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Tumor Suppression

MedGen UID:
274321
•Concept ID:
C1519692
•
Molecular Function
Synonym: Tumor Suppression, Molecular

Definition

Tumor suppression involves inhibition of tumor cell growth, proliferation, malignancy, or metastasis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTumor Suppression

Professional guidelines

PubMed

A HER2 target antibody drug conjugate combined with anti-PD-(L)1 treatment eliminates hHER2+ tumors in hPD-1 transgenic mouse model and contributes immune memory formation.
Huang L, Wang R, Xie K, Zhang J, Tao F, Pi C, Feng Y, Gu H, Fang J
Breast Cancer Res Treat 2022 Jan;191(1):51-61. Epub 2021 Oct 16 doi: 10.1007/s10549-021-06384-4. PMID: 34657203
AMPK signaling and its targeting in cancer progression and treatment.
Hsu CC, Peng D, Cai Z, Lin HK
Semin Cancer Biol 2022 Oct;85:52-68. Epub 2021 Apr 18 doi: 10.1016/j.semcancer.2021.04.006. PMID: 33862221Free PMC Article
The diagnosis and management of NK/T-cell lymphomas.
Tse E, Kwong YL
J Hematol Oncol 2017 Apr 14;10(1):85. doi: 10.1186/s13045-017-0452-9. PMID: 28410601Free PMC Article

Recent clinical studies

Etiology

iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4.
Chen D, Chu B, Yang X, Liu Z, Jin Y, Kon N, Rabadan R, Jiang X, Stockwell BR, Gu W
Nat Commun 2021 Jun 15;12(1):3644. doi: 10.1038/s41467-021-23902-6. PMID: 34131139Free PMC Article
The Yin and Yang of YY1 in tumor growth and suppression.
Khachigian LM
Int J Cancer 2018 Aug 1;143(3):460-465. Epub 2018 Jan 31 doi: 10.1002/ijc.31255. PMID: 29322514
Fanconi Anemia Signaling and Cancer.
Nepal M, Che R, Zhang J, Ma C, Fei P
Trends Cancer 2017 Dec;3(12):840-856. Epub 2017 Nov 10 doi: 10.1016/j.trecan.2017.10.005. PMID: 29198440Free PMC Article
DNA methylation and cancer.
Kulis M, Esteller M
Adv Genet 2010;70:27-56. doi: 10.1016/B978-0-12-380866-0.60002-2. PMID: 20920744
The senescence-associated secretory phenotype: the dark side of tumor suppression.
Coppé JP, Desprez PY, Krtolica A, Campisi J
Annu Rev Pathol 2010;5:99-118. doi: 10.1146/annurev-pathol-121808-102144. PMID: 20078217Free PMC Article

Diagnosis

Review on natural killer/T-cell lymphoma.
He X, Gao Y, Li Z, Huang H
Hematol Oncol 2023 Apr;41(2):221-229. Epub 2021 Dec 9 doi: 10.1002/hon.2944. PMID: 34731509
Activation of MAT2A-ACSL3 pathway protects cells from ferroptosis in gastric cancer.
Ma M, Kong P, Huang Y, Wang J, Liu X, Hu Y, Chen X, Du C, Yang H
Free Radic Biol Med 2022 Mar;181:288-299. Epub 2022 Feb 16 doi: 10.1016/j.freeradbiomed.2022.02.015. PMID: 35182729
Tumor suppressor DRD2 facilitates M1 macrophages and restricts NF-κB signaling to trigger pyroptosis in breast cancer.
Tan Y, Sun R, Liu L, Yang D, Xiang Q, Li L, Tang J, Qiu Z, Peng W, Wang Y, Ye L, Ren G, Xiang T
Theranostics 2021;11(11):5214-5231. Epub 2021 Mar 5 doi: 10.7150/thno.58322. PMID: 33859743Free PMC Article
Exosomes: key players in cancer and potential therapeutic strategy.
Dai J, Su Y, Zhong S, Cong L, Liu B, Yang J, Tao Y, He Z, Chen C, Jiang Y
Signal Transduct Target Ther 2020 Aug 5;5(1):145. doi: 10.1038/s41392-020-00261-0. PMID: 32759948Free PMC Article
Genetic Basis of Acute Lymphoblastic Leukemia.
Iacobucci I, Mullighan CG
J Clin Oncol 2017 Mar 20;35(9):975-983. Epub 2017 Feb 13 doi: 10.1200/JCO.2016.70.7836. PMID: 28297628Free PMC Article

Therapy

Targeting ARID1A mutations in cancer.
Mullen J, Kato S, Sicklick JK, Kurzrock R
Cancer Treat Rev 2021 Nov;100:102287. Epub 2021 Sep 6 doi: 10.1016/j.ctrv.2021.102287. PMID: 34619527
Ferroptosis and its potential as a therapeutic target.
Yuan H, Pratte J, Giardina C
Biochem Pharmacol 2021 Apr;186:114486. Epub 2021 Feb 23 doi: 10.1016/j.bcp.2021.114486. PMID: 33631189
Cancer vaccines: Targeting KRAS-driven cancers.
Zhang Y, Ma JA, Zhang HX, Jiang YN, Luo WH
Expert Rev Vaccines 2020 Feb;19(2):163-173. Epub 2020 Mar 14 doi: 10.1080/14760584.2020.1733420. PMID: 32174221
Tumor-Suppressor Functions of the TP53 Pathway.
Aubrey BJ, Strasser A, Kelly GL
Cold Spring Harb Perspect Med 2016 May 2;6(5) doi: 10.1101/cshperspect.a026062. PMID: 27141080Free PMC Article
DNA methylation and cancer.
Kulis M, Esteller M
Adv Genet 2010;70:27-56. doi: 10.1016/B978-0-12-380866-0.60002-2. PMID: 20920744

