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Thyroid gland mucosa-associated lymphoid tissue lymphoma

MedGen UID:
234948
•Concept ID:
C1336754
•
Neoplastic Process
Synonyms: Thyroid Gland Mucosa-Associated Lymphoid Tissue Lymphoma; thyroid gland mucosa-associated lymphoid tissue lymphoma; Thyroid MALT Lymphoma; thyroid MALT lymphoma; Thyroid Mucosa-Associated Lymphoid Tissue Lymphoma; thyroid mucosa-associated lymphoid tissue lymphoma
 
Monarch Initiative: MONDO:0006464

Definition

An extranodal marginal zone B-cell lymphoma arising from mucosa-associated lymphoid tissue in the thyroid gland. The vast majority of cases are associated with chronic lymphocytic thyroiditis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid gland mucosa-associated lymphoid tissue lymphoma

Professional guidelines

PubMed

A Review of Primary Thyroid Lymphoma: Molecular Factors, Diagnosis and Management.
Pavlidis ET, Pavlidis TE
J Invest Surg 2019 Mar;32(2):137-142. Epub 2017 Oct 23 doi: 10.1080/08941939.2017.1383536. PMID: 29058491
Overview on the management of non-gastric MALT lymphomas.
Defrancesco I, Arcaini L
Best Pract Res Clin Haematol 2018 Mar;31(1):57-64. Epub 2017 Nov 14 doi: 10.1016/j.beha.2017.11.001. PMID: 29452667
Clinical features and management of non-gastrointestinal non-ocular extranodal mucosa associated lymphoid tissue (ENMALT) marginal zone lymphomas.
Matutes E, Montalban C
Best Pract Res Clin Haematol 2017 Mar-Jun;30(1-2):99-108. Epub 2016 Nov 5 doi: 10.1016/j.beha.2016.07.005. PMID: 28288723

Recent clinical studies

Etiology

The usefulness of serial ultrasound in thyroid mucosa-associated lymphoid tissue lymphoma.
Zhang X, Wei B, Nong L, Zhang H, Gao Y, Ou J
Front Endocrinol (Lausanne) 2022;13:1054584. Epub 2022 Dec 16 doi: 10.3389/fendo.2022.1054584. PMID: 36589845Free PMC Article
Overview on the management of non-gastric MALT lymphomas.
Defrancesco I, Arcaini L
Best Pract Res Clin Haematol 2018 Mar;31(1):57-64. Epub 2017 Nov 14 doi: 10.1016/j.beha.2017.11.001. PMID: 29452667
Marginal zone lymphoma: Associated autoimmunity and auto-immune disorders.
Teixeira Mendes LS, Wotherspoon A
Best Pract Res Clin Haematol 2017 Mar-Jun;30(1-2):65-76. Epub 2016 Nov 5 doi: 10.1016/j.beha.2016.07.006. PMID: 28288719
Characteristic ultrasound features of mucosa-associated lymphoid tissue lymphoma of the salivary and thyroid gland.
Orita Y, Sato Y, Kimura N, Marunaka H, Tachibana T, Yamashita Y, Hanakawa H, Yoshino T, Nishizaki K
Acta Otolaryngol 2014 Jan;134(1):93-9. Epub 2013 Nov 21 doi: 10.3109/00016489.2013.831994. PMID: 24256049
Bronchus-associated lymphoid tissue lymphomas: an update of a rare extranodal maltoma.
Zinzani PL, Poletti V, Zompatori M, Tani M, Spaggiari L, Tomassetti S, Broccoli A, Derenzini E, Baccarani M
Clin Lymphoma Myeloma 2007 Nov;7(9):566-72. doi: 10.3816/clm.2007.n.042. PMID: 18186964

Diagnosis

The usefulness of serial ultrasound in thyroid mucosa-associated lymphoid tissue lymphoma.
Zhang X, Wei B, Nong L, Zhang H, Gao Y, Ou J
Front Endocrinol (Lausanne) 2022;13:1054584. Epub 2022 Dec 16 doi: 10.3389/fendo.2022.1054584. PMID: 36589845Free PMC Article
Extranodal Lymphoproliferative Processes.
Zeppa P, Cozzolino I
Monogr Clin Cytol 2018;23:81-92. Epub 2017 Nov 13 doi: 10.1159/000478884. PMID: 29130993
Marginal zone lymphoma: Associated autoimmunity and auto-immune disorders.
Teixeira Mendes LS, Wotherspoon A
Best Pract Res Clin Haematol 2017 Mar-Jun;30(1-2):65-76. Epub 2016 Nov 5 doi: 10.1016/j.beha.2016.07.006. PMID: 28288719
Characteristic ultrasound features of mucosa-associated lymphoid tissue lymphoma of the salivary and thyroid gland.
Orita Y, Sato Y, Kimura N, Marunaka H, Tachibana T, Yamashita Y, Hanakawa H, Yoshino T, Nishizaki K
Acta Otolaryngol 2014 Jan;134(1):93-9. Epub 2013 Nov 21 doi: 10.3109/00016489.2013.831994. PMID: 24256049
MALT Lymphomas.
Malek SN, Hatfield AJ, Flinn IW
Curr Treat Options Oncol 2003 Aug;4(4):269-79. doi: 10.1007/s11864-003-0002-2. PMID: 12943607

