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Small Lymphocytic Lymphoma with Plasmacytoid Differentiation

MedGen UID:
234792
•Concept ID:
C1336012
•
Neoplastic Process

Definition

A small lymphocytic lymphoma characterized by the presence of neoplastic lymphocytes with plasmacytoid morphology. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall Lymphocytic Lymphoma with Plasmacytoid Differentiation

Professional guidelines

PubMed

Prognostic factors and indications for treatment of Waldenström's Macroglobulinemia.
Kyle RA, Ansell SM, Kapoor P
Best Pract Res Clin Haematol 2016 Jun;29(2):179-186. Epub 2016 Aug 23 doi: 10.1016/j.beha.2016.08.014. PMID: 27825464Free PMC Article
E2A-positive gastric MALT lymphoma has weaker plasmacytoid infiltrates and stronger expression of the memory B-cell-associated miR-223: possible correlation with stage and treatment response.
Liu TY, Chen SU, Kuo SH, Cheng AL, Lin CW
Mod Pathol 2010 Nov;23(11):1507-17. Epub 2010 Aug 27 doi: 10.1038/modpathol.2010.139. PMID: 20802470
Lymphoplasmacytic lymphoma/immunocytoma: towards a disease-targeted treatment?
Clavio M, Quintino S, Venturino C, Ballerini F, Varaldo R, Gatto S, Galbusera V, Garrone A, Grasso R, Canepa L, Miglino M, Pierri I, Gobbi M
J Exp Clin Cancer Res 2001 Sep;20(3):351-8. PMID: 11718214

Recent clinical studies

Etiology

Prognostic factors and indications for treatment of Waldenström's Macroglobulinemia.
Kyle RA, Ansell SM, Kapoor P
Best Pract Res Clin Haematol 2016 Jun;29(2):179-186. Epub 2016 Aug 23 doi: 10.1016/j.beha.2016.08.014. PMID: 27825464Free PMC Article
Cytomorphologic spectrum of small lymphocytic lymphoma in patients with an accelerated clinical course.
Shin HJ, Caraway NP, Katz RL
Cancer 2003 Oct 25;99(5):293-300. doi: 10.1002/cncr.11441. PMID: 14579296
Lymphoplasmacytic lymphoma/immunocytoma: towards a disease-targeted treatment?
Clavio M, Quintino S, Venturino C, Ballerini F, Varaldo R, Gatto S, Galbusera V, Garrone A, Grasso R, Canepa L, Miglino M, Pierri I, Gobbi M
J Exp Clin Cancer Res 2001 Sep;20(3):351-8. PMID: 11718214
Non-Hodgkin's lymphomas: an ultrastructural study correlating morphology with immunologic cell type.
Said JW, Hargreaves HK, Pinkus GS
Cancer 1979 Aug;44(2):504-28. doi: 10.1002/1097-0142(197908)44:2<504::aid-cncr2820440221>3.0.co;2-h. PMID: 383256
Lymphomas of the gastrointestinal tract: a study of 117 cases presenting with gastrointestinal disease.
Lewin KJ, Ranchod M, Dorfman RF
Cancer 1978 Aug;42(2):693-707. doi: 10.1002/1097-0142(197808)42:2<693::aid-cncr2820420241>3.0.co;2-j. PMID: 354774

Diagnosis

Prognostic factors and indications for treatment of Waldenström's Macroglobulinemia.
Kyle RA, Ansell SM, Kapoor P
Best Pract Res Clin Haematol 2016 Jun;29(2):179-186. Epub 2016 Aug 23 doi: 10.1016/j.beha.2016.08.014. PMID: 27825464Free PMC Article
Regulation of the MIR155 host gene in physiological and pathological processes.
Elton TS, Selemon H, Elton SM, Parinandi NL
Gene 2013 Dec 10;532(1):1-12. Epub 2012 Dec 14 doi: 10.1016/j.gene.2012.12.009. PMID: 23246696
Extranodal lymphoplasmacytoid lymphoma: spectrum of disease.
Guermazi A, Meignin V, Brice P
Eur Radiol 2003 Apr;13(4):771-9. Epub 2002 Jul 18 doi: 10.1007/s00330-002-1532-x. PMID: 12664116
Lymphoplasmacytic lymphoma/immunocytoma: towards a disease-targeted treatment?
Clavio M, Quintino S, Venturino C, Ballerini F, Varaldo R, Gatto S, Galbusera V, Garrone A, Grasso R, Canepa L, Miglino M, Pierri I, Gobbi M
J Exp Clin Cancer Res 2001 Sep;20(3):351-8. PMID: 11718214
Cytochemical analysis of acid hydrolases expression during phorbol diester (TPA)-driven differentiation of B-chronic lymphocytic leukaemia cells in vitro.
Dufer J, Bernard J
Leuk Res 1984;8(5):813-20. doi: 10.1016/0145-2126(84)90102-4. PMID: 6333564

