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Adult central nervous system choriocarcinoma

MedGen UID:
234582
•Concept ID:
C1370505
•
Neoplastic Process
Synonyms: Adult Central Nervous System Choriocarcinoma; adult central nervous system choriocarcinoma; adult choriocarcinoma of the central nervous system; Adult CNS Choriocarcinoma; adult CNS choriocarcinoma; Choriocarcinoma of Adult Central Nervous System; choriocarcinoma of adult central nervous system; Choriocarcinoma of Adult CNS; choriocarcinoma of adult CNS; Choriocarcinoma of the Adult Central Nervous System; choriocarcinoma of the adult central nervous system; Choriocarcinoma of the Adult CNS; choriocarcinoma of the adult CNS; choriocarcinoma of the central nervous system of adults
 
Monarch Initiative: MONDO:0003952

Definition

A choriocarcinoma affecting the central nervous system and occurring in adulthood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult central nervous system choriocarcinoma

Professional guidelines

PubMed

Central nervous system germ cell tumors: classification, clinical features, and treatment with a historical overview.
Fujimaki T
J Child Neurol 2009 Nov;24(11):1439-45. doi: 10.1177/0883073809342127. PMID: 19841431
Radiation therapy in the management of gestational choriocarcinoma metastatic to the central nervous system.
Yordan EL Jr, Schlaerth J, Gaddis O, Morrow CP
Obstet Gynecol 1987 Apr;69(4):627-30. PMID: 3822306

Recent clinical studies

Etiology

Clinicopathological and immunohistochemical features of primary central nervous system germ cell tumors: a 24-years experience.
Gao Y, Jiang J, Liu Q
Int J Clin Exp Pathol 2014;7(10):6965-72. Epub 2014 Sep 15 PMID: 25400782Free PMC Article
Pediatric central nervous system tumors: a single-center experience from 1989 to 2009.
Pinho RS, Andreoni S, Silva NS, Cappellano AM, Masruha MR, Cavalheiro S, Vilanova LC
J Pediatr Hematol Oncol 2011 Dec;33(8):605-9. doi: 10.1097/MPH.0b013e31822031d9. PMID: 22031123
Primary intracranial choriocarcinoma: MR imaging findings.
Lv XF, Qiu YW, Zhang XL, Han LJ, Qiu SJ, Xiong W, Wen G, Zhang YZ, Zhang J
AJNR Am J Neuroradiol 2010 Nov;31(10):1994-8. Epub 2010 Jul 8 doi: 10.3174/ajnr.A2194. PMID: 20616180Free PMC Article
Radiation therapy in the management of gestational choriocarcinoma metastatic to the central nervous system.
Yordan EL Jr, Schlaerth J, Gaddis O, Morrow CP
Obstet Gynecol 1987 Apr;69(4):627-30. PMID: 3822306
Central nervous system metastases of choriocarcinoma. 23 years' experience at Charing Cross Hospital.
Athanassiou A, Begent RH, Newlands ES, Parker D, Rustin GJ, Bagshawe KD
Cancer 1983 Nov 1;52(9):1728-35. doi: 10.1002/1097-0142(19831101)52:9<1728::aid-cncr2820520929>3.0.co;2-u. PMID: 6684500

Diagnosis

Extragonadal Non-gestational Choriocarcinoma with Tonsillar Presentation.
Payne T, Di Palma S, Walker D, Dakin J, Thompson LDR
Head Neck Pathol 2021 Sep;15(3):1047-1053. Epub 2020 Oct 31 doi: 10.1007/s12105-020-01245-w. PMID: 33128732Free PMC Article
Unusual clinical presentations of choriocarcinoma: A systematic review of case reports.
Mangla M, Singla D, Kaur H, Sharma S
Taiwan J Obstet Gynecol 2017 Feb;56(1):1-8. doi: 10.1016/j.tjog.2015.05.011. PMID: 28254207
Clinicopathological and immunohistochemical features of primary central nervous system germ cell tumors: a 24-years experience.
Gao Y, Jiang J, Liu Q
Int J Clin Exp Pathol 2014;7(10):6965-72. Epub 2014 Sep 15 PMID: 25400782Free PMC Article
Central nervous system germ cell tumors: classification, clinical features, and treatment with a historical overview.
Fujimaki T
J Child Neurol 2009 Nov;24(11):1439-45. doi: 10.1177/0883073809342127. PMID: 19841431
The clinical significance of human alpha-fetoprotein.
Yachnin S
Ann Clin Lab Sci 1978 Mar-Apr;8(2):84-90. PMID: 76458

Therapy

Central nervous system involvement in gestational trophoblastic neoplasia.
Ayhan A, Tuncer ZS, Tanir M, Erbengi A
Acta Obstet Gynecol Scand 1996 Jul;75(6):548-50. doi: 10.3109/00016349609054669. PMID: 8693931
Radiation therapy for primary intracranial germ-cell tumors.
Wolden SL, Wara WM, Larson DA, Prados MD, Edwards MS, Sneed PK
Int J Radiat Oncol Biol Phys 1995 Jul 15;32(4):943-9. doi: 10.1016/0360-3016(95)00067-9. PMID: 7607968
Radiation therapy in the management of gestational choriocarcinoma metastatic to the central nervous system.
Yordan EL Jr, Schlaerth J, Gaddis O, Morrow CP
Obstet Gynecol 1987 Apr;69(4):627-30. PMID: 3822306
Chemotherapy trials in recurrent primary intracranial germ cell tumors.
Allen JC, Bosl G, Walker R
J Neurooncol 1985;3(2):147-52. doi: 10.1007/BF02228891. PMID: 3897472
Central nervous system metastases of choriocarcinoma. 23 years' experience at Charing Cross Hospital.
Athanassiou A, Begent RH, Newlands ES, Parker D, Rustin GJ, Bagshawe KD
Cancer 1983 Nov 1;52(9):1728-35. doi: 10.1002/1097-0142(19831101)52:9<1728::aid-cncr2820520929>3.0.co;2-u. PMID: 6684500