Therapy

A Review of Primary Thyroid Lymphoma: Molecular Factors, Diagnosis and Management.
Pavlidis ET, Pavlidis TE
J Invest Surg 2019 Mar;32(2):137-142. Epub 2017 Oct 23 doi: 10.1080/08941939.2017.1383536. PMID: 29058491
Overview on the management of non-gastric MALT lymphomas.
Defrancesco I, Arcaini L
Best Pract Res Clin Haematol 2018 Mar;31(1):57-64. Epub 2017 Nov 14 doi: 10.1016/j.beha.2017.11.001. PMID: 29452667
Primary thyroid lymphoma associated with Graves' disease.
Doi Y, Goto A, Murakami T, Yamashita H, Yamashita H, Noguchi S
Thyroid 2004 Sep;14(9):772-6. doi: 10.1089/thy.2004.14.772. PMID: 15361265
Localized mucosa-associated lymphoid tissue lymphoma treated with radiation therapy has excellent clinical outcome.
Tsang RW, Gospodarowicz MK, Pintilie M, Wells W, Hodgson DC, Sun A, Crump M, Patterson BJ
J Clin Oncol 2003 Nov 15;21(22):4157-64. doi: 10.1200/JCO.2003.06.085. PMID: 14615444
Malignant lymphoma of the thyroid gland: a clinicopathologic study of 108 cases.
Derringer GA, Thompson LD, Frommelt RA, Bijwaard KE, Heffess CS, Abbondanzo SL
Am J Surg Pathol 2000 May;24(5):623-39. doi: 10.1097/00000478-200005000-00001. PMID: 10800981

Prognosis

The usefulness of serial ultrasound in thyroid mucosa-associated lymphoid tissue lymphoma.
Zhang X, Wei B, Nong L, Zhang H, Gao Y, Ou J
Front Endocrinol (Lausanne) 2022;13:1054584. Epub 2022 Dec 16 doi: 10.3389/fendo.2022.1054584. PMID: 36589845Free PMC Article
Clinical features and management of non-gastrointestinal non-ocular extranodal mucosa associated lymphoid tissue (ENMALT) marginal zone lymphomas.
Matutes E, Montalban C
Best Pract Res Clin Haematol 2017 Mar-Jun;30(1-2):99-108. Epub 2016 Nov 5 doi: 10.1016/j.beha.2016.07.005. PMID: 28288723
Marginal zone lymphoma: Associated autoimmunity and auto-immune disorders.
Teixeira Mendes LS, Wotherspoon A
Best Pract Res Clin Haematol 2017 Mar-Jun;30(1-2):65-76. Epub 2016 Nov 5 doi: 10.1016/j.beha.2016.07.006. PMID: 28288719
Extranodal hematopoietic neoplasms and mimics in the head and neck: an update.
Thakral B, Zhou J, Medeiros LJ
Hum Pathol 2015 Aug;46(8):1079-100. Epub 2015 Jun 1 doi: 10.1016/j.humpath.2015.05.007. PMID: 26118762
Bronchus-associated lymphoid tissue lymphomas: an update of a rare extranodal maltoma.
Zinzani PL, Poletti V, Zompatori M, Tani M, Spaggiari L, Tomassetti S, Broccoli A, Derenzini E, Baccarani M
Clin Lymphoma Myeloma 2007 Nov;7(9):566-72. doi: 10.3816/clm.2007.n.042. PMID: 18186964

Clinical prediction guides

The usefulness of serial ultrasound in thyroid mucosa-associated lymphoid tissue lymphoma.
Zhang X, Wei B, Nong L, Zhang H, Gao Y, Ou J
Front Endocrinol (Lausanne) 2022;13:1054584. Epub 2022 Dec 16 doi: 10.3389/fendo.2022.1054584. PMID: 36589845Free PMC Article
Preoperative diagnostic algorithm of primary thyroid lymphoma using ultrasound, aspiration cytology, and flow cytometry.
Hirokawa M, Kudo T, Ota H, Suzuki A, Kobayashi K, Miyauchi A
Endocr J 2017 Sep 30;64(9):859-865. Epub 2017 Jul 8 doi: 10.1507/endocrj.EJ17-0111. PMID: 28690277
Characteristic ultrasound features of mucosa-associated lymphoid tissue lymphoma of the salivary and thyroid gland.
Orita Y, Sato Y, Kimura N, Marunaka H, Tachibana T, Yamashita Y, Hanakawa H, Yoshino T, Nishizaki K
Acta Otolaryngol 2014 Jan;134(1):93-9. Epub 2013 Nov 21 doi: 10.3109/00016489.2013.831994. PMID: 24256049
Clinical features of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue.
Ishii Y, Tomita N, Takasaki H, Ogusa E, Hattori Y, Matsuura S, Matsumoto C, Takemura S, Kuwabara H, Ishigatsubo Y
Hematol Oncol 2012 Dec;30(4):186-9. Epub 2012 Jan 27 doi: 10.1002/hon.2006. PMID: 22287488
Localized mucosa-associated lymphoid tissue lymphoma treated with radiation therapy has excellent clinical outcome.
Tsang RW, Gospodarowicz MK, Pintilie M, Wells W, Hodgson DC, Sun A, Crump M, Patterson BJ
J Clin Oncol 2003 Nov 15;21(22):4157-64. doi: 10.1200/JCO.2003.06.085. PMID: 14615444

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