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Neuropathogenesis

MedGen UID:
273578
•Concept ID:
C1518296
•
Disease or Syndrome

Definition

The origin or causation of a disease of the nervous system. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeuropathogenesis

Professional guidelines

PubMed

In vitro and in silico Models to Study Mosquito-Borne Flavivirus Neuropathogenesis, Prevention, and Treatment.
Chesnut M, Muñoz LS, Harris G, Freeman D, Gama L, Pardo CA, Pamies D
Front Cell Infect Microbiol 2019;9:223. Epub 2019 Jul 9 doi: 10.3389/fcimb.2019.00223. PMID: 31338335Free PMC Article
HIV-associated neurocognitive disorder--pathogenesis and prospects for treatment.
Saylor D, Dickens AM, Sacktor N, Haughey N, Slusher B, Pletnikov M, Mankowski JL, Brown A, Volsky DJ, McArthur JC
Nat Rev Neurol 2016 Apr;12(4):234-48. Epub 2016 Mar 11 doi: 10.1038/nrneurol.2016.27. PMID: 26965674Free PMC Article
Human rabies: neuropathogenesis, diagnosis, and management.
Hemachudha T, Ugolini G, Wacharapluesadee S, Sungkarat W, Shuangshoti S, Laothamatas J
Lancet Neurol 2013 May;12(5):498-513. doi: 10.1016/S1474-4422(13)70038-3. PMID: 23602163

Recent clinical studies

Etiology

The neuroimmune axis of Alzheimer's disease.
Jorfi M, Maaser-Hecker A, Tanzi RE
Genome Med 2023 Jan 26;15(1):6. doi: 10.1186/s13073-023-01155-w. PMID: 36703235Free PMC Article
Neuroimaging the Neuropathogenesis of HIV.
Boerwinkle AH, Meeker KL, Luckett P, Ances BM
Curr HIV/AIDS Rep 2021 Jun;18(3):221-228. Epub 2021 Feb 25 doi: 10.1007/s11904-021-00548-z. PMID: 33630240Free PMC Article
The Effects of Opioids on HIV Neuropathogenesis.
Murphy A, Barbaro J, Martínez-Aguado P, Chilunda V, Jaureguiberry-Bravo M, Berman JW
Front Immunol 2019;10:2445. Epub 2019 Oct 18 doi: 10.3389/fimmu.2019.02445. PMID: 31681322Free PMC Article
Encephalitic Arboviruses: Emergence, Clinical Presentation, and Neuropathogenesis.
Salimi H, Cain MD, Klein RS
Neurotherapeutics 2016 Jul;13(3):514-34. doi: 10.1007/s13311-016-0443-5. PMID: 27220616Free PMC Article
Neuropsychiatric symptoms in Alzheimer's disease.
Lyketsos CG, Carrillo MC, Ryan JM, Khachaturian AS, Trzepacz P, Amatniek J, Cedarbaum J, Brashear R, Miller DS
Alzheimers Dement 2011 Sep;7(5):532-9. doi: 10.1016/j.jalz.2011.05.2410. PMID: 21889116Free PMC Article

