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Myelodysplastic/myeloproliferative disease

MedGen UID:
977559
Concept ID:
CN294254
Disease or Syndrome
Synonym: myelodysplastic/myeloproliferative disease
 
Monarch Initiative: MONDO:0020077
Orphanet: ORPHA98275

Definition

Clonal myeloid disorders that possess both dysplastic and proliferative features but are not properly classified as either MYELODYSPLASTIC SYNDROMES or MYELOPROLIFERATIVE disorderS. [from MONDO]

Professional guidelines

PubMed

Tefferi A, Vannucchi AM, Barbui T
Am J Hematol 2024 Apr;99(4):697-718. Epub 2024 Jan 25 doi: 10.1002/ajh.27216. PMID: 38269572
Patnaik MM, Tefferi A
Am J Hematol 2022 Mar 1;97(3):352-372. Epub 2022 Jan 27 doi: 10.1002/ajh.26455. PMID: 34985762
Stockklausner C, Duffert CM, Cario H, Knöfler R, Streif W, Kulozik AE; THROMKID-Plus Studiengruppe der Gesellschaft für Thrombose- und Hämostaseforschung (GTH) and of Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH)
Ann Hematol 2021 Jul;100(7):1647-1665. Epub 2021 Mar 12 doi: 10.1007/s00277-021-04485-0. PMID: 33712866Free PMC Article

Recent clinical studies

Etiology

Thomopoulos TP, Bouhla A, Papageorgiou SG, Pappa V
Expert Rev Hematol 2021 Jan;14(1):59-77. Epub 2020 Dec 12 doi: 10.1080/17474086.2021.1860004. PMID: 33275852
Jiang G, Capo-Chichi JM, Liu A, Atenafu EG, Guo R, Tierens A, Minden MD, Chang H
Hum Pathol 2020 Oct;104:117-126. Epub 2020 Aug 13 doi: 10.1016/j.humpath.2020.08.003. PMID: 32798550
Warlick ED, Cioc A, Defor T, Dolan M, Weisdorf D
Biol Blood Marrow Transplant 2009 Jan;15(1):30-8. doi: 10.1016/j.bbmt.2008.10.012. PMID: 19135940
Stachurski D, Smith BR, Pozdnyakova O, Andersen M, Xiao Z, Raza A, Woda BA, Wang SA
Leuk Res 2008 Feb;32(2):215-24. Epub 2007 Aug 1 doi: 10.1016/j.leukres.2007.06.012. PMID: 17675229
Schmitt-Graeff A, Thiele J, Zuk I, Kvasnicka HM
Haematologica 2002 Apr;87(4):392-9. PMID: 11940483

Diagnosis

Onaka T, Nakano K, Uemoto Y, Miyakawa N, Otsuka Y, Ogura-Kato A, Iwai F, Tanaka Y, Yonezawa A
Mod Rheumatol Case Rep 2022 Jun 24;6(2):273-277. doi: 10.1093/mrcr/rxac032. PMID: 35365826
Thomopoulos TP, Bouhla A, Papageorgiou SG, Pappa V
Expert Rev Hematol 2021 Jan;14(1):59-77. Epub 2020 Dec 12 doi: 10.1080/17474086.2021.1860004. PMID: 33275852
Jiang G, Capo-Chichi JM, Liu A, Atenafu EG, Guo R, Tierens A, Minden MD, Chang H
Hum Pathol 2020 Oct;104:117-126. Epub 2020 Aug 13 doi: 10.1016/j.humpath.2020.08.003. PMID: 32798550
Ismael O, Shimada A, Hama A, Elshazley M, Muramatsu H, Goto A, Sakaguchi H, Tanaka M, Takahashi Y, Yinyan X, Fukuda M, Miyajima Y, Yamashita Y, Horibe K, Hanada R, Ito M, Kojima S
Br J Haematol 2012 Jul;158(1):129-37. Epub 2012 May 10 doi: 10.1111/j.1365-2141.2012.09140.x. PMID: 22571758
Stachurski D, Smith BR, Pozdnyakova O, Andersen M, Xiao Z, Raza A, Woda BA, Wang SA
Leuk Res 2008 Feb;32(2):215-24. Epub 2007 Aug 1 doi: 10.1016/j.leukres.2007.06.012. PMID: 17675229

