U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

t(8;21)(q22;q22)

MedGen UID:
272967
•Concept ID:
C1515794
•
Cell or Molecular Dysfunction
Synonyms: Eight-Twenty-One; t(8;21)(q21.3;q22); t(8;21)(q22; q22.1)

Definition

A cytogenetic abnormality that involves a translocation between 8q22 and 21q22. It is associated with the development of acute myeloid leukemia with RUNX1-RUNX1T1 fusion protein expression. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVt(8;21)(q22;q22)

Professional guidelines

PubMed

Core binding factor acute myelogenous leukemia-2021 treatment algorithm.
Borthakur G, Kantarjian H
Blood Cancer J 2021 Jun 16;11(6):114. doi: 10.1038/s41408-021-00503-6. PMID: 34135311Free PMC Article
Advances in molecular genetics and treatment of core-binding factor acute myeloid leukemia.
Mrózek K, Marcucci G, Paschka P, Bloomfield CD
Curr Opin Oncol 2008 Nov;20(6):711-8. doi: 10.1097/CCO.0b013e32831369df. PMID: 18841055Free PMC Article
Prognosis and treatment outcome in patients with acute myeloid leukemia with t(8;21)(q22;q22).
Chen CC, Gau JP, Yu YB, Lu CH, Lee KD, You JY
Adv Ther 2007 Jul-Aug;24(4):907-20. doi: 10.1007/BF02849984. PMID: 17901040

Recent clinical studies

Etiology

Modeling and therapeutic targeting of t(8;21) AML with/without TP53 deficiency.
Zhang W, Li J, Yamamoto K, Goyama S
Int J Hematol 2024 Aug;120(2):186-193. Epub 2024 May 3 doi: 10.1007/s12185-024-03783-3. PMID: 38702444Free PMC Article
Validation of the prognostic significance of the 2022 European LeukemiaNet risk stratification system in intensive chemotherapy treated aged 18 to 65 years patients with de novo acute myeloid leukemia.
Lo MY, Tsai XC, Lin CC, Tien FM, Kuo YY, Lee WH, Peng YL, Liu MC, Tseng MH, Hsu CA, Chen JC, Lin LI, Sun HI, Chuang YK, Ko BS, Tang JL, Yao M, Chou WC, Hou HA, Tien HF
Am J Hematol 2023 May;98(5):760-769. Epub 2023 Mar 13 doi: 10.1002/ajh.26892. PMID: 36861732
Core binding factor acute myelogenous leukemia-2021 treatment algorithm.
Borthakur G, Kantarjian H
Blood Cancer J 2021 Jun 16;11(6):114. doi: 10.1038/s41408-021-00503-6. PMID: 34135311Free PMC Article
Core-binding factor acute myeloid leukemia.
Sangle NA, Perkins SL
Arch Pathol Lab Med 2011 Nov;135(11):1504-9. doi: 10.5858/arpa.2010-0482-RS. PMID: 22032582
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793

Diagnosis

Single-cell RNA-seq reveals novel immune-associated biomarkers for predicting prognosis in AML patients with RUNX1::RUNX1T1.
Li XP, Dai Y, Zhang WN, Pan MM, Mao J, Zhao B, Jiang L, Gao Y
Int Immunopharmacol 2023 Dec;125(Pt B):111178. Epub 2023 Nov 9 doi: 10.1016/j.intimp.2023.111178. PMID: 37951201
Validation of the prognostic significance of the 2022 European LeukemiaNet risk stratification system in intensive chemotherapy treated aged 18 to 65 years patients with de novo acute myeloid leukemia.
Lo MY, Tsai XC, Lin CC, Tien FM, Kuo YY, Lee WH, Peng YL, Liu MC, Tseng MH, Hsu CA, Chen JC, Lin LI, Sun HI, Chuang YK, Ko BS, Tang JL, Yao M, Chou WC, Hou HA, Tien HF
Am J Hematol 2023 May;98(5):760-769. Epub 2023 Mar 13 doi: 10.1002/ajh.26892. PMID: 36861732
Coexistent t(8;21)(q22;q22) Translocation and 5q Deletion in Acute Myeloid Leukemia.
Yamamoto K, Yakushijin K, Sanada Y, Kawamoto S, Matsuoka H, Minami H
J Clin Exp Hematop 2015;55(3):181-5. doi: 10.3960/jslrt.55.181. PMID: 26763368
Core-binding factor acute myeloid leukemia.
Sangle NA, Perkins SL
Arch Pathol Lab Med 2011 Nov;135(11):1504-9. doi: 10.5858/arpa.2010-0482-RS. PMID: 22032582
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793

