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Loss of Chromosome 10q

MedGen UID:
273493
•Concept ID:
C1517949
•
Cell or Molecular Dysfunction
Synonym: del(10q)

Definition

A cytogenetic abnormality that refers to the loss of all or part of the long arm of chromosome 10 (10q). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLoss of Chromosome 10q

Professional guidelines

PubMed

Molecular profiling of oligodendrogliomas: impact on prognosis, treatment, and future directions.
Ney DE, Lassman AB
Curr Oncol Rep 2009 Jan;11(1):62-7. doi: 10.1007/s11912-009-0010-x. PMID: 19080743
Oligodendroglioma: impact of molecular biology on its definition, diagnosis and management.
Ueki K
Neuropathology 2005 Sep;25(3):247-53. doi: 10.1111/j.1440-1789.2005.00637.x. PMID: 16193843
Impact of genotype and morphology on the prognosis of glioblastoma.
Schmidt MC, Antweiler S, Urban N, Mueller W, Kuklik A, Meyer-Puttlitz B, Wiestler OD, Louis DN, Fimmers R, von Deimling A
J Neuropathol Exp Neurol 2002 Apr;61(4):321-8. doi: 10.1093/jnen/61.4.321. PMID: 11939587

Recent clinical studies

Etiology

Subgroup and subtype-specific outcomes in adult medulloblastoma.
Coltin H, Sundaresan L, Smith KS, Skowron P, Massimi L, Eberhart CG, Schreck KC, Gupta N, Weiss WA, Tirapelli D, Carlotti C, Li KKW, Ryzhova M, Golanov A, Zheludkova O, Absalyamova O, Okonechnikov K, Stichel D, von Deimling A, Giannini C, Raskin S, Van Meir EG, Chan JA, Fults D, Chambless LB, Kim SK, Vasiljevic A, Faure-Conter C, Vibhakar R, Jung S, Leary S, Mora J, McLendon RE, Pollack IF, Hauser P, Grajkowska WA, Rubin JB, van Veelen MC, French PJ, Kros JM, Liau LM, Pfister SM, Kool M, Kijima N, Taylor MD, Packer RJ, Northcott PA, Korshunov A, Ramaswamy V
Acta Neuropathol 2021 Nov;142(5):859-871. Epub 2021 Aug 18 doi: 10.1007/s00401-021-02358-4. PMID: 34409497Free PMC Article
Distribution of EGFR amplification, combined chromosome 7 gain and chromosome 10 loss, and TERT promoter mutation in brain tumors and their potential for the reclassification of IDHwt astrocytoma to glioblastoma.
Stichel D, Ebrahimi A, Reuss D, Schrimpf D, Ono T, Shirahata M, Reifenberger G, Weller M, Hänggi D, Wick W, Herold-Mende C, Westphal M, Brandner S, Pfister SM, Capper D, Sahm F, von Deimling A
Acta Neuropathol 2018 Nov;136(5):793-803. Epub 2018 Sep 5 doi: 10.1007/s00401-018-1905-0. PMID: 30187121
ANXA7-GTPase as Tumor Suppressor: Mechanisms and Therapeutic Opportunities.
Leighton X, Eidelman O, Jozwik C, Pollard HB, Srivastava M
Methods Mol Biol 2017;1513:23-35. doi: 10.1007/978-1-4939-6539-7_3. PMID: 27807828
Clonality of oligoastrocytomas.
Dong ZQ, Pang JC, Tong CY, Zhou LF, Ng HK
Hum Pathol 2002 May;33(5):528-35. doi: 10.1053/hupa.2002.124784. PMID: 12094379
Inherited peripheral neuropathy.
Keller MP, Chance PF
Semin Neurol 1999;19(4):353-62. doi: 10.1055/s-2008-1040850. PMID: 10716658

