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Neuropathogenesis

MedGen UID:
273578
•Concept ID:
C1518296
•
Disease or Syndrome

Definition

The origin or causation of a disease of the nervous system. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeuropathogenesis

Professional guidelines

PubMed

Mechanisms underlying HIV-associated cognitive impairment and emerging therapies for its management.
Ellis RJ, Marquine MJ, Kaul M, Fields JA, Schlachetzki JCM
Nat Rev Neurol 2023 Nov;19(11):668-687. Epub 2023 Oct 10 doi: 10.1038/s41582-023-00879-y. PMID: 37816937Free PMC Article
In vitro and in silico Models to Study Mosquito-Borne Flavivirus Neuropathogenesis, Prevention, and Treatment.
Chesnut M, Muñoz LS, Harris G, Freeman D, Gama L, Pardo CA, Pamies D
Front Cell Infect Microbiol 2019;9:223. Epub 2019 Jul 9 doi: 10.3389/fcimb.2019.00223. PMID: 31338335Free PMC Article
Human rabies: neuropathogenesis, diagnosis, and management.
Hemachudha T, Ugolini G, Wacharapluesadee S, Sungkarat W, Shuangshoti S, Laothamatas J
Lancet Neurol 2013 May;12(5):498-513. doi: 10.1016/S1474-4422(13)70038-3. PMID: 23602163

Recent clinical studies

Etiology

The neuroimmune axis of Alzheimer's disease.
Jorfi M, Maaser-Hecker A, Tanzi RE
Genome Med 2023 Jan 26;15(1):6. doi: 10.1186/s13073-023-01155-w. PMID: 36703235Free PMC Article
Neuroimaging the Neuropathogenesis of HIV.
Boerwinkle AH, Meeker KL, Luckett P, Ances BM
Curr HIV/AIDS Rep 2021 Jun;18(3):221-228. Epub 2021 Feb 25 doi: 10.1007/s11904-021-00548-z. PMID: 33630240Free PMC Article
The Effects of Opioids on HIV Neuropathogenesis.
Murphy A, Barbaro J, Martínez-Aguado P, Chilunda V, Jaureguiberry-Bravo M, Berman JW
Front Immunol 2019;10:2445. Epub 2019 Oct 18 doi: 10.3389/fimmu.2019.02445. PMID: 31681322Free PMC Article
Encephalitic Arboviruses: Emergence, Clinical Presentation, and Neuropathogenesis.
Salimi H, Cain MD, Klein RS
Neurotherapeutics 2016 Jul;13(3):514-34. doi: 10.1007/s13311-016-0443-5. PMID: 27220616Free PMC Article
Neuropsychiatric symptoms in Alzheimer's disease.
Lyketsos CG, Carrillo MC, Ryan JM, Khachaturian AS, Trzepacz P, Amatniek J, Cedarbaum J, Brashear R, Miller DS
Alzheimers Dement 2011 Sep;7(5):532-9. doi: 10.1016/j.jalz.2011.05.2410. PMID: 21889116Free PMC Article

Diagnosis

Neuropathogenesis-on-chips for neurodegenerative diseases.
Amartumur S, Nguyen H, Huynh T, Kim TS, Woo RS, Oh E, Kim KK, Lee LP, Heo C
Nat Commun 2024 Mar 12;15(1):2219. doi: 10.1038/s41467-024-46554-8. PMID: 38472255Free PMC Article
Review of dengue, zika and chikungunya infections in nervous system in endemic areas.
Puccioni-Sohler M, Nascimento Soares C, Christo PP, Almeida SM
Arq Neuropsiquiatr 2023 Dec;81(12):1112-1124. Epub 2023 Dec 29 doi: 10.1055/s-0043-1777104. PMID: 38157877Free PMC Article
Human rabies: neuropathogenesis, diagnosis, and management.
Hemachudha T, Ugolini G, Wacharapluesadee S, Sungkarat W, Shuangshoti S, Laothamatas J
Lancet Neurol 2013 May;12(5):498-513. doi: 10.1016/S1474-4422(13)70038-3. PMID: 23602163
Neuropsychiatric symptoms in Alzheimer's disease.
Lyketsos CG, Carrillo MC, Ryan JM, Khachaturian AS, Trzepacz P, Amatniek J, Cedarbaum J, Brashear R, Miller DS
Alzheimers Dement 2011 Sep;7(5):532-9. doi: 10.1016/j.jalz.2011.05.2410. PMID: 21889116Free PMC Article
Down's syndrome.
Roizen NJ, Patterson D
Lancet 2003 Apr 12;361(9365):1281-9. doi: 10.1016/S0140-6736(03)12987-X. PMID: 12699967

Therapy

Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson's Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment.
Que R, Zheng J, Chang Z, Zhang W, Li H, Xie Z, Huang Z, Wang HT, Xu J, Jin D, Yang W, Tan EK, Wang Q
Front Immunol 2021;12:794770. Epub 2021 Dec 1 doi: 10.3389/fimmu.2021.794770. PMID: 34925379Free PMC Article
Opioid-Mediated HIV-1 Immunopathogenesis.
Buch S, Periyasamy P, Thangaraj A, Sil S, Chivero ET, Tripathi A
J Neuroimmune Pharmacol 2020 Dec;15(4):628-642. Epub 2020 Oct 8 doi: 10.1007/s11481-020-09960-5. PMID: 33029670Free PMC Article
Effects of COVID-19 on the Nervous System.
Iadecola C, Anrather J, Kamel H
Cell 2020 Oct 1;183(1):16-27.e1. Epub 2020 Aug 19 doi: 10.1016/j.cell.2020.08.028. PMID: 32882182Free PMC Article
The Effects of Opioids on HIV Neuropathogenesis.
Murphy A, Barbaro J, Martínez-Aguado P, Chilunda V, Jaureguiberry-Bravo M, Berman JW
Front Immunol 2019;10:2445. Epub 2019 Oct 18 doi: 10.3389/fimmu.2019.02445. PMID: 31681322Free PMC Article
Pathogenesis of age-related HIV neurodegeneration.
Mackiewicz MM, Overk C, Achim CL, Masliah E
J Neurovirol 2019 Oct;25(5):622-633. Epub 2019 Feb 21 doi: 10.1007/s13365-019-00728-z. PMID: 30790184Free PMC Article

