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Metanephric adenoma

MedGen UID:
266093
•Concept ID:
C1266045
•
Neoplastic Process
Synonyms: Kidney Embryonal Adenoma; Metanephric Adenoma; metanephric adenoma; metanephric adenoma (morphologic abnormality)
SNOMED CT: Metanephric adenoma (128670007)
 
Monarch Initiative: MONDO:0006301

Definition

A benign, well-circumscribed renal cortical neoplasm affecting females more often than males. Polycythemia has been reported in twelve-percent of patients. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetanephric adenoma

Professional guidelines

PubMed

Embryonal Origin of Metanephric Adenoma and its Differential Diagnosis.
Sarlos DP, Banyai D, Peterfi L, Szanto A, Kovacs G
Anticancer Res 2018 Dec;38(12):6663-6667. doi: 10.21873/anticanres.13033. PMID: 30504374
Metanephric adenoma: the utility of immunohistochemical and cytogenetic analyses in differential diagnosis, including solid variant papillary renal cell carcinoma and epithelial-predominant nephroblastoma.
Kinney SN, Eble JN, Hes O, Williamson SR, Grignon DJ, Wang M, Zhang S, Baldrige LA, Martignoni G, Brunelli M, Wang L, Comperat E, Fan R, Montironi R, MacLennan GT, Cheng L
Mod Pathol 2015 Sep;28(9):1236-48. Epub 2015 Aug 7 doi: 10.1038/modpathol.2015.81. PMID: 26248896
Alpha-methylacyl-CoA racemase as a marker in the differential diagnosis of metanephric adenoma.
Olgac S, Hutchinson B, Tickoo SK, Reuter VE
Mod Pathol 2006 Feb;19(2):218-24. doi: 10.1038/modpathol.3800520. PMID: 16424894

Recent clinical studies

Etiology

Key Renal Neoplasms With a Female Predominance.
Baniak N, Barletta JA, Hirsch MS
Adv Anat Pathol 2021 Jul 1;28(4):228-250. doi: 10.1097/PAP.0000000000000301. PMID: 34009777
The history of urologic pathology: an overview.
Young RH, Eble JN
Histopathology 2019 Jan;74(1):184-212. doi: 10.1111/his.13753. PMID: 30565309
Novel clinicopathological and molecular characterization of metanephric adenoma: a study of 28 cases.
Ding Y, Wang C, Li X, Jiang Y, Mei P, Huang W, Song G, Wang J, Ping G, Hu R, Miao C, He X, Chen G, Li H, Zhu Y, Zhang Z
Diagn Pathol 2018 Aug 16;13(1):54. doi: 10.1186/s13000-018-0732-x. PMID: 30111351Free PMC Article
The clinical and CT imaging features of metanephric adenoma.
Zhu Q, Zhu W, Wu J, Chen W, Wang S
Acta Radiol 2014 Mar;55(2):231-8. Epub 2013 Jul 24 doi: 10.1177/0284185113493411. PMID: 23884840
Evolving classification of renal cell neoplasia.
Delahunt B, Velickovic M, Grebe SK
Expert Rev Anticancer Ther 2001 Dec;1(4):576-84. doi: 10.1586/14737140.1.4.576. PMID: 12113090

Diagnosis

Metanephric adenoma: molecular study and review of the literature.
Rodríguez-Zarco E, Machuca-Aguado J, Macías-García L, Vallejo-Benítez A, Ríos-Martín JJ
Oncotarget 2022;13:387-392. Epub 2022 Feb 17 doi: 10.18632/oncotarget.28192. PMID: 35198098Free PMC Article
Key Renal Neoplasms With a Female Predominance.
Baniak N, Barletta JA, Hirsch MS
Adv Anat Pathol 2021 Jul 1;28(4):228-250. doi: 10.1097/PAP.0000000000000301. PMID: 34009777
Pediatric Renal Neoplasms:: MR Imaging-Based Practical Diagnostic Approach.
Stanescu AL, Acharya PT, Lee EY, Phillips GS
Magn Reson Imaging Clin N Am 2019 May;27(2):279-290. doi: 10.1016/j.mric.2019.01.006. PMID: 30910098
Embryonal Origin of Metanephric Adenoma and its Differential Diagnosis.
Sarlos DP, Banyai D, Peterfi L, Szanto A, Kovacs G
Anticancer Res 2018 Dec;38(12):6663-6667. doi: 10.21873/anticanres.13033. PMID: 30504374
Metanephric adenoma.
Birgisson H, Einarsson GV, Steinarsdóttir M, Jónasson JG
Scand J Urol Nephrol 1999 Oct;33(5):340-3. doi: 10.1080/003655999750017464. PMID: 10573002

