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Melanomatosis

MedGen UID:
235317
•Concept ID:
C1334691
•
Neoplastic Process
Synonym: melanomatosis
 
Monarch Initiative: MONDO:0004141

Definition

A condition characterized by multiple melanomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMelanomatosis

Professional guidelines

PubMed

Rare and challenging extra-axial brain lesions: CT and MRI findings with clinico-radiological differential diagnosis and pathological correlation.
Demir MK, Yapıcıer O, Onat E, Toktaş ZO, Akakın A, Urgun K, Kılıç T
Diagn Interv Radiol 2014 Sep-Oct;20(5):448-52. doi: 10.5152/dir.2014.14031. PMID: 25010368Free PMC Article

Recent clinical studies

Etiology

Treating TB human neuroectodermal cell line with retinoic acid induces the appearance of neuron-like voltage-gated ionic currents.
Santillo S, Martini A, Polverino A, Mercuri NB, Guatteo E, Sorrentino G
Brain Res 2019 May 15;1711:97-105. Epub 2019 Jan 17 doi: 10.1016/j.brainres.2019.01.019. PMID: 30660613
Spectrum of Clinical, Neuroimaging, and Cerebrospinal Fluid Features of Adult Neurocutaneous Melanocytosis.
Qian M, Ren H, Qu T, Lu Z, Zou Y, He J, Zhao Y, Chen L, Guan H
Eur Neurol 2018;80(1-2):1-6. Epub 2018 Jul 13 doi: 10.1159/000488687. PMID: 30007971
Meningeal melanomatosis following discontinuation of dabrafenib: implications for the maintenance of long-term complete remission.
Grätz V, Lüttmann N, Haase O, Langan EA, Kemmling A, Zillikens D, Terheyden P
Melanoma Res 2017 Oct;27(5):503-506. doi: 10.1097/CMR.0000000000000373. PMID: 28723725
Meningeal melanomatosis: a challenge for timely diagnosis.
Berzero G, Diamanti L, Di Stefano AL, Bini P, Franciotta D, Imarisio I, Pedrazzoli P, Magrassi L, Morbini P, Farina LM, Bastianello S, Ceroni M, Marchioni E
Biomed Res Int 2015;2015:948497. Epub 2015 Jan 14 doi: 10.1155/2015/948497. PMID: 25648721Free PMC Article
Pigmented lesions of the central nervous system: radiologic-pathologic correlation.
Smith AB, Rushing EJ, Smirniotopoulos JG
Radiographics 2009 Sep-Oct;29(5):1503-24. doi: 10.1148/rg.295095109. PMID: 19755608

Diagnosis

Primary Diffuse Meningeal Melanomatosis.
Wen L, Cai L
N Engl J Med 2023 May 18;388(20):1892. Epub 2023 May 13 doi: 10.1056/NEJMicm2212333. PMID: 37183981
Diagnostic challenges of primary diffuse leptomeningeal melanomatosis in early adolescence: A case report.
Yamauhci S, Fukuyama T, Inaba Y, Nakajima H, Hattori Y, Miyairi Y, Ogiso Y
Brain Dev 2022 Jun;44(6):421-425. Epub 2022 Mar 5 doi: 10.1016/j.braindev.2022.02.004. PMID: 35260265
Brain Atrophy Associated with Primary Diffuse Meningeal Melanomatosis.
Ma Y, Xing X, Li Y, Ao R, He M, Lan X, Zhao Y, Zhang J, Yu S
World Neurosurg 2020 Apr;136:311-314. Epub 2020 Jan 29 doi: 10.1016/j.wneu.2020.01.164. PMID: 32004738
Primary Diffuse Leptomeningeal Melanomatosis: Case Report and Review of the Literature.
Eichberg DG, Achua JK, Locatelli E, Shah AH, Komotar RJ, Ghods AJ
World Neurosurg 2019 Feb;122:648-655. Epub 2018 Nov 26 doi: 10.1016/j.wneu.2018.11.163. PMID: 30496931
Rare and challenging extra-axial brain lesions: CT and MRI findings with clinico-radiological differential diagnosis and pathological correlation.
Demir MK, Yapıcıer O, Onat E, Toktaş ZO, Akakın A, Urgun K, Kılıç T
Diagn Interv Radiol 2014 Sep-Oct;20(5):448-52. doi: 10.5152/dir.2014.14031. PMID: 25010368Free PMC Article

