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p190 Fusion Protein Expression

MedGen UID:
271858
•Concept ID:
C1515674
•
Cell or Molecular Dysfunction
Synonyms: p190 BCR-ABL1 Fusion Protein Expression; p190 BCR/ABL1 Fusion Protein Expression

Definition

Expression of a fusion protein with an apparent molecular weight of 190 kilodaltons that results from a fusion of the human genes BCR and ABL1. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVp190 Fusion Protein Expression

Professional guidelines

PubMed

Pak1 gene functioned differentially in different BCR-ABL subtypes in leukemiagenesis and treatment response through STAT5 pathway.
Yuanxin Y, Yanhong Z, Qin Z, Sishi T, Yang D, Yi Z, Minjin W, Juan Z, Xiaojun L, Lanlan W, Binwu Y
Leuk Res 2019 Apr;79:6-16. Epub 2019 Jan 24 doi: 10.1016/j.leukres.2019.01.012. PMID: 30784762
In vivo inhibition by a site-specific catalytic RNA subunit of RNase P designed against the BCR-ABL oncogenic products: a novel approach for cancer treatment.
Cobaleda C, Sánchez-García I
Blood 2000 Feb 1;95(3):731-7. PMID: 10648380

Recent clinical studies

Etiology

Characterization of p190-Bcr-Abl chronic myeloid leukemia reveals specific signaling pathways and therapeutic targets.
Adnan-Awad S, Kim D, Hohtari H, Javarappa KK, Brandstoetter T, Mayer I, Potdar S, Heckman CA, Kytölä S, Porkka K, Doma E, Sexl V, Kankainen M, Mustjoki S
Leukemia 2021 Jul;35(7):1964-1975. Epub 2020 Nov 9 doi: 10.1038/s41375-020-01082-4. PMID: 33168949Free PMC Article
A rare BCR-ABL1 transcript in Philadelphia-positive acute myeloid leukemia: case report and literature review.
Piedimonte M, Ottone T, Alfonso V, Ferrari A, Conte E, Divona M, Bianchi MP, Ricciardi MR, Mirabilii S, Licchetta R, Campagna A, Cicconi L, Galassi G, Pelliccia S, Leporace A, Lo Coco F, Tafuri A
BMC Cancer 2019 Jan 10;19(1):50. doi: 10.1186/s12885-019-5265-5. PMID: 30630459Free PMC Article
Incidence of bcr‑abl fusion transcripts in healthy individuals.
Ismail SI, Naffa RG, Yousef AM, Ghanim MT
Mol Med Rep 2014 Apr;9(4):1271-6. Epub 2014 Feb 13 doi: 10.3892/mmr.2014.1951. PMID: 24535287
Philadelphia chromosome-positive chronic myeloid leukemia expressing p190(BCR-ABL).
Ohsaka A, Shiina S, Kobayashi M, Kudo H, Kawaguchi R
Intern Med 2002 Dec;41(12):1183-7. doi: 10.2169/internalmedicine.41.1183. PMID: 12521212
BCR/ABL p210, p190 and p230 fusion genes in 250 Mexican patients with chronic myeloid leukaemia (CML).
Arana-Trejo RM, Ruíz Sánchez E, Ignacio-Ibarra G, Báez de la Fuente E, Garces O, Gómez Morales E, Castro Granados M, Ovilla Martínez R, Rubio-Borja ME, Solís Anaya L, Herrera P, Delgado Llamas J, Kofman S
Clin Lab Haematol 2002 Jun;24(3):145-50. doi: 10.1046/j.1365-2257.2002.00413.x. PMID: 12067277

