific antigen (PSA) or a medical exam called a digital rectal exam (DRE). As the tumor grows larger, signs and symptoms can include difficulty starting or stopping the flow of urine, a feeling of not being able to empty the bladder completely, blood in the urine or semen, or pain with ejaculation. However, these changes can also occur with many other genitourinary conditions. Having one or more of these symptoms does not necessarily mean that a man has prostate cancer.\n\nThe severity and outcome of prostate cancer varies widely. Early-stage prostate cancer can usually be treated successfully, and some older men have prostate tumors that grow so slowly that they may never cause health problems during their lifetime, even without treatment. In other men, however, the cancer is much more aggressive; in these cases, prostate cancer can be life-threatening.\n\nSome cancerous tumors can invade surrounding tissue and spread to other parts of the body. Tumors that begin at one site and then spread to other areas of the body are called metastatic cancers. The signs and symptoms of metastatic cancer depend on where the disease has spread. If prostate cancer spreads, cancerous cells most often appear in the lymph nodes, bones, lungs, liver, or brain. \n\nA small percentage of prostate cancers are hereditary and occur in families. These hereditary cancers are associated with inherited gene variants. Hereditary prostate cancers tend to develop earlier in life than non-inherited (sporadic) cases.

Professional guidelines

PubMed

Bartusik-Aebisher D, Żołyniak A, Barnaś E, Machorowska-Pieniążek A, Oleś P, Kawczyk-Krupka A, Aebisher D
Molecules 2022 Oct 13;27(20) doi: 10.3390/molecules27206847. PMID: 36296440Free PMC Article
Tabibkhooei A, Izadpanahi M, Arab A, Zare-Mirzaei A, Minaeian S, Rostami A, Mohsenian A
Clin Neurol Neurosurg 2020 Mar;190:105652. Epub 2019 Dec 27 doi: 10.1016/j.clineuro.2019.105652. PMID: 31896490

Recent clinical studies

Etiology

Onyekachi IA, Chidiebere CE, Bankole DO, Okechukwu CO, Babatunde JO
West Afr J Med 2023 Nov 10;40(11 Suppl 1):S23. PMID: 37976251
Miller KE, Schieffer KM, Grischow O, Rodriguez DP, Cottrell CE, Leonard JR, Finlay JL, Mardis ER
Cold Spring Harb Mol Case Stud 2021 Apr;7(2) Epub 2021 Apr 8 doi: 10.1101/mcs.a006023. PMID: 33637608Free PMC Article
Junior LGD, Baroni M, Lira RCP, Teixeira S, Fedatto PF, Silveira VS, Suazo VK, Veronez LC, Panepucci RA, Antônio DSM, Yunes JA, Brandalise SR, Dos Santos Aguiar S, Neder L, de Oliveira RS, Machado HR, Carlotti CG Jr, Tone LG, Valera ET, Scrideli CA
Mol Biol Rep 2020 Sep;47(9):6949-6959. Epub 2020 Sep 4 doi: 10.1007/s11033-020-05754-3. PMID: 32888124
Tabibkhooei A, Izadpanahi M, Arab A, Zare-Mirzaei A, Minaeian S, Rostami A, Mohsenian A
Clin Neurol Neurosurg 2020 Mar;190:105652. Epub 2019 Dec 27 doi: 10.1016/j.clineuro.2019.105652. PMID: 31896490
Classen J, Hehr T, Paulus W, Plate K, Bamberg M
J Neurooncol 2002 May;58(1):39-46. doi: 10.1023/a:1015872207398. PMID: 12160139

Diagnosis

Bartusik-Aebisher D, Żołyniak A, Barnaś E, Machorowska-Pieniążek A, Oleś P, Kawczyk-Krupka A, Aebisher D
Molecules 2022 Oct 13;27(20) doi: 10.3390/molecules27206847. PMID: 36296440Free PMC Article
Mende KC, Pantel TF, Flitsch J
Exp Clin Endocrinol Diabetes 2021 Mar;129(3):172-177. Epub 2020 Aug 4 doi: 10.1055/a-1217-7282. PMID: 32750720
Gessler DJ, Ferreira C, Dusenbery K, Chen CC
Future Oncol 2020 Oct;16(30):2445-2455. Epub 2020 Jul 3 doi: 10.2217/fon-2020-0558. PMID: 32618209
Deng SL, Li YQ, Zhao G
Chin Med J (Engl) 2018 Mar 20;131(6):721-730. doi: 10.4103/0366-6999.226900. PMID: 29521296Free PMC Article
Gopal P, Parker JR, Debski R, Parker JC Jr
Arch Pathol Lab Med 2008 Aug;132(8):1350-4. doi: 10.5858/2008-132-1350-CPC. PMID: 18684041

