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Tumor Suppression

MedGen UID:
274321
•Concept ID:
C1519692
•
Molecular Function
Synonym: Tumor Suppression, Molecular

Definition

Tumor suppression involves inhibition of tumor cell growth, proliferation, malignancy, or metastasis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTumor Suppression

Professional guidelines

PubMed

AMPK signaling and its targeting in cancer progression and treatment.
Hsu CC, Peng D, Cai Z, Lin HK
Semin Cancer Biol 2022 Oct;85:52-68. Epub 2021 Apr 18 doi: 10.1016/j.semcancer.2021.04.006. PMID: 33862221Free PMC Article
The diagnosis and management of NK/T-cell lymphomas.
Tse E, Kwong YL
J Hematol Oncol 2017 Apr 14;10(1):85. doi: 10.1186/s13045-017-0452-9. PMID: 28410601Free PMC Article
Richter syndrome: pathogenesis and management.
Rossi D, Gaidano G
Semin Oncol 2016 Apr;43(2):311-9. Epub 2016 Feb 15 doi: 10.1053/j.seminoncol.2016.02.012. PMID: 27040710

Recent clinical studies

Etiology

An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression.
Indeglia A, Leung JC, Miller SA, Leu JI, Dougherty JF, Clarke NL, Kirven NA, Shao C, Ke L, Lovell S, Barnoud T, Lu DY, Lin C, Kannan T, Battaile KP, Yang THL, Batista Oliva I, Claiborne DT, Vogel P, Liu L, Liu Q, Nefedova Y, Cassel J, Auslander N, Kossenkov AV, Karanicolas J, Murphy ME
Cancer Discov 2023 Jul 7;13(7):1696-1719. doi: 10.1158/2159-8290.CD-22-1315. PMID: 37140445Free PMC Article
iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4.
Chen D, Chu B, Yang X, Liu Z, Jin Y, Kon N, Rabadan R, Jiang X, Stockwell BR, Gu W
Nat Commun 2021 Jun 15;12(1):3644. doi: 10.1038/s41467-021-23902-6. PMID: 34131139Free PMC Article
Sex disparities matter in cancer development and therapy.
Haupt S, Caramia F, Klein SL, Rubin JB, Haupt Y
Nat Rev Cancer 2021 Jun;21(6):393-407. Epub 2021 Apr 20 doi: 10.1038/s41568-021-00348-y. PMID: 33879867Free PMC Article
DNA methylation and cancer.
Kulis M, Esteller M
Adv Genet 2010;70:27-56. doi: 10.1016/B978-0-12-380866-0.60002-2. PMID: 20920744
The senescence-associated secretory phenotype: the dark side of tumor suppression.
Coppé JP, Desprez PY, Krtolica A, Campisi J
Annu Rev Pathol 2010;5:99-118. doi: 10.1146/annurev-pathol-121808-102144. PMID: 20078217Free PMC Article