Diagnosis

Subgroup and subtype-specific outcomes in adult medulloblastoma.
Coltin H, Sundaresan L, Smith KS, Skowron P, Massimi L, Eberhart CG, Schreck KC, Gupta N, Weiss WA, Tirapelli D, Carlotti C, Li KKW, Ryzhova M, Golanov A, Zheludkova O, Absalyamova O, Okonechnikov K, Stichel D, von Deimling A, Giannini C, Raskin S, Van Meir EG, Chan JA, Fults D, Chambless LB, Kim SK, Vasiljevic A, Faure-Conter C, Vibhakar R, Jung S, Leary S, Mora J, McLendon RE, Pollack IF, Hauser P, Grajkowska WA, Rubin JB, van Veelen MC, French PJ, Kros JM, Liau LM, Pfister SM, Kool M, Kijima N, Taylor MD, Packer RJ, Northcott PA, Korshunov A, Ramaswamy V
Acta Neuropathol 2021 Nov;142(5):859-871. Epub 2021 Aug 18 doi: 10.1007/s00401-021-02358-4. PMID: 34409497Free PMC Article
Distribution of EGFR amplification, combined chromosome 7 gain and chromosome 10 loss, and TERT promoter mutation in brain tumors and their potential for the reclassification of IDHwt astrocytoma to glioblastoma.
Stichel D, Ebrahimi A, Reuss D, Schrimpf D, Ono T, Shirahata M, Reifenberger G, Weller M, Hänggi D, Wick W, Herold-Mende C, Westphal M, Brandner S, Pfister SM, Capper D, Sahm F, von Deimling A
Acta Neuropathol 2018 Nov;136(5):793-803. Epub 2018 Sep 5 doi: 10.1007/s00401-018-1905-0. PMID: 30187121
Molecular biology of glioblastoma: Classification and mutational locations.
Soomro SH, Ting LR, Qing YY, Ren M
J Pak Med Assoc 2017 Sep;67(9):1410-1414. PMID: 28924284
ANXA7-GTPase as Tumor Suppressor: Mechanisms and Therapeutic Opportunities.
Leighton X, Eidelman O, Jozwik C, Pollard HB, Srivastava M
Methods Mol Biol 2017;1513:23-35. doi: 10.1007/978-1-4939-6539-7_3. PMID: 27807828
The usher syndromes.
Keats BJ, Corey DP
Am J Med Genet 1999 Sep 24;89(3):158-66. PMID: 10704190

Therapy

Dual MGMT inactivation by promoter hypermethylation and loss of the long arm of chromosome 10 in glioblastoma.
Richard S, Tachon G, Milin S, Wager M, Karayan-Tapon L
Cancer Med 2020 Sep;9(17):6344-6353. Epub 2020 Jul 14 doi: 10.1002/cam4.3217. PMID: 32666673Free PMC Article
Loss of retinoblastoma in pleomorphic fibroma: An immunohistochemical and genomic analysis.
Hinds B, Agulló Pérez AD, LeBoit PE, McCalmont TH, North JP
J Cutan Pathol 2017 Aug;44(8):665-671. Epub 2017 Jun 13 doi: 10.1111/cup.12965. PMID: 28543636
ANXA7-GTPase as Tumor Suppressor: Mechanisms and Therapeutic Opportunities.
Leighton X, Eidelman O, Jozwik C, Pollard HB, Srivastava M
Methods Mol Biol 2017;1513:23-35. doi: 10.1007/978-1-4939-6539-7_3. PMID: 27807828
A novel literature-based approach to identify genetic and molecular predictors of survival in glioblastoma multiforme: Analysis of 14,678 patients using systematic review and meta-analytical tools.
Thuy MN, Kam JK, Lee GC, Tao PL, Ling DQ, Cheng M, Goh SK, Papachristos AJ, Shukla L, Wall KL, Smoll NR, Jones JJ, Gikenye N, Soh B, Moffat B, Johnson N, Drummond KJ
J Clin Neurosci 2015 May;22(5):785-99. Epub 2015 Feb 16 doi: 10.1016/j.jocn.2014.10.029. PMID: 25698544
Loss of 1p, 19q, and 10q heterozygosity prospectively predicts prognosis of oligodendroglial tumors--towards individualized tumor treatment?
Ramirez C, Bowman C, Maurage CA, Dubois F, Blond S, Porchet N, Escande F
Neuro Oncol 2010 May;12(5):490-9. Epub 2010 Feb 14 doi: 10.1093/neuonc/nop071. PMID: 20156805Free PMC Article

