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Morphologic finding

MedGen UID:
147104
•Concept ID:
C0700329
•
Finding
Synonyms: Morphologic Finding; Morphology findings
SNOMED CT: Morphologic finding (72724002); Morphology findings (72724002)

Definition

A light microscopic finding that describes the cellular characteristics and architectural patterns of cell populations in a tissue sample. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMorphologic finding

Professional guidelines

PubMed

VisualDx: decision-support software for the diagnosis and management of dermatologic disorders.
Tleyjeh IM, Nada H, Baddour LM
Clin Infect Dis 2006 Nov 1;43(9):1177-84. Epub 2006 Sep 21 doi: 10.1086/508283. PMID: 17029139
Surgical treatment of phyllodes tumors of the breast: retrospective review of 172 cases.
Chen WH, Cheng SP, Tzen CY, Yang TL, Jeng KS, Liu CL, Liu TP
J Surg Oncol 2005 Sep 1;91(3):185-94. doi: 10.1002/jso.20334. PMID: 16118768
The differential diagnosis of eosinophilic esophagitis.
Ahmad M, Soetikno RM, Ahmed A
J Clin Gastroenterol 2000 Apr;30(3):242-4. doi: 10.1097/00004836-200004000-00007. PMID: 10777180

Recent clinical studies

Etiology

Interobserver Reproducibility in Assessing Eosinophilic Cells in Ovarian Serous Borderline Tumors to Predict BRAF Mutational Status.
Chui MH, Murali R, Soslow RA, Matrai C, Xing D, Vang R
Int J Gynecol Pathol 2023 Sep 1;42(5):472-481. Epub 2023 Jan 23 doi: 10.1097/PGP.0000000000000933. PMID: 36867514Free PMC Article
Evaluation of the sense of taste and smell in patients with Neurofibromatosis Type 1.
Speth US, König D, Burg S, Gosau M, Friedrich RE
J Stomatol Oral Maxillofac Surg 2023 Feb;124(1):101271. Epub 2022 Aug 28 doi: 10.1016/j.jormas.2022.08.014. PMID: 36038126
Monitoring jaw osteomyelitis therapy with single-photon emission computed tomography/computed tomography.
Heimann I, Kuttenberger J, Della Chiesa A, Bhure U, Del Sol Pérez-Lago M, Roos JE, Lima TVM, Strobel K
Nucl Med Commun 2021 Jan;42(1):51-57. doi: 10.1097/MNM.0000000000001297. PMID: 32991397
Langerhans cell histiocytosis in children: A retrospective case series of 126 cases.
Dhar S, Srinivas SM, Dhar S, Basu S, Banerjee R, Malakar R, Ghosh A, Bhattacharya A, Ray SK, Bhattacharya A, Chowdhury J
Pediatr Dermatol 2020 Nov;37(6):1085-1089. Epub 2020 Sep 27 doi: 10.1111/pde.14389. PMID: 32981115
Cytomorphology, immunoprofile, and management of renal oncocytic neoplasms.
Zhu B, Rohan SM, Lin X
Cancer Cytopathol 2020 Dec;128(12):962-970. Epub 2020 Jul 22 doi: 10.1002/cncy.22330. PMID: 32697415

Diagnosis

Otolith Membrane Herniation, not Semicircular Canal Duct Dilation, Is Associated with Decreased Caloric Responses in Ménière's Disease.
Shen LL, Andresen NS, Chari DA, Pogson JM, Lauer AM, Rabbitt RD, Carey JP, Santos F, Ward BK
J Assoc Res Otolaryngol 2023 Feb;24(1):95-106. Epub 2022 Dec 20 doi: 10.1007/s10162-022-00883-x. PMID: 36539657Free PMC Article
Evaluation of the sense of taste and smell in patients with Neurofibromatosis Type 1.
Speth US, König D, Burg S, Gosau M, Friedrich RE
J Stomatol Oral Maxillofac Surg 2023 Feb;124(1):101271. Epub 2022 Aug 28 doi: 10.1016/j.jormas.2022.08.014. PMID: 36038126
Cytomorphology, immunoprofile, and management of renal oncocytic neoplasms.
Zhu B, Rohan SM, Lin X
Cancer Cytopathol 2020 Dec;128(12):962-970. Epub 2020 Jul 22 doi: 10.1002/cncy.22330. PMID: 32697415
Adipositas cordis, fatty infiltration of the right ventricle, and arrhythmogenic right ventricular cardiomyopathy. Just a matter of fat?
Basso C, Thiene G
Cardiovasc Pathol 2005 Jan-Feb;14(1):37-41. doi: 10.1016/j.carpath.2004.12.001. PMID: 15710290
The differential diagnosis of eosinophilic esophagitis.
Ahmad M, Soetikno RM, Ahmed A
J Clin Gastroenterol 2000 Apr;30(3):242-4. doi: 10.1097/00004836-200004000-00007. PMID: 10777180

