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Fusion Protein Expression

MedGen UID:: 274542
•Concept ID:: C1517332
•: Cell or Molecular Dysfunction

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVFusion Protein Expression

Molecular Abnormality
- Molecular Sequence Variation
  - Molecular Genetic Variation
    - Gene Abnormality
      - Deregulation of Protein and Messenger RNA Expression
        Protein Deregulation
        Fusion Protein Expression
        ALK Fusion Protein Expression
        ALO17-ALK Fusion Protein Expression
        ATIC-ALK Fusion Protein Expression
        CLTC-ALK Fusion Protein Expression
        MSN-ALK Fusion Protein Expression
        MYH9-ALK Fusion Protein Expression
        NPM-ALK Fusion Protein Expression
        TFG-ALK Fusion Protein Expression
        TFG-ALKlong Fusion Protein Expression
        TFG-ALKshort Fusion Protein Expression
        TPM3-ALK Fusion Protein Expression
        TPM4-ALK Fusion Protein Expression
        AML1-ETO Fusion Protein Expression
        API2-MLT Fusion Protein Expression
        ASPL-TFE3 Fusion Protein Expression
        BCOR-CCNB3 Fusion Protein Expression
        BCR-ABL1 Fusion Protein Expression
        p190 Fusion Protein Expression
        p210 Fusion Protein Expression
        p230 Fusion Protein Expression
        BCR-FGFR1 Fusion Protein Expression
        BCR-JAK2 Fusion Protein Expression
        BCR-PDGFRAlpha Fusion Protein Expression
        BRD4-NUT Fusion Protein Expression
        CBFB-MYH11 Fusion Protein Expression
        CIC-DUX4 Fusion Protein Expression
        CIC-DUX4L Fusion Protein Expression
        COL1A1-PDGFbeta Fusion Protein Expression
        COL1A2-PLAG1 Fusion Protein Expression
        CRTC1-MAML2 Fusion Protein Expression
        DEK-NUP214 Fusion Protein Expression
        ETV6-ABL1 Fusion Protein Expression
        ETV6-JAK2 Fusion Protein Expression
        ETV6-NTRK3 Fusion Protein Expression
        ETV6-PDGFRB Fusion Protein Expression
        ETV6-RUNX1 Fusion Protein Expression
        EWSR1-ATF1 Fusion Protein Expression
        EWSR1-CREB1 Fusion Protein Expression
        EWSR1-DDIT3 Fusion Protein Expression
        EWSR1-ERG Fusion Protein Expression
        EWSR1-ETV1 Fusion Protein Expression
        EWSR1-ETV4 Fusion Protein Expression
        EWSR1-FEV Fusion Protein Expression
        EWSR1-FLI1 Fusion Protein Expression
        EWSR1-NFATC2 Fusion Protein Expression
        EWSR1-NR4A3 Fusion Protein Expression
        EWSR1-PATZ1 Fusion Protein Expression
        EWSR1-WT1 Fusion Protein Expression
        FIP1L1-PDGFRalpha Fusion Protein Expression
        FN1-FGF1 Fusion Protein Expression
        FN1-FGFR1 Fusion Protein Expression
        FUS-ATF1 Fusion Protein Expression
        FUS-CREB3L1 Fusion Protein Expression
        FUS-CREB3L2 Fusion Protein Expression
        FUS-DDIT3 Fusion Protein Expression
        FUS-ERG Fusion Protein Expression
        FUS-NFATC2 Fusion Protein Expression
        HAS2-PLAG1 Fusion Protein Expression
        HMGA2-LPP Fusion Protein Expression
        JAZF1-SUZ12 Fusion Protein Expression
        KMT2A-AFF1 Fusion Protein Expression
        KMT2A-EEN Fusion Protein Expression
        KMT2A-ELL Fusion Protein Expression
        KMT2A-MLLT1 Fusion Protein Expression
        KMT2A-MLLT10 Fusion Protein Expression
        MECOM-RUNX1 Fusion Protein Expression
        MLLT3-KMT2A Fusion Protein Expression
        MOZ-V Fusion Protein Expression
        NONO-TFE3 Fusion Protein Expression
        NPM1-RARA Fusion Protein Expression
        NUMA1-RARA Fusion Protein Expression
        PAX3-FOXO1 Fusion Protein Expression
        PAX3-FOXO4 Fusion Protein Expression
        PAX3-NCOA1 Fusion Protein Expression
        PAX7-FOXO1 Fusion Protein Expression
        PCM1-JAK2 Fusion Protein Expression
        PML-RARA Fusion Protein Expression
        PRCC-TFE3 Fusion Protein Expression
        PSF-TFE3 Fusion Protein Expression
        RBM15-MKL1 Fusion Protein Expression
        SS18-SSX Fusion Protein Expression
        SS18-SSX1 Fusion Protein Expression
        SS18-SSX2 Fusion Protein Expression
        SS18-SSX4 Fusion Protein Expression
        SS18L1-SSX1 Fusion Protein Expression
        STAT5B-RARA Fusion Protein Expression
        TAF15-NR4A3 Fusion Protein Expression
        TCF12-NR4A3 Fusion Protein Expression
        TCF3-PBX1 Fusion Protein Expression
        TFG-NR4A3 Fusion Protein Expression
        TMPRSS2-ERG Fusion Protein Expression
        V-MLL Fusion Protein Expression
        WWTR1-CAMTA1 Fusion Protein Expression
        YWHAE-FAM22 Fusion Protein Expression
        ZBTB16-RARA Fusion Protein Expression
        ZFTA-MRTFB Fusion Protein Expression
        ZFTA-RELA Fusion Protein Expression