Diagnosis

Chronic Myelogenous Leukemia with Double Philadelphia Chromosome and Coexpression of p210 and p190 Fusion Transcripts.
Cruz SSD, Seabra AD, Macambira LHR, Carneiro DM, Nunes PF, Pontes TB, Mello-Junior FAR, Leão LBC, Cordeiro FNCDS, Carneiro TX, Moreira-Nunes CA, Burbano RMR
Genes (Basel) 2022 Mar 25;13(4) doi: 10.3390/genes13040580. PMID: 35456386Free PMC Article
Characterization of p190-Bcr-Abl chronic myeloid leukemia reveals specific signaling pathways and therapeutic targets.
Adnan-Awad S, Kim D, Hohtari H, Javarappa KK, Brandstoetter T, Mayer I, Potdar S, Heckman CA, Kytölä S, Porkka K, Doma E, Sexl V, Kankainen M, Mustjoki S
Leukemia 2021 Jul;35(7):1964-1975. Epub 2020 Nov 9 doi: 10.1038/s41375-020-01082-4. PMID: 33168949Free PMC Article
Incidence of bcr‑abl fusion transcripts in healthy individuals.
Ismail SI, Naffa RG, Yousef AM, Ghanim MT
Mol Med Rep 2014 Apr;9(4):1271-6. Epub 2014 Feb 13 doi: 10.3892/mmr.2014.1951. PMID: 24535287
BCR/ABL p210, p190 and p230 fusion genes in 250 Mexican patients with chronic myeloid leukaemia (CML).
Arana-Trejo RM, Ruíz Sánchez E, Ignacio-Ibarra G, Báez de la Fuente E, Garces O, Gómez Morales E, Castro Granados M, Ovilla Martínez R, Rubio-Borja ME, Solís Anaya L, Herrera P, Delgado Llamas J, Kofman S
Clin Lab Haematol 2002 Jun;24(3):145-50. doi: 10.1046/j.1365-2257.2002.00413.x. PMID: 12067277
Expression of p210 and p190 BCR-ABL due to alternative splicing in chronic myelogenous leukaemia.
Lichty BD, Keating A, Callum J, Yee K, Croxford R, Corpus G, Nwachukwu B, Kim P, Guo J, Kamel-Reid S
Br J Haematol 1998 Dec;103(3):711-5. doi: 10.1046/j.1365-2141.1998.01033.x. PMID: 9858221

Therapy

Durable Molecular Remission in an Elderly Patient Affected by Relapsed Ph'+ Acute Lymphoblastic Leukemia with T315I and Concomitant p190 and p210 Expression Achieved by Inotuzumab and Ponatinib.
Molica M, Mazzone C, Cordone I, Divona M, Niscola P, de Fabritiis P
Chemotherapy 2021;66(3):78-81. Epub 2021 Jun 8 doi: 10.1159/000516593. PMID: 34102636
Philadelphia Chromosome-Positive Leukemia in the Lymphoid Lineage-Similarities and Differences with the Myeloid Lineage and Specific Vulnerabilities.
Komorowski L, Fidyt K, Patkowska E, Firczuk M
Int J Mol Sci 2020 Aug 12;21(16) doi: 10.3390/ijms21165776. PMID: 32806528Free PMC Article
BCR-ABL-positive acute myeloid leukemia: a new entity? Analysis of clinical and molecular features.
Neuendorff NR, Burmeister T, Dörken B, Westermann J
Ann Hematol 2016 Aug;95(8):1211-21. Epub 2016 Jun 14 doi: 10.1007/s00277-016-2721-z. PMID: 27297971
Prognostic significance of immunophenotypic and karyotypic features of Philadelphia positive B-lymphoblastic leukemia in the era of tyrosine kinase inhibitors.
Jaso J, Thomas DA, Cunningham K, Jorgensen JL, Kantarjian HM, Medeiros LJ, Wang SA
Cancer 2011 Sep 1;117(17):4009-17. Epub 2011 Mar 1 doi: 10.1002/cncr.25978. PMID: 21365622Free PMC Article
In vivo inhibition by a site-specific catalytic RNA subunit of RNase P designed against the BCR-ABL oncogenic products: a novel approach for cancer treatment.
Cobaleda C, Sánchez-García I
Blood 2000 Feb 1;95(3):731-7. PMID: 10648380

