U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Stage IV Extrahepatic Bile Duct Cancer

MedGen UID:
234883
•Concept ID:
C1336417
•
Neoplastic Process

Definition

Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 6th ed.) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStage IV Extrahepatic Bile Duct Cancer

Professional guidelines

PubMed

Surgical treatment and prognostic factors in perihilar tumors.
Polyakov AN, Patyutko YI, Kotelnikov AG, Frantsev DY, Korshak AV, Uzbekova AA, Egenov OA, Pokataev IA, Savchenko IV, Podluzhny DV
Khirurgiia (Mosk) 2024;(2):14-23. doi: 10.17116/hirurgia202402114. PMID: 38344956
Stereotactic body radiotherapy in the management of oligometastatic and recurrent biliary tract cancer: single-institution analysis of outcome and toxicity.
Franzese C, Bonu ML, Comito T, Clerici E, Loi M, Navarria P, Franceschini D, Pressiani T, Rimassa L, Scorsetti M
J Cancer Res Clin Oncol 2020 Sep;146(9):2289-2297. Epub 2020 Jun 10 doi: 10.1007/s00432-020-03285-9. PMID: 32524292
Management of hepatic vascular diseases.
Plessier A, Rautou PE, Valla DC
J Hepatol 2012;56 Suppl 1:S25-38. doi: 10.1016/S0168-8278(12)60004-X. PMID: 22300463

Recent clinical studies

Etiology

Serum carcinoembryonic antigen and carbohydrate antigen 19-9 as preoperative diagnostic biomarkers of extrahepatic bile duct cancer.
Kim HS, Han Y, Kang JS, Kang YH, Lee M, Sohn HJ, Kim H, Kwon W, Jang JY
BJS Open 2021 Nov 9;5(6) doi: 10.1093/bjsopen/zrab127. PMID: 34935900Free PMC Article
The expressions of HMGA2 and Thy1 in extrahepatic cholangiocarcinoma and their clinicopathological significances.
Liu R, Yang Z, Huang S, Li D, Zou Q, Yuan Y
Surg Oncol 2019 Jun;29:41-47. Epub 2019 Feb 14 doi: 10.1016/j.suronc.2019.01.013. PMID: 31196492
Combined extrahepatic bile duct resection for locally advanced gallbladder carcinoma: does it work?
Igami T, Ebata T, Yokoyama Y, Sugawara G, Mizuno T, Yamaguchi J, Shimoyama Y, Nagino M
World J Surg 2015 Jul;39(7):1810-7. doi: 10.1007/s00268-015-3011-y. PMID: 25663014
Salvage surgery for uncontrollable hepatocellular carcinoma treated with repeated non-surgical therapies.
Ochiai T, Sonoyama T, Ikoma H, Kuriu Y, Nakanishi M, Kubota T, Kikuchi S, Ichikawa D, Fujiwara H, Okamoto K, Sakakura C, Kokuba Y, Otsuji E
Hepatogastroenterology 2010 Jul-Aug;57(101):858-64. PMID: 21033242
Management of carcinoma of the gallbladder: a single-institution experience in 16 years.
Chan SY, Poon RT, Lo CM, Ng KK, Fan ST
J Surg Oncol 2008 Feb 1;97(2):156-64. doi: 10.1002/jso.20885. PMID: 18050290