Therapy

Focal and segmental glomerular sclerosis (FSGS) in a man and a woman with Fabry's disease.
Svarstad E, Bostad L, Kaarbøe O, Houge G, Tøndel C, Lyngdal PT, Iversen BM
Clin Nephrol 2005 May;63(5):394-401. doi: 10.5414/cnp63394. PMID: 15909601
Prognostic value of AML 1/ETO fusion transcripts in patients with acute myelogenous leukemia.
Cho EK, Bang SM, Ahn JY, Yoo SM, Park PW, Seo YH, Shin DB, Lee JH
Korean J Intern Med 2003 Mar;18(1):13-20. doi: 10.3904/kjim.2003.18.1.13. PMID: 12760263Free PMC Article
Red cell fragmentation (schistocytosis) after bone marrow transplantation.
Zomas A, Saso R, Powles R, Mackay H, Singhal S, Treleaven J, Mehta J
Bone Marrow Transplant 1998 Oct;22(8):777-80. doi: 10.1038/sj.bmt.1701442. PMID: 9827975
Platelet cancer cell interaction in metastasis formation. Platelet aggregation inhibitors: a possible approach to metastasis prevention.
Gastpar H, Ambrus JL, Ambrus CM
Prog Clin Biol Res 1982;89:63-82. PMID: 7111310
Eosinophilic fibrohistiocytic lesion of bone marrow: a distinctive new morphologic finding, probably related to drug hypersensitivity.
Rywlin AM, Hoffman EP, Ortega RS
Blood 1972 Oct;40(4):464-72. PMID: 5075294

Prognosis

Interobserver Reproducibility in Assessing Eosinophilic Cells in Ovarian Serous Borderline Tumors to Predict BRAF Mutational Status.
Chui MH, Murali R, Soslow RA, Matrai C, Xing D, Vang R
Int J Gynecol Pathol 2023 Sep 1;42(5):472-481. Epub 2023 Jan 23 doi: 10.1097/PGP.0000000000000933. PMID: 36867514Free PMC Article
Monitoring jaw osteomyelitis therapy with single-photon emission computed tomography/computed tomography.
Heimann I, Kuttenberger J, Della Chiesa A, Bhure U, Del Sol Pérez-Lago M, Roos JE, Lima TVM, Strobel K
Nucl Med Commun 2021 Jan;42(1):51-57. doi: 10.1097/MNM.0000000000001297. PMID: 32991397
Langerhans cell histiocytosis in children: A retrospective case series of 126 cases.
Dhar S, Srinivas SM, Dhar S, Basu S, Banerjee R, Malakar R, Ghosh A, Bhattacharya A, Ray SK, Bhattacharya A, Chowdhury J
Pediatr Dermatol 2020 Nov;37(6):1085-1089. Epub 2020 Sep 27 doi: 10.1111/pde.14389. PMID: 32981115
Cytomorphology, immunoprofile, and management of renal oncocytic neoplasms.
Zhu B, Rohan SM, Lin X
Cancer Cytopathol 2020 Dec;128(12):962-970. Epub 2020 Jul 22 doi: 10.1002/cncy.22330. PMID: 32697415
Near-triploid and near-tetraploid acute lymphoblastic leukemia of childhood.
Pui CH, Carroll AJ, Head D, Raimondi SC, Shuster JJ, Crist WM, Link MP, Borowitz MJ, Behm FG, Land VJ
Blood 1990 Aug 1;76(3):590-6. PMID: 2378987

Clinical prediction guides

Interobserver Reproducibility in Assessing Eosinophilic Cells in Ovarian Serous Borderline Tumors to Predict BRAF Mutational Status.
Chui MH, Murali R, Soslow RA, Matrai C, Xing D, Vang R
Int J Gynecol Pathol 2023 Sep 1;42(5):472-481. Epub 2023 Jan 23 doi: 10.1097/PGP.0000000000000933. PMID: 36867514Free PMC Article
Genetic and Clinical Studies of Patients With Increased Multinucleated Megakaryocytes in Bone Marrow as an Isolated Finding: A Diagnostic Pitfall for Myelodysplastic Syndrome.
Zheng G, He R, Reichard KK, Peterson JF, Olteanu H, Oliveira JL, Rangan A, Chen D, Shi M
Am J Surg Pathol 2021 Nov 1;45(11):1534-1540. doi: 10.1097/PAS.0000000000001732. PMID: 33999554
Langerhans cell histiocytosis in children: A retrospective case series of 126 cases.
Dhar S, Srinivas SM, Dhar S, Basu S, Banerjee R, Malakar R, Ghosh A, Bhattacharya A, Ray SK, Bhattacharya A, Chowdhury J
Pediatr Dermatol 2020 Nov;37(6):1085-1089. Epub 2020 Sep 27 doi: 10.1111/pde.14389. PMID: 32981115
Association of glomerular podocytopathy and nephrotic proteinuria in mesangial lupus nephritis.
Han TS, Schwartz MM, Lewis EJ
Lupus 2006;15(2):71-5. doi: 10.1191/0961203306lu2264oa. PMID: 16539276
Surgical treatment of phyllodes tumors of the breast: retrospective review of 172 cases.
Chen WH, Cheng SP, Tzen CY, Yang TL, Jeng KS, Liu CL, Liu TP
J Surg Oncol 2005 Sep 1;91(3):185-94. doi: 10.1002/jso.20334. PMID: 16118768

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