Prognosis

Targeting the CDK6 Dependence of Ph+ Acute Lymphoblastic Leukemia.
Porazzi P, De Dominici M, Salvino J, Calabretta B
Genes (Basel) 2021 Aug 29;12(9) doi: 10.3390/genes12091355. PMID: 34573335Free PMC Article
Frequency of rare BCR-ABL1 fusion transcripts in chronic myeloid leukemia patients.
Arun AK, Senthamizhselvi A, Mani S, Vinodhini K, Janet NB, Lakshmi KM, Abraham A, George B, Srivastava A, Srivastava VM, Mathews V, Balasubramanian P
Int J Lab Hematol 2017 Jun;39(3):235-242. Epub 2016 Dec 29 doi: 10.1111/ijlh.12616. PMID: 28035733
Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival.
Chang KH, Sanchez-Aguilera A, Shen S, Sengupta A, Madhu MN, Ficker AM, Dunn SK, Kuenzi AM, Arnett JL, Santho RA, Agirre X, Perentesis JP, Deininger MW, Zheng Y, Bustelo XR, Williams DA, Cancelas JA
Blood 2012 Jul 26;120(4):800-11. Epub 2012 Jun 12 doi: 10.1182/blood-2011-06-361709. PMID: 22692505Free PMC Article
Philadelphia chromosome-positive chronic myeloid leukemia expressing p190(BCR-ABL).
Ohsaka A, Shiina S, Kobayashi M, Kudo H, Kawaguchi R
Intern Med 2002 Dec;41(12):1183-7. doi: 10.2169/internalmedicine.41.1183. PMID: 12521212
BCR/ABL p210, p190 and p230 fusion genes in 250 Mexican patients with chronic myeloid leukaemia (CML).
Arana-Trejo RM, Ruíz Sánchez E, Ignacio-Ibarra G, Báez de la Fuente E, Garces O, Gómez Morales E, Castro Granados M, Ovilla Martínez R, Rubio-Borja ME, Solís Anaya L, Herrera P, Delgado Llamas J, Kofman S
Clin Lab Haematol 2002 Jun;24(3):145-50. doi: 10.1046/j.1365-2257.2002.00413.x. PMID: 12067277

Clinical prediction guides

De Novo Linear Phosphorylation Site Motifs for BCR-ABL Kinase Revealed by Phospho-Proteomics in Yeast.
Smolnig M, Fasching S, Stelzl U
J Proteome Res 2023 Jun 2;22(6):1790-1799. Epub 2023 Apr 13 doi: 10.1021/acs.jproteome.2c00795. PMID: 37053475Free PMC Article
Chronic Myelogenous Leukemia with Double Philadelphia Chromosome and Coexpression of p210 and p190 Fusion Transcripts.
Cruz SSD, Seabra AD, Macambira LHR, Carneiro DM, Nunes PF, Pontes TB, Mello-Junior FAR, Leão LBC, Cordeiro FNCDS, Carneiro TX, Moreira-Nunes CA, Burbano RMR
Genes (Basel) 2022 Mar 25;13(4) doi: 10.3390/genes13040580. PMID: 35456386Free PMC Article
Durable Molecular Remission in an Elderly Patient Affected by Relapsed Ph'+ Acute Lymphoblastic Leukemia with T315I and Concomitant p190 and p210 Expression Achieved by Inotuzumab and Ponatinib.
Molica M, Mazzone C, Cordone I, Divona M, Niscola P, de Fabritiis P
Chemotherapy 2021;66(3):78-81. Epub 2021 Jun 8 doi: 10.1159/000516593. PMID: 34102636
Loss of Pax5 Exploits Sca1-BCR-ABL(p190) Susceptibility to Confer the Metabolic Shift Essential for pB-ALL.
Martín-Lorenzo A, Auer F, Chan LN, García-Ramírez I, González-Herrero I, Rodríguez-Hernández G, Bartenhagen C, Dugas M, Gombert M, Ginzel S, Blanco O, Orfao A, Alonso-López D, Rivas JL, García-Cenador MB, García-Criado FJ, Müschen M, Sánchez-García I, Borkhardt A, Vicente-Dueñas C, Hauer J
Cancer Res 2018 May 15;78(10):2669-2679. Epub 2018 Feb 28 doi: 10.1158/0008-5472.CAN-17-3262. PMID: 29490943Free PMC Article
Incidence of bcr‑abl fusion transcripts in healthy individuals.
Ismail SI, Naffa RG, Yousef AM, Ghanim MT
Mol Med Rep 2014 Apr;9(4):1271-6. Epub 2014 Feb 13 doi: 10.3892/mmr.2014.1951. PMID: 24535287

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