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Neuronal Differentiation

MedGen UID:
273576
•Concept ID:
C1518294
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeuronal Differentiation

Professional guidelines

PubMed

Diversified Treatment Options of Adult Stem Cells for Optic Neuropathies.
Tan S, Yao Y, Yang Q, Yuan XL, Cen LP, Ng TK
Cell Transplant 2022 Jan-Dec;31:9636897221123512. doi: 10.1177/09636897221123512. PMID: 36165292Free PMC Article
Combination of Ribociclib and Gemcitabine for the Treatment of Medulloblastoma.
Pribnow A, Jonchere B, Liu J, Smith KS, Campagne O, Xu K, Robinson S, Patel Y, Onar-Thomas A, Wu G, Stewart CF, Northcott PA, Yu J, Robinson GW, Roussel MF
Mol Cancer Ther 2022 Aug 2;21(8):1306-1317. doi: 10.1158/1535-7163.MCT-21-0598. PMID: 35709750Free PMC Article
Bone mesenchymal stem cell-derived exosome-loaded injectable hydrogel for minimally invasive treatment of spinal cord injury.
Cheng J, Chen Z, Liu C, Zhong M, Wang S, Sun Y, Wen H, Shu T
Nanomedicine (Lond) 2021 Aug;16(18):1567-1579. Epub 2021 Jun 30 doi: 10.2217/nnm-2021-0025. PMID: 34189939

Recent clinical studies

Etiology

Astrocytic cell adhesion genes linked to schizophrenia correlate with synaptic programs in neurons.
Pietiläinen O, Trehan A, Meyer D, Mitchell J, Tegtmeyer M, Valakh V, Gebre H, Chen T, Vartiainen E, Farhi SL, Eggan K, McCarroll SA, Nehme R
Cell Rep 2023 Jan 31;42(1):111988. Epub 2023 Jan 12 doi: 10.1016/j.celrep.2022.111988. PMID: 36640364Free PMC Article
Overview of the 2022 WHO Classification of Pituitary Tumors.
Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
Cotargeting among microRNAs in the brain.
Cherone JM, Jorgji V, Burge CB
Genome Res 2019 Nov;29(11):1791-1804. Epub 2019 Oct 24 doi: 10.1101/gr.249201.119. PMID: 31649056Free PMC Article
Childhood-Onset Schizophrenia: Insights from Induced Pluripotent Stem Cells.
Hoffmann A, Ziller M, Spengler D
Int J Mol Sci 2018 Nov 30;19(12) doi: 10.3390/ijms19123829. PMID: 30513688Free PMC Article
Long noncoding RNAs and neuroblastoma.
Pandey GK, Kanduri C
Oncotarget 2015 Jul 30;6(21):18265-75. doi: 10.18632/oncotarget.4251. PMID: 26087192Free PMC Article

Diagnosis

DDX3X syndrome: From clinical phenotypes to biological insights.
von Mueffling A, Garcia-Forn M, De Rubeis S
J Neurochem 2024 Sep;168(9):2147-2154. Epub 2024 Jul 8 doi: 10.1111/jnc.16174. PMID: 38976626Free PMC Article
Overview of the 2022 WHO Classification of Pituitary Tumors.
Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
NGN2 induces diverse neuron types from human pluripotency.
Lin HC, He Z, Ebert S, Schörnig M, Santel M, Nikolova MT, Weigert A, Hevers W, Kasri NN, Taverna E, Camp JG, Treutlein B
Stem Cell Reports 2021 Sep 14;16(9):2118-2127. Epub 2021 Aug 5 doi: 10.1016/j.stemcr.2021.07.006. PMID: 34358451Free PMC Article
Editorial brain malformation surveillance in the Zika era.
Trevathan E
Birth Defects Res A Clin Mol Teratol 2016 Nov;106(11):869-874. doi: 10.1002/bdra.23582. PMID: 27891785Free PMC Article
Long noncoding RNAs and neuroblastoma.
Pandey GK, Kanduri C
Oncotarget 2015 Jul 30;6(21):18265-75. doi: 10.18632/oncotarget.4251. PMID: 26087192Free PMC Article

Therapy

Diversified Treatment Options of Adult Stem Cells for Optic Neuropathies.
Tan S, Yao Y, Yang Q, Yuan XL, Cen LP, Ng TK
Cell Transplant 2022 Jan-Dec;31:9636897221123512. doi: 10.1177/09636897221123512. PMID: 36165292Free PMC Article
Tanshinones and mental diseases: from chemistry to medicine.
Javed S, Tariq A, Ahmed T, Budzyńska B, Tejada S, Daglia M, Nabavi SF, Sobarzo-Sánchez E, Nabavi SM
Rev Neurosci 2016 Dec 1;27(8):777-791. doi: 10.1515/revneuro-2016-0012. PMID: 27487490
Nanomedicine Approaches to Modulate Neural Stem Cells in Brain Repair.
Santos T, Boto C, Saraiva CM, Bernardino L, Ferreira L
Trends Biotechnol 2016 Jun;34(6):437-439. Epub 2016 Feb 22 doi: 10.1016/j.tibtech.2016.02.003. PMID: 26917252
Retinoic acid signaling and neuronal differentiation.
Janesick A, Wu SC, Blumberg B
Cell Mol Life Sci 2015 Apr;72(8):1559-76. Epub 2015 Jan 6 doi: 10.1007/s00018-014-1815-9. PMID: 25558812Free PMC Article
Mesenchymal autologous stem cells.
Falavigna A, da Costa JC
World Neurosurg 2015 Feb;83(2):236-50. Epub 2013 Feb 9 doi: 10.1016/j.wneu.2013.02.026. PMID: 23402865

