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Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable

MedGen UID:
272202
•Concept ID:
C1328061
•
Neoplastic Process
Synonyms: Mixed Myelodysplastic/Myeloproliferative Disease, Unclassifiable; Mixed Myeloproliferative/Myelodysplastic Syndrome, Unclassifiable; Myelodysplastic/Myeloproliferative Disease, Unclassifiable; Myelodysplastic/myeloproliferative neoplasm, unclassifiable; Myeloproliferative neoplasm, unclassifiable; Unclassifiable Myelodysplastic/Myeloproliferative Disease; Unclassifiable Myeloproliferative/Myelodysplastic Syndrome
SNOMED CT: Myelodysplastic/myeloproliferative neoplasm, unclassifiable (447240002); Myelodysplastic/myeloproliferative neoplasm, unclassifiable (447596005); Myeloproliferative neoplasm, unclassifiable (447240002)

Definition

This entity includes cases that have clinical, laboratory, and morphologic features that support the diagnosis of both a myelodysplastic syndrome and a myeloproliferative neoplasm, but do not meet the criteria for any of the other entities included in the myelodysplastic/myeloproliferative neoplasm category. (WHO, 2001) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMyelodysplastic/Myeloproliferative Neoplasm, Unclassifiable

Professional guidelines

PubMed

Therapy-related myeloid neoplasms following treatment with radioiodine.
Schroeder T, Kuendgen A, Kayser S, Kröger N, Braulke F, Platzbecker U, Klärner V, Zohren F, Haase D, Stadler M, Schlenk R, Czibere AG, Bruns I, Fenk R, Gattermann N, Haas R, Kobbe G, Germing U
Haematologica 2012 Feb;97(2):206-12. Epub 2011 Oct 11 doi: 10.3324/haematol.2011.049114. PMID: 21993688Free PMC Article

Recent clinical studies

Etiology

MDS/MPN-Unclassifiable with t(X;17)(q28;q21) and KANSL1-MTCP1/CMC4 Fusion Gene.
Molony P, Smith AC, Selvarajah S, Sakhdari A
Cytogenet Genome Res 2021;161(12):564-568. Epub 2022 Jan 17 doi: 10.1159/000521509. PMID: 35038703Free PMC Article
Development of a myelodysplastic/myeloproliferative neoplasm-unclassifiable in a patient with acute myeloid leukemia: a case report and literature review.
Zhao M, Sun J, Liu S, Fan H, Fu Y, Tan Y, Gao S
J Int Med Res 2021 May;49(5):3000605211018426. doi: 10.1177/03000605211018426. PMID: 34057843Free PMC Article
Oligomonocytic chronic myelomonocytic leukemia (chronic myelomonocytic leukemia without absolute monocytosis) displays a similar clinicopathologic and mutational profile to classical chronic myelomonocytic leukemia.
Geyer JT, Tam W, Liu YC, Chen Z, Wang SA, Bueso-Ramos C, Oak J, Arber DA, Hsi E, Rogers HJ, Levinson K, Bagg A, Hassane DC, Hasserjian RP, Orazi A
Mod Pathol 2017 Sep;30(9):1213-1222. Epub 2017 May 26 doi: 10.1038/modpathol.2017.45. PMID: 28548124
Therapy-related myeloid neoplasms following treatment with radioiodine.
Schroeder T, Kuendgen A, Kayser S, Kröger N, Braulke F, Platzbecker U, Klärner V, Zohren F, Haase D, Stadler M, Schlenk R, Czibere AG, Bruns I, Fenk R, Gattermann N, Haas R, Kobbe G, Germing U
Haematologica 2012 Feb;97(2):206-12. Epub 2011 Oct 11 doi: 10.3324/haematol.2011.049114. PMID: 21993688Free PMC Article

