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Carcinoma of Cowper glands

MedGen UID:
273091
•Concept ID:
C1516284
•
Neoplastic Process
Synonyms: Adenocarcinoma of Cowper Glands; bulbo-urethral gland carcinoma; carcinoma of bulbo-urethral gland; carcinoma of Cowper glands; Cowper Gland Adenocarcinoma of the Urethra; Cowper gland carcinoma
 
Monarch Initiative: MONDO:0004311

Definition

An adenocarcinoma that arises from the Cowper glands. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCarcinoma of Cowper glands

Professional guidelines

PubMed

Imaging of the Bulbourethral (Cowper) Gland: Abnormalities and Differential Diagnosis.
Takahashi H, Potretzke TA, Kawashima A, Cheville JC, Masuoka S, Kim B
Radiographics 2022 Nov-Dec;42(7):2037-2053. Epub 2022 Sep 23 doi: 10.1148/rg.220099. PMID: 36149823
Best practice in diagnostic immunohistochemistry: prostate carcinoma and its mimics in needle core biopsies.
Paner GP, Luthringer DJ, Amin MB
Arch Pathol Lab Med 2008 Sep;132(9):1388-96. doi: 10.5858/2008-132-1388-BPIDIP. PMID: 18788849
Differential diagnosis of glandular proliferations in the prostate. A conventional and immunohistochemical approach.
Helpap B
Virchows Arch 1998 Nov;433(5):397-405. doi: 10.1007/s004280050266. PMID: 9849853

Recent clinical studies

Etiology

Bulbourethral gland adenocarcinoma in a 25-year-old man without comorbidities: radical resection of proximal urethrae with Mitrofanoff-type appendicovesicostomy.
Syvänen KT, Taimen P, Salminen A, Kuusisto K, Boström PJ
Scand J Urol 2014 Aug;48(4):405-9. Epub 2013 Nov 11 doi: 10.3109/21681805.2013.852622. PMID: 24215360
Adenoid cystic carcinoma of Cowper's gland: case report.
Carpenter AA, Bernardo JR Jr
J Urol 1971 Nov;106(5):701-3. doi: 10.1016/s0022-5347(17)61379-x. PMID: 4329938

Diagnosis

Imaging of the Bulbourethral (Cowper) Gland: Abnormalities and Differential Diagnosis.
Takahashi H, Potretzke TA, Kawashima A, Cheville JC, Masuoka S, Kim B
Radiographics 2022 Nov-Dec;42(7):2037-2053. Epub 2022 Sep 23 doi: 10.1148/rg.220099. PMID: 36149823
Mucin-producing tumors and tumor-like lesions involving the prostate: a comprehensive review.
Bohman KD, Osunkoya AO
Adv Anat Pathol 2012 Nov;19(6):374-87. doi: 10.1097/PAP.0b013e318271a361. PMID: 23060063
Benign mimickers of prostatic adenocarcinoma.
Srigley JR
Mod Pathol 2004 Mar;17(3):328-48. doi: 10.1038/modpathol.3800055. PMID: 14976539
Differential diagnosis of glandular proliferations in the prostate. A conventional and immunohistochemical approach.
Helpap B
Virchows Arch 1998 Nov;433(5):397-405. doi: 10.1007/s004280050266. PMID: 9849853
Diagnosis of Cowper's glands on prostate needle biopsy.
Cina SJ, Silberman MA, Kahane H, Epstein JI
Am J Surg Pathol 1997 May;21(5):550-5. doi: 10.1097/00000478-199705000-00007. PMID: 9158679

Therapy

Mucous gland metaplasia of the prostate.
Shiraishi T, Kusano I, Watanabe M, Yatani R, Liu PI
Am J Surg Pathol 1993 Jun;17(6):618-22. doi: 10.1097/00000478-199306000-00010. PMID: 7687414
Primary carcinoma of Cowper's gland.
Bourque JL, Charghi A, Gauthier GE, Drouin G, Charbonneau J
J Urol 1970 Jun;103(6):758-61. doi: 10.1016/s0022-5347(17)62042-1. PMID: 5446457

Prognosis

Adenoid cystic carcinoma of the urethra/Cowper's gland with concurrent high-grade prostatic adenocarcinoma: a detailed clinicopathologic case report and review of the literature.
Zhang M, Pettaway C, Vikram R, Tamboli P
Hum Pathol 2016 Dec;58:138-144. Epub 2016 Aug 20 doi: 10.1016/j.humpath.2016.07.027. PMID: 27554206
Mucin-producing tumors and tumor-like lesions involving the prostate: a comprehensive review.
Bohman KD, Osunkoya AO
Adv Anat Pathol 2012 Nov;19(6):374-87. doi: 10.1097/PAP.0b013e318271a361. PMID: 23060063
Adenoid cystic carcinoma of Cowper's gland.
Hisamatsu H, Sakai H, Igawa T, Iseki M, Hayashi T, Kanetake H
BJU Int 2003 Dec;92 Suppl 3:e56-e57. doi: 10.1111/j.1464-410x.2003.04198.x. PMID: 19127687
Small-acinar patterns in the prostate gland with emphasis on atypical adenomatous hyperplasia and small-acinar carcinoma.
Srigley JR
Semin Diagn Pathol 1988 Aug;5(3):254-72. PMID: 2459751
Adenoid cystic carcinoma of Cowper's gland: case report.
Carpenter AA, Bernardo JR Jr
J Urol 1971 Nov;106(5):701-3. doi: 10.1016/s0022-5347(17)61379-x. PMID: 4329938

Clinical prediction guides

Mucous gland metaplasia of the prostate.
Shiraishi T, Kusano I, Watanabe M, Yatani R, Liu PI
Am J Surg Pathol 1993 Jun;17(6):618-22. doi: 10.1097/00000478-199306000-00010. PMID: 7687414

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