U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Duodenal gastrin-producing neuroendocrine tumor

MedGen UID:
272550
Concept ID:
C1333321
Neoplastic Process
Synonyms: Duodenal G-Cell Gastrin Producing Tumor; duodenal G-cell gastrin producing tumor; duodenal G-cell gastrin producing tumour; Duodenal Gastrin-Producing NET; duodenal gastrin-producing NET; Duodenal Gastrin-Producing Neuroendocrine Tumor; duodenal gastrin-producing neuroendocrine tumor; Duodenal Gastrinoma; duodenal gastrinoma; duodenum gastrin-producing neuroendocrine tumor; duodenum gastrin-producing neuroendocrine tumour; Gastrin Producing Tumor of Duodenum; gastrin producing tumor of duodenum; Gastrin Producing Tumor of the Duodenum; gastrin producing tumor of the duodenum; gastrin producing tumour of duodenum; gastrin producing tumour of the duodenum; gastrin-producing neuroendocrine tumor of duodenum; gastrin-producing neuroendocrine tumour of duodenum; Gastrinoma of duodenum; Gastrinoma of Duodenum; gastrinoma of duodenum; Gastrinoma of the Duodenum; gastrinoma of the duodenum; malignant duodenal gastrinoma
SNOMED CT: Gastrinoma of duodenum (879992009)
 
Monarch Initiative: MONDO:0004411

Definition

A gastrin-producing neuroendocrine tumor that arises from the duodenum. It is characterized by the presence of uniform cells that form pseudorosettes. The neoplastic cells have uniform nuclei and small amount of eosinophilic cytoplasm. [from NCI]

Professional guidelines

PubMed

Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807Free PMC Article
De Angelis C, Cortegoso Valdivia P, Venezia L, Bruno M, Pellicano R
Minerva Endocrinol 2018 Jun;43(2):212-220. Epub 2017 Sep 25 doi: 10.23736/S0391-1977.17.02745-6. PMID: 28949124
Niederle B
Wien Klin Wochenschr 2007;119(19-20):561-3. doi: 10.1007/s00508-007-0897-x. PMID: 17985087

Recent clinical studies

Etiology

de Jorge Huerta L, Solares Fernández I, Sánchez-Moreno B, Males Maldonado D, de Ibarrola Andrés C, Díaz-Simón R
J Dig Dis 2022 Aug;23(8-9):455-461. Epub 2022 Nov 10 doi: 10.1111/1751-2980.13129. PMID: 36168962Free PMC Article
Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807Free PMC Article
Norton JA, Foster DS, Blumgart LH, Poultsides GA, Visser BC, Fraker DL, Alexander HR, Jensen RT
JAMA Surg 2018 Mar 1;153(3):e175083. doi: 10.1001/jamasurg.2017.5083. PMID: 29365025Free PMC Article
De Angelis C, Cortegoso Valdivia P, Venezia L, Bruno M, Pellicano R
Minerva Endocrinol 2018 Jun;43(2):212-220. Epub 2017 Sep 25 doi: 10.23736/S0391-1977.17.02745-6. PMID: 28949124
Mertz HR, Walsh JH
Med Clin North Am 1991 Jul;75(4):799-814. doi: 10.1016/s0025-7125(16)30412-6. PMID: 2072787

Diagnosis

Hofland J, Falconi M, Christ E, Castaño JP, Faggiano A, Lamarca A, Perren A, Petrucci S, Prasad V, Ruszniewski P, Thirlwell C, Vullierme MP, Welin S, Bartsch DK
J Neuroendocrinol 2023 Aug;35(8):e13318. Epub 2023 Aug 14 doi: 10.1111/jne.13318. PMID: 37578384
Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807Free PMC Article
Norton JA, Foster DS, Blumgart LH, Poultsides GA, Visser BC, Fraker DL, Alexander HR, Jensen RT
JAMA Surg 2018 Mar 1;153(3):e175083. doi: 10.1001/jamasurg.2017.5083. PMID: 29365025Free PMC Article
Klöppel G, Anlauf M
Wien Klin Wochenschr 2007;119(19-20):579-84. doi: 10.1007/s00508-007-0885-1. PMID: 17985091
Niederle B
Wien Klin Wochenschr 2007;119(19-20):561-3. doi: 10.1007/s00508-007-0897-x. PMID: 17985087

