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Adult Diffuse Astrocytoma

MedGen UID:
272295
Concept ID:
C1332200
Neoplastic Process
Synonyms: WHO Grade 2 Astrocytoma; WHO Grade II Astrocytoma

Definition

A low grade (WHO grade II) astrocytoma occurring during adulthood. It is characterized by a high degree of cellular differentiation, slow growth, and diffuse infiltration of neighboring brain structures. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Mitchell D, Shireman JM, Dey M
Neurol Clin 2022 May;40(2):437-453. Epub 2022 Mar 31 doi: 10.1016/j.ncl.2021.11.003. PMID: 35465885Free PMC Article
Laperriere NJ
Neuro Oncol 2021 Aug 2;23(8):1223-1224. doi: 10.1093/neuonc/noab121. PMID: 34036373Free PMC Article
Davis ME
Clin J Oncol Nurs 2016 Oct 1;20(5 Suppl):S2-8. doi: 10.1188/16.CJON.S1.2-8. PMID: 27668386Free PMC Article

Recent clinical studies

Etiology

Berger TR, Wen PY, Lang-Orsini M, Chukwueke UN
JAMA Oncol 2022 Oct 1;8(10):1493-1501. doi: 10.1001/jamaoncol.2022.2844. PMID: 36006639
Morshed RA, Young JS, Hervey-Jumper SL, Berger MS
J Neurosurg Sci 2019 Aug;63(4):450-457. Epub 2019 Mar 27 doi: 10.23736/S0390-5616.19.04701-5. PMID: 30916536
Korshunov A, Casalini B, Chavez L, Hielscher T, Sill M, Ryzhova M, Sharma T, Schrimpf D, Stichel D, Capper D, Reuss DE, Sturm D, Absalyamova O, Golanov A, Lambo S, Bewerunge-Hudler M, Lichter P, Herold-Mende C, Wick W, Pfister SM, Kool M, Jones DTW, von Deimling A, Sahm F
Neuropathol Appl Neurobiol 2019 Feb;45(2):108-118. Epub 2018 Nov 15 doi: 10.1111/nan.12523. PMID: 30326163
Stupp R, Reni M, Gatta G, Mazza E, Vecht C
Crit Rev Oncol Hematol 2007 Jul;63(1):72-80. Epub 2007 May 2 doi: 10.1016/j.critrevonc.2007.03.003. PMID: 17478095
Wen PY, Fine HA, Black PM, Shrieve DC, Alexander E 3rd, Loeffler JS
Neurol Clin 1995 Nov;13(4):875-900. PMID: 8584002

Diagnosis

Nabors LB, Portnow J, Ahluwalia M, Baehring J, Brem H, Brem S, Butowski N, Campian JL, Clark SW, Fabiano AJ, Forsyth P, Hattangadi-Gluth J, Holdhoff M, Horbinski C, Junck L, Kaley T, Kumthekar P, Loeffler JS, Mrugala MM, Nagpal S, Pandey M, Parney I, Peters K, Puduvalli VK, Robins I, Rockhill J, Rusthoven C, Shonka N, Shrieve DC, Swinnen LJ, Weiss S, Wen PY, Willmarth NE, Bergman MA, Darlow SD
J Natl Compr Canc Netw 2020 Nov 2;18(11):1537-1570. doi: 10.6004/jnccn.2020.0052. PMID: 33152694
Morshed RA, Young JS, Hervey-Jumper SL, Berger MS
J Neurosurg Sci 2019 Aug;63(4):450-457. Epub 2019 Mar 27 doi: 10.23736/S0390-5616.19.04701-5. PMID: 30916536
Nagia L, Doyle JI, Hackney JR, Vaphiades MS, Kline LB, Levin MH
Surv Ophthalmol 2015 Nov-Dec;60(6):596-9. Epub 2015 Jun 14 doi: 10.1016/j.survophthal.2015.06.002. PMID: 26079932
Yong EX, McKelvie P, Murphy M, Wang YY
J Clin Neurosci 2014 Nov;21(11):1993-6. Epub 2014 Jun 19 doi: 10.1016/j.jocn.2014.02.014. PMID: 24954244
Ichimura K, Ohgaki H, Kleihues P, Collins VP
J Neurooncol 2004 Nov;70(2):137-60. doi: 10.1007/s11060-004-2747-2. PMID: 15674475

Therapy

Lamb YN
Drugs 2024 Oct;84(10):1325-1331. Epub 2024 Oct 8 doi: 10.1007/s40265-024-02097-2. PMID: 39375303
Audrey C, Lim KS, Ahmad Zaki R, Fong SL, Chan CY, Sathis Kumar T, Narayanan V, Tan CT
Epilepsy Res 2022 Nov;187:107033. Epub 2022 Oct 10 doi: 10.1016/j.eplepsyres.2022.107033. PMID: 36274423
Melnick K, Dastmalchi F, Mitchell D, Rahman M, Sayour EJ
Neuromolecular Med 2022 Mar;24(1):8-12. Epub 2021 Jun 8 doi: 10.1007/s12017-021-08669-9. PMID: 34101090Free PMC Article
Rominiyi O, Vanderlinden A, Clenton SJ, Bridgewater C, Al-Tamimi Y, Collis SJ
Br J Cancer 2021 Feb;124(4):697-709. Epub 2020 Nov 4 doi: 10.1038/s41416-020-01136-5. PMID: 33144698Free PMC Article
Holdhoff M, Rothenberger R, Browner IE
Aging (Albany NY) 2018 Feb 1;10(2):154-155. doi: 10.18632/aging.101377. PMID: 29394496Free PMC Article

