U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Trisomy 5

MedGen UID:
274309
•Concept ID:
C1519654
•
Cell or Molecular Dysfunction

Definition

A chromosomal abnormality consisting of the presence of a third copy of chromosome 5 in somatic cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrisomy 5

Professional guidelines

PubMed

Chances and Challenges of New Genetic Screening Technologies (NIPT) in Prenatal Medicine from a Clinical Perspective: A Narrative Review.
Bedei I, Wolter A, Weber A, Signore F, Axt-Fliedner R
Genes (Basel) 2021 Mar 29;12(4) doi: 10.3390/genes12040501. PMID: 33805390Free PMC Article
Multiorgan involvement and management in children with Down syndrome.
Lagan N, Huggard D, Mc Grane F, Leahy TR, Franklin O, Roche E, Webb D, O' Marcaigh A, Cox D, El-Khuffash A, Greally P, Balfe J, Molloy EJ
Acta Paediatr 2020 Jun;109(6):1096-1111. Epub 2020 Jan 24 doi: 10.1111/apa.15153. PMID: 31899550
Practice Bulletin No. 162: Prenatal Diagnostic Testing for Genetic Disorders.
Obstet Gynecol 2016 May;127(5):e108-e122. doi: 10.1097/AOG.0000000000001405. PMID: 26938573

Recent clinical studies

Etiology

Chromosome-wide aneuploidy study of cultured circulating myeloid progenitor cells from workers occupationally exposed to formaldehyde.
Lan Q, Smith MT, Tang X, Guo W, Vermeulen R, Ji Z, Hu W, Hubbard AE, Shen M, McHale CM, Qiu C, Liu S, Reiss B, Beane-Freeman L, Blair A, Ge Y, Xiong J, Li L, Rappaport SM, Huang H, Rothman N, Zhang L
Carcinogenesis 2015 Jan;36(1):160-7. Epub 2014 Nov 12 doi: 10.1093/carcin/bgu229. PMID: 25391402Free PMC Article
Chromosomal abnormalities associated with neural tube defects (I): full aneuploidy.
Chen CP
Taiwan J Obstet Gynecol 2007 Dec;46(4):325-35. doi: 10.1016/S1028-4559(08)60002-9. PMID: 18182338
Chromosomal analyses of 52 cases of follicular lymphoma with t(14;18), including blastic/blastoid variant.
Mohamed AN, Palutke M, Eisenberg L, Al-Katib A
Cancer Genet Cytogenet 2001 Apr 1;126(1):45-51. doi: 10.1016/s0165-4608(00)00383-6. PMID: 11343778
Double trisomy in spontaneous abortions.
Reddy KS
Hum Genet 1997 Dec;101(3):339-45. doi: 10.1007/s004390050638. PMID: 9439664
Trisomy 5 and t(5;14)(q11;q32) as the sole abnormalities in two different clones from a centroblastic non-Hodgkin's lymphoma.
Kristoffersson U, Heim S, Mandahl N, Olsson H, Akerman M, Mitelman F
Cancer Genet Cytogenet 1988 Dec;36(2):173-6. doi: 10.1016/0165-4608(88)90141-0. PMID: 3203305

Diagnosis

Mosaic trisomy 5 in amniotic fluid in a live fetus with Ebstein anomaly and complete trisomy 5 in chorionic villus sampling.
Andrade A, Cunha A, Teles N, Guedes-Martins L
BMJ Case Rep 2023 Dec 30;16(12) doi: 10.1136/bcr-2023-256474. PMID: 38160022Free PMC Article
Prenatal Diagnosis of Fetal Trisomy 5 Mosaicism with Congenital Pulmonary Airway Malformation Type 3: A Case Report.
Bonasoni MP, Comitini G, Tonni G, Asioli S, Barbieri V, Rinaldini M, Marinelli M
Fetal Pediatr Pathol 2022 Jun;41(3):516-522. Epub 2020 Oct 14 doi: 10.1080/15513815.2020.1831660. PMID: 33411590
Prenatal diagnosis of maternal uniparental disomy 5 by amniocentesis associated with confined placental mosaicism for trisomy 5 and fetal trisomy 21 in a pregnancy.
Chen CP, Chern SR, Wang LK, Wu PS, Wu FT, Chen YY, Town DD, Pan CW, Wang W
Taiwan J Obstet Gynecol 2020 Nov;59(6):938-940. doi: 10.1016/j.tjog.2020.09.023. PMID: 33218416
Chromosomal abnormalities associated with neural tube defects (I): full aneuploidy.
Chen CP
Taiwan J Obstet Gynecol 2007 Dec;46(4):325-35. doi: 10.1016/S1028-4559(08)60002-9. PMID: 18182338
The trisomy (5)(q31-qter) syndrome: study of a family with a t(5:14) translocation.
Elias-Jones AC, Habibi P, Larcher VF, Spencer T, Butler LJ
Arch Dis Child 1988 Apr;63(4):427-31. doi: 10.1136/adc.63.4.427. PMID: 3284482Free PMC Article