Diagnosis

Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression.
Jana S, Brahma S, Arora S, Wladyka CL, Hoang P, Blinka S, Hough R, Horn JL, Liu Y, Wang LJ, Depeille P, Smith E, Montgomery RB, Lee JK, Haffner MC, Vakar-Lopez F, Grivas P, Wright JL, Lam HM, Black PC, Roose JP, Ryazanov AG, Subramaniam AR, Henikoff S, Hsieh AC
Cancer Cell 2023 May 8;41(5):853-870.e13. Epub 2023 Apr 20 doi: 10.1016/j.ccell.2023.03.021. PMID: 37084735Free PMC Article
Review on natural killer/T-cell lymphoma.
He X, Gao Y, Li Z, Huang H
Hematol Oncol 2023 Apr;41(2):221-229. Epub 2021 Dec 9 doi: 10.1002/hon.2944. PMID: 34731509
Tumor suppressor DRD2 facilitates M1 macrophages and restricts NF-κB signaling to trigger pyroptosis in breast cancer.
Tan Y, Sun R, Liu L, Yang D, Xiang Q, Li L, Tang J, Qiu Z, Peng W, Wang Y, Ye L, Ren G, Xiang T
Theranostics 2021;11(11):5214-5231. Epub 2021 Mar 5 doi: 10.7150/thno.58322. PMID: 33859743Free PMC Article
Exosomes: key players in cancer and potential therapeutic strategy.
Dai J, Su Y, Zhong S, Cong L, Liu B, Yang J, Tao Y, He Z, Chen C, Jiang Y
Signal Transduct Target Ther 2020 Aug 5;5(1):145. doi: 10.1038/s41392-020-00261-0. PMID: 32759948Free PMC Article
Genetic Basis of Acute Lymphoblastic Leukemia.
Iacobucci I, Mullighan CG
J Clin Oncol 2017 Mar 20;35(9):975-983. Epub 2017 Feb 13 doi: 10.1200/JCO.2016.70.7836. PMID: 28297628Free PMC Article

Therapy

Targeting ARID1A mutations in cancer.
Mullen J, Kato S, Sicklick JK, Kurzrock R
Cancer Treat Rev 2021 Nov;100:102287. Epub 2021 Sep 6 doi: 10.1016/j.ctrv.2021.102287. PMID: 34619527
Epigenetic modulation and understanding of HDAC inhibitors in cancer therapy.
Ramaiah MJ, Tangutur AD, Manyam RR
Life Sci 2021 Jul 15;277:119504. Epub 2021 Apr 16 doi: 10.1016/j.lfs.2021.119504. PMID: 33872660
Cancer vaccines: Targeting KRAS-driven cancers.
Zhang Y, Ma JA, Zhang HX, Jiang YN, Luo WH
Expert Rev Vaccines 2020 Feb;19(2):163-173. Epub 2020 Mar 14 doi: 10.1080/14760584.2020.1733420. PMID: 32174221
Tumor-Suppressor Functions of the TP53 Pathway.
Aubrey BJ, Strasser A, Kelly GL
Cold Spring Harb Perspect Med 2016 May 2;6(5) doi: 10.1101/cshperspect.a026062. PMID: 27141080Free PMC Article
DNA methylation and cancer.
Kulis M, Esteller M
Adv Genet 2010;70:27-56. doi: 10.1016/B978-0-12-380866-0.60002-2. PMID: 20920744

Prognosis

TP53 in Acute Myeloid Leukemia: Molecular Aspects and Patterns of Mutation.
George B, Kantarjian H, Baran N, Krocker JD, Rios A
Int J Mol Sci 2021 Oct 5;22(19) doi: 10.3390/ijms221910782. PMID: 34639121Free PMC Article
Sex disparities matter in cancer development and therapy.
Haupt S, Caramia F, Klein SL, Rubin JB, Haupt Y
Nat Rev Cancer 2021 Jun;21(6):393-407. Epub 2021 Apr 20 doi: 10.1038/s41568-021-00348-y. PMID: 33879867Free PMC Article
Tumor suppressor DRD2 facilitates M1 macrophages and restricts NF-κB signaling to trigger pyroptosis in breast cancer.
Tan Y, Sun R, Liu L, Yang D, Xiang Q, Li L, Tang J, Qiu Z, Peng W, Wang Y, Ye L, Ren G, Xiang T
Theranostics 2021;11(11):5214-5231. Epub 2021 Mar 5 doi: 10.7150/thno.58322. PMID: 33859743Free PMC Article
Exosomes: key players in cancer and potential therapeutic strategy.
Dai J, Su Y, Zhong S, Cong L, Liu B, Yang J, Tao Y, He Z, Chen C, Jiang Y
Signal Transduct Target Ther 2020 Aug 5;5(1):145. doi: 10.1038/s41392-020-00261-0. PMID: 32759948Free PMC Article
Senescence in Health and Disease.
He S, Sharpless NE
Cell 2017 Jun 1;169(6):1000-1011. doi: 10.1016/j.cell.2017.05.015. PMID: 28575665Free PMC Article