Diagnosis

Serum carcinoembryonic antigen and carbohydrate antigen 19-9 as preoperative diagnostic biomarkers of extrahepatic bile duct cancer.
Kim HS, Han Y, Kang JS, Kang YH, Lee M, Sohn HJ, Kim H, Kwon W, Jang JY
BJS Open 2021 Nov 9;5(6) doi: 10.1093/bjsopen/zrab127. PMID: 34935900Free PMC Article
Overall Survival and Clinical Characteristics of BRCA-Associated Cholangiocarcinoma: A Multicenter Retrospective Study.
Golan T, Raitses-Gurevich M, Kelley RK, Bocobo AG, Borgida A, Shroff RT, Holter S, Gallinger S, Ahn DH, Aderka D, Apurva J, Bekaii-Saab T, Friedman E, Javle M
Oncologist 2017 Jul;22(7):804-810. Epub 2017 May 9 doi: 10.1634/theoncologist.2016-0415. PMID: 28487467Free PMC Article
Management of hepatic vascular diseases.
Plessier A, Rautou PE, Valla DC
J Hepatol 2012;56 Suppl 1:S25-38. doi: 10.1016/S0168-8278(12)60004-X. PMID: 22300463
Management of carcinoma of the gallbladder: a single-institution experience in 16 years.
Chan SY, Poon RT, Lo CM, Ng KK, Fan ST
J Surg Oncol 2008 Feb 1;97(2):156-64. doi: 10.1002/jso.20885. PMID: 18050290
Proximal bile duct cancer: high resectability rate and 5-year survival.
Launois B, Terblanche J, Lakehal M, Catheline JM, Bardaxoglou E, Landen S, Campion JP, Sutherland F, Meunier B
Ann Surg 1999 Aug;230(2):266-75. doi: 10.1097/00000658-199908000-00018. PMID: 10450742Free PMC Article

Therapy

Surgical treatment and prognostic factors in perihilar tumors.
Polyakov AN, Patyutko YI, Kotelnikov AG, Frantsev DY, Korshak AV, Uzbekova AA, Egenov OA, Pokataev IA, Savchenko IV, Podluzhny DV
Khirurgiia (Mosk) 2024;(2):14-23. doi: 10.17116/hirurgia202402114. PMID: 38344956
Phase II Study of Ramucirumab in Advanced Biliary Tract Cancer Previously Treated By Gemcitabine-Based Chemotherapy.
Lee S, Shroff RT, Makawita S, Xiao L, Danner De Armas A, Bhosale P, Reddy K, Shalaby A, Raghav K, Pant S, Wolff RA, Javle M
Clin Cancer Res 2022 Jun 1;28(11):2229-2236. doi: 10.1158/1078-0432.CCR-21-3548. PMID: 35312753
Stereotactic body radiotherapy in the management of oligometastatic and recurrent biliary tract cancer: single-institution analysis of outcome and toxicity.
Franzese C, Bonu ML, Comito T, Clerici E, Loi M, Navarria P, Franceschini D, Pressiani T, Rimassa L, Scorsetti M
J Cancer Res Clin Oncol 2020 Sep;146(9):2289-2297. Epub 2020 Jun 10 doi: 10.1007/s00432-020-03285-9. PMID: 32524292
The Efficacy and Limitations of Postoperative Adjuvant Chemotherapy in Patients With Extrahepatic Cholangiocarcinoma.
Morino K, Seo S, Yoh T, Nishino H, Yamanaka K, Fukumitsu K, Ishii T, Taura K, Okajima H, Kaido T, Uemoto S
Anticancer Res 2019 Apr;39(4):2155-2161. doi: 10.21873/anticanres.13329. PMID: 30952762
Proximal bile duct cancer: high resectability rate and 5-year survival.
Launois B, Terblanche J, Lakehal M, Catheline JM, Bardaxoglou E, Landen S, Campion JP, Sutherland F, Meunier B
Ann Surg 1999 Aug;230(2):266-75. doi: 10.1097/00000658-199908000-00018. PMID: 10450742Free PMC Article

