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Neuropathogenesis

MedGen UID:
273578
•Concept ID:
C1518296
•
Disease or Syndrome

Definition

The origin or causation of a disease of the nervous system. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeuropathogenesis

Professional guidelines

PubMed

In vitro and in silico Models to Study Mosquito-Borne Flavivirus Neuropathogenesis, Prevention, and Treatment.
Chesnut M, Muñoz LS, Harris G, Freeman D, Gama L, Pardo CA, Pamies D
Front Cell Infect Microbiol 2019;9:223. Epub 2019 Jul 9 doi: 10.3389/fcimb.2019.00223. PMID: 31338335Free PMC Article
Is deep brain stimulation a treatment option for anorexia nervosa?
Oudijn MS, Storosum JG, Nelis E, Denys D
BMC Psychiatry 2013 Oct 31;13:277. doi: 10.1186/1471-244X-13-277. PMID: 24175936Free PMC Article
Human rabies: neuropathogenesis, diagnosis, and management.
Hemachudha T, Ugolini G, Wacharapluesadee S, Sungkarat W, Shuangshoti S, Laothamatas J
Lancet Neurol 2013 May;12(5):498-513. doi: 10.1016/S1474-4422(13)70038-3. PMID: 23602163

Recent clinical studies

Etiology

The neuroimmune axis of Alzheimer's disease.
Jorfi M, Maaser-Hecker A, Tanzi RE
Genome Med 2023 Jan 26;15(1):6. doi: 10.1186/s13073-023-01155-w. PMID: 36703235Free PMC Article
Impaired interhemispheric synchrony in Parkinson's disease patients with apathy.
Zhang H, Shan AD, Gan CT, Zhang L, Wang LN, Sun HM, Yuan YS, Zhang KZ
J Affect Disord 2022 Dec 1;318:283-290. Epub 2022 Sep 9 doi: 10.1016/j.jad.2022.09.006. PMID: 36096372
COVID-19 encephalopathy: Clinical and neurobiological features.
Uginet M, Breville G, Assal F, Lövblad KO, Vargas MI, Pugin J, Serratrice J, Herrmann FR, Lalive PH, Allali G
J Med Virol 2021 Jul;93(7):4374-4381. Epub 2021 Apr 23 doi: 10.1002/jmv.26973. PMID: 33782993Free PMC Article
Update on human African trypanosomiasis (sleeping sickness).
Kennedy PGE
J Neurol 2019 Sep;266(9):2334-2337. Epub 2019 Jun 17 doi: 10.1007/s00415-019-09425-7. PMID: 31209574
Neuropsychiatric symptoms in Alzheimer's disease.
Lyketsos CG, Carrillo MC, Ryan JM, Khachaturian AS, Trzepacz P, Amatniek J, Cedarbaum J, Brashear R, Miller DS
Alzheimers Dement 2011 Sep;7(5):532-9. doi: 10.1016/j.jalz.2011.05.2410. PMID: 21889116Free PMC Article

Diagnosis

The Effects of Opioids on HIV Neuropathogenesis.
Murphy A, Barbaro J, Martínez-Aguado P, Chilunda V, Jaureguiberry-Bravo M, Berman JW
Front Immunol 2019;10:2445. Epub 2019 Oct 18 doi: 10.3389/fimmu.2019.02445. PMID: 31681322Free PMC Article
Update on human African trypanosomiasis (sleeping sickness).
Kennedy PGE
J Neurol 2019 Sep;266(9):2334-2337. Epub 2019 Jun 17 doi: 10.1007/s00415-019-09425-7. PMID: 31209574
Human rabies: neuropathogenesis, diagnosis, and management.
Hemachudha T, Ugolini G, Wacharapluesadee S, Sungkarat W, Shuangshoti S, Laothamatas J
Lancet Neurol 2013 May;12(5):498-513. doi: 10.1016/S1474-4422(13)70038-3. PMID: 23602163
Neuropsychiatric symptoms in Alzheimer's disease.
Lyketsos CG, Carrillo MC, Ryan JM, Khachaturian AS, Trzepacz P, Amatniek J, Cedarbaum J, Brashear R, Miller DS
Alzheimers Dement 2011 Sep;7(5):532-9. doi: 10.1016/j.jalz.2011.05.2410. PMID: 21889116Free PMC Article
Down's syndrome.
Roizen NJ, Patterson D
Lancet 2003 Apr 12;361(9365):1281-9. doi: 10.1016/S0140-6736(03)12987-X. PMID: 12699967

Therapy

Role of ketone bodies in diabetes-induced dementia: sirtuins, insulin resistance, synaptic plasticity, mitochondrial dysfunction, and neurotransmitter.
Chung JY, Kim OY, Song J
Nutr Rev 2022 Mar 10;80(4):774-785. doi: 10.1093/nutrit/nuab118. PMID: 34957519Free PMC Article
Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson's Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment.
Que R, Zheng J, Chang Z, Zhang W, Li H, Xie Z, Huang Z, Wang HT, Xu J, Jin D, Yang W, Tan EK, Wang Q
Front Immunol 2021;12:794770. Epub 2021 Dec 1 doi: 10.3389/fimmu.2021.794770. PMID: 34925379Free PMC Article
Opioid-Mediated HIV-1 Immunopathogenesis.
Buch S, Periyasamy P, Thangaraj A, Sil S, Chivero ET, Tripathi A
J Neuroimmune Pharmacol 2020 Dec;15(4):628-642. Epub 2020 Oct 8 doi: 10.1007/s11481-020-09960-5. PMID: 33029670Free PMC Article
Effects of COVID-19 on the Nervous System.
Iadecola C, Anrather J, Kamel H
Cell 2020 Oct 1;183(1):16-27.e1. Epub 2020 Aug 19 doi: 10.1016/j.cell.2020.08.028. PMID: 32882182Free PMC Article
Update on human African trypanosomiasis (sleeping sickness).
Kennedy PGE
J Neurol 2019 Sep;266(9):2334-2337. Epub 2019 Jun 17 doi: 10.1007/s00415-019-09425-7. PMID: 31209574

