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Intestinal Graft Versus Host Disease

MedGen UID:
272765
•Concept ID:
C1334228
•
Disease or Syndrome
Synonym: Intestinal GVHD

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntestinal Graft Versus Host Disease

Professional guidelines

PubMed

GVHD, IBD, and primary immunodeficiencies: The gut as a target of immunopathology resulting from impaired immunity.
Zeiser R, Warnatz K, Rosshart S, Sagar, Tanriver Y
Eur J Immunol 2022 Sep;52(9):1406-1418. Epub 2022 Apr 13 doi: 10.1002/eji.202149530. PMID: 35339113
Intestinal graft-versus-host disease: mechanisms and management.
Takatsuka H, Iwasaki T, Okamoto T, Kakishita E
Drugs 2003;63(1):1-15. doi: 10.2165/00003495-200363010-00001. PMID: 12487619
Treatment of intestinal graft-versus-host disease using betamethasone enemas.
Wada H, Mori A, Okada M, Takatsuka H, Tamura A, Seto Y, Iwata N, Fujimori Y, Okamoto T, Takemoto Y, Kakishita E
Transplantation 2001 Oct 27;72(8):1451-3. doi: 10.1097/00007890-200110270-00020. PMID: 11685119

Recent clinical studies

Etiology

(18)F-FDG-PET-MRI for the assessment of acute intestinal graft-versus-host-disease (GvHD).
Roll W, Schindler P, Masthoff M, Strotmann R, Albring J, Reicherts C, Weckesser M, Noto B, Stelljes M, Schäfers M, Evers G
BMC Cancer 2021 Sep 10;21(1):1015. doi: 10.1186/s12885-021-08748-x. PMID: 34507549Free PMC Article
Resolution of acute intestinal graft-versus-host disease.
Thiagarajan S, Neurath MF, Hildner K
Semin Immunopathol 2019 Nov;41(6):655-664. Epub 2019 Oct 31 doi: 10.1007/s00281-019-00769-w. PMID: 31673757
Histologic diagnosis and grading of esophageal acute graft-versus-host disease.
Kreft A, Neumann H, von Bach DS, Wagner-Drouet EM
Virchows Arch 2019 Mar;474(3):325-332. Epub 2019 Jan 3 doi: 10.1007/s00428-018-2507-x. PMID: 30607554
Endoscopic evaluation of acute intestinal graft-versus-host disease after allogeneic hematopoietic cell transplantation.
Altun R, Gökmen A, Tek İ, Soydan E, Kurt Yüksel M
Turk J Gastroenterol 2016 Jul;27(4):312-6. doi: 10.5152/tjg.2016.15353. PMID: 27458845
Innate lymphoid cells in graft-versus-host disease.
Konya V, Mjösberg J
Am J Transplant 2015 Nov;15(11):2795-801. Epub 2015 Jul 30 doi: 10.1111/ajt.13394. PMID: 26228632Free PMC Article

Diagnosis

Resolution of acute intestinal graft-versus-host disease.
Thiagarajan S, Neurath MF, Hildner K
Semin Immunopathol 2019 Nov;41(6):655-664. Epub 2019 Oct 31 doi: 10.1007/s00281-019-00769-w. PMID: 31673757
Histologic diagnosis and grading of esophageal acute graft-versus-host disease.
Kreft A, Neumann H, von Bach DS, Wagner-Drouet EM
Virchows Arch 2019 Mar;474(3):325-332. Epub 2019 Jan 3 doi: 10.1007/s00428-018-2507-x. PMID: 30607554
Pediatric oncologic emergencies: Clinical and imaging review for pediatricians.
Handa A, Nozaki T, Makidono A, Okabe T, Morita Y, Fujita K, Matsusako M, Kono T, Kurihara Y, Hasegawa D, Kumamoto T, Ogawa C, Yuza Y, Manabe A
Pediatr Int 2019 Feb;61(2):122-139. Epub 2019 Feb 7 doi: 10.1111/ped.13755. PMID: 30565795
Diagnosis of intestinal graft-versus-host disease and thrombotic microangiopathy after allogeneic stem cell transplantation.
Yamada-Fujiwara M, Miyamura K, Fujiwara T, Tohmiya Y, Endo K, Onishi Y, Ishizawa K, Kameoka J, Ito M, Harigae H
Tohoku J Exp Med 2012 May;227(1):31-7. doi: 10.1620/tjem.227.31. PMID: 22531159
Intestinal graft-versus-host disease: mechanisms and management.
Takatsuka H, Iwasaki T, Okamoto T, Kakishita E
Drugs 2003;63(1):1-15. doi: 10.2165/00003495-200363010-00001. PMID: 12487619

