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t(8;16)(p11;p13)

MedGen UID:
272966
•Concept ID:
C1515793
•
Cell or Molecular Dysfunction

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVt(8;16)(p11;p13)

Professional guidelines

PubMed

A large co-operative biological and clinical study to better understand and improve treatment of the rare t(8;16)(p11;p13) acute myeloid leukaemia.
Becker MW, Angelucci E
Br J Haematol 2021 Mar;192(5):800-802. Epub 2021 Feb 4 doi: 10.1111/bjh.17332. PMID: 33540474

Recent clinical studies

Etiology

Characteristics and outcome of patients with acute myeloid leukaemia and t(8;16)(p11;p13): results from an International Collaborative Study.
Kayser S, Hills RK, Langova R, Kramer M, Guijarro F, Sustkova Z, Estey EH, Shaw CM, Ráčil Z, Mayer J, Zak P, Baer MR, Brunner AM, Szotkowski T, Cetkovsky P, Grimwade D, Walter RB, Burnett AK, Ho AD, Ehninger G, Müller-Tidow C, Platzbecker U, Thiede C, Röllig C, Schulz A, Warsow G, Brors B, Esteve J, Russell NH, Schlenk RF, Levis MJ
Br J Haematol 2021 Mar;192(5):832-842. Epub 2021 Feb 2 doi: 10.1111/bjh.17336. PMID: 33529373
Pediatric acute myeloid leukemia with t(8;16)(p11;p13), a distinct clinical and biological entity: a collaborative study by the International-Berlin-Frankfurt-Munster AML-study group.
Coenen EA, Zwaan CM, Reinhardt D, Harrison CJ, Haas OA, de Haas V, Mihál V, De Moerloose B, Jeison M, Rubnitz JE, Tomizawa D, Johnston D, Alonzo TA, Hasle H, Auvrignon A, Dworzak M, Pession A, van der Velden VH, Swansbury J, Wong KF, Terui K, Savasan S, Winstanley M, Vaitkeviciene G, Zimmermann M, Pieters R, van den Heuvel-Eibrink MM
Blood 2013 Oct 10;122(15):2704-13. Epub 2013 Aug 23 doi: 10.1182/blood-2013-02-485524. PMID: 23974201Free PMC Article
Acute myeloid leukemia with translocation (8;16)(p11;p13) and MYST3-CREBBP rearrangement harbors a distinctive microRNA signature targeting RET proto-oncogene.
Díaz-Beyá M, Navarro A, Ferrer G, Díaz T, Gel B, Camós M, Pratcorona M, Torrebadell M, Rozman M, Colomer D, Monzo M, Esteve J
Leukemia 2013 Mar;27(3):595-603. Epub 2012 Oct 1 doi: 10.1038/leu.2012.278. PMID: 23022987
Interactive diagnostics in the indication to allogeneic SCT in AML.
Bacher U, Haferlach C, Schnittger S, Kern W, Kroeger N, Zander AR, Haferlach T
Bone Marrow Transplant 2009 May;43(10):745-56. Epub 2009 Apr 13 doi: 10.1038/bmt.2009.54. PMID: 19363529
The classification of acute leukaemia.
Catovsky D, Matutes E
Leukemia 1992;6 Suppl 2:1-6. PMID: 1578905