Clinical prediction guides

An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression.
Indeglia A, Leung JC, Miller SA, Leu JI, Dougherty JF, Clarke NL, Kirven NA, Shao C, Ke L, Lovell S, Barnoud T, Lu DY, Lin C, Kannan T, Battaile KP, Yang THL, Batista Oliva I, Claiborne DT, Vogel P, Liu L, Liu Q, Nefedova Y, Cassel J, Auslander N, Kossenkov AV, Karanicolas J, Murphy ME
Cancer Discov 2023 Jul 7;13(7):1696-1719. doi: 10.1158/2159-8290.CD-22-1315. PMID: 37140445Free PMC Article
AKR1C3 suppresses ferroptosis in hepatocellular carcinoma through regulation of YAP/SLC7A11 signaling pathway.
Chen J, Zhang J, Tian W, Ge C, Su Y, Li J, Tian H
Mol Carcinog 2023 Jun;62(6):833-844. Epub 2023 Mar 15 doi: 10.1002/mc.23527. PMID: 36920042
Roles and mechanisms of BAP1 deubiquitinase in tumor suppression.
Masclef L, Ahmed O, Estavoyer B, Larrivée B, Labrecque N, Nijnik A, Affar EB
Cell Death Differ 2021 Feb;28(2):606-625. Epub 2021 Jan 18 doi: 10.1038/s41418-020-00709-4. PMID: 33462414Free PMC Article
Senescence in Health and Disease.
He S, Sharpless NE
Cell 2017 Jun 1;169(6):1000-1011. doi: 10.1016/j.cell.2017.05.015. PMID: 28575665Free PMC Article
Massively Parallel Functional Analysis of BRCA1 RING Domain Variants.
Starita LM, Young DL, Islam M, Kitzman JO, Gullingsrud J, Hause RJ, Fowler DM, Parvin JD, Shendure J, Fields S
Genetics 2015 Jun;200(2):413-22. Epub 2015 Mar 30 doi: 10.1534/genetics.115.175802. PMID: 25823446Free PMC Article

Recent systematic reviews

Heat shock proteins and cellular senescence in humans: A systematic review.
Hebishy M, Shintouo CM, Dufait I, Debacq-Chainiaux F, Bautmans I, Njemini R
Arch Gerontol Geriatr 2023 Oct;113:105057. Epub 2023 May 11 doi: 10.1016/j.archger.2023.105057. PMID: 37207540
Consumption and supplementation of vitamin E in breast cancer risk, treatment, and outcomes: A systematic review with meta-analysis.
de Oliveira VA, Oliveira IKF, Pereira IC, Mendes LKF, Carneiro da Silva FC, Torres-Leal FL, de Castro E Sousa JM, Paiva AA
Clin Nutr ESPEN 2023 Apr;54:215-226. Epub 2023 Jan 31 doi: 10.1016/j.clnesp.2023.01.032. PMID: 36963866
Targeting p53 pathways: mechanisms, structures, and advances in therapy.
Wang H, Guo M, Wei H, Chen Y
Signal Transduct Target Ther 2023 Mar 1;8(1):92. doi: 10.1038/s41392-023-01347-1. PMID: 36859359Free PMC Article
An Updated View of the Roles of p53 in Embryonic Stem Cells.
Ayaz G, Yan H, Malik N, Huang J
Stem Cells 2022 Oct 21;40(10):883-891. doi: 10.1093/stmcls/sxac051. PMID: 35904997Free PMC Article
Perspectives of long non-coding RNAs in cancer.
Rao AKDM, Rajkumar T, Mani S
Mol Biol Rep 2017 Apr;44(2):203-218. Epub 2017 Apr 8 doi: 10.1007/s11033-017-4103-6. PMID: 28391434

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