Professional guidelines

PubMed

Construction of Anti-CD20 Single-Chain Antibody-CD28-CD137-TCRζ Recombinant Genetic Modified T Cells and its Treatment Effect on B Cell Lymphoma.

Chen F, Fan C, Gu X, Zhang H, Liu Q, Gao X, Lu J, He B, Lai X
Med Sci Monit 2015 Jul 21;21:2110-5. doi: 10.12659/MSM.893791. PMID: 26195067 Free PMC Article

See all (1)

Recent clinical studies

Etiology

Anaplastic lymphoma kinase fusion protein expression is associated with a favorable prognosis in resected invasive mucinous lung adenocarcinoma: A retrospective study from two Chinese tertiary hospitals.

Wang J, Wei P, Liu J, Su P, Xing A, Jing H, Hao J
J Cancer Res Ther 2022 Apr;18(2):445-451. doi: 10.4103/jcrt.jcrt_2334_21. PMID: 35645113

Development of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 Antibody.

Peng S, Ferrall L, Gaillard S, Wang C, Chi WY, Huang CH, Roden RBS, Wu TC, Chang YN, Hung CF
mBio 2021 Jan 19;12(1) doi: 10.1128/mBio.03224-20. PMID: 33468698 Free PMC Article

Engineering and expression of a human rotavirus candidate vaccine in Nicotiana benthamiana.

Pêra FF, Mutepfa DL, Khan AM, Els JH, Mbewana S, van Dijk AA, Rybicki EP, Hitzeroth II
Virol J 2015 Dec 2;12:205. doi: 10.1186/s12985-015-0436-8. PMID: 26626122 Free PMC Article

The protective effect of intrasplenic transplantation of Ad-IL-18BP/IL-4 gene-modified fetal hepatocytes on ConA-induced hepatitis in mice.

Shao X, Qian Y, Xu C, Hong B, Xu W, Shen L, Jin C, Wu Z, Tong X, Yao H
PLoS One 2013;8(3):e58836. Epub 2013 Mar 13 doi: 10.1371/journal.pone.0058836. PMID: 23516562 Free PMC Article

Tocopherol-associated protein is a ligand-dependent transcriptional activator.