Therapy

Onaka T, Nakano K, Uemoto Y, Miyakawa N, Otsuka Y, Ogura-Kato A, Iwai F, Tanaka Y, Yonezawa A
Mod Rheumatol Case Rep 2022 Jun 24;6(2):273-277. doi: 10.1093/mrcr/rxac032. PMID: 35365826
Jiang G, Capo-Chichi JM, Liu A, Atenafu EG, Guo R, Tierens A, Minden MD, Chang H
Hum Pathol 2020 Oct;104:117-126. Epub 2020 Aug 13 doi: 10.1016/j.humpath.2020.08.003. PMID: 32798550
Cossellu G, Seramondi R, Benedicenti S, Farronato G, Olivi G, Angiero F
Eur J Paediatr Dent 2013 Dec;14(4):328-32. PMID: 24313588
Yamazaki R, Mori T, Nakazato T, Aisa Y, Imaeda H, Hisamatsu T, Hibi T, Okamoto S
Intern Med 2010;49(12):1191-3. Epub 2010 Jun 15 doi: 10.2169/internalmedicine.49.3288. PMID: 20558941
Azma RZ, Zarina AL, Hamidah A, Jamal R, Sharifah NA, Ainoon O, Hamidah NH
Malays J Pathol 2009 Dec;31(2):121-8. PMID: 20514855

Prognosis

Thomopoulos TP, Bouhla A, Papageorgiou SG, Pappa V
Expert Rev Hematol 2021 Jan;14(1):59-77. Epub 2020 Dec 12 doi: 10.1080/17474086.2021.1860004. PMID: 33275852
Jiang G, Capo-Chichi JM, Liu A, Atenafu EG, Guo R, Tierens A, Minden MD, Chang H
Hum Pathol 2020 Oct;104:117-126. Epub 2020 Aug 13 doi: 10.1016/j.humpath.2020.08.003. PMID: 32798550
Warlick ED, Cioc A, Defor T, Dolan M, Weisdorf D
Biol Blood Marrow Transplant 2009 Jan;15(1):30-8. doi: 10.1016/j.bbmt.2008.10.012. PMID: 19135940
Wang SA, Pozdnyakova O, Jorgensen JL, Medeiros LJ, Stachurski D, Anderson M, Raza A, Woda BA
Haematologica 2009 Jan;94(1):29-37. Epub 2008 Nov 10 doi: 10.3324/haematol.13601. PMID: 19001281Free PMC Article
Kraemer D, Rüdiger T, Reimer P, Müller-Hermelink HK, Wilhelm M
Ann Hematol 2002 Jun;81(6):308-11. Epub 2002 Jun 4 doi: 10.1007/s00277-002-0474-3. PMID: 12107559

Clinical prediction guides

Jiang G, Capo-Chichi JM, Liu A, Atenafu EG, Guo R, Tierens A, Minden MD, Chang H
Hum Pathol 2020 Oct;104:117-126. Epub 2020 Aug 13 doi: 10.1016/j.humpath.2020.08.003. PMID: 32798550
Ismael O, Shimada A, Hama A, Elshazley M, Muramatsu H, Goto A, Sakaguchi H, Tanaka M, Takahashi Y, Yinyan X, Fukuda M, Miyajima Y, Yamashita Y, Horibe K, Hanada R, Ito M, Kojima S
Br J Haematol 2012 Jul;158(1):129-37. Epub 2012 May 10 doi: 10.1111/j.1365-2141.2012.09140.x. PMID: 22571758
Warlick ED, Cioc A, Defor T, Dolan M, Weisdorf D
Biol Blood Marrow Transplant 2009 Jan;15(1):30-8. doi: 10.1016/j.bbmt.2008.10.012. PMID: 19135940
Stachurski D, Smith BR, Pozdnyakova O, Andersen M, Xiao Z, Raza A, Woda BA, Wang SA
Leuk Res 2008 Feb;32(2):215-24. Epub 2007 Aug 1 doi: 10.1016/j.leukres.2007.06.012. PMID: 17675229
Kuerbitz SJ, Pahys J, Wilson A, Compitello N, Gray TA
Carcinogenesis 2002 Apr;23(4):559-64. doi: 10.1093/carcin/23.4.559. PMID: 11960906

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