Therapy

Secondary renal neoplasia following chemotherapy or radiation in pediatric patients.
Gupta S, Vanderbilt CM, Leibovich BC, Herrera-Hernandez L, Raghunathan A, Sukov WR, Voss JS, Barr Fritcher EG, Reed KA, Lohse CM, Reuter VE, Jimenez RE, Thompson RH, Cheville JC
Hum Pathol 2020 Sep;103:1-13. Epub 2020 Jul 15 doi: 10.1016/j.humpath.2020.07.014. PMID: 32681944Free PMC Article
Robotic-assisted laparoscopic surgery for pediatric tumors: a bicenter experience.
Meignan P, Ballouhey Q, Lejeune J, Braik K, Longis B, Cook AR, Lardy H, Fourcade L, Binet A
J Robot Surg 2018 Sep;12(3):501-508. Epub 2017 Dec 29 doi: 10.1007/s11701-017-0773-2. PMID: 29288372
Chimerism of metanephric adenoma but not of carcinoma in kidney transplants.
Mengel M, Jonigk D, Wilkens L, Radermacher J, von Wasielewski R, Lehmann U, Haller H, Mihatsch M, Kreipe H
Am J Pathol 2004 Dec;165(6):2079-85. doi: 10.1016/S0002-9440(10)63258-0. PMID: 15579450Free PMC Article
Pure cystic nephroblastoma of the ovary with a review of extrarenal Wilms' tumors.
Isaac MA, Vijayalakshmi S, Madhu CS, Bosincu L, Nogales FF
Hum Pathol 2000 Jun;31(6):761-4. doi: 10.1053/hupa.2000.7627. PMID: 10872672
Metanephric adenofibroma: report of a case and review of the literature.
Shek TW, Luk IS, Peh WC, Chan KL, Chan GC
Am J Surg Pathol 1999 Jun;23(6):727-33. doi: 10.1097/00000478-199906000-00014. PMID: 10366157

Prognosis

Metanephric adenoma: molecular study and review of the literature.
Rodríguez-Zarco E, Machuca-Aguado J, Macías-García L, Vallejo-Benítez A, Ríos-Martín JJ
Oncotarget 2022;13:387-392. Epub 2022 Feb 17 doi: 10.18632/oncotarget.28192. PMID: 35198098Free PMC Article
Immunohistochemical phenotype and molecular pathological characteristics of metanephric adenoma.
Sun Z, Kan S, Zhang L, Zhang Y, Jing H, Huang G, Yu Q, Wu J
Int J Clin Exp Pathol 2015;8(6):6031-6. Epub 2015 Jun 1 PMID: 26261480Free PMC Article
The clinical and CT imaging features of metanephric adenoma.
Zhu Q, Zhu W, Wu J, Chen W, Wang S
Acta Radiol 2014 Mar;55(2):231-8. Epub 2013 Jul 24 doi: 10.1177/0284185113493411. PMID: 23884840
Evolving classification of renal cell neoplasia.
Delahunt B, Velickovic M, Grebe SK
Expert Rev Anticancer Ther 2001 Dec;1(4):576-84. doi: 10.1586/14737140.1.4.576. PMID: 12113090
Metanephric adenoma.
Birgisson H, Einarsson GV, Steinarsdóttir M, Jónasson JG
Scand J Urol Nephrol 1999 Oct;33(5):340-3. doi: 10.1080/003655999750017464. PMID: 10573002

Clinical prediction guides

Molecular Characterization of Metanephric Adenoma, Epithelial Wilms Tumor, and Overlap Lesions: An Integrated Whole-exome and Transcriptome Sequencing Analysis.
Pan CC, Tseng CE, Kuroda N, Yano M, Yasuda M, Nagashima Y, Yeh YC, Wang YC, Chang YH, Epstein JI
Appl Immunohistochem Mol Morphol 2022 Apr 1;30(4):257-263. doi: 10.1097/PAI.0000000000000996. PMID: 35384875
The history of urologic pathology: an overview.
Young RH, Eble JN
Histopathology 2019 Jan;74(1):184-212. doi: 10.1111/his.13753. PMID: 30565309
The findings of CT and MRI in patients with metanephric adenoma.
Yan J, Cheng JL, Li CF, Lian YB, Zheng Y, Zhang XP, Wang CY
Diagn Pathol 2016 Oct 27;11(1):104. doi: 10.1186/s13000-016-0535-x. PMID: 27784295Free PMC Article
Immunohistochemical phenotype and molecular pathological characteristics of metanephric adenoma.
Sun Z, Kan S, Zhang L, Zhang Y, Jing H, Huang G, Yu Q, Wu J
Int J Clin Exp Pathol 2015;8(6):6031-6. Epub 2015 Jun 1 PMID: 26261480Free PMC Article
Adult metanephric adenoma presumed to be all benign? A clinical perspective.
Li G, Tang Y, Zhang R, Song H, Zhang S, Niu Y
BMC Cancer 2015 Apr 25;15:310. doi: 10.1186/s12885-015-1211-3. PMID: 25907695Free PMC Article

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