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Potassium deficiency disease

MedGen UID:
271346
•Concept ID:
C1514284
•
Disease or Syndrome
Synonyms: hypokalemia; hypopotassemia; potassium deficiency disease; Potassium Deficiency Disorder; potassium deficiency disorder
 
Monarch Initiative: MONDO:0003019

Definition

Any disorder caused by an insufficient amount or availability of potassium, which generally manifests with myalgia, tetany, hypotension, polyuria, and polydipsia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPotassium deficiency disease

Professional guidelines

PubMed

Metabolic Alkalosis Pathogenesis, Diagnosis, and Treatment: Core Curriculum 2022.
Do C, Vasquez PC, Soleimani M
Am J Kidney Dis 2022 Oct;80(4):536-551. Epub 2022 May 5 doi: 10.1053/j.ajkd.2021.12.016. PMID: 35525634Free PMC Article
Renal Tubular Acidosis and Management Strategies: A Narrative Review.
Palmer BF, Kelepouris E, Clegg DJ
Adv Ther 2021 Feb;38(2):949-968. Epub 2020 Dec 26 doi: 10.1007/s12325-020-01587-5. PMID: 33367987Free PMC Article
Micronutrient Intake in the Etiology, Prevention and Treatment of Osteosarcopenic Obesity.
Kelly OJ, Gilman JC, Kim Y, Ilich JZ
Curr Aging Sci 2016;9(4):260-278. doi: 10.2174/1874609809666160509122001. PMID: 27156952

Recent clinical studies

Etiology

Essential metals in health and disease.
Jomova K, Makova M, Alomar SY, Alwasel SH, Nepovimova E, Kuca K, Rhodes CJ, Valko M
Chem Biol Interact 2022 Nov 1;367:110173. Epub 2022 Sep 22 doi: 10.1016/j.cbi.2022.110173. PMID: 36152810
Parkinson's disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes.
Hu M, Li P, Wang C, Feng X, Geng Q, Chen W, Marthi M, Zhang W, Gao C, Reid W, Swanson J, Du W, Hume RI, Xu H
Cell 2022 Jun 23;185(13):2292-2308.e20. doi: 10.1016/j.cell.2022.05.021. PMID: 35750034Free PMC Article
Magnesium and Cardiovascular Disease.
Tangvoraphonkchai K, Davenport A
Adv Chronic Kidney Dis 2018 May;25(3):251-260. doi: 10.1053/j.ackd.2018.02.010. PMID: 29793664
Potassium Intake, Bioavailability, Hypertension, and Glucose Control.
Stone MS, Martyn L, Weaver CM
Nutrients 2016 Jul 22;8(7) doi: 10.3390/nu8070444. PMID: 27455317Free PMC Article
Health effects of vegan diets.
Craig WJ
Am J Clin Nutr 2009 May;89(5):1627S-1633S. Epub 2009 Mar 11 doi: 10.3945/ajcn.2009.26736N. PMID: 19279075

Diagnosis

Pathophysiologic approach in genetic hypokalemia: An update.
Blanchard A
Ann Endocrinol (Paris) 2023 Apr;84(2):298-307. Epub 2023 Jan 10 doi: 10.1016/j.ando.2022.11.005. PMID: 36639120
The Genetic Landscape of Complex Childhood-Onset Hyperkinetic Movement Disorders.
Pérez-Dueñas B, Gorman K, Marcé-Grau A, Ortigoza-Escobar JD, Macaya A, Danti FR, Barwick K, Papandreou A, Ng J, Meyer E, Mohammad SS, Smith M, Muntoni F, Munot P, Uusimaa J, Vieira P, Sheridan E, Guerrini R, Cobben J, Yilmaz S, De Grandis E, Dale RC, Pons R, Peall KJ, Leuzzi V, Kurian MA
Mov Disord 2022 Nov;37(11):2197-2209. Epub 2022 Aug 25 doi: 10.1002/mds.29182. PMID: 36054588Free PMC Article
Metabolic Alkalosis Pathogenesis, Diagnosis, and Treatment: Core Curriculum 2022.
Do C, Vasquez PC, Soleimani M
Am J Kidney Dis 2022 Oct;80(4):536-551. Epub 2022 May 5 doi: 10.1053/j.ajkd.2021.12.016. PMID: 35525634Free PMC Article
Renal Tubular Acidosis and Management Strategies: A Narrative Review.
Palmer BF, Kelepouris E, Clegg DJ
Adv Ther 2021 Feb;38(2):949-968. Epub 2020 Dec 26 doi: 10.1007/s12325-020-01587-5. PMID: 33367987Free PMC Article
Quantitative assessment of nutrition in patients with polycystic ovary syndrome (PCOS).
Szczuko M, Skowronek M, Zapałowska-Chwyć M, Starczewski A
Rocz Panstw Zakl Hig 2016;67(4):419-426. PMID: 27925712

