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AML1-ETO Fusion Protein Expression

MedGen UID:
271896
•Concept ID:
C1515851
•
Cell or Molecular Dysfunction
Synonyms: AML1/ETO Fusion Protein Expression; CBFalpha2-ETO Fusion Protein Expression; RUNX1-RUNX1T1 Fusion Protein Expression; RUNX1/RUNX1T1 Fusion Protein Expression

Definition

Expression of a fusion protein that results from a t(8;21)(q22;q22) translocation, which involves the human genes RUNX1 and RUNX1T1 and is associated with acute myeloid leukemia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAML1-ETO Fusion Protein Expression

Professional guidelines

PubMed

Potential Therapeutic Approaches for the Treatment of Acute Myeloid Leukemia with AML1-ETO Translocation.
Arora R, Sawney S, Saluja D
Curr Cancer Drug Targets 2016;16(3):215-25. doi: 10.2174/1568009616666151113120146. PMID: 26563884
Antigen expression patterns reflecting genotype of acute leukemias.
Hrusák O, Porwit-MacDonald A
Leukemia 2002 Jul;16(7):1233-58. doi: 10.1038/sj.leu.2402504. PMID: 12094248
Histone deacetylases: a common molecular target for differentiation treatment of acute myeloid leukemias?
Minucci S, Nervi C, Lo Coco F, Pelicci PG
Oncogene 2001 May 28;20(24):3110-5. doi: 10.1038/sj.onc.1204336. PMID: 11420727

Recent clinical studies

Etiology

YTHDF2 is a potential target of AML1/ETO-HIF1α loop-mediated cell proliferation in t(8;21) AML.
Chen Z, Shao YL, Wang LL, Lin J, Zhang JB, Ding Y, Gao BB, Liu DH, Gao XN
Oncogene 2021 Jun;40(22):3786-3798. Epub 2021 May 6 doi: 10.1038/s41388-021-01818-1. PMID: 33958724
The RUNX1/RUNX1T1 network: translating insights into therapeutic options.
Swart LE, Heidenreich O
Exp Hematol 2021 Feb;94:1-10. Epub 2020 Nov 17 doi: 10.1016/j.exphem.2020.11.005. PMID: 33217477Free PMC Article
Monitoring the AML1/ETO fusion transcript to predict outcome in childhood acute myeloid leukemia.
Zhang L, Cao Z, Ruan M, Zeng Q, Zhao L, Li Q, Zou Y, Wang J, Zhu X
Pediatr Blood Cancer 2014 Oct;61(10):1761-6. Epub 2014 Jun 11 doi: 10.1002/pbc.25109. PMID: 24920269
Dynamics of epigenetic modifications in leukemia.
Uribesalgo I, Di Croce L
Brief Funct Genomics 2011 Jan;10(1):18-29. Epub 2011 Jan 21 doi: 10.1093/bfgp/elr002. PMID: 21258047Free PMC Article
Acute leukemia in early childhood.
Emerenciano M, Koifman S, Pombo-de-Oliveira MS
Braz J Med Biol Res 2007 Jun;40(6):749-60. doi: 10.1590/s0100-879x2007000600002. PMID: 17581672

Diagnosis

AML1-ETO-Related Fusion Circular RNAs Contribute to the Proliferation of Leukemia Cells.
Wang Y, Liu Y, Xu Y, Xing H, Tian Z, Tang K, Rao Q, Wang M, Wang J
Int J Mol Sci 2022 Dec 21;24(1) doi: 10.3390/ijms24010071. PMID: 36613512Free PMC Article
AML1-ETO promotes SIRT1 expression to enhance leukemogenesis of t(8;21) acute myeloid leukemia.
Zhou L, Wang Q, Chen X, Fu L, Zhang X, Wang L, Deng A, Li D, Liu J, Lv N, Wang L, Li Y, Liu D, Yu L, Dou L
Exp Hematol 2017 Feb;46:62-69. Epub 2016 Oct 8 doi: 10.1016/j.exphem.2016.09.013. PMID: 27725192
Monitoring the AML1/ETO fusion transcript to predict outcome in childhood acute myeloid leukemia.
Zhang L, Cao Z, Ruan M, Zeng Q, Zhao L, Li Q, Zou Y, Wang J, Zhu X
Pediatr Blood Cancer 2014 Oct;61(10):1761-6. Epub 2014 Jun 11 doi: 10.1002/pbc.25109. PMID: 24920269
Valproic acid triggers differentiation and apoptosis in AML1/ETO-positive leukemic cells specifically.
Zapotocky M, Mejstrikova E, Smetana K, Stary J, Trka J, Starkova J
Cancer Lett 2012 Jun 28;319(2):144-153. Epub 2012 Jan 17 doi: 10.1016/j.canlet.2011.12.041. PMID: 22261333
Acute leukemia in early childhood.
Emerenciano M, Koifman S, Pombo-de-Oliveira MS
Braz J Med Biol Res 2007 Jun;40(6):749-60. doi: 10.1590/s0100-879x2007000600002. PMID: 17581672

