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t(2;13)(q35;q14)

MedGen UID:
271875
Concept ID:
C1515752
Cell or Molecular Dysfunction

Definition

A chromosomal translocation involving the PAX3 gene on chromosome 2q35 and the FOXO1 gene on chromosome 13q14. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVt(2;13)(q35;q14)

Professional guidelines

PubMed

Koscielniak E, Morgan M, Treuner J
Paediatr Drugs 2002;4(1):21-8. doi: 10.2165/00128072-200204010-00003. PMID: 11817983
Dockhorn-Dworniczak B, Schäfer KL, Blasius S, Christiansen H, Koscielniak E, Ritter J, Winkelmann W, Jürgens H, Böcker W
Klin Padiatr 1997 Jul-Aug;209(4):156-64. doi: 10.1055/s-2008-1043964. PMID: 9293447
Downing JR, Khandekar A, Shurtleff SA, Head DR, Parham DM, Webber BL, Pappo AS, Hulshof MG, Conn WP, Shapiro DN
Am J Pathol 1995 Mar;146(3):626-34. PMID: 7887445Free PMC Article

Recent clinical studies

Therapy

Nguyen TH, Barr FG
Molecules 2018 Oct 28;23(11) doi: 10.3390/molecules23112798. PMID: 30373318Free PMC Article
Pappo AS, Shapiro DN, Crist WM, Maurer HM
J Clin Oncol 1995 Aug;13(8):2123-39. doi: 10.1200/JCO.1995.13.8.2123. PMID: 7636557
Brichard B, Ninane J, Gosseye S, Verellen-Dumoulin C, Vermylen C, Rodhain J, Cornu G
Pediatr Hematol Oncol 1991 Jul-Sep;8(3):215-9. doi: 10.3109/08880019109033454. PMID: 1742179

Prognosis

Azorsa DO, Bode PK, Wachtel M, Cheuk ATC, Meltzer PS, Vokuhl C, Camenisch U, Khov HL, Bode B, Schäfer BW, Khan J
Mod Pathol 2021 Apr;34(4):748-757. Epub 2020 Dec 9 doi: 10.1038/s41379-020-00719-0. PMID: 33299109Free PMC Article
Kazanowska B, Reich A, Stegmaier S, Békássy AN, Leuschner I, Chybicka A, Koscielniak E
Fetal Pediatr Pathol 2007 Jan-Feb;26(1):17-31. doi: 10.1080/15513810701394702. PMID: 17613043
Mercado GE, Barr FG
Curr Mol Med 2007 Feb;7(1):47-61. doi: 10.2174/156652407779940440. PMID: 17311532
Hibshoosh H, Lattes R
Semin Oncol 1997 Oct;24(5):515-25. PMID: 9344317
Pappo AS, Shapiro DN, Crist WM, Maurer HM
J Clin Oncol 1995 Aug;13(8):2123-39. doi: 10.1200/JCO.1995.13.8.2123. PMID: 7636557

Clinical prediction guides

Azorsa DO, Bode PK, Wachtel M, Cheuk ATC, Meltzer PS, Vokuhl C, Camenisch U, Khov HL, Bode B, Schäfer BW, Khan J
Mod Pathol 2021 Apr;34(4):748-757. Epub 2020 Dec 9 doi: 10.1038/s41379-020-00719-0. PMID: 33299109Free PMC Article
Hollenbach AD, Sublett JE, McPherson CJ, Grosveld G
EMBO J 1999 Jul 1;18(13):3702-11. doi: 10.1093/emboj/18.13.3702. PMID: 10393185Free PMC Article
Coignet LJ, Lima CS, Min T, Streubel B, Swansbury J, Telford N, Swanton S, Bowen A, Nagai M, Catovsky D, Fonatsch C, Dyer MJ
Genes Chromosomes Cancer 1999 Jul;25(3):222-9. doi: 10.1002/(sici)1098-2264(199907)25:3<222::aid-gcc4>3.0.co;2-c. PMID: 10379868
Dei Tos AP, Dal Cin P
Virchows Arch 1997 Aug;431(2):83-94. doi: 10.1007/s004280050073. PMID: 9293889
Borkhardt A, Repp R, Haas OA, Leis T, Harbott J, Kreuder J, Hammermann J, Henn T, Lampert F
Oncogene 1997 Jan 16;14(2):195-202. doi: 10.1038/sj.onc.1200814. PMID: 9010221

Supplemental Content

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