Therapy

Blastic plasmacytoid dendritic cell neoplasm in the background of myeloproliferative disorder and chronic lymphocytic leukaemia.
Khan AM, Munir A, Raval M, Mehdi S
BMJ Case Rep 2019 Jul 15;12(7) doi: 10.1136/bcr-2019-230332. PMID: 31308179Free PMC Article
Chronic lymphocytic leukemia With t(2;14)(p16;q32) involves the BCL11A and IgH genes and is associated with atypical morphologic features and unmutated IgVH genes.
Yin CC, Lin KI, Ketterling RP, Knudson RA, Medeiros LJ, Barron LL, Huh YO, Luthra R, Keating MJ, Abruzzo LV
Am J Clin Pathol 2009 May;131(5):663-70. doi: 10.1309/AJCPXLY46UPFLISC. PMID: 19369625
t(14;18)(q32;q21)-bearing pleural MALT lymphoma with IgM paraproteinemia: value of detection of specific cytogenetic abnormalities in the differential diagnosis of MALT lymphoma and lymphoplasmacytic lymphoma.
Gomyo H, Kajimoto K, Maeda A, Mizuno I, Funada Y, Koizumi T, Fukui E, Hanioka K, Ogura M, Murayama T
Hematology 2007 Aug;12(4):315-8. doi: 10.1080/10245330701383866. PMID: 17654058
Monoclonal gammopathy after low-grade MALT lymphoma: evidence for a second neoplasm.
Pachmann S, Anderegg B, Müller-Höcker J, Nathrath W, Brack N, Tigges FJ, Hartenstein R, Munker R
Am J Hematol 2002 Jun;70(2):167-73. doi: 10.1002/ajh.10104. PMID: 12111792
Lymphoplasmacytic lymphoma/immunocytoma: towards a disease-targeted treatment?
Clavio M, Quintino S, Venturino C, Ballerini F, Varaldo R, Gatto S, Galbusera V, Garrone A, Grasso R, Canepa L, Miglino M, Pierri I, Gobbi M
J Exp Clin Cancer Res 2001 Sep;20(3):351-8. PMID: 11718214

Prognosis

Blastic plasmacytoid dendritic cell neoplasm in the background of myeloproliferative disorder and chronic lymphocytic leukaemia.
Khan AM, Munir A, Raval M, Mehdi S
BMJ Case Rep 2019 Jul 15;12(7) doi: 10.1136/bcr-2019-230332. PMID: 31308179Free PMC Article
Prognostic factors and indications for treatment of Waldenström's Macroglobulinemia.
Kyle RA, Ansell SM, Kapoor P
Best Pract Res Clin Haematol 2016 Jun;29(2):179-186. Epub 2016 Aug 23 doi: 10.1016/j.beha.2016.08.014. PMID: 27825464Free PMC Article
Cytomorphologic spectrum of small lymphocytic lymphoma in patients with an accelerated clinical course.
Shin HJ, Caraway NP, Katz RL
Cancer 2003 Oct 25;99(5):293-300. doi: 10.1002/cncr.11441. PMID: 14579296
Extranodal lymphoplasmacytoid lymphoma: spectrum of disease.
Guermazi A, Meignin V, Brice P
Eur Radiol 2003 Apr;13(4):771-9. Epub 2002 Jul 18 doi: 10.1007/s00330-002-1532-x. PMID: 12664116
Non-Hodgkin's lymphomas: an ultrastructural study correlating morphology with immunologic cell type.
Said JW, Hargreaves HK, Pinkus GS
Cancer 1979 Aug;44(2):504-28. doi: 10.1002/1097-0142(197908)44:2<504::aid-cncr2820440221>3.0.co;2-h. PMID: 383256

Clinical prediction guides

Comparison of Myocyte Enhancer Factor 2B Versus Other Germinal Center-associated Antigens in the Differential Diagnosis of B-Cell Non-Hodgkin Lymphomas.
Moore EM, Swerdlow SH, Gibson SE
Am J Surg Pathol 2018 Mar;42(3):342-350. doi: 10.1097/PAS.0000000000001015. PMID: 29309299
Clinicopathologic features of Waldenstrom's macroglobulinemia and marginal zone lymphoma: are they distinct or the same entity?
Berger F, Traverse-Glehen A, Felman P, Callet-Bauchu E, Baseggio L, Gazzo S, Thieblemont C, Ffrench M, Magaud JP, Salles G, Coiffer B
Clin Lymphoma 2005 Mar;5(4):220-4. doi: 10.3816/clm.2005.n.003. PMID: 15794852
Distinction between small lymphocytic and mantle cell lymphoma by immunoreactivity for CD23.
Dorfman DM, Pinkus GS
Mod Pathol 1994 Apr;7(3):326-31. PMID: 8058704
"Well-differentiated" lymphocytic neoplasms. Immunologic findings correlated with clinical presentation and morphologic features.
Medeiros LJ, Strickler JG, Picker LJ, Gelb AB, Weiss LM, Warnke RA
Am J Pathol 1987 Dec;129(3):523-35. PMID: 3322023Free PMC Article
Non-Hodgkin's lymphomas: an ultrastructural study correlating morphology with immunologic cell type.
Said JW, Hargreaves HK, Pinkus GS
Cancer 1979 Aug;44(2):504-28. doi: 10.1002/1097-0142(197908)44:2<504::aid-cncr2820440221>3.0.co;2-h. PMID: 383256

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