Therapy

Potential Therapeutic Approaches for the Treatment of Acute Myeloid Leukemia with AML1-ETO Translocation.
Arora R, Sawney S, Saluja D
Curr Cancer Drug Targets 2016;16(3):215-25. doi: 10.2174/1568009616666151113120146. PMID: 26563884
Monitoring the AML1/ETO fusion transcript to predict outcome in childhood acute myeloid leukemia.
Zhang L, Cao Z, Ruan M, Zeng Q, Zhao L, Li Q, Zou Y, Wang J, Zhu X
Pediatr Blood Cancer 2014 Oct;61(10):1761-6. Epub 2014 Jun 11 doi: 10.1002/pbc.25109. PMID: 24920269
Quantification of AML1-ETO fusion transcript as a prognostic indicator in acute myeloid leukemia.
Yoo SJ, Chi HS, Jang S, Seo EJ, Seo JJ, Lee JH, Park HS, Park CJ
Haematologica 2005 Nov;90(11):1493-501. PMID: 16266896
Cloning, expression, purification and crystallization of NHR3 domain from acute myelogenous leukemia-related protein AML1-ETO.
Yang HT, Wu DH, Xue XY, Liang WX, Miao XY, Pang H, Chen SJ
Acta Biochim Biophys Sin (Shanghai) 2004 Aug;36(8):566-70. doi: 10.1093/abbs/36.8.566. PMID: 15295650
Histone deacetylases: a common molecular target for differentiation treatment of acute myeloid leukemias?
Minucci S, Nervi C, Lo Coco F, Pelicci PG
Oncogene 2001 May 28;20(24):3110-5. doi: 10.1038/sj.onc.1204336. PMID: 11420727

Prognosis

AML1-ETO inhibits acute myeloid leukemia immune escape by CD48.
Wang Z, Guan W, Wang M, Chen J, Zhang L, Xiao Y, Wang L, Li Y, Yu L
Leuk Lymphoma 2021 Apr;62(4):937-943. Epub 2020 Nov 21 doi: 10.1080/10428194.2020.1849680. PMID: 33225787
Relationships between AML1-ETO and MLL-AF9 fusion gene expressions and hematological parameters in acute myeloid leukemia.
Muddathir ARM, Hamid TAM, Mohamed Elamin E, Khabour OF
Gulf J Oncolog 2020 Sep;1(34):65-69. PMID: 33431365
Protein lysine 43 methylation by EZH1 promotes AML1-ETO transcriptional repression in leukemia.
Dou L, Yan F, Pang J, Zheng D, Li D, Gao L, Wang L, Xu Y, Shi J, Wang Q, Zhou L, Shen N, Singh P, Wang L, Li Y, Gao Y, Liu T, Chen C, Al-Kali A, Litzow MR, Chi YI, Bode AM, Liu C, Huang H, Liu D, Marcucci G, Liu S, Yu L
Nat Commun 2019 Nov 7;10(1):5051. doi: 10.1038/s41467-019-12960-6. PMID: 31699991Free PMC Article
Potential Therapeutic Approaches for the Treatment of Acute Myeloid Leukemia with AML1-ETO Translocation.
Arora R, Sawney S, Saluja D
Curr Cancer Drug Targets 2016;16(3):215-25. doi: 10.2174/1568009616666151113120146. PMID: 26563884
Monitoring the AML1/ETO fusion transcript to predict outcome in childhood acute myeloid leukemia.
Zhang L, Cao Z, Ruan M, Zeng Q, Zhao L, Li Q, Zou Y, Wang J, Zhu X
Pediatr Blood Cancer 2014 Oct;61(10):1761-6. Epub 2014 Jun 11 doi: 10.1002/pbc.25109. PMID: 24920269

Clinical prediction guides

Relationships between AML1-ETO and MLL-AF9 fusion gene expressions and hematological parameters in acute myeloid leukemia.
Muddathir ARM, Hamid TAM, Mohamed Elamin E, Khabour OF
Gulf J Oncolog 2020 Sep;1(34):65-69. PMID: 33431365
Heterodimerization of AML1/ETO with CBFβ is required for leukemogenesis but not for myeloproliferation.
Thiel VN, Giaimo BD, Schwarz P, Soller K, Vas V, Bartkuhn M, Blätte TJ, Döhner K, Bullinger L, Borggrefe T, Geiger H, Oswald F
Leukemia 2017 Nov;31(11):2491-2502. Epub 2017 Mar 31 doi: 10.1038/leu.2017.105. PMID: 28360416Free PMC Article
Monitoring the AML1/ETO fusion transcript to predict outcome in childhood acute myeloid leukemia.
Zhang L, Cao Z, Ruan M, Zeng Q, Zhao L, Li Q, Zou Y, Wang J, Zhu X
Pediatr Blood Cancer 2014 Oct;61(10):1761-6. Epub 2014 Jun 11 doi: 10.1002/pbc.25109. PMID: 24920269
Silencing AML1-ETO gene expression leads to simultaneous activation of both pro-apoptotic and proliferation signaling.
Spirin PV, Lebedev TD, Orlova NN, Gornostaeva AS, Prokofjeva MM, Nikitenko NA, Dmitriev SE, Buzdin AA, Borisov NM, Aliper AM, Garazha AV, Rubtsov PM, Stocking C, Prassolov VS
Leukemia 2014 Nov;28(11):2222-8. Epub 2014 Apr 14 doi: 10.1038/leu.2014.130. PMID: 24727677
Valproic acid triggers differentiation and apoptosis in AML1/ETO-positive leukemic cells specifically.
Zapotocky M, Mejstrikova E, Smetana K, Stary J, Trka J, Starkova J
Cancer Lett 2012 Jun 28;319(2):144-153. Epub 2012 Jan 17 doi: 10.1016/j.canlet.2011.12.041. PMID: 22261333

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