Therapy

Meningeal Melanomatosis with a Spinal Meningeal Melanocytoma Trigger by an in vitro Fertilization.
Ramos AA, Ferrara P, Fernández VM, Sanchez CR, Alvarez Vega MA
Neurol India 2022 Sep-Oct;70(Supplement):S318-S321. doi: 10.4103/0028-3886.360914. PMID: 36412389
A case report of a patient with inoperable primary diffuse leptomeningeal melanomatosis treated with whole-brain radiotherapy and pembrolizumab.
Palacka P, Slopovsky J, Makovnik M, Kajo K, Obertova J, Mego M
Medicine (Baltimore) 2022 Jan 21;101(3):e28613. doi: 10.1097/MD.0000000000028613. PMID: 35060532Free PMC Article
Meningeal melanomatosis following discontinuation of dabrafenib: implications for the maintenance of long-term complete remission.
Grätz V, Lüttmann N, Haase O, Langan EA, Kemmling A, Zillikens D, Terheyden P
Melanoma Res 2017 Oct;27(5):503-506. doi: 10.1097/CMR.0000000000000373. PMID: 28723725
Vemurafenib for leptomeningeal melanomatosis.
Schäfer N, Scheffler B, Stuplich M, Schaub C, Kebir S, Rehkämper C, Mack F, Niehusmann P, Simon M, Greschus S, Kuchelmeister K, Herrlinger U, Glas M
J Clin Oncol 2013 Apr 10;31(11):e173-4. Epub 2013 Mar 4 doi: 10.1200/JCO.2012.46.5773. PMID: 23460716
Unusual cases: melanomatosis and nephroblastomatosis treated with hyperthermic intraperitoneal chemotherapy.
Hayes-Jordan A, Green H, Prieto V, Wolff JE
J Pediatr Surg 2012 Apr;47(4):782-7. doi: 10.1016/j.jpedsurg.2011.12.018. PMID: 22498396

Prognosis

Meningeal Melanomatosis with a Spinal Meningeal Melanocytoma Trigger by an in vitro Fertilization.
Ramos AA, Ferrara P, Fernández VM, Sanchez CR, Alvarez Vega MA
Neurol India 2022 Sep-Oct;70(Supplement):S318-S321. doi: 10.4103/0028-3886.360914. PMID: 36412389
Unusual cases: melanomatosis and nephroblastomatosis treated with hyperthermic intraperitoneal chemotherapy.
Hayes-Jordan A, Green H, Prieto V, Wolff JE
J Pediatr Surg 2012 Apr;47(4):782-7. doi: 10.1016/j.jpedsurg.2011.12.018. PMID: 22498396
Primary melanocytic neoplasms of the central nervous system.
Liubinas SV, Maartens N, Drummond KJ
J Clin Neurosci 2010 Oct;17(10):1227-32. Epub 2010 Jun 16 doi: 10.1016/j.jocn.2010.01.017. PMID: 20558070
Primary leptomeningeal melanoma.
Schneider F, Putzier M
Spine (Phila Pa 1976) 2002 Dec 15;27(24):E545-7. doi: 10.1097/00007632-200212150-00026. PMID: 12486366
Primary leptomeningeal melanomatosis: early leptomeningeal enhancement on MRI.
Celli P, Acqui M, Trillò G, Ramundo EO, D'Andrea G, Roperto R, Ferrante L
J Neurosurg Sci 2001 Dec;45(4):235-40. PMID: 11912478

Clinical prediction guides

Imaging and Clinical Features of Neurocutaneous Melanosis in the Pediatric Population.
Mormina E, Granata F, Vinci SL, Coglitore A, Caragliano AA, Tessitore A, Longo M, Visalli C
Curr Med Imaging 2021;17(12):1391-1402. doi: 10.2174/1573405617666210527091109. PMID: 34047260
Brain Atrophy Associated with Primary Diffuse Meningeal Melanomatosis.
Ma Y, Xing X, Li Y, Ao R, He M, Lan X, Zhao Y, Zhang J, Yu S
World Neurosurg 2020 Apr;136:311-314. Epub 2020 Jan 29 doi: 10.1016/j.wneu.2020.01.164. PMID: 32004738
Meningeal melanomatosis following discontinuation of dabrafenib: implications for the maintenance of long-term complete remission.
Grätz V, Lüttmann N, Haase O, Langan EA, Kemmling A, Zillikens D, Terheyden P
Melanoma Res 2017 Oct;27(5):503-506. doi: 10.1097/CMR.0000000000000373. PMID: 28723725
Prognostic factors and outcomes in patients with leptomeningeal melanomatosis.
Harstad L, Hess KR, Groves MD
Neuro Oncol 2008 Dec;10(6):1010-8. Epub 2008 Aug 14 doi: 10.1215/15228517-2008-062. PMID: 18708343Free PMC Article
Primary leptomeningeal melanomatosis: early leptomeningeal enhancement on MRI.
Celli P, Acqui M, Trillò G, Ramundo EO, D'Andrea G, Roperto R, Ferrante L
J Neurosurg Sci 2001 Dec;45(4):235-40. PMID: 11912478

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