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Melanomatosis

MedGen UID:
235317
•Concept ID:
C1334691
•
Neoplastic Process
Synonym: melanomatosis
 
Monarch Initiative: MONDO:0004141

Definition

A condition characterized by multiple melanomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMelanomatosis

Professional guidelines

PubMed

Rare and challenging extra-axial brain lesions: CT and MRI findings with clinico-radiological differential diagnosis and pathological correlation.
Demir MK, Yapıcıer O, Onat E, Toktaş ZO, Akakın A, Urgun K, Kılıç T
Diagn Interv Radiol 2014 Sep-Oct;20(5):448-52. doi: 10.5152/dir.2014.14031. PMID: 25010368Free PMC Article

Recent clinical studies

Etiology

Spectrum of Clinical, Neuroimaging, and Cerebrospinal Fluid Features of Adult Neurocutaneous Melanocytosis.
Qian M, Ren H, Qu T, Lu Z, Zou Y, He J, Zhao Y, Chen L, Guan H
Eur Neurol 2018;80(1-2):1-6. Epub 2018 Jul 13 doi: 10.1159/000488687. PMID: 30007971
Meningeal melanomatosis following discontinuation of dabrafenib: implications for the maintenance of long-term complete remission.
Grätz V, Lüttmann N, Haase O, Langan EA, Kemmling A, Zillikens D, Terheyden P
Melanoma Res 2017 Oct;27(5):503-506. doi: 10.1097/CMR.0000000000000373. PMID: 28723725
Meningeal melanomatosis: a challenge for timely diagnosis.
Berzero G, Diamanti L, Di Stefano AL, Bini P, Franciotta D, Imarisio I, Pedrazzoli P, Magrassi L, Morbini P, Farina LM, Bastianello S, Ceroni M, Marchioni E
Biomed Res Int 2015;2015:948497. Epub 2015 Jan 14 doi: 10.1155/2015/948497. PMID: 25648721Free PMC Article
Pigmented lesions of the central nervous system: radiologic-pathologic correlation.
Smith AB, Rushing EJ, Smirniotopoulos JG
Radiographics 2009 Sep-Oct;29(5):1503-24. doi: 10.1148/rg.295095109. PMID: 19755608
Cranial computed tomography of malignant melanoma.
Ginaldi S, Wallace S, Shalen P, Luna M, Handel S
AJR Am J Roentgenol 1981 Jan;136(1):145-9. doi: 10.2214/ajr.136.1.145. PMID: 6779562

Diagnosis

Primary Diffuse Leptomeningeal Melanomatosis in an Indian Child With Review of Literature.
Kumar A, Gunasekaran PK, Aggarwal D, Janu V, Manjunathan S, Laxmi V, Tiwari S, Saini L
Pediatr Neurol 2024 Mar;152:23-29. Epub 2023 Dec 14 doi: 10.1016/j.pediatrneurol.2023.12.007. PMID: 38176225
Primary Diffuse Meningeal Melanomatosis.
Wen L, Cai L
N Engl J Med 2023 May 18;388(20):1892. Epub 2023 May 13 doi: 10.1056/NEJMicm2212333. PMID: 37183981
Primary Diffuse Leptomeningeal Melanomatosis: Case Report and Review of the Literature.
Eichberg DG, Achua JK, Locatelli E, Shah AH, Komotar RJ, Ghods AJ
World Neurosurg 2019 Feb;122:648-655. Epub 2018 Nov 26 doi: 10.1016/j.wneu.2018.11.163. PMID: 30496931
Pigmented lesions of the central nervous system: radiologic-pathologic correlation.
Smith AB, Rushing EJ, Smirniotopoulos JG
Radiographics 2009 Sep-Oct;29(5):1503-24. doi: 10.1148/rg.295095109. PMID: 19755608
Primary leptomeningeal melanomatosis: early leptomeningeal enhancement on MRI.
Celli P, Acqui M, Trillò G, Ramundo EO, D'Andrea G, Roperto R, Ferrante L
J Neurosurg Sci 2001 Dec;45(4):235-40. PMID: 11912478