Therapy

Bartusik-Aebisher D, Żołyniak A, Barnaś E, Machorowska-Pieniążek A, Oleś P, Kawczyk-Krupka A, Aebisher D
Molecules 2022 Oct 13;27(20) doi: 10.3390/molecules27206847. PMID: 36296440Free PMC Article
Genoud V, Migliorini D
Int J Mol Sci 2021 Mar 28;22(7) doi: 10.3390/ijms22073493. PMID: 33800593Free PMC Article
Miller KE, Schieffer KM, Grischow O, Rodriguez DP, Cottrell CE, Leonard JR, Finlay JL, Mardis ER
Cold Spring Harb Mol Case Stud 2021 Apr;7(2) Epub 2021 Apr 8 doi: 10.1101/mcs.a006023. PMID: 33637608Free PMC Article
Gessler DJ, Ferreira C, Dusenbery K, Chen CC
Future Oncol 2020 Oct;16(30):2445-2455. Epub 2020 Jul 3 doi: 10.2217/fon-2020-0558. PMID: 32618209
Salvati M, Puzzilli F, Bristot R, Cervoni L
Tumori 1994 Jun 30;80(3):220-3. doi: 10.1177/030089169408000311. PMID: 8053080

Prognosis

Hosein Yazdi A, Zarrinpour V, Moslemi E, Forghanifard MM
Iran Biomed J 2022 Jul 1;26(4):301-12. doi: 10.52547/ibj.3671. [Epub ahead of print] PMID: 35490305Free PMC Article
Mende KC, Pantel TF, Flitsch J
Exp Clin Endocrinol Diabetes 2021 Mar;129(3):172-177. Epub 2020 Aug 4 doi: 10.1055/a-1217-7282. PMID: 32750720
Gessler DJ, Ferreira C, Dusenbery K, Chen CC
Future Oncol 2020 Oct;16(30):2445-2455. Epub 2020 Jul 3 doi: 10.2217/fon-2020-0558. PMID: 32618209
Sinha P, Ahmad M, Varghese A, Parekh T, Ismail A, Chakrabarty A, Tyagi A, Chumas P
Eur Spine J 2015 May;24 Suppl 4:S472-84. Epub 2014 Nov 6 doi: 10.1007/s00586-014-3445-1. PMID: 25374299
Gopal P, Parker JR, Debski R, Parker JC Jr
Arch Pathol Lab Med 2008 Aug;132(8):1350-4. doi: 10.5858/2008-132-1350-CPC. PMID: 18684041

Clinical prediction guides

Wang L, Liu Y, Yu Z, Gong J, Deng Z, Ren N, Zhong Z, Cai H, Tang Z, Cheng H, Chen S, He Z
J Transl Med 2021 May 17;19(1):213. doi: 10.1186/s12967-021-02880-9. PMID: 34001135Free PMC Article
Junior LGD, Baroni M, Lira RCP, Teixeira S, Fedatto PF, Silveira VS, Suazo VK, Veronez LC, Panepucci RA, Antônio DSM, Yunes JA, Brandalise SR, Dos Santos Aguiar S, Neder L, de Oliveira RS, Machado HR, Carlotti CG Jr, Tone LG, Valera ET, Scrideli CA
Mol Biol Rep 2020 Sep;47(9):6949-6959. Epub 2020 Sep 4 doi: 10.1007/s11033-020-05754-3. PMID: 32888124
Zanazzi G, Liechty BL, Pendrick D, Krasnozhen-Ratush O, Snuderl M, Allen JC, Garvin JH, Mansukhani MM, Roth KA, Hsiao SJ
Cold Spring Harb Mol Case Stud 2020 Oct;6(5) Epub 2020 Oct 7 doi: 10.1101/mcs.a005660. PMID: 32839179Free PMC Article
Tabibkhooei A, Izadpanahi M, Arab A, Zare-Mirzaei A, Minaeian S, Rostami A, Mohsenian A
Clin Neurol Neurosurg 2020 Mar;190:105652. Epub 2019 Dec 27 doi: 10.1016/j.clineuro.2019.105652. PMID: 31896490
Classen J, Hehr T, Paulus W, Plate K, Bamberg M
J Neurooncol 2002 May;58(1):39-46. doi: 10.1023/a:1015872207398. PMID: 12160139

Recent systematic reviews

Orozco-Mera J, Peralta-Pizza F, Escobar-Vidarte O, Coll-Tello B, Ariza A
Oncology (Williston Park) 2023 Mar 21;37(3):107-117. doi: 10.46883/2023.25920986. PMID: 36961958

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...