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Mucosa-associated lymphoma

MedGen UID:
66942
•Concept ID:
C0242647
•
Neoplastic Process
Synonyms: MALT lymphoma; MALT LYMPHOMA, SOMATIC
SNOMED CT: Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (397350003); Nodal marginal zone lymphoma (128803008); Mucosal-associated lymphoid tissue lymphoma (128803008); MALT lymphoma (128803008); Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT-lymphoma) (445269007); Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (445269007); Mucosa-associated lymphoma (277622004); Maltoma (277622004)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
•Concept ID:
C0600599
•
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Non-Mendelian inheritance (Orphanet)
Not genetically inherited (Orphanet)
 
Gene (location): BCL10 (1p22.3)
 
Monarch Initiative: MONDO:0007650
OMIM®: 137245
Orphanet: ORPHA52417

Definition

MALT (mucosa-associated lymphoid tissue) lymphoma is a rare form of malignant non-Hodgkin lymphoma (see this term) that affects B cells and grows at the expense of lymphoid tissue associated with mucous membranes, but also occurs, more rarely, in lymph nodes. [from ORDO]

Clinical features

From HPO
Gastric lymphoma
MedGen UID:
87603
•Concept ID:
C0349532
•
Neoplastic Process
Lymphoma that originates in the stomach itself.
See: Feature record | Search on this feature

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMucosa-associated lymphoma

Professional guidelines

PubMed

Primary gastric non-Hodgkin lymphomas: Recent advances regarding disease pathogenesis and treatment.
Diamantidis MD, Papaioannou M, Hatjiharissi E
World J Gastroenterol 2021 Sep 21;27(35):5932-5945. doi: 10.3748/wjg.v27.i35.5932. PMID: 34629810Free PMC Article
Gastric mucosa-associated lymphoid tissue (MALT) lymphoma: clinicopathological study and treatment outcome in 50 patients.
Zenzri Y, Charfi L, Sahraoui G, Yahyaoui Y, Mrad K, Boujelbene N, Doghri R
Pan Afr Med J 2020;37:372. Epub 2020 Dec 23 doi: 10.11604/pamj.2020.37.372.27094. PMID: 33796185Free PMC Article
The differential diagnosis of early gastric mucosa-associated lymphoma: polymerase chain reaction and paraffin section immunophenotyping.
El-Zimaity HM, El-Zaatari FA, Dore MP, Oweiss S, Gutierrez O, Yuksul M, Ramchatesingh J, Graham DY
Mod Pathol 1999 Sep;12(9):885-93. PMID: 10496597

Recent clinical studies

Etiology

Sonographic Features of Primary Breast Lymphoma: An Analysis of 10 Cases.
Liu X, Liu J, Chen S
Curr Med Imaging 2023;19(6):579-586. doi: 10.2174/1573405618666220816105051. PMID: 35975864
Primary gastric non-Hodgkin lymphomas: Recent advances regarding disease pathogenesis and treatment.
Diamantidis MD, Papaioannou M, Hatjiharissi E
World J Gastroenterol 2021 Sep 21;27(35):5932-5945. doi: 10.3748/wjg.v27.i35.5932. PMID: 34629810Free PMC Article
Retrospective Analysis of 9 Cases of Primary Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma and Literature Review.
Du C, Zhang J, Wei Y, Bai J, Duan MC, Liu G, He Z, Deng J
Med Sci Monit Basic Res 2018 Dec 24;24:233-240. doi: 10.12659/MSMBR.912762. PMID: 30581188Free PMC Article
Localized orbital mucosa-associated lymphoma tissue lymphoma managed with primary radiation therapy: efficacy and toxicity.
Goda JS, Le LW, Lapperriere NJ, Millar BA, Payne D, Gospodarowicz MK, Wells W, Hodgson DC, Sun A, Simpson R, Tsang RW
Int J Radiat Oncol Biol Phys 2011 Nov 15;81(4):e659-66. Epub 2011 Jun 2 doi: 10.1016/j.ijrobp.2011.03.050. PMID: 21640514
Helicobacter pylori infection--current status in Singapore.
Fock KM
Ann Acad Med Singap 1997 Sep;26(5):637-41. PMID: 9494671