Diagnosis

Neuropathogenesis-on-chips for neurodegenerative diseases.
Amartumur S, Nguyen H, Huynh T, Kim TS, Woo RS, Oh E, Kim KK, Lee LP, Heo C
Nat Commun 2024 Mar 12;15(1):2219. doi: 10.1038/s41467-024-46554-8. PMID: 38472255Free PMC Article
Encephalitic Arboviruses: Emergence, Clinical Presentation, and Neuropathogenesis.
Salimi H, Cain MD, Klein RS
Neurotherapeutics 2016 Jul;13(3):514-34. doi: 10.1007/s13311-016-0443-5. PMID: 27220616Free PMC Article
Human rabies: neuropathogenesis, diagnosis, and management.
Hemachudha T, Ugolini G, Wacharapluesadee S, Sungkarat W, Shuangshoti S, Laothamatas J
Lancet Neurol 2013 May;12(5):498-513. doi: 10.1016/S1474-4422(13)70038-3. PMID: 23602163
Neuropsychiatric symptoms in Alzheimer's disease.
Lyketsos CG, Carrillo MC, Ryan JM, Khachaturian AS, Trzepacz P, Amatniek J, Cedarbaum J, Brashear R, Miller DS
Alzheimers Dement 2011 Sep;7(5):532-9. doi: 10.1016/j.jalz.2011.05.2410. PMID: 21889116Free PMC Article
Down's syndrome.
Roizen NJ, Patterson D
Lancet 2003 Apr 12;361(9365):1281-9. doi: 10.1016/S0140-6736(03)12987-X. PMID: 12699967

Therapy

Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson's Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment.
Que R, Zheng J, Chang Z, Zhang W, Li H, Xie Z, Huang Z, Wang HT, Xu J, Jin D, Yang W, Tan EK, Wang Q
Front Immunol 2021;12:794770. Epub 2021 Dec 1 doi: 10.3389/fimmu.2021.794770. PMID: 34925379Free PMC Article
Co-receptor signaling in the pathogenesis of neuroHIV.
Nickoloff-Bybel EA, Festa L, Meucci O, Gaskill PJ
Retrovirology 2021 Aug 24;18(1):24. doi: 10.1186/s12977-021-00569-x. PMID: 34429135Free PMC Article
Opioid-Mediated HIV-1 Immunopathogenesis.
Buch S, Periyasamy P, Thangaraj A, Sil S, Chivero ET, Tripathi A
J Neuroimmune Pharmacol 2020 Dec;15(4):628-642. Epub 2020 Oct 8 doi: 10.1007/s11481-020-09960-5. PMID: 33029670Free PMC Article
Effects of COVID-19 on the Nervous System.
Iadecola C, Anrather J, Kamel H
Cell 2020 Oct 1;183(1):16-27.e1. Epub 2020 Aug 19 doi: 10.1016/j.cell.2020.08.028. PMID: 32882182Free PMC Article
Pathogenesis of age-related HIV neurodegeneration.
Mackiewicz MM, Overk C, Achim CL, Masliah E
J Neurovirol 2019 Oct;25(5):622-633. Epub 2019 Feb 21 doi: 10.1007/s13365-019-00728-z. PMID: 30790184Free PMC Article

Prognosis

Neuropathogenesis of HIV and emerging therapeutic targets.
Siddiqui A, He C, Lee G, Figueroa A, Slaughter A, Robinson-Papp J
Expert Opin Ther Targets 2022 Jul;26(7):603-615. Epub 2022 Jul 18 doi: 10.1080/14728222.2022.2100253. PMID: 35815686Free PMC Article
Malaria Related Neurocognitive Deficits and Behavioral Alterations.
Rosa-Gonçalves P, Ribeiro-Gomes FL, Daniel-Ribeiro CT
Front Cell Infect Microbiol 2022;12:829413. Epub 2022 Feb 22 doi: 10.3389/fcimb.2022.829413. PMID: 35281436Free PMC Article
In vitro and in silico Models to Study Mosquito-Borne Flavivirus Neuropathogenesis, Prevention, and Treatment.
Chesnut M, Muñoz LS, Harris G, Freeman D, Gama L, Pardo CA, Pamies D
Front Cell Infect Microbiol 2019;9:223. Epub 2019 Jul 9 doi: 10.3389/fcimb.2019.00223. PMID: 31338335Free PMC Article
Advances and new insights in the neuropathogenesis of dengue infection.
Puccioni-Sohler M, Rosadas C
Arq Neuropsiquiatr 2015 Aug;73(8):698-703. doi: 10.1590/0004-282X20150074. PMID: 26222363
Glutamate metabolism and HIV-associated neurocognitive disorders.
Vázquez-Santiago FJ, Noel RJ Jr, Porter JT, Rivera-Amill V
J Neurovirol 2014 Aug;20(4):315-31. Epub 2014 May 28 doi: 10.1007/s13365-014-0258-2. PMID: 24867611Free PMC Article

