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Digestive system neuroendocrine tumor, grade 1/2

MedGen UID:
443945
Concept ID:
C2930967
Neoplastic Process
Synonyms: Gastro-enteropancreatic neuroendocrine tumor; Gastroenteropancreatic neuroendocrine tumor; GEP neuroendocrine tumor
 
Monarch Initiative: MONDO:0000386

Definition

A well-differentiated neuroendocrine neoplasm of low, intermediate, or high grade arising from the digestive system. It is characterized by the presence of cells with features similar to those of the normal endocrine cells of the digestive system. The neoplastic cells express immunohistochemical evidence of neuroendocrine differentiation and hormones. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDigestive system neuroendocrine tumor, grade 1/2

Professional guidelines

PubMed

Shah SC, Piazuelo MB, Kuipers EJ, Li D
Gastroenterology 2021 Oct;161(4):1325-1332.e7. Epub 2021 Aug 26 doi: 10.1053/j.gastro.2021.06.078. PMID: 34454714Free PMC Article

Recent clinical studies

Etiology

Morizane C, Machida N, Honma Y, Okusaka T, Boku N, Kato K, Nomura S, Hiraoka N, Sekine S, Taniguchi H, Okano N, Yamaguchi K, Sato T, Ikeda M, Mizuno N, Ozaka M, Kataoka T, Ueno M, Kitagawa Y, Terashima M, Furuse J; Japan Clinical Oncology Group (JCOG)
JAMA Oncol 2022 Oct 1;8(10):1447-1455. doi: 10.1001/jamaoncol.2022.3395. PMID: 35980649Free PMC Article
Gogna S, Samson D, Gachabayov M, Rojas A, Felsenreich DM, Koo D, Gu K, Quintero L, Miller KR, Azim A, Da Eric Dong X
Langenbecks Arch Surg 2022 Feb;407(1):197-206. Epub 2021 Jul 8 doi: 10.1007/s00423-021-02256-z. PMID: 34236488
Shah SC, Piazuelo MB, Kuipers EJ, Li D
Gastroenterology 2021 Oct;161(4):1325-1332.e7. Epub 2021 Aug 26 doi: 10.1053/j.gastro.2021.06.078. PMID: 34454714Free PMC Article
Storino A, Wong D, Ore AS, Gaytan-Fuentes IA, Fabrizio A, Cataldo T, Messaris E
J Gastrointest Surg 2021 Sep;25(9):2398-2400. Epub 2020 Dec 2 doi: 10.1007/s11605-020-04854-6. PMID: 33269457
Park HJ, Kim HJ, Kim KW, Kim SY, Choi SH, You MW, Hwang HS, Hong SM
Eur Radiol 2020 Sep;30(9):4772-4782. Epub 2020 Apr 28 doi: 10.1007/s00330-020-06867-w. PMID: 32346794

Diagnosis

Gogna S, Samson D, Gachabayov M, Rojas A, Felsenreich DM, Koo D, Gu K, Quintero L, Miller KR, Azim A, Da Eric Dong X
Langenbecks Arch Surg 2022 Feb;407(1):197-206. Epub 2021 Jul 8 doi: 10.1007/s00423-021-02256-z. PMID: 34236488
Shah SC, Piazuelo MB, Kuipers EJ, Li D
Gastroenterology 2021 Oct;161(4):1325-1332.e7. Epub 2021 Aug 26 doi: 10.1053/j.gastro.2021.06.078. PMID: 34454714Free PMC Article
Storino A, Wong D, Ore AS, Gaytan-Fuentes IA, Fabrizio A, Cataldo T, Messaris E
J Gastrointest Surg 2021 Sep;25(9):2398-2400. Epub 2020 Dec 2 doi: 10.1007/s11605-020-04854-6. PMID: 33269457
Ali AS, Perren A, Lindskog C, Welin S, Sorbye H, Grönberg M, Janson ET
Sci Rep 2020 Jun 30;10(1):10639. doi: 10.1038/s41598-020-67670-7. PMID: 32606315Free PMC Article
Park HJ, Kim HJ, Kim KW, Kim SY, Choi SH, You MW, Hwang HS, Hong SM
Eur Radiol 2020 Sep;30(9):4772-4782. Epub 2020 Apr 28 doi: 10.1007/s00330-020-06867-w. PMID: 32346794

