U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Adult central nervous system choriocarcinoma

MedGen UID:
234582
•Concept ID:
C1370505
•
Neoplastic Process
Synonyms: Adult Central Nervous System Choriocarcinoma; adult central nervous system choriocarcinoma; adult choriocarcinoma of the central nervous system; Adult CNS Choriocarcinoma; adult CNS choriocarcinoma; Choriocarcinoma of Adult Central Nervous System; choriocarcinoma of adult central nervous system; Choriocarcinoma of Adult CNS; choriocarcinoma of adult CNS; Choriocarcinoma of the Adult Central Nervous System; choriocarcinoma of the adult central nervous system; Choriocarcinoma of the Adult CNS; choriocarcinoma of the adult CNS; choriocarcinoma of the central nervous system of adults
 
Monarch Initiative: MONDO:0003952

Definition

A choriocarcinoma affecting the central nervous system and occurring in adulthood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult central nervous system choriocarcinoma

Professional guidelines

PubMed

Central nervous system germ cell tumors: classification, clinical features, and treatment with a historical overview.
Fujimaki T
J Child Neurol 2009 Nov;24(11):1439-45. doi: 10.1177/0883073809342127. PMID: 19841431
Radiation therapy in the management of gestational choriocarcinoma metastatic to the central nervous system.
Yordan EL Jr, Schlaerth J, Gaddis O, Morrow CP
Obstet Gynecol 1987 Apr;69(4):627-30. PMID: 3822306

Recent clinical studies

Etiology

A rare manifestation of choriocarcinoma syndrome in a child with primary intracranial germ cell tumor and extracranial metastases: A case report and review of the literature.
Keenan C, Ramirez N, Elijovich L, Klimo P Jr, Bag AK, Acharya S, Upadhyaya SA
Pediatr Blood Cancer 2021 Jun;68(6):e29000. Epub 2021 Apr 5 doi: 10.1002/pbc.29000. PMID: 33818876Free PMC Article
Clinicopathological and immunohistochemical features of primary central nervous system germ cell tumors: a 24-years experience.
Gao Y, Jiang J, Liu Q
Int J Clin Exp Pathol 2014;7(10):6965-72. Epub 2014 Sep 15 PMID: 25400782Free PMC Article
Pediatric central nervous system tumors: a single-center experience from 1989 to 2009.
Pinho RS, Andreoni S, Silva NS, Cappellano AM, Masruha MR, Cavalheiro S, Vilanova LC
J Pediatr Hematol Oncol 2011 Dec;33(8):605-9. doi: 10.1097/MPH.0b013e31822031d9. PMID: 22031123
Radiation therapy in the management of gestational choriocarcinoma metastatic to the central nervous system.
Yordan EL Jr, Schlaerth J, Gaddis O, Morrow CP
Obstet Gynecol 1987 Apr;69(4):627-30. PMID: 3822306
Central nervous system metastases of choriocarcinoma. 23 years' experience at Charing Cross Hospital.
Athanassiou A, Begent RH, Newlands ES, Parker D, Rustin GJ, Bagshawe KD
Cancer 1983 Nov 1;52(9):1728-35. doi: 10.1002/1097-0142(19831101)52:9<1728::aid-cncr2820520929>3.0.co;2-u. PMID: 6684500

Diagnosis

Primary central nervous system lymphomas with massive intratumoral hemorrhage: Clinical, radiological, pathological, and molecular features of six cases.
Yamada S, Muto J, Iba S, Shiogama K, Tsuyuki Y, Satou A, Ohba S, Murayama K, Sugita Y, Nakamura S, Yokoo H, Tomita A, Hirose Y, Tsukamoto T, Abe M
Neuropathology 2021 Oct;41(5):335-348. Epub 2021 Jul 13 doi: 10.1111/neup.12739. PMID: 34254378
Unusual clinical presentations of choriocarcinoma: A systematic review of case reports.
Mangla M, Singla D, Kaur H, Sharma S
Taiwan J Obstet Gynecol 2017 Feb;56(1):1-8. doi: 10.1016/j.tjog.2015.05.011. PMID: 28254207
Clinicopathological and immunohistochemical features of primary central nervous system germ cell tumors: a 24-years experience.
Gao Y, Jiang J, Liu Q
Int J Clin Exp Pathol 2014;7(10):6965-72. Epub 2014 Sep 15 PMID: 25400782Free PMC Article
Pediatric central nervous system tumors: a single-center experience from 1989 to 2009.
Pinho RS, Andreoni S, Silva NS, Cappellano AM, Masruha MR, Cavalheiro S, Vilanova LC
J Pediatr Hematol Oncol 2011 Dec;33(8):605-9. doi: 10.1097/MPH.0b013e31822031d9. PMID: 22031123
Central nervous system germ cell tumors: classification, clinical features, and treatment with a historical overview.
Fujimaki T
J Child Neurol 2009 Nov;24(11):1439-45. doi: 10.1177/0883073809342127. PMID: 19841431