Diagnosis

Recurrent bilateral adrenal infarction with myelodysplastic/myeloproliferative neoplasm-unclassifiable (MDS/MPN-U): a case report.
Hoshino Y, Manaka K, Sato J, Asatsuma Y, Horikoshi H, Takeuchi M, Ito N, Fujita M, Yasunaga M, Matsuda K, Honda A, Maki H, Masamoto Y, Kurokawa M, Nangaku M, Makita N
BMC Endocr Disord 2023 Jun 5;23(1):128. doi: 10.1186/s12902-023-01384-5. PMID: 37277771Free PMC Article
Development of a myelodysplastic/myeloproliferative neoplasm-unclassifiable in a patient with acute myeloid leukemia: a case report and literature review.
Zhao M, Sun J, Liu S, Fan H, Fu Y, Tan Y, Gao S
J Int Med Res 2021 May;49(5):3000605211018426. doi: 10.1177/03000605211018426. PMID: 34057843Free PMC Article
Myelodysplastic/myeloproliferative neoplasm, unclassifiable (MDS/MPN-U): More than just a "catch-all" term?
Shallis RM, Zeidan AM
Best Pract Res Clin Haematol 2020 Jun;33(2):101132. Epub 2019 Dec 6 doi: 10.1016/j.beha.2019.101132. PMID: 32460977
Oligomonocytic chronic myelomonocytic leukemia (chronic myelomonocytic leukemia without absolute monocytosis) displays a similar clinicopathologic and mutational profile to classical chronic myelomonocytic leukemia.
Geyer JT, Tam W, Liu YC, Chen Z, Wang SA, Bueso-Ramos C, Oak J, Arber DA, Hsi E, Rogers HJ, Levinson K, Bagg A, Hassane DC, Hasserjian RP, Orazi A
Mod Pathol 2017 Sep;30(9):1213-1222. Epub 2017 May 26 doi: 10.1038/modpathol.2017.45. PMID: 28548124
Diagnosing myelodysplastic/myeloproliferative neoplasms: laboratory testing strategies to exclude other disorders.
Hall J, Foucar K
Int J Lab Hematol 2010 Dec;32(6 Pt 2):559-71. doi: 10.1111/j.1751-553X.2010.01251.x. PMID: 20670271

Therapy

Successful prevention of severe allergic transfusion reactions with omalizumab.
Shi S, Han J, Yao Y, Xu Y, Wu D, Wang Y
Transfusion 2020 Jul;60(7):1639-1642. Epub 2020 Mar 5 doi: 10.1111/trf.15735. PMID: 32134497
Therapy-related myeloid neoplasms following treatment with radioiodine.
Schroeder T, Kuendgen A, Kayser S, Kröger N, Braulke F, Platzbecker U, Klärner V, Zohren F, Haase D, Stadler M, Schlenk R, Czibere AG, Bruns I, Fenk R, Gattermann N, Haas R, Kobbe G, Germing U
Haematologica 2012 Feb;97(2):206-12. Epub 2011 Oct 11 doi: 10.3324/haematol.2011.049114. PMID: 21993688Free PMC Article

Prognosis

Oligomonocytic chronic myelomonocytic leukemia (chronic myelomonocytic leukemia without absolute monocytosis) displays a similar clinicopathologic and mutational profile to classical chronic myelomonocytic leukemia.
Geyer JT, Tam W, Liu YC, Chen Z, Wang SA, Bueso-Ramos C, Oak J, Arber DA, Hsi E, Rogers HJ, Levinson K, Bagg A, Hassane DC, Hasserjian RP, Orazi A
Mod Pathol 2017 Sep;30(9):1213-1222. Epub 2017 May 26 doi: 10.1038/modpathol.2017.45. PMID: 28548124
Therapy-related myeloid neoplasms following treatment with radioiodine.
Schroeder T, Kuendgen A, Kayser S, Kröger N, Braulke F, Platzbecker U, Klärner V, Zohren F, Haase D, Stadler M, Schlenk R, Czibere AG, Bruns I, Fenk R, Gattermann N, Haas R, Kobbe G, Germing U
Haematologica 2012 Feb;97(2):206-12. Epub 2011 Oct 11 doi: 10.3324/haematol.2011.049114. PMID: 21993688Free PMC Article

Clinical prediction guides

Oligomonocytic chronic myelomonocytic leukemia (chronic myelomonocytic leukemia without absolute monocytosis) displays a similar clinicopathologic and mutational profile to classical chronic myelomonocytic leukemia.
Geyer JT, Tam W, Liu YC, Chen Z, Wang SA, Bueso-Ramos C, Oak J, Arber DA, Hsi E, Rogers HJ, Levinson K, Bagg A, Hassane DC, Hasserjian RP, Orazi A
Mod Pathol 2017 Sep;30(9):1213-1222. Epub 2017 May 26 doi: 10.1038/modpathol.2017.45. PMID: 28548124
Therapy-related myeloid neoplasms following treatment with radioiodine.
Schroeder T, Kuendgen A, Kayser S, Kröger N, Braulke F, Platzbecker U, Klärner V, Zohren F, Haase D, Stadler M, Schlenk R, Czibere AG, Bruns I, Fenk R, Gattermann N, Haas R, Kobbe G, Germing U
Haematologica 2012 Feb;97(2):206-12. Epub 2011 Oct 11 doi: 10.3324/haematol.2011.049114. PMID: 21993688Free PMC Article

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