Diagnosis

Distinctive Flow Cytometric and Mutational Profile of Acute Myeloid Leukemia With t(8;16)(p11;p13) Translocation.
Aqil B, Gao J, Stalling M, Sukhanova M, Duncavage EJ, Lu X, Wolniak KL, Kreisel F, Yaseen NR
Am J Clin Pathol 2022 May 4;157(5):701-708. doi: 10.1093/ajcp/aqab178. PMID: 34698340
Pediatric acute myeloid leukemia with t(8;16)(p11;p13), a distinct clinical and biological entity: a collaborative study by the International-Berlin-Frankfurt-Munster AML-study group.
Coenen EA, Zwaan CM, Reinhardt D, Harrison CJ, Haas OA, de Haas V, Mihál V, De Moerloose B, Jeison M, Rubnitz JE, Tomizawa D, Johnston D, Alonzo TA, Hasle H, Auvrignon A, Dworzak M, Pession A, van der Velden VH, Swansbury J, Wong KF, Terui K, Savasan S, Winstanley M, Vaitkeviciene G, Zimmermann M, Pieters R, van den Heuvel-Eibrink MM
Blood 2013 Oct 10;122(15):2704-13. Epub 2013 Aug 23 doi: 10.1182/blood-2013-02-485524. PMID: 23974201Free PMC Article
Interactive diagnostics in the indication to allogeneic SCT in AML.
Bacher U, Haferlach C, Schnittger S, Kern W, Kroeger N, Zander AR, Haferlach T
Bone Marrow Transplant 2009 May;43(10):745-56. Epub 2009 Apr 13 doi: 10.1038/bmt.2009.54. PMID: 19363529
The classification of acute leukaemia.
Catovsky D, Matutes E
Leukemia 1992;6 Suppl 2:1-6. PMID: 1578905
Quantitative acute leukemia cytogenetics.
Mitelman F, Heim S
Genes Chromosomes Cancer 1992 Jul;5(1):57-66. doi: 10.1002/gcc.2870050109. PMID: 1384663

Therapy

Characteristics and outcome of patients with acute myeloid leukaemia and t(8;16)(p11;p13): results from an International Collaborative Study.
Kayser S, Hills RK, Langova R, Kramer M, Guijarro F, Sustkova Z, Estey EH, Shaw CM, Ráčil Z, Mayer J, Zak P, Baer MR, Brunner AM, Szotkowski T, Cetkovsky P, Grimwade D, Walter RB, Burnett AK, Ho AD, Ehninger G, Müller-Tidow C, Platzbecker U, Thiede C, Röllig C, Schulz A, Warsow G, Brors B, Esteve J, Russell NH, Schlenk RF, Levis MJ
Br J Haematol 2021 Mar;192(5):832-842. Epub 2021 Feb 2 doi: 10.1111/bjh.17336. PMID: 33529373
Acute myeloid leukemia with a severe coagulopathy and t(8;16)(p11;p13).
Hastings A, Apperley JF, Nadal-Melsio E, Brown L, Bain BJ
Am J Hematol 2021 Jan;96(1):163-164. Epub 2020 Jul 28 doi: 10.1002/ajh.25903. PMID: 32520413
The clinical utility of genetic testing for t(8;16)(p11;p13) in congenital acute myeloid leukemia.
Daifu T, Kato I, Kozuki K, Umeda K, Hiramatsu H, Watanabe K, Kamiya I, Taki T, Nakahata T, Heike T, Adachi S
J Pediatr Hematol Oncol 2014 Jul;36(5):e325-7. doi: 10.1097/MPH.0000000000000099. PMID: 24390445
Secondary acute monocytic leukemia with a translocation t(8;16)(p11;p13): case report and review of the literature.
Tasaka T, Matsuhashi Y, Uehara E, Tamura T, Kakazu N, Abe T, Nagai M
Leuk Lymphoma 2004 Mar;45(3):621-5. doi: 10.1080/10428190310001593058. PMID: 15160929
Therapy-related acute myeloid leukemia with t(8;21), inv(16), and t(8;16): a report on 25 cases and review of the literature.
Quesnel B, Kantarjian H, Bjergaard JP, Brault P, Estey E, Lai JL, Tilly H, Stoppa AM, Archimbaud E, Harousseau JL
J Clin Oncol 1993 Dec;11(12):2370-9. doi: 10.1200/JCO.1993.11.12.2370. PMID: 8246025