Prognosis

12p gain is predominantly observed in non-germinomatous germ cell tumors and identifies an unfavorable subgroup of central nervous system germ cell tumors.
Satomi K, Takami H, Fukushima S, Yamashita S, Matsushita Y, Nakazato Y, Suzuki T, Tanaka S, Mukasa A, Saito N, Kanamori M, Kumabe T, Tominaga T, Kobayashi K, Nagane M, Iuchi T, Yoshimoto K, Tamura K, Maehara T, Sakai K, Sugiyama K, Yokogami K, Takeshima H, Nonaka M, Asai A, Ushijima T, Matsutani M, Nishikawa R, Ichimura K
Neuro Oncol 2022 May 4;24(5):834-846. doi: 10.1093/neuonc/noab246. PMID: 34698864Free PMC Article
Unusual clinical presentations of choriocarcinoma: A systematic review of case reports.
Mangla M, Singla D, Kaur H, Sharma S
Taiwan J Obstet Gynecol 2017 Feb;56(1):1-8. doi: 10.1016/j.tjog.2015.05.011. PMID: 28254207
Clinicopathological and immunohistochemical features of primary central nervous system germ cell tumors: a 24-years experience.
Gao Y, Jiang J, Liu Q
Int J Clin Exp Pathol 2014;7(10):6965-72. Epub 2014 Sep 15 PMID: 25400782Free PMC Article
Nestin expression in central nervous system germ cell tumors.
Sakurada K, Saino M, Mouri W, Sato A, Kitanaka C, Kayama T
Neurosurg Rev 2008 Apr;31(2):173-6; discussion 176-7. Epub 2007 Dec 19 doi: 10.1007/s10143-007-0115-3. PMID: 18092184
Central nervous system metastases of choriocarcinoma. 23 years' experience at Charing Cross Hospital.
Athanassiou A, Begent RH, Newlands ES, Parker D, Rustin GJ, Bagshawe KD
Cancer 1983 Nov 1;52(9):1728-35. doi: 10.1002/1097-0142(19831101)52:9<1728::aid-cncr2820520929>3.0.co;2-u. PMID: 6684500

Clinical prediction guides

12p gain is predominantly observed in non-germinomatous germ cell tumors and identifies an unfavorable subgroup of central nervous system germ cell tumors.
Satomi K, Takami H, Fukushima S, Yamashita S, Matsushita Y, Nakazato Y, Suzuki T, Tanaka S, Mukasa A, Saito N, Kanamori M, Kumabe T, Tominaga T, Kobayashi K, Nagane M, Iuchi T, Yoshimoto K, Tamura K, Maehara T, Sakai K, Sugiyama K, Yokogami K, Takeshima H, Nonaka M, Asai A, Ushijima T, Matsutani M, Nishikawa R, Ichimura K
Neuro Oncol 2022 May 4;24(5):834-846. doi: 10.1093/neuonc/noab246. PMID: 34698864Free PMC Article
Primary central nervous system lymphomas with massive intratumoral hemorrhage: Clinical, radiological, pathological, and molecular features of six cases.
Yamada S, Muto J, Iba S, Shiogama K, Tsuyuki Y, Satou A, Ohba S, Murayama K, Sugita Y, Nakamura S, Yokoo H, Tomita A, Hirose Y, Tsukamoto T, Abe M
Neuropathology 2021 Oct;41(5):335-348. Epub 2021 Jul 13 doi: 10.1111/neup.12739. PMID: 34254378
Clinicopathological and immunohistochemical features of primary central nervous system germ cell tumors: a 24-years experience.
Gao Y, Jiang J, Liu Q
Int J Clin Exp Pathol 2014;7(10):6965-72. Epub 2014 Sep 15 PMID: 25400782Free PMC Article
Primary choriocarcinoma of the liver: a clinicopathological study of five cases in males.
Shi H, Cao D, Wei L, Sun L, Guo A
Virchows Arch 2010 Jan;456(1):65-70. Epub 2009 Dec 16 doi: 10.1007/s00428-009-0864-1. PMID: 20013345
Nestin expression in central nervous system germ cell tumors.
Sakurada K, Saino M, Mouri W, Sato A, Kitanaka C, Kayama T
Neurosurg Rev 2008 Apr;31(2):173-6; discussion 176-7. Epub 2007 Dec 19 doi: 10.1007/s10143-007-0115-3. PMID: 18092184

Recent systematic reviews

Unusual clinical presentations of choriocarcinoma: A systematic review of case reports.
Mangla M, Singla D, Kaur H, Sharma S
Taiwan J Obstet Gynecol 2017 Feb;56(1):1-8. doi: 10.1016/j.tjog.2015.05.011. PMID: 28254207

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