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Pancreatic somatostatinoma

MedGen UID:
235079
•Concept ID:
C1368041
•
Neoplastic Process
Synonyms: pancreatic delta cell somatostatin producing neoplasm; pancreatic somatostatin cell tumor; pancreatic somatostatin cell tumour; Pancreatic Somatostatinoma; pancreatic somatostatinoma
 
Monarch Initiative: MONDO:0002993

Definition

A neuroendocrine tumor arising from the delta cells of the pancreas. It is characterized by inappropriate secretion of somatostatin and associated with diabetes mellitus, hypochlorhydria, gallbladder disease, diarrhea, steatorrhea, anemia, and weight loss. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic somatostatinoma

Professional guidelines

PubMed

Diagnostic Management of Gastroenteropancreatic Neuroendocrine Neoplasms: Technique Optimization and Tips and Tricks for Radiologists.
Pellegrino F, Granata V, Fusco R, Grassi F, Tafuto S, Perrucci L, Tralli G, Scaglione M
Tomography 2023 Jan 27;9(1):217-246. doi: 10.3390/tomography9010018. PMID: 36828370Free PMC Article
Pancreatic neuroendocrine tumors: contemporary diagnosis and management.
Parbhu SK, Adler DG
Hosp Pract (1995) 2016 Aug;44(3):109-19. Epub 2016 Jul 18 doi: 10.1080/21548331.2016.1210474. PMID: 27404266
Pancreatic neuroendocrine tumors: clinical features, diagnosis and medical treatment: advances.
Ito T, Igarashi H, Jensen RT
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):737-53. doi: 10.1016/j.bpg.2012.12.003. PMID: 23582916Free PMC Article

Recent clinical studies

Diagnosis

Pancreatic somatostatinoma with von Recklinghausen's disease.
Takai A, Setoyama T, Miyamoto S
Clin Gastroenterol Hepatol 2009 May;7(5):A28. Epub 2008 Sep 3 doi: 10.1016/j.cgh.2008.08.036. PMID: 18926936
Pancreatic somatostatinoma.
Soldati T, Del Noce G, Garino M, Farina EC, De Paolis P, Balbo G
Panminerva Med 1990 Jul-Sep;32(3):141-4. PMID: 2077482
Pancreatic somatostatinoma.
Sakazaki S, Umeyama K, Nakagawa H, Hashimoto H, Kamino K, Mitsuhashi T, Yamaguchi K
Am J Surg 1983 Nov;146(5):674-9. doi: 10.1016/0002-9610(83)90310-0. PMID: 6314831
Pancreatic somatostatinoma.
Kelly TR
Am J Surg 1983 Nov;146(5):671-3. doi: 10.1016/0002-9610(83)90309-4. PMID: 6314830
Pancreatic somatostatinoma presenting with hypoglycaemia.
Wright J, Abolfathi A, Penman E, Marks V
Clin Endocrinol (Oxf) 1980 Jun;12(6):603-8. doi: 10.1111/j.1365-2265.1980.tb01382.x. PMID: 6105026

Therapy

Malignant pancreatic somatostatinoma in a patient with dermatitis herpetiformis and coeliac disease.
Levi S, Bjarnason I, Swinson CM, Polak JM, Murray W, Levi AJ
Digestion 1988;39(1):1-6. doi: 10.1159/000199601. PMID: 2899527
Pancreatic somatostatinoma presenting with hypoglycaemia.
Wright J, Abolfathi A, Penman E, Marks V
Clin Endocrinol (Oxf) 1980 Jun;12(6):603-8. doi: 10.1111/j.1365-2265.1980.tb01382.x. PMID: 6105026

Prognosis

Periampullary pancreatic somatostatinoma.
House MG, Yeo CJ, Schulick RD
Ann Surg Oncol 2002 Nov;9(9):869-74. doi: 10.1007/BF02557523. PMID: 12417508
Reciprocal changes in progression of gastric mucosa-associated lymphoid tissue lymphoma and pancreatic somatostatinoma.
Maekawa T, Kinoshita Y, Fukui H, Matsumoto S, Hirota S, Chihara K, Fujimori T, Chiba T
Am J Med 1998 Dec;105(6):539-41. doi: 10.1016/s0002-9343(98)00320-9. PMID: 9870841
Pancreatic somatostatinoma.
Soldati T, Del Noce G, Garino M, Farina EC, De Paolis P, Balbo G
Panminerva Med 1990 Jul-Sep;32(3):141-4. PMID: 2077482
Human somatostatin I: sequence of the cDNA.
Shen LP, Pictet RL, Rutter WJ
Proc Natl Acad Sci U S A 1982 Aug;79(15):4575-9. doi: 10.1073/pnas.79.15.4575. PMID: 6126875Free PMC Article

Clinical prediction guides

Periampullary pancreatic somatostatinoma.
House MG, Yeo CJ, Schulick RD
Ann Surg Oncol 2002 Nov;9(9):869-74. doi: 10.1007/BF02557523. PMID: 12417508
Human somatostatin I: sequence of the cDNA.
Shen LP, Pictet RL, Rutter WJ
Proc Natl Acad Sci U S A 1982 Aug;79(15):4575-9. doi: 10.1073/pnas.79.15.4575. PMID: 6126875Free PMC Article
Molecular forms of somatostatin in normal subjects and in patients with pancreatic somatostatinoma.
Penman E, Lowry PJ, Wass JA, Marks V, Dawson AM, Besser GM, Rees LH
Clin Endocrinol (Oxf) 1980 Jun;12(6):611-20. doi: 10.1111/j.1365-2265.1980.tb01383.x. PMID: 6105027

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