Prognosis

The expressions of HMGA2 and Thy1 in extrahepatic cholangiocarcinoma and their clinicopathological significances.
Liu R, Yang Z, Huang S, Li D, Zou Q, Yuan Y
Surg Oncol 2019 Jun;29:41-47. Epub 2019 Feb 14 doi: 10.1016/j.suronc.2019.01.013. PMID: 31196492
Combined extrahepatic bile duct resection for locally advanced gallbladder carcinoma: does it work?
Igami T, Ebata T, Yokoyama Y, Sugawara G, Mizuno T, Yamaguchi J, Shimoyama Y, Nagino M
World J Surg 2015 Jul;39(7):1810-7. doi: 10.1007/s00268-015-3011-y. PMID: 25663014
Salvage surgery for uncontrollable hepatocellular carcinoma treated with repeated non-surgical therapies.
Ochiai T, Sonoyama T, Ikoma H, Kuriu Y, Nakanishi M, Kubota T, Kikuchi S, Ichikawa D, Fujiwara H, Okamoto K, Sakakura C, Kokuba Y, Otsuji E
Hepatogastroenterology 2010 Jul-Aug;57(101):858-64. PMID: 21033242
Management of carcinoma of the gallbladder: a single-institution experience in 16 years.
Chan SY, Poon RT, Lo CM, Ng KK, Fan ST
J Surg Oncol 2008 Feb 1;97(2):156-64. doi: 10.1002/jso.20885. PMID: 18050290
Hepatopancreatoduodenectomy: its suitability for bile duct cancer versus gallbladder cancer.
Kaneoka Y, Yamaguchi A, Isogai M
J Hepatobiliary Pancreat Surg 2007;14(2):142-8. Epub 2007 Mar 27 doi: 10.1007/s00534-006-1108-2. PMID: 17384904

Clinical prediction guides

Impact of histopathological type on the prognosis of ampullary carcinoma: A systematic review and meta-analysis.
Shin DW, Kim S, Jung K, Jung JH, Kim B, Ahn J, Kim J, Hwang JH, Lee JC
Eur J Surg Oncol 2023 Feb;49(2):306-315. Epub 2022 Oct 9 doi: 10.1016/j.ejso.2022.10.001. PMID: 36272870
Early-stage T1b adenocarcinoma arising in the remnant cystic duct after laparoscopic cholecystectomy: a case report and literature review.
Prasoon P, Hirose Y, Sakata J, Yuza K, Moro K, Toge K, Miura K, Nagahashi M, Kobayashi T, Nihei K, Nakamura A, Wakai T
BMC Surg 2019 Nov 29;19(1):183. doi: 10.1186/s12893-019-0647-9. PMID: 31783817Free PMC Article
Annexin10 promotes extrahepatic cholangiocarcinoma metastasis by facilitating EMT via PLA2G4A/PGE2/STAT3 pathway.
Sun R, Liu Z, Qiu B, Chen T, Li Z, Zhang X, Xu Y, Zhang Z
EBioMedicine 2019 Sep;47:142-155. Epub 2019 Sep 3 doi: 10.1016/j.ebiom.2019.08.062. PMID: 31492557Free PMC Article
A new clinically based staging system for perihilar cholangiocarcinoma.
Chaiteerakij R, Harmsen WS, Marrero CR, Aboelsoud MM, Ndzengue A, Kaiya J, Therneau TM, Sanchez W, Gores GJ, Roberts LR
Am J Gastroenterol 2014 Dec;109(12):1881-90. Epub 2014 Nov 11 doi: 10.1038/ajg.2014.327. PMID: 25384902Free PMC Article
Centrosome abnormalities in human carcinomas of the gallbladder and intrahepatic and extrahepatic bile ducts.
Kuo KK, Sato N, Mizumoto K, Maehara N, Yonemasu H, Ker CG, Sheen PC, Tanaka M
Hepatology 2000 Jan;31(1):59-64. doi: 10.1002/hep.510310112. PMID: 10613729

Recent systematic reviews

Impact of histopathological type on the prognosis of ampullary carcinoma: A systematic review and meta-analysis.
Shin DW, Kim S, Jung K, Jung JH, Kim B, Ahn J, Kim J, Hwang JH, Lee JC
Eur J Surg Oncol 2023 Feb;49(2):306-315. Epub 2022 Oct 9 doi: 10.1016/j.ejso.2022.10.001. PMID: 36272870
Systematic review: should routine resection of the extra-hepatic bile duct be performed in gallbladder cancer?
Shukla PJ, Barreto SG
Saudi J Gastroenterol 2010 Jul-Sep;16(3):161-7. doi: 10.4103/1319-3767.65184. PMID: 20616410Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...