Prognosis

Detti B, Scoccianti S, Maragna V, Lucidi S, Ganovelli M, Teriaca MA, Caini S, Desideri I, Agresti B, Greto D, Buccoliero AM, Puppa AD, Sardi I, Livi L
Radiol Med 2022 Oct;127(10):1134-1141. Epub 2022 Aug 11 doi: 10.1007/s11547-022-01531-3. PMID: 35951279Free PMC Article
Banan R, Stichel D, Bleck A, Hong B, Lehmann U, Suwala A, Reinhardt A, Schrimpf D, Buslei R, Stadelmann C, Ehlert K, Prinz M, Acker T, Schittenhelm J, Kaul D, Schweizer L, Capper D, Harter PN, Etminan N, Jones DTW, Pfister SM, Herold-Mende C, Wick W, Sahm F, von Deimling A, Hartmann C, Reuss DE
Acta Neuropathol 2020 Oct;140(4):569-581. Epub 2020 Aug 10 doi: 10.1007/s00401-020-02194-y. PMID: 32776277
Morshed RA, Young JS, Hervey-Jumper SL, Berger MS
J Neurosurg Sci 2019 Aug;63(4):450-457. Epub 2019 Mar 27 doi: 10.23736/S0390-5616.19.04701-5. PMID: 30916536
Ichimura K, Ohgaki H, Kleihues P, Collins VP
J Neurooncol 2004 Nov;70(2):137-60. doi: 10.1007/s11060-004-2747-2. PMID: 15674475
Wen PY, Fine HA, Black PM, Shrieve DC, Alexander E 3rd, Loeffler JS
Neurol Clin 1995 Nov;13(4):875-900. PMID: 8584002

Clinical prediction guides

Ferreyra Vega S, Olsson Bontell T, Kling T, Jakola AS, Carén H
Acta Neuropathol Commun 2023 Feb 4;11(1):23. doi: 10.1186/s40478-023-01520-1. PMID: 36739454Free PMC Article
Berger TR, Wen PY, Lang-Orsini M, Chukwueke UN
JAMA Oncol 2022 Oct 1;8(10):1493-1501. doi: 10.1001/jamaoncol.2022.2844. PMID: 36006639
Mohile NA, Messersmith H, Gatson NT, Hottinger AF, Lassman A, Morton J, Ney D, Nghiemphu PL, Olar A, Olson J, Perry J, Portnow J, Schiff D, Shannon A, Shih HA, Strowd R, van den Bent M, Ziu M, Blakeley J
J Clin Oncol 2022 Feb 1;40(4):403-426. Epub 2021 Dec 13 doi: 10.1200/JCO.21.02036. PMID: 34898238
Deguchi S, Oishi T, Mitsuya K, Kakuda Y, Endo M, Sugino T, Hayashi N
Sci Rep 2020 Jun 22;10(1):10113. doi: 10.1038/s41598-020-67244-7. PMID: 32572107Free PMC Article
Shirahata M, Ono T, Stichel D, Schrimpf D, Reuss DE, Sahm F, Koelsche C, Wefers A, Reinhardt A, Huang K, Sievers P, Shimizu H, Nanjo H, Kobayashi Y, Miyake Y, Suzuki T, Adachi JI, Mishima K, Sasaki A, Nishikawa R, Bewerunge-Hudler M, Ryzhova M, Absalyamova O, Golanov A, Sinn P, Platten M, Jungk C, Winkler F, Wick A, Hänggi D, Unterberg A, Pfister SM, Jones DTW, van den Bent M, Hegi M, French P, Baumert BG, Stupp R, Gorlia T, Weller M, Capper D, Korshunov A, Herold-Mende C, Wick W, Louis DN, von Deimling A
Acta Neuropathol 2018 Jul;136(1):153-166. Epub 2018 Apr 23 doi: 10.1007/s00401-018-1849-4. PMID: 29687258

Recent systematic reviews

D'Alessandris QG, Battistelli M, Pennisi G, Offi M, Martini M, Cenci T, Falchetti ML, Lauretti L, Olivi A, Pallini R, Montano N
Expert Rev Mol Med 2023 Mar 15;25:e10. doi: 10.1017/erm.2023.6. PMID: 36919343
Fazzari FGT, Rose F, Pauls M, Guay E, Ibrahim MFK, Basulaiman B, Tu M, Hutton B, Nicholas G, Ng TL
Crit Rev Oncol Hematol 2022 Jan;169:103540. Epub 2021 Nov 19 doi: 10.1016/j.critrevonc.2021.103540. PMID: 34808376
Mallick S, Benson R, Melgandi W, Giridhar P, Rath GK
J Clin Neurosci 2018 Aug;54:57-62. Epub 2018 May 24 doi: 10.1016/j.jocn.2018.05.003. PMID: 29803334
Asmaa A, Dixit S, Rowland-Hill C, Achawal S, Rajaraman C, O'Reilly G, Highley R, Hussain M, Baker L, Gill L, Morris H, Hingorani M
Br J Radiol 2018 Jul;91(1088):20170271. Epub 2018 Mar 9 doi: 10.1259/bjr.20170271. PMID: 29376741Free PMC Article
Hernández-Durán S, Bregy A, Shah AH, Hanft S, Komotar RJ, Manzano GR
J Clin Neurosci 2015 Dec;22(12):1877-82. Epub 2015 Oct 23 doi: 10.1016/j.jocn.2015.04.017. PMID: 26601809

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