Prognosis

Neuropathogenesis of HIV and emerging therapeutic targets.
Siddiqui A, He C, Lee G, Figueroa A, Slaughter A, Robinson-Papp J
Expert Opin Ther Targets 2022 Jul;26(7):603-615. Epub 2022 Jul 18 doi: 10.1080/14728222.2022.2100253. PMID: 35815686Free PMC Article
Malaria Related Neurocognitive Deficits and Behavioral Alterations.
Rosa-Gonçalves P, Ribeiro-Gomes FL, Daniel-Ribeiro CT
Front Cell Infect Microbiol 2022;12:829413. Epub 2022 Feb 22 doi: 10.3389/fcimb.2022.829413. PMID: 35281436Free PMC Article
Neuroinflammation associated with scrub typhus and spotted fever group rickettsioses.
Fisher J, Card G, Soong L
PLoS Negl Trop Dis 2020 Oct;14(10):e0008675. Epub 2020 Oct 22 doi: 10.1371/journal.pntd.0008675. PMID: 33091013Free PMC Article
In vitro and in silico Models to Study Mosquito-Borne Flavivirus Neuropathogenesis, Prevention, and Treatment.
Chesnut M, Muñoz LS, Harris G, Freeman D, Gama L, Pardo CA, Pamies D
Front Cell Infect Microbiol 2019;9:223. Epub 2019 Jul 9 doi: 10.3389/fcimb.2019.00223. PMID: 31338335Free PMC Article
Advances and new insights in the neuropathogenesis of dengue infection.
Puccioni-Sohler M, Rosadas C
Arq Neuropsiquiatr 2015 Aug;73(8):698-703. doi: 10.1590/0004-282X20150074. PMID: 26222363

Clinical prediction guides

Neuroimaging the Neuropathogenesis of HIV.
Boerwinkle AH, Meeker KL, Luckett P, Ances BM
Curr HIV/AIDS Rep 2021 Jun;18(3):221-228. Epub 2021 Feb 25 doi: 10.1007/s11904-021-00548-z. PMID: 33630240Free PMC Article
Cellular mechanisms underlying neurological/neuropsychiatric manifestations of COVID-19.
Bodnar B, Patel K, Ho W, Luo JJ, Hu W
J Med Virol 2021 Apr;93(4):1983-1998. Epub 2020 Dec 23 doi: 10.1002/jmv.26720. PMID: 33300152Free PMC Article
In vitro and in silico Models to Study Mosquito-Borne Flavivirus Neuropathogenesis, Prevention, and Treatment.
Chesnut M, Muñoz LS, Harris G, Freeman D, Gama L, Pardo CA, Pamies D
Front Cell Infect Microbiol 2019;9:223. Epub 2019 Jul 9 doi: 10.3389/fcimb.2019.00223. PMID: 31338335Free PMC Article
Mechanisms of neuropathogenesis in HIV and HCV: similarities, differences, and unknowns.
Abutaleb A, Kattakuzhy S, Kottilil S, O'Connor E, Wilson E
J Neurovirol 2018 Dec;24(6):670-678. Epub 2018 Oct 5 doi: 10.1007/s13365-018-0678-5. PMID: 30291565Free PMC Article
Neuropathogenesis of delirium: review of current etiologic theories and common pathways.
Maldonado JR
Am J Geriatr Psychiatry 2013 Dec;21(12):1190-222. doi: 10.1016/j.jagp.2013.09.005. PMID: 24206937

Recent systematic reviews

Computational Prediction of RNA-RNA Interactions between Small RNA Tracks from Betacoronavirus Nonstructural Protein 3 and Neurotrophin Genes during Infection of an Epithelial Lung Cancer Cell Line: Potential Role of Novel Small Regulatory RNA.
Rojas-Cruz AF, Bermúdez-Santana CI
Viruses 2023 Jul 28;15(8) doi: 10.3390/v15081647. PMID: 37631989Free PMC Article
Use of Cerebrospinal Fluid for the Diagnosis of Neuroinvasive Dengue, Zika, and Chikungunya: A 19-year systematic review.
Mello CDS, Cabral-Castro MJ, Faria LCS, Peralta JM, Puccioni-Sohler M
Rev Soc Bras Med Trop 2021;54:e0891 2020. Epub 2021 Apr 28 doi: 10.1590/0037-8682-0891-2020. PMID: 33950132Free PMC Article
Coronavirus disease 2019 and neurodegenerative disease: what will the future bring?
McAlpine LS, Fesharaki-Zadeh A, Spudich S
Curr Opin Psychiatry 2021 Mar 1;34(2):177-185. doi: 10.1097/YCO.0000000000000688. PMID: 33395100Free PMC Article
Systematic review of structural and functional brain alterations in psychosis of epilepsy.
Allebone J, Kanaan R, Wilson SJ
J Neurol Neurosurg Psychiatry 2018 Jun;89(6):611-617. Epub 2017 Dec 23 doi: 10.1136/jnnp-2017-317102. PMID: 29275328
The Range of Neurological Complications in Chikungunya Fever.
Cerny T, Schwarz M, Schwarz U, Lemant J, Gérardin P, Keller E
Neurocrit Care 2017 Dec;27(3):447-457. doi: 10.1007/s12028-017-0413-8. PMID: 28741102

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