Therapy

Albers MB, Manoharan J, Bartsch DK
Best Pract Res Clin Endocrinol Metab 2019 Oct;33(5):101318. Epub 2019 Aug 31 doi: 10.1016/j.beem.2019.101318. PMID: 31521501
Norton JA, Foster DS, Blumgart LH, Poultsides GA, Visser BC, Fraker DL, Alexander HR, Jensen RT
JAMA Surg 2018 Mar 1;153(3):e175083. doi: 10.1001/jamasurg.2017.5083. PMID: 29365025Free PMC Article
Krampitz GW, Norton JA
Adv Surg 2013;47:59-79. doi: 10.1016/j.yasu.2013.02.004. PMID: 24298844
Auernhammer CJ, Göke B
Wien Klin Wochenschr 2007;119(19-20):609-15. doi: 10.1007/s00508-007-0877-1. PMID: 17985097
Hirschowitz BI
N Engl Reg Allergy Proc 1985 Winter;6(1):21-7. doi: 10.2500/108854185779048942. PMID: 3916579

Prognosis

de Jorge Huerta L, Solares Fernández I, Sánchez-Moreno B, Males Maldonado D, de Ibarrola Andrés C, Díaz-Simón R
J Dig Dis 2022 Aug;23(8-9):455-461. Epub 2022 Nov 10 doi: 10.1111/1751-2980.13129. PMID: 36168962Free PMC Article
Rossi RE, Rausa E, Cavalcoli F, Conte D, Massironi S
Scand J Gastroenterol 2018 Jun-Jul;53(7):835-842. Epub 2018 May 4 doi: 10.1080/00365521.2018.1468479. PMID: 29726295
Norton JA, Foster DS, Blumgart LH, Poultsides GA, Visser BC, Fraker DL, Alexander HR, Jensen RT
JAMA Surg 2018 Mar 1;153(3):e175083. doi: 10.1001/jamasurg.2017.5083. PMID: 29365025Free PMC Article
Klöppel G, Anlauf M
Wien Klin Wochenschr 2007;119(19-20):579-84. doi: 10.1007/s00508-007-0885-1. PMID: 17985091
Norton JA
Best Pract Res Clin Gastroenterol 2005 Oct;19(5):699-704. doi: 10.1016/j.bpg.2005.05.001. PMID: 16253894

Clinical prediction guides

Imamura M, Komoto I, Taki Y
Surg Today 2023 Dec;53(12):1325-1334. Epub 2022 Dec 7 doi: 10.1007/s00595-022-02627-z. PMID: 36473964Free PMC Article
de Jorge Huerta L, Solares Fernández I, Sánchez-Moreno B, Males Maldonado D, de Ibarrola Andrés C, Díaz-Simón R
J Dig Dis 2022 Aug;23(8-9):455-461. Epub 2022 Nov 10 doi: 10.1111/1751-2980.13129. PMID: 36168962Free PMC Article
Sun S, Wang W, He C
Med Sci Monit 2020 Jun 21;26:e922613. doi: 10.12659/MSM.922613. PMID: 32564052Free PMC Article
Bordi C
Endocr Pathol 2014 Jun;25(2):171-80. doi: 10.1007/s12022-014-9315-x. PMID: 24782101
Herrmann ME, Ciesla MC, Chejfec G, DeJong SA, Yong SL
Arch Pathol Lab Med 2000 Jun;124(6):832-5. doi: 10.5858/2000-124-0832-PNG. PMID: 10835515

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...