Diagnosis

Sonographic Features of Primary Breast Lymphoma: An Analysis of 10 Cases.
Liu X, Liu J, Chen S
Curr Med Imaging 2023;19(6):579-586. doi: 10.2174/1573405618666220816105051. PMID: 35975864
Primary gastric non-Hodgkin lymphomas: Recent advances regarding disease pathogenesis and treatment.
Diamantidis MD, Papaioannou M, Hatjiharissi E
World J Gastroenterol 2021 Sep 21;27(35):5932-5945. doi: 10.3748/wjg.v27.i35.5932. PMID: 34629810Free PMC Article
Glycopeptidomics Analysis of a Cell Line Model Revealing Pathogenesis and Potential Marker Molecules for the Early Diagnosis of Gastric MALT Lymphoma.
Xiao D, Zou Q, Meng L, Xu Y, Zhang H, Meng F, He L, Zhang J
Front Cell Infect Microbiol 2021;11:715454. Epub 2021 Aug 12 doi: 10.3389/fcimb.2021.715454. PMID: 34476221Free PMC Article
Retrospective Analysis of 9 Cases of Primary Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma and Literature Review.
Du C, Zhang J, Wei Y, Bai J, Duan MC, Liu G, He Z, Deng J
Med Sci Monit Basic Res 2018 Dec 24;24:233-240. doi: 10.12659/MSMBR.912762. PMID: 30581188Free PMC Article
Helicobacter pylori infection--current status in Singapore.
Fock KM
Ann Acad Med Singap 1997 Sep;26(5):637-41. PMID: 9494671

Therapy

Successful Treatment of a Patient With Gastric Mucosa-Associated Lymphoma.
Kothadia JP, Kone V, Raza A
Clin Gastroenterol Hepatol 2018 Jul;16(7):e79. Epub 2017 Sep 9 doi: 10.1016/j.cgh.2017.09.006. PMID: 28899669
Sarcoidosis lymphoma syndrome - the value of PET-CT in the diagnosis.
Kis A, Eszes N, Tamasi L, Losonczy G, Csekeo A, Csomor J, Muller V
World J Surg Oncol 2013 Sep 18;11:235. doi: 10.1186/1477-7819-11-235. PMID: 24047276Free PMC Article
Localized orbital mucosa-associated lymphoma tissue lymphoma managed with primary radiation therapy: efficacy and toxicity.
Goda JS, Le LW, Lapperriere NJ, Millar BA, Payne D, Gospodarowicz MK, Wells W, Hodgson DC, Sun A, Simpson R, Tsang RW
Int J Radiat Oncol Biol Phys 2011 Nov 15;81(4):e659-66. Epub 2011 Jun 2 doi: 10.1016/j.ijrobp.2011.03.050. PMID: 21640514
Thyroid lymphoma. The case for combined modality therapy.
Doria R, Jekel JF, Cooper DL
Cancer 1994 Jan 1;73(1):200-6. doi: 10.1002/1097-0142(19940101)73:1<200::aid-cncr2820730135>3.0.co;2-#. PMID: 8275426
Mucosa associated lymphoma of the lung.
Bolton-Maggs PH, Colman A, Dixon GR, Myskow MW, Williams JG, Donnelly RJ, Hind CR
Thorax 1993 Jun;48(6):670-2. doi: 10.1136/thx.48.6.670. PMID: 8346501Free PMC Article

