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Lung occult large cell carcinoma

MedGen UID:
235399
•Concept ID:
C1335095
•
Neoplastic Process
Synonyms: lung occult large cell carcinoma; Occult Large Cell Carcinoma of Lung; occult large cell carcinoma of lung; Occult Large Cell Carcinoma of the Lung; occult large cell carcinoma of the lung; Occult Large Cell Lung Carcinoma; occult large cell lung carcinoma; Occult Lung Large Cell Carcinoma
 
Monarch Initiative: MONDO:0004128

Definition

A large cell lung carcinoma detectable by sputum cytology only. The primary tumor is undetectable radiographically or during bronchoscopy; therefore, it can not be assessed. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung occult large cell carcinoma

Professional guidelines

PubMed

Primary lung cancer after treatment of head and neck cancer without lymph node metastasis: is there a role for autofluorescence bronchoscopy?
Lee P, de Bree R, Brokx HA, Leemans CR, Postmus PE, Sutedja TG
Lung Cancer 2008 Dec;62(3):309-15. Epub 2008 May 19 doi: 10.1016/j.lungcan.2008.03.034. PMID: 18486989
Treatment of stage IIIA non-small cell lung cancer.
Robinson LA, Wagner H Jr, Ruckdeschel JC; American College of Chest Physicians
Chest 2003 Jan;123(1 Suppl):202S-220S. doi: 10.1378/chest.123.1_suppl.202s. PMID: 12527580
Treatment of patients with cancer of unknown primary site.
Hainsworth JD, Greco FA
Important Adv Oncol 1991:173-90. PMID: 1869276

Recent clinical studies

Etiology

Programmed death ligand-1 expression and occult lymph node metastasis in non-small cell lung cancer.
Mitsui S, Tanaka Y, Jimbo N, Doi T, Tane S, Hokka D, Maniwa Y
Thorac Cancer 2023 Jun;14(18):1774-1781. Epub 2023 May 9 doi: 10.1111/1759-7714.14922. PMID: 37160414Free PMC Article
Prevalence and Predictability of Occult Satellite Nodules in Clinical Stage Ia Non-small Cell Lung Cancer following Lobectomy.
Kneuertz PJ, Abdel-Rasoul M, D'Souza DM, Moffatt-Bruce SD, Merritt RE
Clin Lung Cancer 2023 May;24(3):e134-e140. Epub 2022 Dec 27 doi: 10.1016/j.cllc.2022.12.009. PMID: 36682930Free PMC Article
Clinical Misstagings and Risk Factors of Occult Nodal Disease in Non-Small Cell Lung Cancer.
Dyas AR, King RW, Ghanim AF, Cerfolio RJ
Ann Thorac Surg 2018 Nov;106(5):1492-1498. Epub 2018 Jun 15 doi: 10.1016/j.athoracsur.2018.05.045. PMID: 29908981
Characteristics and prognosis of Japanese male and female lung cancer patients: The BioBank Japan Project.
Nakamura K, Ukawa S, Okada E, Hirata M, Nagai A, Yamagata Z, Ninomiya T, Muto K, Kiyohara Y, Matsuda K, Kamatani Y, Kubo M, Nakamura Y; BioBank Japan Cooperative Hospital Group, Tamakoshi A
J Epidemiol 2017 Mar;27(3S):S49-S57. Epub 2017 Feb 13 doi: 10.1016/j.je.2016.12.010. PMID: 28202209Free PMC Article
Tumors of unknown origin.
Greco FA, Hainsworth JD
CA Cancer J Clin 1992 Mar-Apr;42(2):96-115. doi: 10.3322/canjclin.42.2.96. PMID: 1540854

Diagnosis

Clinical Misstagings and Risk Factors of Occult Nodal Disease in Non-Small Cell Lung Cancer.
Dyas AR, King RW, Ghanim AF, Cerfolio RJ
Ann Thorac Surg 2018 Nov;106(5):1492-1498. Epub 2018 Jun 15 doi: 10.1016/j.athoracsur.2018.05.045. PMID: 29908981
Characteristics and prognosis of Japanese male and female lung cancer patients: The BioBank Japan Project.
Nakamura K, Ukawa S, Okada E, Hirata M, Nagai A, Yamagata Z, Ninomiya T, Muto K, Kiyohara Y, Matsuda K, Kamatani Y, Kubo M, Nakamura Y; BioBank Japan Cooperative Hospital Group, Tamakoshi A
J Epidemiol 2017 Mar;27(3S):S49-S57. Epub 2017 Feb 13 doi: 10.1016/j.je.2016.12.010. PMID: 28202209Free PMC Article
Large cell neuroendocrine carcinoma of the lung: an aggressive disease potentially treatable with surgery.
Doddoli C, Barlesi F, Chetaille B, Garbe L, Thomas P, Giudicelli R, Fuentes P
Ann Thorac Surg 2004 Apr;77(4):1168-72. doi: 10.1016/j.athoracsur.2003.09.049. PMID: 15063228
Surgery for nonsmall cell lung cancer: can improvements be made?
Spiro SG
Eur Respir J Suppl 2003 Jan;39:52s-56s. doi: 10.1183/09031936.03.00063502. PMID: 12572702
Tumors of unknown origin.
Greco FA, Hainsworth JD
CA Cancer J Clin 1992 Mar-Apr;42(2):96-115. doi: 10.3322/canjclin.42.2.96. PMID: 1540854