Yamauchi J, Iwamoto T, Kida S, Masushige S, Yamada K, Esashi T
Biochem Biophys Res Commun 2001 Jul 13;285(2):295-9. doi: 10.1006/bbrc.2001.5162. PMID: 11444841

See all (13)

Diagnosis

Wang J, Wei P, Liu J, Su P, Xing A, Jing H, Hao J
J Cancer Res Ther 2022 Apr;18(2):445-451. doi: 10.4103/jcrt.jcrt_2334_21. PMID: 35645113

Development of bacterial biosensor for sensitive and selective detection of acetaldehyde.

Liang B, Liu Y, Zhao Y, Xia T, Chen R, Yang J
Biosens Bioelectron 2021 Dec 1;193:113566. Epub 2021 Aug 13 doi: 10.1016/j.bios.2021.113566. PMID: 34416430

miR-96 acts as a tumor suppressor via targeting the BCR-ABL1 oncogene in chronic myeloid leukemia blastic transformation.

Huang T, Fu Y, Wang S, Xu M, Yin X, Zhou M, Wang X, Chen C
Biomed Pharmacother 2019 Nov;119:109413. Epub 2019 Sep 10 doi: 10.1016/j.biopha.2019.109413. PMID: 31518872

A luciferase immunoprecipitation assay for the detection of proinsulin/insulin autoantibodies.

Ling Y, Jiang P, Li N, Yan Q, Wang X
Clin Biochem 2018 Apr;54:51-55. Epub 2018 Feb 21 doi: 10.1016/j.clinbiochem.2018.02.011. PMID: 29476720

γ-Secretase processing and effects of γ-secretase inhibitors and modulators on long Aβ peptides in cells.

Ran Y, Cruz PE, Ladd TB, Fauq AH, Jung JI, Matthews J, Felsenstein KM, Golde TE
J Biol Chem 2014 Feb 7;289(6):3276-87. Epub 2013 Dec 18 doi: 10.1074/jbc.M113.512921. PMID: 24352661 Free PMC Article

See all (15)

Therapy

Aberrant splicing events caused by insertion of genes of interest into expression vectors.

Cheng Y, Kang XZ, Chan P, Ye ZW, Chan CP, Jin DY
Int J Biol Sci 2022;18(13):4914-4931. Epub 2022 Jul 18 doi: 10.7150/ijbs.72408. PMID: 35982889 Free PMC Article

Activated TRPA1 plays a therapeutic role in TMZ resistance in glioblastoma by altering mitochondrial dynamics.

Chen H, Li C, Hu H, Zhang B
BMC Mol Cell Biol 2022 Aug 19;23(1):38. doi: 10.1186/s12860-022-00438-1. PMID: 35982414 Free PMC Article

SAC-TRAIL, a novel anticancer fusion protein: expression, purification, and functional characterization.

Zhang J, Dong W, Ren Y, Wei D
Appl Microbiol Biotechnol 2022 Feb;106(4):1511-1520. Epub 2022 Feb 8 doi: 10.1007/s00253-022-11807-3. PMID: 35133472

Development of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 Antibody.

Peng S, Ferrall L, Gaillard S, Wang C, Chi WY, Huang CH, Roden RBS, Wu TC, Chang YN, Hung CF
mBio 2021 Jan 19;12(1) doi: 10.1128/mBio.03224-20. PMID: 33468698 Free PMC Article

A luciferase immunoprecipitation assay for the detection of proinsulin/insulin autoantibodies.

Ling Y, Jiang P, Li N, Yan Q, Wang X
Clin Biochem 2018 Apr;54:51-55. Epub 2018 Feb 21 doi: 10.1016/j.clinbiochem.2018.02.011. PMID: 29476720

See all (15)

Prognosis

ABCE1 selectively promotes HIF-1α transactivation of angiogenic gene expression.