Prognosis

NGN2 induces diverse neuron types from human pluripotency.
Lin HC, He Z, Ebert S, Schörnig M, Santel M, Nikolova MT, Weigert A, Hevers W, Kasri NN, Taverna E, Camp JG, Treutlein B
Stem Cell Reports 2021 Sep 14;16(9):2118-2127. Epub 2021 Aug 5 doi: 10.1016/j.stemcr.2021.07.006. PMID: 34358451Free PMC Article
Childhood-Onset Schizophrenia: Insights from Induced Pluripotent Stem Cells.
Hoffmann A, Ziller M, Spengler D
Int J Mol Sci 2018 Nov 30;19(12) doi: 10.3390/ijms19123829. PMID: 30513688Free PMC Article
The role of growth factors in nerve regeneration.
Önger ME, Delibaş B, Türkmen AP, Erener E, Altunkaynak BZ, Kaplan S
Drug Discov Ther 2017 Jan 15;10(6):285-291. Epub 2016 Oct 17 doi: 10.5582/ddt.2016.01058. PMID: 27746416
The role of redox environment in neurogenic development.
Ostrakhovitch EA, Semenikhin OA
Arch Biochem Biophys 2013 Jun;534(1-2):44-54. Epub 2012 Aug 14 doi: 10.1016/j.abb.2012.08.002. PMID: 22910298
Alternative splicing takes shape during neuronal development.
Grabowski P
Curr Opin Genet Dev 2011 Aug;21(4):388-94. Epub 2011 Apr 19 doi: 10.1016/j.gde.2011.03.005. PMID: 21511457

Clinical prediction guides

Antidepressants escitalopram and venlafaxine up-regulate BDNF promoter IV but down-regulate neurite outgrowth in differentiating SH-SY5Y neurons.
Zosen D, Kondratskaya E, Kaplan-Arabaci O, Haugen F, Paulsen RE
Neurochem Int 2023 Oct;169:105571. Epub 2023 Jul 13 doi: 10.1016/j.neuint.2023.105571. PMID: 37451345
In vitro-derived medium spiny neurons recapitulate human striatal development and complexity at single-cell resolution.
Conforti P, Bocchi VD, Campus I, Scaramuzza L, Galimberti M, Lischetti T, Talpo F, Pedrazzoli M, Murgia A, Ferrari I, Cordiglieri C, Fasciani A, Arenas E, Felsenfeld D, Biella G, Besusso D, Cattaneo E
Cell Rep Methods 2022 Dec 19;2(12):100367. doi: 10.1016/j.crmeth.2022.100367. PMID: 36590694Free PMC Article
The functional landscape of the human phosphoproteome.
Ochoa D, Jarnuczak AF, Viéitez C, Gehre M, Soucheray M, Mateus A, Kleefeldt AA, Hill A, Garcia-Alonso L, Stein F, Krogan NJ, Savitski MM, Swaney DL, Vizcaíno JA, Noh KM, Beltrao P
Nat Biotechnol 2020 Mar;38(3):365-373. Epub 2019 Dec 9 doi: 10.1038/s41587-019-0344-3. PMID: 31819260Free PMC Article
Non-classical Transcriptional Activity of Retinoic Acid.
Noy N
Subcell Biochem 2016;81:179-199. doi: 10.1007/978-94-024-0945-1_7. PMID: 27830505
Midkine regulation of the renin-angiotensin system.
Kadomatsu K
Curr Hypertens Rep 2010 Apr;12(2):74-9. doi: 10.1007/s11906-010-0092-8. PMID: 20424942

Recent systematic reviews

The effect of nanomaterials on embryonic stem cell neural differentiation: a systematic review.
Rahimi Darehbagh R, Mahmoodi M, Amini N, Babahajiani M, Allavaisie A, Moradi Y
Eur J Med Res 2023 Dec 9;28(1):576. doi: 10.1186/s40001-023-01546-0. PMID: 38071365Free PMC Article
MicroRNAs-mediated regulation of the differentiation of dental pulp-derived mesenchymal stem cells: a systematic review and bioinformatic analysis.
Iranmanesh P, Vedaei A, Salehi-Mazandarani S, Nikpour P, Khazaei S, Khademi A, Galler KM, Nekoofar MH, Dummer PMH
Stem Cell Res Ther 2023 Apr 11;14(1):76. doi: 10.1186/s13287-023-03289-5. PMID: 37038220Free PMC Article
In vitro and in vivo evaluation of AFB1 and OTA-toxicity through immunofluorescence and flow cytometry techniques: A systematic review.
Frangiamone M, Cimbalo A, Alonso-Garrido M, Vila-Donat P, Manyes L
Food Chem Toxicol 2022 Feb;160:112798. Epub 2021 Dec 30 doi: 10.1016/j.fct.2021.112798. PMID: 34973406
MicroRNAs expressed in neuronal differentiation and their associated pathways: Systematic review and bioinformatics analysis.
Giorgi Silveira R, Perelló Ferrúa C, do Amaral CC, Fernandez Garcia T, de Souza KB, Nedel F
Brain Res Bull 2020 Apr;157:140-148. Epub 2020 Jan 13 doi: 10.1016/j.brainresbull.2020.01.009. PMID: 31945407
The MAP1B case: an old MAP that is new again.
Villarroel-Campos D, Gonzalez-Billault C
Dev Neurobiol 2014 Oct;74(10):953-71. Epub 2014 Apr 17 doi: 10.1002/dneu.22178. PMID: 24700609

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