Prognosis

Characteristics and outcome of patients with acute myeloid leukaemia and t(8;16)(p11;p13): results from an International Collaborative Study.
Kayser S, Hills RK, Langova R, Kramer M, Guijarro F, Sustkova Z, Estey EH, Shaw CM, Ráčil Z, Mayer J, Zak P, Baer MR, Brunner AM, Szotkowski T, Cetkovsky P, Grimwade D, Walter RB, Burnett AK, Ho AD, Ehninger G, Müller-Tidow C, Platzbecker U, Thiede C, Röllig C, Schulz A, Warsow G, Brors B, Esteve J, Russell NH, Schlenk RF, Levis MJ
Br J Haematol 2021 Mar;192(5):832-842. Epub 2021 Feb 2 doi: 10.1111/bjh.17336. PMID: 33529373
Acute myeloid leukemia with translocation (8;16)(p11;p13) and MYST3-CREBBP rearrangement harbors a distinctive microRNA signature targeting RET proto-oncogene.
Díaz-Beyá M, Navarro A, Ferrer G, Díaz T, Gel B, Camós M, Pratcorona M, Torrebadell M, Rozman M, Colomer D, Monzo M, Esteve J
Leukemia 2013 Mar;27(3):595-603. Epub 2012 Oct 1 doi: 10.1038/leu.2012.278. PMID: 23022987
Interactive diagnostics in the indication to allogeneic SCT in AML.
Bacher U, Haferlach C, Schnittger S, Kern W, Kroeger N, Zander AR, Haferlach T
Bone Marrow Transplant 2009 May;43(10):745-56. Epub 2009 Apr 13 doi: 10.1038/bmt.2009.54. PMID: 19363529
AML with translocation t(8;16)(p11;p13) demonstrates unique cytomorphological, cytogenetic, molecular and prognostic features.
Haferlach T, Kohlmann A, Klein HU, Ruckert C, Dugas M, Williams PM, Kern W, Schnittger S, Bacher U, Löffler H, Haferlach C
Leukemia 2009 May;23(5):934-43. Epub 2009 Feb 5 doi: 10.1038/leu.2008.388. PMID: 19194466
Quantitative acute leukemia cytogenetics.
Mitelman F, Heim S
Genes Chromosomes Cancer 1992 Jul;5(1):57-66. doi: 10.1002/gcc.2870050109. PMID: 1384663

Clinical prediction guides

AML with translocation t(8;16)(p11;p13) demonstrates unique cytomorphological, cytogenetic, molecular and prognostic features.
Haferlach T, Kohlmann A, Klein HU, Ruckert C, Dugas M, Williams PM, Kern W, Schnittger S, Bacher U, Löffler H, Haferlach C
Leukemia 2009 May;23(5):934-43. Epub 2009 Feb 5 doi: 10.1038/leu.2008.388. PMID: 19194466
t(8;16)(p11;p13) predisposes to a transient but potentially recurring neonatal leukemia.
Wong KF, Yuen HL, Siu LL, Pang A, Kwong YL
Hum Pathol 2008 Nov;39(11):1702-7. Epub 2008 Jul 26 doi: 10.1016/j.humpath.2008.02.018. PMID: 18657848
Type I MOZ/CBP (MYST3/CREBBP) is the most common chimeric transcript in acute myeloid leukemia with t(8;16)(p11;p13) translocation.
Rozman M, Camós M, Colomer D, Villamor N, Esteve J, Costa D, Carrió A, Aymerich M, Aguilar JL, Domingo A, Solé F, Gomis F, Florensa L, Montserrat E, Campo E
Genes Chromosomes Cancer 2004 Jun;40(2):140-5. doi: 10.1002/gcc.20022. PMID: 15101047
The classification of acute leukaemia.
Catovsky D, Matutes E
Leukemia 1992;6 Suppl 2:1-6. PMID: 1578905
Quantitative acute leukemia cytogenetics.
Mitelman F, Heim S
Genes Chromosomes Cancer 1992 Jul;5(1):57-66. doi: 10.1002/gcc.2870050109. PMID: 1384663

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