Clinical prediction guides

Inhibition of cGAS-STING pathway alleviates neuroinflammation-induced retinal ganglion cell death after ischemia/reperfusion injury.
Wu X, Yu N, Ye Z, Gu Y, Zhang C, Chen M, Wang K
Cell Death Dis 2023 Sep 19;14(9):615. doi: 10.1038/s41419-023-06140-0. PMID: 37726272Free PMC Article
Neuroimaging the Neuropathogenesis of HIV.
Boerwinkle AH, Meeker KL, Luckett P, Ances BM
Curr HIV/AIDS Rep 2021 Jun;18(3):221-228. Epub 2021 Feb 25 doi: 10.1007/s11904-021-00548-z. PMID: 33630240Free PMC Article
Cellular mechanisms underlying neurological/neuropsychiatric manifestations of COVID-19.
Bodnar B, Patel K, Ho W, Luo JJ, Hu W
J Med Virol 2021 Apr;93(4):1983-1998. Epub 2020 Dec 23 doi: 10.1002/jmv.26720. PMID: 33300152Free PMC Article
In vitro and in silico Models to Study Mosquito-Borne Flavivirus Neuropathogenesis, Prevention, and Treatment.
Chesnut M, Muñoz LS, Harris G, Freeman D, Gama L, Pardo CA, Pamies D
Front Cell Infect Microbiol 2019;9:223. Epub 2019 Jul 9 doi: 10.3389/fcimb.2019.00223. PMID: 31338335Free PMC Article
Neuropathogenesis of delirium: review of current etiologic theories and common pathways.
Maldonado JR
Am J Geriatr Psychiatry 2013 Dec;21(12):1190-222. doi: 10.1016/j.jagp.2013.09.005. PMID: 24206937

Recent systematic reviews

Computational Prediction of RNA-RNA Interactions between Small RNA Tracks from Betacoronavirus Nonstructural Protein 3 and Neurotrophin Genes during Infection of an Epithelial Lung Cancer Cell Line: Potential Role of Novel Small Regulatory RNA.
Rojas-Cruz AF, Bermúdez-Santana CI
Viruses 2023 Jul 28;15(8) doi: 10.3390/v15081647. PMID: 37631989Free PMC Article
Use of Cerebrospinal Fluid for the Diagnosis of Neuroinvasive Dengue, Zika, and Chikungunya: A 19-year systematic review.
Mello CDS, Cabral-Castro MJ, Faria LCS, Peralta JM, Puccioni-Sohler M
Rev Soc Bras Med Trop 2021;54:e0891 2020. Epub 2021 Apr 28 doi: 10.1590/0037-8682-0891-2020. PMID: 33950132Free PMC Article
Coronavirus disease 2019 and neurodegenerative disease: what will the future bring?
McAlpine LS, Fesharaki-Zadeh A, Spudich S
Curr Opin Psychiatry 2021 Mar 1;34(2):177-185. doi: 10.1097/YCO.0000000000000688. PMID: 33395100Free PMC Article
Systematic review of structural and functional brain alterations in psychosis of epilepsy.
Allebone J, Kanaan R, Wilson SJ
J Neurol Neurosurg Psychiatry 2018 Jun;89(6):611-617. Epub 2017 Dec 23 doi: 10.1136/jnnp-2017-317102. PMID: 29275328
The Range of Neurological Complications in Chikungunya Fever.
Cerny T, Schwarz M, Schwarz U, Lemant J, Gérardin P, Keller E
Neurocrit Care 2017 Dec;27(3):447-457. doi: 10.1007/s12028-017-0413-8. PMID: 28741102

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