Prognosis

Subgroup and subtype-specific outcomes in adult medulloblastoma.
Coltin H, Sundaresan L, Smith KS, Skowron P, Massimi L, Eberhart CG, Schreck KC, Gupta N, Weiss WA, Tirapelli D, Carlotti C, Li KKW, Ryzhova M, Golanov A, Zheludkova O, Absalyamova O, Okonechnikov K, Stichel D, von Deimling A, Giannini C, Raskin S, Van Meir EG, Chan JA, Fults D, Chambless LB, Kim SK, Vasiljevic A, Faure-Conter C, Vibhakar R, Jung S, Leary S, Mora J, McLendon RE, Pollack IF, Hauser P, Grajkowska WA, Rubin JB, van Veelen MC, French PJ, Kros JM, Liau LM, Pfister SM, Kool M, Kijima N, Taylor MD, Packer RJ, Northcott PA, Korshunov A, Ramaswamy V
Acta Neuropathol 2021 Nov;142(5):859-871. Epub 2021 Aug 18 doi: 10.1007/s00401-021-02358-4. PMID: 34409497Free PMC Article
Ultra high-risk PFA ependymoma is characterized by loss of chromosome 6q.
Baroni LV, Sundaresan L, Heled A, Coltin H, Pajtler KW, Lin T, Merchant TE, McLendon R, Faria C, Buntine M, White CL, Pfister SM, Gilbert MR, Armstrong TS, Bouffet E, Kumar S, Taylor MD, Aldape KD, Ellison DW, Gottardo NG, Kool M, Korshunov A, Hansford JR, Ramaswamy V
Neuro Oncol 2021 Aug 2;23(8):1360-1370. doi: 10.1093/neuonc/noab034. PMID: 33580238Free PMC Article
Subtype-specific signaling pathways and genomic aberrations associated with prognosis of glioblastoma.
Park AK, Kim P, Ballester LY, Esquenazi Y, Zhao Z
Neuro Oncol 2019 Jan 1;21(1):59-70. doi: 10.1093/neuonc/noy120. PMID: 30053126Free PMC Article
Distribution of EGFR amplification, combined chromosome 7 gain and chromosome 10 loss, and TERT promoter mutation in brain tumors and their potential for the reclassification of IDHwt astrocytoma to glioblastoma.
Stichel D, Ebrahimi A, Reuss D, Schrimpf D, Ono T, Shirahata M, Reifenberger G, Weller M, Hänggi D, Wick W, Herold-Mende C, Westphal M, Brandner S, Pfister SM, Capper D, Sahm F, von Deimling A
Acta Neuropathol 2018 Nov;136(5):793-803. Epub 2018 Sep 5 doi: 10.1007/s00401-018-1905-0. PMID: 30187121
Molecular biology of glioblastoma: Classification and mutational locations.
Soomro SH, Ting LR, Qing YY, Ren M
J Pak Med Assoc 2017 Sep;67(9):1410-1414. PMID: 28924284

Clinical prediction guides

Ultra high-risk PFA ependymoma is characterized by loss of chromosome 6q.
Baroni LV, Sundaresan L, Heled A, Coltin H, Pajtler KW, Lin T, Merchant TE, McLendon R, Faria C, Buntine M, White CL, Pfister SM, Gilbert MR, Armstrong TS, Bouffet E, Kumar S, Taylor MD, Aldape KD, Ellison DW, Gottardo NG, Kool M, Korshunov A, Hansford JR, Ramaswamy V
Neuro Oncol 2021 Aug 2;23(8):1360-1370. doi: 10.1093/neuonc/noab034. PMID: 33580238Free PMC Article
Distribution of EGFR amplification, combined chromosome 7 gain and chromosome 10 loss, and TERT promoter mutation in brain tumors and their potential for the reclassification of IDHwt astrocytoma to glioblastoma.
Stichel D, Ebrahimi A, Reuss D, Schrimpf D, Ono T, Shirahata M, Reifenberger G, Weller M, Hänggi D, Wick W, Herold-Mende C, Westphal M, Brandner S, Pfister SM, Capper D, Sahm F, von Deimling A
Acta Neuropathol 2018 Nov;136(5):793-803. Epub 2018 Sep 5 doi: 10.1007/s00401-018-1905-0. PMID: 30187121
Molecular biology of glioblastoma: Classification and mutational locations.
Soomro SH, Ting LR, Qing YY, Ren M
J Pak Med Assoc 2017 Sep;67(9):1410-1414. PMID: 28924284
ANXA7-GTPase as Tumor Suppressor: Mechanisms and Therapeutic Opportunities.
Leighton X, Eidelman O, Jozwik C, Pollard HB, Srivastava M
Methods Mol Biol 2017;1513:23-35. doi: 10.1007/978-1-4939-6539-7_3. PMID: 27807828
The correlation of clinical and chromosomal alterations of benign meningiomas and their recurrences.
Och W, Szmuda T, Kulbacki K, Witek K, Sikorska B, Zakrzewska M, Springer J, Reszeć J, Parda A, Liberski PP
Neurol Neurochir Pol 2016 Nov-Dec;50(6):395-402. Epub 2016 Jul 26 doi: 10.1016/j.pjnns.2016.07.001. PMID: 27480481

Recent systematic reviews

A novel literature-based approach to identify genetic and molecular predictors of survival in glioblastoma multiforme: Analysis of 14,678 patients using systematic review and meta-analytical tools.
Thuy MN, Kam JK, Lee GC, Tao PL, Ling DQ, Cheng M, Goh SK, Papachristos AJ, Shukla L, Wall KL, Smoll NR, Jones JJ, Gikenye N, Soh B, Moffat B, Johnson N, Drummond KJ
J Clin Neurosci 2015 May;22(5):785-99. Epub 2015 Feb 16 doi: 10.1016/j.jocn.2014.10.029. PMID: 25698544
Molecular cytogenetic characterization of Sézary syndrome.
Mao X, Lillington DM, Czepulkowski B, Russell-Jones R, Young BD, Whittaker S
Genes Chromosomes Cancer 2003 Mar;36(3):250-60. doi: 10.1002/gcc.10152. PMID: 12557225

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