Prognosis

Tumor suppressor DRD2 facilitates M1 macrophages and restricts NF-κB signaling to trigger pyroptosis in breast cancer.
Tan Y, Sun R, Liu L, Yang D, Xiang Q, Li L, Tang J, Qiu Z, Peng W, Wang Y, Ye L, Ren G, Xiang T
Theranostics 2021;11(11):5214-5231. Epub 2021 Mar 5 doi: 10.7150/thno.58322. PMID: 33859743Free PMC Article
Exosomes: key players in cancer and potential therapeutic strategy.
Dai J, Su Y, Zhong S, Cong L, Liu B, Yang J, Tao Y, He Z, Chen C, Jiang Y
Signal Transduct Target Ther 2020 Aug 5;5(1):145. doi: 10.1038/s41392-020-00261-0. PMID: 32759948Free PMC Article
Fibronectin in Cancer: Friend or Foe.
Lin TC, Yang CH, Cheng LH, Chang WT, Lin YR, Cheng HC
Cells 2019 Dec 20;9(1) doi: 10.3390/cells9010027. PMID: 31861892Free PMC Article
Fanconi Anemia Signaling and Cancer.
Nepal M, Che R, Zhang J, Ma C, Fei P
Trends Cancer 2017 Dec;3(12):840-856. Epub 2017 Nov 10 doi: 10.1016/j.trecan.2017.10.005. PMID: 29198440Free PMC Article
Senescence in Health and Disease.
He S, Sharpless NE
Cell 2017 Jun 1;169(6):1000-1011. doi: 10.1016/j.cell.2017.05.015. PMID: 28575665Free PMC Article

Clinical prediction guides

Ionizing Radiation Triggers the Antitumor Immunity by Inducing Gasdermin E-Mediated Pyroptosis in Tumor Cells.
Cao W, Chen G, Wu L, Yu KN, Sun M, Yang M, Jiang Y, Jiang Y, Xu Y, Peng S, Han W
Int J Radiat Oncol Biol Phys 2023 Feb 1;115(2):440-452. Epub 2022 Jul 30 doi: 10.1016/j.ijrobp.2022.07.1841. PMID: 35918054
TP53 in Acute Myeloid Leukemia: Molecular Aspects and Patterns of Mutation.
George B, Kantarjian H, Baran N, Krocker JD, Rios A
Int J Mol Sci 2021 Oct 5;22(19) doi: 10.3390/ijms221910782. PMID: 34639121Free PMC Article
Roles and mechanisms of BAP1 deubiquitinase in tumor suppression.
Masclef L, Ahmed O, Estavoyer B, Larrivée B, Labrecque N, Nijnik A, Affar EB
Cell Death Differ 2021 Feb;28(2):606-625. Epub 2021 Jan 18 doi: 10.1038/s41418-020-00709-4. PMID: 33462414Free PMC Article
Senescence in Health and Disease.
He S, Sharpless NE
Cell 2017 Jun 1;169(6):1000-1011. doi: 10.1016/j.cell.2017.05.015. PMID: 28575665Free PMC Article
Apoptosis: its origin, history, maintenance and the medical implications for cancer and aging.
Kaczanowski S
Phys Biol 2016 May 11;13(3):031001. doi: 10.1088/1478-3975/13/3/031001. PMID: 27172135

Recent systematic reviews

Heat shock proteins and cellular senescence in humans: A systematic review.
Hebishy M, Shintouo CM, Dufait I, Debacq-Chainiaux F, Bautmans I, Njemini R
Arch Gerontol Geriatr 2023 Oct;113:105057. Epub 2023 May 11 doi: 10.1016/j.archger.2023.105057. PMID: 37207540
Targeting p53 pathways: mechanisms, structures, and advances in therapy.
Wang H, Guo M, Wei H, Chen Y
Signal Transduct Target Ther 2023 Mar 1;8(1):92. doi: 10.1038/s41392-023-01347-1. PMID: 36859359Free PMC Article
An Updated View of the Roles of p53 in Embryonic Stem Cells.
Ayaz G, Yan H, Malik N, Huang J
Stem Cells 2022 Oct 21;40(10):883-891. doi: 10.1093/stmcls/sxac051. PMID: 35904997Free PMC Article
The diagnostic role of microRNA-34a in breast cancer: a systematic review and meta-analysis.
Imani S, Zhang X, Hosseinifard H, Fu S, Fu J
Oncotarget 2017 Apr 4;8(14):23177-23187. doi: 10.18632/oncotarget.15520. PMID: 28423566Free PMC Article
Perspectives of long non-coding RNAs in cancer.
Rao AKDM, Rajkumar T, Mani S
Mol Biol Rep 2017 Apr;44(2):203-218. Epub 2017 Apr 8 doi: 10.1007/s11033-017-4103-6. PMID: 28391434

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