Therapy

Immune checkpoint inhibitor use and the incidence of hepatitis B virus reactivation or immune-related hepatitis in non-small cell lung cancer patients with chronic hepatitis B.
Hong J, Lee J, Park S, Jung HA, Sun JM, Lee SH, Ahn JS, Sinn DH, Ahn MJ
Cancer 2024 May 1;130(9):1693-1701. Epub 2024 Jan 2 doi: 10.1002/cncr.35175. PMID: 38165808
Prognosis of Incidental Brain Metastases in Patients With Advanced Renal Cell Carcinoma.
Kotecha RR, Flippot R, Nortman T, Guida A, Patil S, Escudier B, Motzer RJ, Albiges L, Voss MH
J Natl Compr Canc Netw 2021 Apr;19(4):432-438. Epub 2021 Feb 12 doi: 10.6004/jnccn.2020.7634. PMID: 33578374Free PMC Article
Complete mediastinal lymphadenectomy: the core component of the multidisciplinary therapy in resectable non-small cell lung cancer.
Zhong W, Yang X, Bai J, Yang J, Manegold C, Wu Y
Eur J Cardiothorac Surg 2008 Jul;34(1):187-95. Epub 2008 May 23 doi: 10.1016/j.ejcts.2008.03.060. PMID: 18457958
Surgery for nonsmall cell lung cancer: can improvements be made?
Spiro SG
Eur Respir J Suppl 2003 Jan;39:52s-56s. doi: 10.1183/09031936.03.00063502. PMID: 12572702
Tumors of unknown origin.
Greco FA, Hainsworth JD
CA Cancer J Clin 1992 Mar-Apr;42(2):96-115. doi: 10.3322/canjclin.42.2.96. PMID: 1540854

Prognosis

Programmed death ligand-1 expression and occult lymph node metastasis in non-small cell lung cancer.
Mitsui S, Tanaka Y, Jimbo N, Doi T, Tane S, Hokka D, Maniwa Y
Thorac Cancer 2023 Jun;14(18):1774-1781. Epub 2023 May 9 doi: 10.1111/1759-7714.14922. PMID: 37160414Free PMC Article
Prognosis of Incidental Brain Metastases in Patients With Advanced Renal Cell Carcinoma.
Kotecha RR, Flippot R, Nortman T, Guida A, Patil S, Escudier B, Motzer RJ, Albiges L, Voss MH
J Natl Compr Canc Netw 2021 Apr;19(4):432-438. Epub 2021 Feb 12 doi: 10.6004/jnccn.2020.7634. PMID: 33578374Free PMC Article
Clinical Misstagings and Risk Factors of Occult Nodal Disease in Non-Small Cell Lung Cancer.
Dyas AR, King RW, Ghanim AF, Cerfolio RJ
Ann Thorac Surg 2018 Nov;106(5):1492-1498. Epub 2018 Jun 15 doi: 10.1016/j.athoracsur.2018.05.045. PMID: 29908981
Characteristics and prognosis of Japanese male and female lung cancer patients: The BioBank Japan Project.
Nakamura K, Ukawa S, Okada E, Hirata M, Nagai A, Yamagata Z, Ninomiya T, Muto K, Kiyohara Y, Matsuda K, Kamatani Y, Kubo M, Nakamura Y; BioBank Japan Cooperative Hospital Group, Tamakoshi A
J Epidemiol 2017 Mar;27(3S):S49-S57. Epub 2017 Feb 13 doi: 10.1016/j.je.2016.12.010. PMID: 28202209Free PMC Article
Large cell neuroendocrine carcinoma of the lung: an aggressive disease potentially treatable with surgery.
Doddoli C, Barlesi F, Chetaille B, Garbe L, Thomas P, Giudicelli R, Fuentes P
Ann Thorac Surg 2004 Apr;77(4):1168-72. doi: 10.1016/j.athoracsur.2003.09.049. PMID: 15063228

Clinical prediction guides

Immune checkpoint inhibitor use and the incidence of hepatitis B virus reactivation or immune-related hepatitis in non-small cell lung cancer patients with chronic hepatitis B.
Hong J, Lee J, Park S, Jung HA, Sun JM, Lee SH, Ahn JS, Sinn DH, Ahn MJ
Cancer 2024 May 1;130(9):1693-1701. Epub 2024 Jan 2 doi: 10.1002/cncr.35175. PMID: 38165808
Programmed death ligand-1 expression and occult lymph node metastasis in non-small cell lung cancer.
Mitsui S, Tanaka Y, Jimbo N, Doi T, Tane S, Hokka D, Maniwa Y
Thorac Cancer 2023 Jun;14(18):1774-1781. Epub 2023 May 9 doi: 10.1111/1759-7714.14922. PMID: 37160414Free PMC Article
Prevalence and Predictability of Occult Satellite Nodules in Clinical Stage Ia Non-small Cell Lung Cancer following Lobectomy.
Kneuertz PJ, Abdel-Rasoul M, D'Souza DM, Moffatt-Bruce SD, Merritt RE
Clin Lung Cancer 2023 May;24(3):e134-e140. Epub 2022 Dec 27 doi: 10.1016/j.cllc.2022.12.009. PMID: 36682930Free PMC Article
Clinical Misstagings and Risk Factors of Occult Nodal Disease in Non-Small Cell Lung Cancer.
Dyas AR, King RW, Ghanim AF, Cerfolio RJ
Ann Thorac Surg 2018 Nov;106(5):1492-1498. Epub 2018 Jun 15 doi: 10.1016/j.athoracsur.2018.05.045. PMID: 29908981
Molecular staging of lung and esophageal cancer.
Lau CL, Moore MB, Brooks KR, D'Amico TA, Harpole DH Jr
Surg Clin North Am 2002 Jun;82(3):497-523. doi: 10.1016/s0039-6109(02)00024-5. PMID: 12371582

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