BCR-FGFR1 Fusion Protein Expression

MedGen UID:: 271963
•Concept ID:: C1516133
•: Cell or Molecular Dysfunction

Synonym:

BCR/FGFR1 Fusion Protein Expression

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBCR-FGFR1 Fusion Protein Expression

Molecular Sequence Variation
- Molecular Genetic Variation
  - Gene Abnormality
    - Deregulation of Protein and Messenger RNA Expression
      - Protein Deregulation
        Fusion Protein Expression
        BCR-FGFR1 Fusion Protein Expression

Recent clinical studies

Diagnosis

Oncogenic fusion protein BCR-FGFR1 requires the breakpoint cluster region-mediated oligomerization and chaperonin Hsp90 for activation.

Peiris MN, Meyer AN, Nelson KN, Bisom-Rapp EW, Donoghue DJ
Haematologica 2020 May;105(5):1262-1273. Epub 2019 Aug 22 doi: 10.3324/haematol.2019.220871. PMID: 31439673 Free PMC Article

Acute leukemia showing t(8;22)(p11;q11), myelodysplasia, CD13/CD33/CD19 expression and immunoglobulin heavy chain gene rearrangement.

Shimanuki M, Sonoki T, Hosoi H, Watanuki J, Murata S, Mushino T, Kuriyama K, Tamura S, Hatanaka K, Hanaoka N, Nakakuma H
Acta Haematol 2013;129(4):238-42. Epub 2013 Jan 12 doi: 10.1159/000345727. PMID: 23328683

The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins.

Demiroglu A, Steer EJ, Heath C, Taylor K, Bentley M, Allen SL, Koduru P, Brody JP, Hawson G, Rodwell R, Doody ML, Carnicero F, Reiter A, Goldman JM, Melo JV, Cross NC
Blood 2001 Dec 15;98(13):3778-83. doi: 10.1182/blood.v98.13.3778. PMID: 11739186

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Therapy

Enhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex Mre11-RAD50-Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR/ABL-positive leukemia cells.

Rink L, Slupianek A, Stoklosa T, Nieborowska-Skorska M, Urbanska K, Seferynska I, Reiss K, Skorski T
Blood 2007 Jul 15;110(2):651-60. Epub 2007 Apr 12 doi: 10.1182/blood-2006-08-042630. PMID: 17431132 Free PMC Article

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Clinical prediction guides

Acute leukemia showing t(8;22)(p11;q11), myelodysplasia, CD13/CD33/CD19 expression and immunoglobulin heavy chain gene rearrangement.

Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice.

Agerstam H, Järås M, Andersson A, Johnels P, Hansen N, Lassen C, Rissler M, Gisselsson D, Olofsson T, Richter J, Fan X, Ehinger M, Fioretos T
Blood 2010 Sep 23;116(12):2103-11. Epub 2010 Jun 16 doi: 10.1182/blood-2009-05-217182. PMID: 20554971

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BCR-FGFR1 Fusion Protein Expression

Term Hierarchy

Recent clinical studies

Diagnosis

Therapy

Clinical prediction guides

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Table of contents

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