Therapy

Pediatric acute myeloid leukemia with t(8;21) and KIT mutation treatment with avapritinib post-stem cell transplantation: a report of four cases.
Wang Q, Hu Y, Gao L, Zhang S, Lu J, Li B, Li J, Yao Y, Cheng S, Xiao P, Hu S
Ann Hematol 2024 Sep;103(9):3795-3800. Epub 2024 May 28 doi: 10.1007/s00277-024-05810-z. PMID: 38802593Free PMC Article
Core binding factor acute myelogenous leukemia-2021 treatment algorithm.
Borthakur G, Kantarjian H
Blood Cancer J 2021 Jun 16;11(6):114. doi: 10.1038/s41408-021-00503-6. PMID: 34135311Free PMC Article
Frequent ASXL2 mutations in acute myeloid leukemia patients with t(8;21)/RUNX1-RUNX1T1 chromosomal translocations.
Micol JB, Duployez N, Boissel N, Petit A, Geffroy S, Nibourel O, Lacombe C, Lapillonne H, Etancelin P, Figeac M, Renneville A, Castaigne S, Leverger G, Ifrah N, Dombret H, Preudhomme C, Abdel-Wahab O, Jourdan E
Blood 2014 Aug 28;124(9):1445-9. Epub 2014 Jun 27 doi: 10.1182/blood-2014-04-571018. PMID: 24973361Free PMC Article
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
t(8;21) (q22;q22) acute myelogenous leukemia in Mexico: a single institution experience.
Ruiz-Argüelles GJ, Morales-Toquero A, Manzano C, Ruiz-Delgado GJ, Jaramillo P, Gonzalez-Carrillo ML, Reyes-Núñez V
Hematology 2006 Aug;11(4):235-8. doi: 10.1080/10245330600702893. PMID: 17178661

Prognosis

Single-cell RNA-seq reveals novel immune-associated biomarkers for predicting prognosis in AML patients with RUNX1::RUNX1T1.
Li XP, Dai Y, Zhang WN, Pan MM, Mao J, Zhao B, Jiang L, Gao Y
Int Immunopharmacol 2023 Dec;125(Pt B):111178. Epub 2023 Nov 9 doi: 10.1016/j.intimp.2023.111178. PMID: 37951201
Validation of the prognostic significance of the 2022 European LeukemiaNet risk stratification system in intensive chemotherapy treated aged 18 to 65 years patients with de novo acute myeloid leukemia.
Lo MY, Tsai XC, Lin CC, Tien FM, Kuo YY, Lee WH, Peng YL, Liu MC, Tseng MH, Hsu CA, Chen JC, Lin LI, Sun HI, Chuang YK, Ko BS, Tang JL, Yao M, Chou WC, Hou HA, Tien HF
Am J Hematol 2023 May;98(5):760-769. Epub 2023 Mar 13 doi: 10.1002/ajh.26892. PMID: 36861732
Core binding factor acute myelogenous leukemia-2021 treatment algorithm.
Borthakur G, Kantarjian H
Blood Cancer J 2021 Jun 16;11(6):114. doi: 10.1038/s41408-021-00503-6. PMID: 34135311Free PMC Article
Core-binding factor acute myeloid leukemia.
Sangle NA, Perkins SL
Arch Pathol Lab Med 2011 Nov;135(11):1504-9. doi: 10.5858/arpa.2010-0482-RS. PMID: 22032582
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793

Clinical prediction guides

Single-cell RNA sequencing of a new transgenic t(8;21) preleukemia mouse model reveals regulatory networks promoting leukemic transformation.
Yan M, Liu M, Davis AG, Stoner SA, Zhang DE
Leukemia 2024 Jan;38(1):31-44. Epub 2023 Oct 14 doi: 10.1038/s41375-023-02063-z. PMID: 37838757Free PMC Article
Single-cell RNA-seq reveals novel immune-associated biomarkers for predicting prognosis in AML patients with RUNX1::RUNX1T1.
Li XP, Dai Y, Zhang WN, Pan MM, Mao J, Zhao B, Jiang L, Gao Y
Int Immunopharmacol 2023 Dec;125(Pt B):111178. Epub 2023 Nov 9 doi: 10.1016/j.intimp.2023.111178. PMID: 37951201
Validation of the prognostic significance of the 2022 European LeukemiaNet risk stratification system in intensive chemotherapy treated aged 18 to 65 years patients with de novo acute myeloid leukemia.
Lo MY, Tsai XC, Lin CC, Tien FM, Kuo YY, Lee WH, Peng YL, Liu MC, Tseng MH, Hsu CA, Chen JC, Lin LI, Sun HI, Chuang YK, Ko BS, Tang JL, Yao M, Chou WC, Hou HA, Tien HF
Am J Hematol 2023 May;98(5):760-769. Epub 2023 Mar 13 doi: 10.1002/ajh.26892. PMID: 36861732
Coexistent t(8;21)(q22;q22) Translocation and 5q Deletion in Acute Myeloid Leukemia.
Yamamoto K, Yakushijin K, Sanada Y, Kawamoto S, Matsuoka H, Minami H
J Clin Exp Hematop 2015;55(3):181-5. doi: 10.3960/jslrt.55.181. PMID: 26763368
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793

Recent systematic reviews

Prognostic Importance of C-KIT Mutations in Core Binding Factor Acute Myeloid Leukemia: A Systematic Review.
Ayatollahi H, Shajiei A, Sadeghian MH, Sheikhi M, Yazdandoust E, Ghazanfarpour M, Shams SF, Shakeri S
Hematol Oncol Stem Cell Ther 2017 Mar;10(1):1-7. Epub 2016 Sep 3 doi: 10.1016/j.hemonc.2016.08.005. PMID: 27613372

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...