Therapy

Chromosome-wide aneuploidy study of cultured circulating myeloid progenitor cells from workers occupationally exposed to formaldehyde.
Lan Q, Smith MT, Tang X, Guo W, Vermeulen R, Ji Z, Hu W, Hubbard AE, Shen M, McHale CM, Qiu C, Liu S, Reiss B, Beane-Freeman L, Blair A, Ge Y, Xiong J, Li L, Rappaport SM, Huang H, Rothman N, Zhang L
Carcinogenesis 2015 Jan;36(1):160-7. Epub 2014 Nov 12 doi: 10.1093/carcin/bgu229. PMID: 25391402Free PMC Article
Chromosome-wide aneuploidy study (CWAS) in workers exposed to an established leukemogen, benzene.
Zhang L, Lan Q, Guo W, Hubbard AE, Li G, Rappaport SM, McHale CM, Shen M, Ji Z, Vermeulen R, Yin S, Rothman N, Smith MT
Carcinogenesis 2011 Apr;32(4):605-12. Epub 2011 Jan 7 doi: 10.1093/carcin/bgq286. PMID: 21216845Free PMC Article
Detection of chromosome-specific aneusomy and translocation by benzene metabolites in human lymphocytes using fluorescence in situ hybridization with DNA probes for chromosomes 5, 7, 8, and 21.
Chung HW, Kim SY
J Toxicol Environ Health A 2002 Mar;65(5-6):365-72. doi: 10.1080/15287390252808037. PMID: 11936217

Prognosis

Prenatal Diagnosis of Fetal Trisomy 5 Mosaicism with Congenital Pulmonary Airway Malformation Type 3: A Case Report.
Bonasoni MP, Comitini G, Tonni G, Asioli S, Barbieri V, Rinaldini M, Marinelli M
Fetal Pediatr Pathol 2022 Jun;41(3):516-522. Epub 2020 Oct 14 doi: 10.1080/15513815.2020.1831660. PMID: 33411590
A pediatric BAL case with double Ph chromosomes and trisomy 5.
Gunden G, Isik S, Ozdemir C, Cİlİngİr O, Bor O, Gokalp EE, Kocagil S, Artan S, Aras BD
Cancer Genet 2021 Nov;258-259:7-9. Epub 2021 Jun 22 doi: 10.1016/j.cancergen.2021.06.005. PMID: 34225100
Full trisomy 5 in a sample of spontaneous abortion and Arias Stella reaction.
Čulić V, Lozic B, Kuzmić-Prusac I, Mijaljica G, Pavelić J
Med Sci Monit 2011 Oct;17(10):CS116-9. doi: 10.12659/msm.881969. PMID: 21959617Free PMC Article
Chromosomal analyses of 52 cases of follicular lymphoma with t(14;18), including blastic/blastoid variant.
Mohamed AN, Palutke M, Eisenberg L, Al-Katib A
Cancer Genet Cytogenet 2001 Apr 1;126(1):45-51. doi: 10.1016/s0165-4608(00)00383-6. PMID: 11343778
Trisomy 5 in two cases of acute monocytic leukemia with hyperdiploid clones.
Ma SK, Wan TS, Au WY, Chan LC
Leuk Res 1998 Oct;22(10):961-4. doi: 10.1016/s0145-2126(98)00095-2. PMID: 9766757

Clinical prediction guides

A pediatric BAL case with double Ph chromosomes and trisomy 5.
Gunden G, Isik S, Ozdemir C, Cİlİngİr O, Bor O, Gokalp EE, Kocagil S, Artan S, Aras BD
Cancer Genet 2021 Nov;258-259:7-9. Epub 2021 Jun 22 doi: 10.1016/j.cancergen.2021.06.005. PMID: 34225100
Chromosome-wide aneuploidy study (CWAS) in workers exposed to an established leukemogen, benzene.
Zhang L, Lan Q, Guo W, Hubbard AE, Li G, Rappaport SM, McHale CM, Shen M, Ji Z, Vermeulen R, Yin S, Rothman N, Smith MT
Carcinogenesis 2011 Apr;32(4):605-12. Epub 2011 Jan 7 doi: 10.1093/carcin/bgq286. PMID: 21216845Free PMC Article
Hyperdiploidy defines a distinct cytogenetic entity of meningiomas.
Ketter R, Kim YJ, Storck S, Rahnenführer J, Romeike BF, Steudel WI, Zang KD, Henn W
J Neurooncol 2007 Jun;83(2):213-21. Epub 2007 Jan 17 doi: 10.1007/s11060-006-9318-7. PMID: 17225936
Chromosomal analyses of 52 cases of follicular lymphoma with t(14;18), including blastic/blastoid variant.
Mohamed AN, Palutke M, Eisenberg L, Al-Katib A
Cancer Genet Cytogenet 2001 Apr 1;126(1):45-51. doi: 10.1016/s0165-4608(00)00383-6. PMID: 11343778
Chromosomal abnormalities in non-neoplastic renal tissue.
van den Berg E, Dijkhuizen T, Störkel S, Molenaar WM, de Jong B
Cancer Genet Cytogenet 1995 Dec;85(2):152-4. doi: 10.1016/0165-4608(95)00035-6. PMID: 8548740

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...