Therapy

Meningeal Melanomatosis with a Spinal Meningeal Melanocytoma Trigger by an in vitro Fertilization.
Ramos AA, Ferrara P, Fernández VM, Sanchez CR, Alvarez Vega MA
Neurol India 2022 Sep-Oct;70(Supplement):S318-S321. doi: 10.4103/0028-3886.360914. PMID: 36412389
A case report of a patient with inoperable primary diffuse leptomeningeal melanomatosis treated with whole-brain radiotherapy and pembrolizumab.
Palacka P, Slopovsky J, Makovnik M, Kajo K, Obertova J, Mego M
Medicine (Baltimore) 2022 Jan 21;101(3):e28613. doi: 10.1097/MD.0000000000028613. PMID: 35060532Free PMC Article
Meningeal melanomatosis following discontinuation of dabrafenib: implications for the maintenance of long-term complete remission.
Grätz V, Lüttmann N, Haase O, Langan EA, Kemmling A, Zillikens D, Terheyden P
Melanoma Res 2017 Oct;27(5):503-506. doi: 10.1097/CMR.0000000000000373. PMID: 28723725
Vemurafenib for leptomeningeal melanomatosis.
Schäfer N, Scheffler B, Stuplich M, Schaub C, Kebir S, Rehkämper C, Mack F, Niehusmann P, Simon M, Greschus S, Kuchelmeister K, Herrlinger U, Glas M
J Clin Oncol 2013 Apr 10;31(11):e173-4. Epub 2013 Mar 4 doi: 10.1200/JCO.2012.46.5773. PMID: 23460716
Unusual cases: melanomatosis and nephroblastomatosis treated with hyperthermic intraperitoneal chemotherapy.
Hayes-Jordan A, Green H, Prieto V, Wolff JE
J Pediatr Surg 2012 Apr;47(4):782-7. doi: 10.1016/j.jpedsurg.2011.12.018. PMID: 22498396

Prognosis

Meningeal Melanomatosis with a Spinal Meningeal Melanocytoma Trigger by an in vitro Fertilization.
Ramos AA, Ferrara P, Fernández VM, Sanchez CR, Alvarez Vega MA
Neurol India 2022 Sep-Oct;70(Supplement):S318-S321. doi: 10.4103/0028-3886.360914. PMID: 36412389
Imaging and Clinical Features of Neurocutaneous Melanosis in the Pediatric Population.
Mormina E, Granata F, Vinci SL, Coglitore A, Caragliano AA, Tessitore A, Longo M, Visalli C
Curr Med Imaging 2021;17(12):1391-1402. doi: 10.2174/1573405617666210527091109. PMID: 34047260
Primary melanocytic neoplasms of the central nervous system.
Liubinas SV, Maartens N, Drummond KJ
J Clin Neurosci 2010 Oct;17(10):1227-32. Epub 2010 Jun 16 doi: 10.1016/j.jocn.2010.01.017. PMID: 20558070
Primary diffuse meningeal melanomatosis.
Zadro I, Brinar VV, Barun B, Ozretić D, Pazanin L, Grahovac G, Habek M
Neurologist 2010 Mar;16(2):117-9. doi: 10.1097/NRL.0b013e3181c29ef8. PMID: 20220448
Primary leptomeningeal melanomatosis: early leptomeningeal enhancement on MRI.
Celli P, Acqui M, Trillò G, Ramundo EO, D'Andrea G, Roperto R, Ferrante L
J Neurosurg Sci 2001 Dec;45(4):235-40. PMID: 11912478

Clinical prediction guides

Imaging and Clinical Features of Neurocutaneous Melanosis in the Pediatric Population.
Mormina E, Granata F, Vinci SL, Coglitore A, Caragliano AA, Tessitore A, Longo M, Visalli C
Curr Med Imaging 2021;17(12):1391-1402. doi: 10.2174/1573405617666210527091109. PMID: 34047260
Brain Atrophy Associated with Primary Diffuse Meningeal Melanomatosis.
Ma Y, Xing X, Li Y, Ao R, He M, Lan X, Zhao Y, Zhang J, Yu S
World Neurosurg 2020 Apr;136:311-314. Epub 2020 Jan 29 doi: 10.1016/j.wneu.2020.01.164. PMID: 32004738
Meningeal melanomatosis following discontinuation of dabrafenib: implications for the maintenance of long-term complete remission.
Grätz V, Lüttmann N, Haase O, Langan EA, Kemmling A, Zillikens D, Terheyden P
Melanoma Res 2017 Oct;27(5):503-506. doi: 10.1097/CMR.0000000000000373. PMID: 28723725
Meningeal melanomatosis: a challenge for timely diagnosis.
Berzero G, Diamanti L, Di Stefano AL, Bini P, Franciotta D, Imarisio I, Pedrazzoli P, Magrassi L, Morbini P, Farina LM, Bastianello S, Ceroni M, Marchioni E
Biomed Res Int 2015;2015:948497. Epub 2015 Jan 14 doi: 10.1155/2015/948497. PMID: 25648721Free PMC Article
Primary leptomeningeal melanomatosis: early leptomeningeal enhancement on MRI.
Celli P, Acqui M, Trillò G, Ramundo EO, D'Andrea G, Roperto R, Ferrante L
J Neurosurg Sci 2001 Dec;45(4):235-40. PMID: 11912478

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