Therapy

Marcisz-Grzanka K, Winiarek M, Pałucki J, Wieszczy P, Olesiński T, Jóźwiak M, Samsel R, Sułkowska U, Kolasińska-Ćwikła A, Wyrwicz LS
Neoplasma 2022 Dec;69(6):1445-1450. Epub 2022 Nov 11 doi: 10.4149/neo_2022_220720N734. PMID: 36353936
Morizane C, Machida N, Honma Y, Okusaka T, Boku N, Kato K, Nomura S, Hiraoka N, Sekine S, Taniguchi H, Okano N, Yamaguchi K, Sato T, Ikeda M, Mizuno N, Ozaka M, Kataoka T, Ueno M, Kitagawa Y, Terashima M, Furuse J; Japan Clinical Oncology Group (JCOG)
JAMA Oncol 2022 Oct 1;8(10):1447-1455. doi: 10.1001/jamaoncol.2022.3395. PMID: 35980649Free PMC Article
Broadbent R, Wheatley R, Stajer S, Jacobs T, Lamarca A, Hubner RA, Valle JW, Amir E, McNamara MG
Cancer Treat Rev 2021 Dec;101:102299. Epub 2021 Oct 11 doi: 10.1016/j.ctrv.2021.102299. PMID: 34662810
Legoux JL, Lombard-Bohas C, Brixi H, Le Malicot K, Lecomte T, Dahan L, Ruszniewski P, Mahamat-Abakar A, Etienne PL, Caroli-Bosc FX, Dominguez S, Paule B, Terrebonne E, Michel P, Lepage C, Choukroun G; for Streptotox-FFCD0906 investigators
Clin Res Hepatol Gastroenterol 2021 Sep;45(5):101572. Epub 2021 Mar 19 doi: 10.1016/j.clinre.2020.10.014. PMID: 33751987
Kourie HR, Ghorra C, Rassy M, Kesserouani C, Kattan J
Asian Pac J Cancer Prev 2016;17(5):2679-81. PMID: 27268650

Prognosis

Gogna S, Samson D, Gachabayov M, Rojas A, Felsenreich DM, Koo D, Gu K, Quintero L, Miller KR, Azim A, Da Eric Dong X
Langenbecks Arch Surg 2022 Feb;407(1):197-206. Epub 2021 Jul 8 doi: 10.1007/s00423-021-02256-z. PMID: 34236488
Shah SC, Piazuelo MB, Kuipers EJ, Li D
Gastroenterology 2021 Oct;161(4):1325-1332.e7. Epub 2021 Aug 26 doi: 10.1053/j.gastro.2021.06.078. PMID: 34454714Free PMC Article
Ali AS, Perren A, Lindskog C, Welin S, Sorbye H, Grönberg M, Janson ET
Sci Rep 2020 Jun 30;10(1):10639. doi: 10.1038/s41598-020-67670-7. PMID: 32606315Free PMC Article
Zhang XF, Wu XN, Tsilimigras DI, Poultsides G, Rocha F, Abbott DE, Fields R, Idrees K, Cho C, Maithel SK, Pawlik TM; other members of the US Neuroendocrine Tumor Study Group
J Surg Oncol 2019 Dec;120(8):1302-1310. Epub 2019 Nov 3 doi: 10.1002/jso.25753. PMID: 31680243Free PMC Article
Kourie HR, Ghorra C, Rassy M, Kesserouani C, Kattan J
Asian Pac J Cancer Prev 2016;17(5):2679-81. PMID: 27268650

Clinical prediction guides

Gogna S, Samson D, Gachabayov M, Rojas A, Felsenreich DM, Koo D, Gu K, Quintero L, Miller KR, Azim A, Da Eric Dong X
Langenbecks Arch Surg 2022 Feb;407(1):197-206. Epub 2021 Jul 8 doi: 10.1007/s00423-021-02256-z. PMID: 34236488
Broadbent R, Wheatley R, Stajer S, Jacobs T, Lamarca A, Hubner RA, Valle JW, Amir E, McNamara MG
Cancer Treat Rev 2021 Dec;101:102299. Epub 2021 Oct 11 doi: 10.1016/j.ctrv.2021.102299. PMID: 34662810
Shah SC, Piazuelo MB, Kuipers EJ, Li D
Gastroenterology 2021 Oct;161(4):1325-1332.e7. Epub 2021 Aug 26 doi: 10.1053/j.gastro.2021.06.078. PMID: 34454714Free PMC Article
Legoux JL, Lombard-Bohas C, Brixi H, Le Malicot K, Lecomte T, Dahan L, Ruszniewski P, Mahamat-Abakar A, Etienne PL, Caroli-Bosc FX, Dominguez S, Paule B, Terrebonne E, Michel P, Lepage C, Choukroun G; for Streptotox-FFCD0906 investigators
Clin Res Hepatol Gastroenterol 2021 Sep;45(5):101572. Epub 2021 Mar 19 doi: 10.1016/j.clinre.2020.10.014. PMID: 33751987
Villa M, Sforza D, Siragusa L, Guida AM, Ciancio Manuelli M, Pirozzi BM, Pocci M, Palmieri G, Grande M
Am J Case Rep 2021 Feb 23;22:e927876. doi: 10.12659/AJCR.927876. PMID: 33619239Free PMC Article

Recent systematic reviews

Broadbent R, Wheatley R, Stajer S, Jacobs T, Lamarca A, Hubner RA, Valle JW, Amir E, McNamara MG
Cancer Treat Rev 2021 Dec;101:102299. Epub 2021 Oct 11 doi: 10.1016/j.ctrv.2021.102299. PMID: 34662810
Ricci C, Ingaldi C, Alberici L, Brighi N, Santini D, Mosconi C, Ambrosini V, Campana D, Minni F, Casadei R
Endocrine 2019 Dec;66(3):460-466. Epub 2019 Jun 21 doi: 10.1007/s12020-019-01984-z. PMID: 31227991

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