Prognosis

Neuropathogenesis of HIV and emerging therapeutic targets.
Siddiqui A, He C, Lee G, Figueroa A, Slaughter A, Robinson-Papp J
Expert Opin Ther Targets 2022 Jul;26(7):603-615. Epub 2022 Jul 18 doi: 10.1080/14728222.2022.2100253. PMID: 35815686Free PMC Article
Malaria Related Neurocognitive Deficits and Behavioral Alterations.
Rosa-Gonçalves P, Ribeiro-Gomes FL, Daniel-Ribeiro CT
Front Cell Infect Microbiol 2022;12:829413. Epub 2022 Feb 22 doi: 10.3389/fcimb.2022.829413. PMID: 35281436Free PMC Article
Neuropathogenesis of acute coronavirus disease 2019.
Farhadian SF, Seilhean D, Spudich S
Curr Opin Neurol 2021 Jun 1;34(3):417-422. doi: 10.1097/WCO.0000000000000944. PMID: 33852526
In vitro and in silico Models to Study Mosquito-Borne Flavivirus Neuropathogenesis, Prevention, and Treatment.
Chesnut M, Muñoz LS, Harris G, Freeman D, Gama L, Pardo CA, Pamies D
Front Cell Infect Microbiol 2019;9:223. Epub 2019 Jul 9 doi: 10.3389/fcimb.2019.00223. PMID: 31338335Free PMC Article
Advances and new insights in the neuropathogenesis of dengue infection.
Puccioni-Sohler M, Rosadas C
Arq Neuropsiquiatr 2015 Aug;73(8):698-703. doi: 10.1590/0004-282X20150074. PMID: 26222363

Clinical prediction guides

Blood-brain barrier injury and neuroinflammation induced by SARS-CoV-2 in a lung-brain microphysiological system.
Wang P, Jin L, Zhang M, Wu Y, Duan Z, Guo Y, Wang C, Guo Y, Chen W, Liao Z, Wang Y, Lai R, Lee LP, Qin J
Nat Biomed Eng 2024 Aug;8(8):1053-1068. Epub 2023 Jun 22 doi: 10.1038/s41551-023-01054-w. PMID: 37349391
Inhibition of cGAS-STING pathway alleviates neuroinflammation-induced retinal ganglion cell death after ischemia/reperfusion injury.
Wu X, Yu N, Ye Z, Gu Y, Zhang C, Chen M, Wang K
Cell Death Dis 2023 Sep 19;14(9):615. doi: 10.1038/s41419-023-06140-0. PMID: 37726272Free PMC Article
Neuropathogenesis of acute coronavirus disease 2019.
Farhadian SF, Seilhean D, Spudich S
Curr Opin Neurol 2021 Jun 1;34(3):417-422. doi: 10.1097/WCO.0000000000000944. PMID: 33852526
Neuroimaging the Neuropathogenesis of HIV.
Boerwinkle AH, Meeker KL, Luckett P, Ances BM
Curr HIV/AIDS Rep 2021 Jun;18(3):221-228. Epub 2021 Feb 25 doi: 10.1007/s11904-021-00548-z. PMID: 33630240Free PMC Article
Neuropathogenesis of delirium: review of current etiologic theories and common pathways.
Maldonado JR
Am J Geriatr Psychiatry 2013 Dec;21(12):1190-222. doi: 10.1016/j.jagp.2013.09.005. PMID: 24206937

Recent systematic reviews

Computational Prediction of RNA-RNA Interactions between Small RNA Tracks from Betacoronavirus Nonstructural Protein 3 and Neurotrophin Genes during Infection of an Epithelial Lung Cancer Cell Line: Potential Role of Novel Small Regulatory RNA.
Rojas-Cruz AF, Bermúdez-Santana CI
Viruses 2023 Jul 28;15(8) doi: 10.3390/v15081647. PMID: 37631989Free PMC Article
Use of Cerebrospinal Fluid for the Diagnosis of Neuroinvasive Dengue, Zika, and Chikungunya: A 19-year systematic review.
Mello CDS, Cabral-Castro MJ, Faria LCS, Peralta JM, Puccioni-Sohler M
Rev Soc Bras Med Trop 2021;54:e0891 2020. Epub 2021 Apr 28 doi: 10.1590/0037-8682-0891-2020. PMID: 33950132Free PMC Article
Coronavirus disease 2019 and neurodegenerative disease: what will the future bring?
McAlpine LS, Fesharaki-Zadeh A, Spudich S
Curr Opin Psychiatry 2021 Mar 1;34(2):177-185. doi: 10.1097/YCO.0000000000000688. PMID: 33395100Free PMC Article
Systematic review of structural and functional brain alterations in psychosis of epilepsy.
Allebone J, Kanaan R, Wilson SJ
J Neurol Neurosurg Psychiatry 2018 Jun;89(6):611-617. Epub 2017 Dec 23 doi: 10.1136/jnnp-2017-317102. PMID: 29275328
The Range of Neurological Complications in Chikungunya Fever.
Cerny T, Schwarz M, Schwarz U, Lemant J, Gérardin P, Keller E
Neurocrit Care 2017 Dec;27(3):447-457. doi: 10.1007/s12028-017-0413-8. PMID: 28741102

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