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Solid Alveolar Rhabdomyosarcoma

MedGen UID:
236830
•Concept ID:
C1336025
•
Neoplastic Process

Definition

A morphologic variant of alveolar rhabdomyosarcoma. It is characterized by the presence of a solid growth pattern and the absence of fibrovascular stroma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSolid Alveolar Rhabdomyosarcoma

Professional guidelines

PubMed

The Presence of ALK Alterations and Clinical Relevance of Crizotinib Treatment in Pediatric Solid Tumors.
Felkai L, Bánusz R, Kovalszky I, Sápi Z, Garami M, Papp G, Karászi K, Varga E, Csóka M
Pathol Oncol Res 2019 Jan;25(1):217-224. Epub 2017 Oct 28 doi: 10.1007/s12253-017-0332-1. PMID: 29081033
Small interfering RNA library screen of human kinases and phosphatases identifies polo-like kinase 1 as a promising new target for the treatment of pediatric rhabdomyosarcomas.
Hu K, Lee C, Qiu D, Fotovati A, Davies A, Abu-Ali S, Wai D, Lawlor ER, Triche TJ, Pallen CJ, Dunn SE
Mol Cancer Ther 2009 Nov;8(11):3024-35. Epub 2009 Nov 3 doi: 10.1158/1535-7163.MCT-09-0365. PMID: 19887553Free PMC Article
Risk-based management: current concepts of treating malignant solid tumors of childhood.
Grosfeld JL
J Am Coll Surg 1999 Oct;189(4):407-25. doi: 10.1016/s1072-7515(99)00167-2. PMID: 10509467

Recent clinical studies

Etiology

Pathologic classification of rhabdomyosarcomas and correlations with molecular studies.
Parham DM
Mod Pathol 2001 May;14(5):506-14. doi: 10.1038/modpathol.3880339. PMID: 11353062
Solid alveolar rhabdomyosarcoma of the hand in adolescence: a clinical, histologic, immunologic, and ultrastructural study.
Bianchi L, Orlandi A, Iraci S, Spagnoli LG, Nini G
Pediatr Dermatol 1995 Dec;12(4):343-7. doi: 10.1111/j.1525-1470.1995.tb00198.x. PMID: 8747583

Diagnosis

Solid alveolar rhabdomyosarcoma of the thorax in a child.
Sartelet H, Lantuejoul S, Armari-Alla C, Pin I, Delattre O, Brambilla E
Histopathology 1998 Feb;32(2):165-71. doi: 10.1046/j.1365-2559.1998.00351.x. PMID: 9543674
Solid alveolar rhabdomyosarcoma of the hand in adolescence: a clinical, histologic, immunologic, and ultrastructural study.
Bianchi L, Orlandi A, Iraci S, Spagnoli LG, Nini G
Pediatr Dermatol 1995 Dec;12(4):343-7. doi: 10.1111/j.1525-1470.1995.tb00198.x. PMID: 8747583
The diagnosis and classification of childhood rhabdomyosarcoma.
Tsokos M
Semin Diagn Pathol 1994 Feb;11(1):26-38. PMID: 8202644

Therapy

Solid alveolar rhabdomyosarcoma with a t(2;13).
Yule SM, Bown N, Malcolm AJ, Reid MM, Pearson AD
Cancer Genet Cytogenet 1995 Apr;80(2):107-9. doi: 10.1016/0165-4608(94)00170-g. PMID: 7736424

Prognosis

Pathologic classification of rhabdomyosarcomas and correlations with molecular studies.
Parham DM
Mod Pathol 2001 May;14(5):506-14. doi: 10.1038/modpathol.3880339. PMID: 11353062
Solid alveolar rhabdomyosarcoma of the hand in adolescence: a clinical, histologic, immunologic, and ultrastructural study.
Bianchi L, Orlandi A, Iraci S, Spagnoli LG, Nini G
Pediatr Dermatol 1995 Dec;12(4):343-7. doi: 10.1111/j.1525-1470.1995.tb00198.x. PMID: 8747583
The diagnosis and classification of childhood rhabdomyosarcoma.
Tsokos M
Semin Diagn Pathol 1994 Feb;11(1):26-38. PMID: 8202644

Clinical prediction guides

Solid alveolar rhabdomyosarcoma of the hand in adolescence: a clinical, histologic, immunologic, and ultrastructural study.
Bianchi L, Orlandi A, Iraci S, Spagnoli LG, Nini G
Pediatr Dermatol 1995 Dec;12(4):343-7. doi: 10.1111/j.1525-1470.1995.tb00198.x. PMID: 8747583

Supplemental Content

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