Prognosis

Retrospective Analysis of 9 Cases of Primary Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma and Literature Review.
Du C, Zhang J, Wei Y, Bai J, Duan MC, Liu G, He Z, Deng J
Med Sci Monit Basic Res 2018 Dec 24;24:233-240. doi: 10.12659/MSMBR.912762. PMID: 30581188Free PMC Article
Localized orbital mucosa-associated lymphoma tissue lymphoma managed with primary radiation therapy: efficacy and toxicity.
Goda JS, Le LW, Lapperriere NJ, Millar BA, Payne D, Gospodarowicz MK, Wells W, Hodgson DC, Sun A, Simpson R, Tsang RW
Int J Radiat Oncol Biol Phys 2011 Nov 15;81(4):e659-66. Epub 2011 Jun 2 doi: 10.1016/j.ijrobp.2011.03.050. PMID: 21640514
Education and Imaging. Gastrointestinal: gastric mucosa-associated lymphoma presented with unique vascular features on magnified endoscopy combined with narrow-band imaging.
Nonaka K, Ishikawa K, Shimizu M, Sakurai T, Nakai Y, Nakao M, Yoshino K, Arai S, Kita H
J Gastroenterol Hepatol 2009 Oct;24(10):1697. doi: 10.1111/j.1440-1746.2009.06030.x. PMID: 19788610
Marginal zone B-cell lymphoma in children and young adults.
Taddesse-Heath L, Pittaluga S, Sorbara L, Bussey M, Raffeld M, Jaffe ES
Am J Surg Pathol 2003 Apr;27(4):522-31. doi: 10.1097/00000478-200304000-00014. PMID: 12657939Free PMC Article
Nongastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue.
Zucca E, Conconi A, Pedrinis E, Cortelazzo S, Motta T, Gospodarowicz MK, Patterson BJ, Ferreri AJ, Ponzoni M, Devizzi L, Giardini R, Pinotti G, Capella C, Zinzani PL, Pileri S, López-Guillermo A, Campo E, Ambrosetti A, Baldini L, Cavalli F; International Extranodal Lymphoma Study Group
Blood 2003 Apr 1;101(7):2489-95. Epub 2002 Nov 27 doi: 10.1182/blood-2002-04-1279. PMID: 12456507

Clinical prediction guides

Primary gastric non-Hodgkin lymphomas: Recent advances regarding disease pathogenesis and treatment.
Diamantidis MD, Papaioannou M, Hatjiharissi E
World J Gastroenterol 2021 Sep 21;27(35):5932-5945. doi: 10.3748/wjg.v27.i35.5932. PMID: 34629810Free PMC Article
Retrospective Analysis of 9 Cases of Primary Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma and Literature Review.
Du C, Zhang J, Wei Y, Bai J, Duan MC, Liu G, He Z, Deng J
Med Sci Monit Basic Res 2018 Dec 24;24:233-240. doi: 10.12659/MSMBR.912762. PMID: 30581188Free PMC Article
Localized orbital mucosa-associated lymphoma tissue lymphoma managed with primary radiation therapy: efficacy and toxicity.
Goda JS, Le LW, Lapperriere NJ, Millar BA, Payne D, Gospodarowicz MK, Wells W, Hodgson DC, Sun A, Simpson R, Tsang RW
Int J Radiat Oncol Biol Phys 2011 Nov 15;81(4):e659-66. Epub 2011 Jun 2 doi: 10.1016/j.ijrobp.2011.03.050. PMID: 21640514
Nongastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue.
Zucca E, Conconi A, Pedrinis E, Cortelazzo S, Motta T, Gospodarowicz MK, Patterson BJ, Ferreri AJ, Ponzoni M, Devizzi L, Giardini R, Pinotti G, Capella C, Zinzani PL, Pileri S, López-Guillermo A, Campo E, Ambrosetti A, Baldini L, Cavalli F; International Extranodal Lymphoma Study Group
Blood 2003 Apr 1;101(7):2489-95. Epub 2002 Nov 27 doi: 10.1182/blood-2002-04-1279. PMID: 12456507
The differential diagnosis of early gastric mucosa-associated lymphoma: polymerase chain reaction and paraffin section immunophenotyping.
El-Zimaity HM, El-Zaatari FA, Dore MP, Oweiss S, Gutierrez O, Yuksul M, Ramchatesingh J, Graham DY
Mod Pathol 1999 Sep;12(9):885-93. PMID: 10496597

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