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Undifferentiated pleomorphic sarcoma, inflammatory variant

MedGen UID:
235211
•Concept ID:
C1334180
•
Neoplastic Process
Synonyms: inflammatory malignant fibrous histiocytoma; inflammatory MFH; malignant xanthogranuloma; Undifferentiated Pleomorphic Sarcoma, Inflammatory Variant; undifferentiated pleomorphic sarcoma, inflammatory variant; Xanthosarcoma
 
Monarch Initiative: MONDO:0006480

Definition

An undifferentiated pleomorphic sarcoma characterized by the presence of numerous inflammatory cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUndifferentiated pleomorphic sarcoma, inflammatory variant

Recent clinical studies

Therapy

A rare presentation of myxofibrosarcoma as a Pancoast tumor: a case report.
Jevremovic V, Yousuf A, Hussain Z, Abboud A, Chedrawy EG
J Med Case Rep 2017 Mar 7;11(1):61. doi: 10.1186/s13256-017-1223-5. PMID: 28264709Free PMC Article
Malignant fibrous histiocytoma of the ovary: a case report.
Dilek TU, Dilek S, Pata O, Tataroglu C, Tok E
Int J Gynecol Cancer 2006 Jan-Feb;16 Suppl 1:352-6. doi: 10.1111/j.1525-1438.2006.00210.x. PMID: 16515621
Analysis of prognostic factors and chemotherapy of malignant fibrous histiocytoma of soft tissue: a preliminary report.
Shinjo K
Jpn J Clin Oncol 1994 Jun;24(3):154-9. PMID: 8007425
Inflammatory fibrous histiocytoma: an important variant of malignant fibrous histiocytoma highly responsive to chemotherapy.
Poon MC, Durant JR, Norgard MJ, Chang-Poon VY
Ann Intern Med 1982 Dec;97(6):858-63. doi: 10.7326/0003-4819-97-6-858. PMID: 6293357

Prognosis

Primary inflammatory malignant fibrous histiocytoma of the breast: a case report of an unusual variant and review of the literature.
Tashjian R, Gilani SM, Falk J, Kelly MJ, Ockner D, Danforth R
Pathol Res Pract 2013 Aug;209(8):534-9. Epub 2013 Jun 6 doi: 10.1016/j.prp.2013.05.005. PMID: 23827212
Inflammatory myofibroblastic tumors of the head and neck: evaluation of clinicopathologic and prognostic features.
Devaney KO, Lafeir DJ, Triantafyllou A, Mendenhall WM, Woolgar JA, Rinaldo A, Ferlito A
Eur Arch Otorhinolaryngol 2012 Dec;269(12):2461-5. Epub 2012 May 16 doi: 10.1007/s00405-012-2026-3. PMID: 22588194
Pleomorphic leiomyosarcoma: clinicopathologic and immunohistochemical study with special emphasis on its distinction from ordinary leiomyosarcoma and malignant fibrous histiocytoma.
Oda Y, Miyajima K, Kawaguchi K, Tamiya S, Oshiro Y, Hachitanda Y, Oya M, Iwamoto Y, Tsuneyoshi M
Am J Surg Pathol 2001 Aug;25(8):1030-8. doi: 10.1097/00000478-200108000-00007. PMID: 11474287
Dedifferentiated liposarcoma with an inflammatory malignant fibrous histiocytoma-like component presenting a leukemoid reaction.
Hisaoka M, Tsuji S, Hashimoto H, Aoki T, Uriu K
Pathol Int 1997 Sep;47(9):642-6. doi: 10.1111/j.1440-1827.1997.tb04556.x. PMID: 9311018
Malignant fibrous histiocytoma: a retrospective study of 167 cases.
Kearney MM, Soule EH, Ivins JC
Cancer 1980 Jan 1;45(1):167-78. doi: 10.1002/1097-0142(19800101)45:1<167::aid-cncr2820450127>3.0.co;2-8. PMID: 6243239

Clinical prediction guides

Primary inflammatory malignant fibrous histiocytoma of the breast: a case report of an unusual variant and review of the literature.
Tashjian R, Gilani SM, Falk J, Kelly MJ, Ockner D, Danforth R
Pathol Res Pract 2013 Aug;209(8):534-9. Epub 2013 Jun 6 doi: 10.1016/j.prp.2013.05.005. PMID: 23827212
Pleomorphic leiomyosarcoma: clinicopathologic and immunohistochemical study with special emphasis on its distinction from ordinary leiomyosarcoma and malignant fibrous histiocytoma.
Oda Y, Miyajima K, Kawaguchi K, Tamiya S, Oshiro Y, Hachitanda Y, Oya M, Iwamoto Y, Tsuneyoshi M
Am J Surg Pathol 2001 Aug;25(8):1030-8. doi: 10.1097/00000478-200108000-00007. PMID: 11474287
Atypical fibroxanthoma with osteoclast-like multinucleated giant cells.
Khan ZM, Cockerell CJ
Am J Dermatopathol 1997 Apr;19(2):174-9. doi: 10.1097/00000372-199704000-00012. PMID: 9129703

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