Therapy

Metabolic Alkalosis Pathogenesis, Diagnosis, and Treatment: Core Curriculum 2022.
Do C, Vasquez PC, Soleimani M
Am J Kidney Dis 2022 Oct;80(4):536-551. Epub 2022 May 5 doi: 10.1053/j.ajkd.2021.12.016. PMID: 35525634Free PMC Article
Role of ion channels in gastrointestinal cancer.
Anderson KJ, Cormier RT, Scott PM
World J Gastroenterol 2019 Oct 14;25(38):5732-5772. doi: 10.3748/wjg.v25.i38.5732. PMID: 31636470Free PMC Article
Magnesium and Cardiovascular Disease.
Tangvoraphonkchai K, Davenport A
Adv Chronic Kidney Dis 2018 May;25(3):251-260. doi: 10.1053/j.ackd.2018.02.010. PMID: 29793664
Potassium Intake, Bioavailability, Hypertension, and Glucose Control.
Stone MS, Martyn L, Weaver CM
Nutrients 2016 Jul 22;8(7) doi: 10.3390/nu8070444. PMID: 27455317Free PMC Article
Magnesium in man: implications for health and disease.
de Baaij JH, Hoenderop JG, Bindels RJ
Physiol Rev 2015 Jan;95(1):1-46. doi: 10.1152/physrev.00012.2014. PMID: 25540137

Prognosis

Role of ion channels in gastrointestinal cancer.
Anderson KJ, Cormier RT, Scott PM
World J Gastroenterol 2019 Oct 14;25(38):5732-5772. doi: 10.3748/wjg.v25.i38.5732. PMID: 31636470Free PMC Article
Using phosphate supplementation to reverse hypophosphatemia and phosphate depletion in neurological disease and disturbance.
Håglin L
Nutr Neurosci 2016 Jun;19(5):213-23. Epub 2015 Apr 24 doi: 10.1179/1476830515Y.0000000024. PMID: 25909152
Dystonia-plus syndromes.
Asmus F, Gasser T
Eur J Neurol 2010 Jul;17 Suppl 1:37-45. doi: 10.1111/j.1468-1331.2010.03049.x. PMID: 20590807
Amiodarone-induced thyrotoxicosis. A review.
Piga M, Serra A, Boi F, Tanda ML, Martino E, Mariotti S
Minerva Endocrinol 2008 Sep;33(3):213-28. PMID: 18846027
Lowe syndrome.
Loi M
Orphanet J Rare Dis 2006 May 18;1:16. doi: 10.1186/1750-1172-1-16. PMID: 16722554Free PMC Article

Clinical prediction guides

The Genetic Landscape of Complex Childhood-Onset Hyperkinetic Movement Disorders.
Pérez-Dueñas B, Gorman K, Marcé-Grau A, Ortigoza-Escobar JD, Macaya A, Danti FR, Barwick K, Papandreou A, Ng J, Meyer E, Mohammad SS, Smith M, Muntoni F, Munot P, Uusimaa J, Vieira P, Sheridan E, Guerrini R, Cobben J, Yilmaz S, De Grandis E, Dale RC, Pons R, Peall KJ, Leuzzi V, Kurian MA
Mov Disord 2022 Nov;37(11):2197-2209. Epub 2022 Aug 25 doi: 10.1002/mds.29182. PMID: 36054588Free PMC Article
Renal Tubular Acidosis and Management Strategies: A Narrative Review.
Palmer BF, Kelepouris E, Clegg DJ
Adv Ther 2021 Feb;38(2):949-968. Epub 2020 Dec 26 doi: 10.1007/s12325-020-01587-5. PMID: 33367987Free PMC Article
Magnesium and Cardiovascular Disease.
Tangvoraphonkchai K, Davenport A
Adv Chronic Kidney Dis 2018 May;25(3):251-260. doi: 10.1053/j.ackd.2018.02.010. PMID: 29793664
Magnesium: its role in nutrition and carcinogenesis.
Blaszczyk U, Duda-Chodak A
Rocz Panstw Zakl Hig 2013;64(3):165-71. PMID: 24325082
Dystonia-plus syndromes.
Asmus F, Gasser T
Eur J Neurol 2010 Jul;17 Suppl 1:37-45. doi: 10.1111/j.1468-1331.2010.03049.x. PMID: 20590807

Recent systematic reviews

A comprehensive review of hypomagnesemia.
Ehrenpreis ED, Jarrouj G, Meader R, Wagner C, Ellis M
Dis Mon 2022 Feb;68(2):101285. Epub 2021 Sep 10 doi: 10.1016/j.disamonth.2021.101285. PMID: 34511254
Trace element status in hemodialysis patients.
Rucker D, Thadhani R, Tonelli M
Semin Dial 2010 Jul-Aug;23(4):389-95. Epub 2010 Jun 14 doi: 10.1111/j.1525-139X.2010.00746.x. PMID: 20557491
Iodised salt for preventing iodine deficiency disorders.
Wu T, Liu GJ, Li P, Clar C
Cochrane Database Syst Rev 2002;2002(3):CD003204. doi: 10.1002/14651858.CD003204. PMID: 12137681Free PMC Article

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