Therapy

Delayed effects of whole brain radiotherapy in germ cell tumor patients with central nervous system metastases.
Doyle DM, Einhorn LH
Int J Radiat Oncol Biol Phys 2008 Apr 1;70(5):1361-4. doi: 10.1016/j.ijrobp.2007.11.005. PMID: 18374223
Central nervous system involvement in gestational trophoblastic neoplasia.
Ayhan A, Tuncer ZS, Tanir M, Erbengi A
Acta Obstet Gynecol Scand 1996 Jul;75(6):548-50. doi: 10.3109/00016349609054669. PMID: 8693931
Cerebral metastases from ovarian carcinoma.
LeRoux PD, Berger MS, Elliott JP, Tamimi HK
Cancer 1991 Apr 15;67(8):2194-9. doi: 10.1002/1097-0142(19910415)67:8<2194::aid-cncr2820670832>3.0.co;2-#. PMID: 2004340
Radiation therapy in the management of gestational choriocarcinoma metastatic to the central nervous system.
Yordan EL Jr, Schlaerth J, Gaddis O, Morrow CP
Obstet Gynecol 1987 Apr;69(4):627-30. PMID: 3822306
Central nervous system metastases of choriocarcinoma. 23 years' experience at Charing Cross Hospital.
Athanassiou A, Begent RH, Newlands ES, Parker D, Rustin GJ, Bagshawe KD
Cancer 1983 Nov 1;52(9):1728-35. doi: 10.1002/1097-0142(19831101)52:9<1728::aid-cncr2820520929>3.0.co;2-u. PMID: 6684500

Prognosis

12p gain is predominantly observed in non-germinomatous germ cell tumors and identifies an unfavorable subgroup of central nervous system germ cell tumors.
Satomi K, Takami H, Fukushima S, Yamashita S, Matsushita Y, Nakazato Y, Suzuki T, Tanaka S, Mukasa A, Saito N, Kanamori M, Kumabe T, Tominaga T, Kobayashi K, Nagane M, Iuchi T, Yoshimoto K, Tamura K, Maehara T, Sakai K, Sugiyama K, Yokogami K, Takeshima H, Nonaka M, Asai A, Ushijima T, Matsutani M, Nishikawa R, Ichimura K
Neuro Oncol 2022 May 4;24(5):834-846. doi: 10.1093/neuonc/noab246. PMID: 34698864Free PMC Article
Unusual clinical presentations of choriocarcinoma: A systematic review of case reports.
Mangla M, Singla D, Kaur H, Sharma S
Taiwan J Obstet Gynecol 2017 Feb;56(1):1-8. doi: 10.1016/j.tjog.2015.05.011. PMID: 28254207
Clinicopathological and immunohistochemical features of primary central nervous system germ cell tumors: a 24-years experience.
Gao Y, Jiang J, Liu Q
Int J Clin Exp Pathol 2014;7(10):6965-72. Epub 2014 Sep 15 PMID: 25400782Free PMC Article
Nestin expression in central nervous system germ cell tumors.
Sakurada K, Saino M, Mouri W, Sato A, Kitanaka C, Kayama T
Neurosurg Rev 2008 Apr;31(2):173-6; discussion 176-7. Epub 2007 Dec 19 doi: 10.1007/s10143-007-0115-3. PMID: 18092184
Central nervous system metastases of choriocarcinoma. 23 years' experience at Charing Cross Hospital.
Athanassiou A, Begent RH, Newlands ES, Parker D, Rustin GJ, Bagshawe KD
Cancer 1983 Nov 1;52(9):1728-35. doi: 10.1002/1097-0142(19831101)52:9<1728::aid-cncr2820520929>3.0.co;2-u. PMID: 6684500

Clinical prediction guides

12p gain is predominantly observed in non-germinomatous germ cell tumors and identifies an unfavorable subgroup of central nervous system germ cell tumors.
Satomi K, Takami H, Fukushima S, Yamashita S, Matsushita Y, Nakazato Y, Suzuki T, Tanaka S, Mukasa A, Saito N, Kanamori M, Kumabe T, Tominaga T, Kobayashi K, Nagane M, Iuchi T, Yoshimoto K, Tamura K, Maehara T, Sakai K, Sugiyama K, Yokogami K, Takeshima H, Nonaka M, Asai A, Ushijima T, Matsutani M, Nishikawa R, Ichimura K
Neuro Oncol 2022 May 4;24(5):834-846. doi: 10.1093/neuonc/noab246. PMID: 34698864Free PMC Article
Primary central nervous system lymphomas with massive intratumoral hemorrhage: Clinical, radiological, pathological, and molecular features of six cases.
Yamada S, Muto J, Iba S, Shiogama K, Tsuyuki Y, Satou A, Ohba S, Murayama K, Sugita Y, Nakamura S, Yokoo H, Tomita A, Hirose Y, Tsukamoto T, Abe M
Neuropathology 2021 Oct;41(5):335-348. Epub 2021 Jul 13 doi: 10.1111/neup.12739. PMID: 34254378
Choriocarcinoma with brain metastasis after term pregnancy: A case report.
Song L, Li Q, Yin R, Wang D
Medicine (Baltimore) 2018 Oct;97(42):e12904. doi: 10.1097/MD.0000000000012904. PMID: 30335019Free PMC Article
Clinicopathological and immunohistochemical features of primary central nervous system germ cell tumors: a 24-years experience.
Gao Y, Jiang J, Liu Q
Int J Clin Exp Pathol 2014;7(10):6965-72. Epub 2014 Sep 15 PMID: 25400782Free PMC Article
Nestin expression in central nervous system germ cell tumors.
Sakurada K, Saino M, Mouri W, Sato A, Kitanaka C, Kayama T
Neurosurg Rev 2008 Apr;31(2):173-6; discussion 176-7. Epub 2007 Dec 19 doi: 10.1007/s10143-007-0115-3. PMID: 18092184

Recent systematic reviews

Unusual clinical presentations of choriocarcinoma: A systematic review of case reports.
Mangla M, Singla D, Kaur H, Sharma S
Taiwan J Obstet Gynecol 2017 Feb;56(1):1-8. doi: 10.1016/j.tjog.2015.05.011. PMID: 28254207

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...