Sun L, Ding X, Kang YJ
J Trace Elem Med Biol 2023 Dec;80:127307. Epub 2023 Sep 18 doi: 10.1016/j.jtemb.2023.127307. PMID: 37738929

Wang J, Wei P, Liu J, Su P, Xing A, Jing H, Hao J
J Cancer Res Ther 2022 Apr;18(2):445-451. doi: 10.4103/jcrt.jcrt_2334_21. PMID: 35645113

Engineering and expression of a human rotavirus candidate vaccine in Nicotiana benthamiana.

Pêra FF, Mutepfa DL, Khan AM, Els JH, Mbewana S, van Dijk AA, Rybicki EP, Hitzeroth II
Virol J 2015 Dec 2;12:205. doi: 10.1186/s12985-015-0436-8. PMID: 26626122 Free PMC Article

The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma.

Parker BC, Annala MJ, Cogdell DE, Granberg KJ, Sun Y, Ji P, Li X, Gumin J, Zheng H, Hu L, Yli-Harja O, Haapasalo H, Visakorpi T, Liu X, Liu CG, Sawaya R, Fuller GN, Chen K, Lang FF, Nykter M, Zhang W
J Clin Invest 2013 Feb;123(2):855-65. Epub 2013 Jan 9 doi: 10.1172/JCI67144. PMID: 23298836 Free PMC Article

14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma.

Lee CH, Ou WB, Mariño-Enriquez A, Zhu M, Mayeda M, Wang Y, Guo X, Brunner AL, Amant F, French CA, West RB, McAlpine JN, Gilks CB, Yaffe MB, Prentice LM, McPherson A, Jones SJ, Marra MA, Shah SP, van de Rijn M, Huntsman DG, Dal Cin P, Debiec-Rychter M, Nucci MR, Fletcher JA
Proc Natl Acad Sci U S A 2012 Jan 17;109(3):929-34. Epub 2012 Jan 5 doi: 10.1073/pnas.1115528109. PMID: 22223660 Free PMC Article

See all (14)

Clinical prediction guides

ABCE1 selectively promotes HIF-1α transactivation of angiogenic gene expression.

Sun L, Ding X, Kang YJ
J Trace Elem Med Biol 2023 Dec;80:127307. Epub 2023 Sep 18 doi: 10.1016/j.jtemb.2023.127307. PMID: 37738929

Wang J, Wei P, Liu J, Su P, Xing A, Jing H, Hao J
J Cancer Res Ther 2022 Apr;18(2):445-451. doi: 10.4103/jcrt.jcrt_2334_21. PMID: 35645113

Expression and purification of an immunogenic SUMO-OmpC fusion protein of Salmonella Typhimurium in Escherichia coli.

Prejit, Pratheesh PT, Nimisha S, Jess V, Asha K, Agarwal RK
Biologicals 2019 Nov;62:22-26. Epub 2019 Oct 25 doi: 10.1016/j.biologicals.2019.10.010. PMID: 31668855

circRNA circAF4 functions as an oncogene to regulate MLL-AF4 fusion protein expression and inhibit MLL leukemia progression.

Huang W, Fang K, Chen TQ, Zeng ZC, Sun YM, Han C, Sun LY, Chen ZH, Yang QQ, Pan Q, Luo XQ, Wang WT, Chen YQ
J Hematol Oncol 2019 Oct 17;12(1):103. doi: 10.1186/s13045-019-0800-z. PMID: 31623653 Free PMC Article

Engineering and expression of a human rotavirus candidate vaccine in Nicotiana benthamiana.

Pêra FF, Mutepfa DL, Khan AM, Els JH, Mbewana S, van Dijk AA, Rybicki EP, Hitzeroth II
Virol J 2015 Dec 2;12:205. doi: 10.1186/s12985-015-0436-8. PMID: 26626122 Free PMC Article

See all (35)

MedGen

National Center for Biotechnology Information

Send to:

Fusion Protein Expression

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Practice guidelines

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