Therapy

Altered intestinal microbiome and epithelial damage aggravate intestinal graft-versus-host disease.
Gao F, Wu H, Wang L, Zhao Y, Huang H
Gut Microbes 2023 Jan-Dec;15(1):2221821. doi: 10.1080/19490976.2023.2221821. PMID: 37305973Free PMC Article
Vedolizumab for children with intestinal graft-versus-host disease: a case report and literature review.
Fukuta T, Muramatsu H, Yamashita D, Sajiki D, Maemura R, Tsumura Y, Yamamori A, Imaya M, Wakamatsu M, Nishikawa E, Narita K, Kataoka S, Taniguchi R, Narita A, Nishio N, Takahashi Y
Int J Hematol 2023 Sep;118(3):411-417. Epub 2023 Apr 19 doi: 10.1007/s12185-023-03590-2. PMID: 37074509
Steroid-Refractory Gut Graft-Versus-Host Disease: What We Have Learned From Basic Immunology and Experimental Mouse Model.
Song Q, Nasri U, Zeng D
Front Immunol 2022;13:844271. Epub 2022 Feb 18 doi: 10.3389/fimmu.2022.844271. PMID: 35251043Free PMC Article
Resolution of acute intestinal graft-versus-host disease.
Thiagarajan S, Neurath MF, Hildner K
Semin Immunopathol 2019 Nov;41(6):655-664. Epub 2019 Oct 31 doi: 10.1007/s00281-019-00769-w. PMID: 31673757
Innate lymphoid cells in graft-versus-host disease.
Konya V, Mjösberg J
Am J Transplant 2015 Nov;15(11):2795-801. Epub 2015 Jul 30 doi: 10.1111/ajt.13394. PMID: 26228632Free PMC Article

Prognosis

Novel T cell/organoid culture system allows ex vivo modeling of intestinal graft-versus-host disease.
Matthe DM, Dinkel M, Schmid B, Vogler T, Neurath MF, Poeck H, Neufert C, Büttner-Herold M, Hildner K
Front Immunol 2023;14:1253514. Epub 2023 Aug 29 doi: 10.3389/fimmu.2023.1253514. PMID: 37705975Free PMC Article
Steroid-Refractory Gut Graft-Versus-Host Disease: What We Have Learned From Basic Immunology and Experimental Mouse Model.
Song Q, Nasri U, Zeng D
Front Immunol 2022;13:844271. Epub 2022 Feb 18 doi: 10.3389/fimmu.2022.844271. PMID: 35251043Free PMC Article
Resolution of acute intestinal graft-versus-host disease.
Thiagarajan S, Neurath MF, Hildner K
Semin Immunopathol 2019 Nov;41(6):655-664. Epub 2019 Oct 31 doi: 10.1007/s00281-019-00769-w. PMID: 31673757
Histologic diagnosis and grading of esophageal acute graft-versus-host disease.
Kreft A, Neumann H, von Bach DS, Wagner-Drouet EM
Virchows Arch 2019 Mar;474(3):325-332. Epub 2019 Jan 3 doi: 10.1007/s00428-018-2507-x. PMID: 30607554
Innate lymphoid cells in graft-versus-host disease.
Konya V, Mjösberg J
Am J Transplant 2015 Nov;15(11):2795-801. Epub 2015 Jul 30 doi: 10.1111/ajt.13394. PMID: 26228632Free PMC Article

Clinical prediction guides

Vedolizumab for children with intestinal graft-versus-host disease: a case report and literature review.
Fukuta T, Muramatsu H, Yamashita D, Sajiki D, Maemura R, Tsumura Y, Yamamori A, Imaya M, Wakamatsu M, Nishikawa E, Narita K, Kataoka S, Taniguchi R, Narita A, Nishio N, Takahashi Y
Int J Hematol 2023 Sep;118(3):411-417. Epub 2023 Apr 19 doi: 10.1007/s12185-023-03590-2. PMID: 37074509
Resolution of acute intestinal graft-versus-host disease.
Thiagarajan S, Neurath MF, Hildner K
Semin Immunopathol 2019 Nov;41(6):655-664. Epub 2019 Oct 31 doi: 10.1007/s00281-019-00769-w. PMID: 31673757
Histologic diagnosis and grading of esophageal acute graft-versus-host disease.
Kreft A, Neumann H, von Bach DS, Wagner-Drouet EM
Virchows Arch 2019 Mar;474(3):325-332. Epub 2019 Jan 3 doi: 10.1007/s00428-018-2507-x. PMID: 30607554
Targeting Integrin α4β7 in Steroid-Refractory Intestinal Graft-versus-Host Disease.
Fløisand Y, Lundin KEA, Lazarevic V, Kristiansen JD, Osnes LTN, Tjønnfjord GE, Reims HM, Gedde-Dahl T
Biol Blood Marrow Transplant 2017 Jan;23(1):172-175. Epub 2016 Oct 21 doi: 10.1016/j.bbmt.2016.10.009. PMID: 27777142
Endoscopic evaluation of acute intestinal graft-versus-host disease after allogeneic hematopoietic cell transplantation.
Altun R, Gökmen A, Tek İ, Soydan E, Kurt Yüksel M
Turk J Gastroenterol 2016 Jul;27(4):312-6. doi: 10.5152/tjg.2016.15353. PMID: 27458845

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