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Mucinous ovarian cancer

MedGen UID:
274767
Concept ID:
C1518233
Neoplastic Process
Synonyms: Malignant Ovarian Mucinous Neoplasm; malignant ovarian mucinous neoplasm; Malignant Ovarian Mucinous Tumor; malignant ovarian mucinous tumor; malignant ovarian mucinous tumour; mucinous ovarian cancer; ovarian mucinous neoplasm, malignant
 
Monarch Initiative: MONDO:0024282

Definition

An invasive malignant neoplasm that arises from the ovary and is characterized by the presence of malignant epithelial cells that contain intracytoplasmic mucin and may resemble the epithelial cells of the endocervix or gastrointestinal tract. It includes mucinous adenocarcinoma and mucinous adenocarcinofibroma. [from NCI]

Professional guidelines

PubMed

Ngoi NY, Syn NL, Goh RM, Goh BC, Huang RY, Soon YY, James E, Cook A, Clamp A, Tan DS
Cochrane Database Syst Rev 2022 Feb 21;2(2):CD012007. doi: 10.1002/14651858.CD012007.pub2. PMID: 35188221Free PMC Article
McLeavy L, Rahman B, Kristeleit R, Ledermann J, Lockley M, McCormack M, Mould T, Side L, Lanceley A
Int J Gynecol Cancer 2020 Feb;30(2):221-226. Epub 2019 Nov 19 doi: 10.1136/ijgc-2019-000630. PMID: 31744886
Rahman B, Lanceley A, Kristeleit RS, Ledermann JA, Lockley M, McCormack M, Mould T, Side L
J Med Genet 2019 Mar;56(3):195-198. Epub 2018 Mar 13 doi: 10.1136/jmedgenet-2017-105140. PMID: 29535157

Curated

UK NICE Clinical guideline (CG122), Ovarian cancer: recognition and initial management, 2023

Recent clinical studies

Etiology

Ma G, Zeng S, Zhao Y, Chi J, Wang L, Li Q, Wang J, Yao S, Zhou Q, Chen Y, Jiao X, Liu X, Yu Y, Huo Y, Li M, Peng Z, Ma D, Hu T, Gao Q
J Ovarian Res 2023 Jun 27;16(1):120. doi: 10.1186/s13048-023-01213-2. PMID: 37370173Free PMC Article
Zhang H, Qiu J, Meng F, Shu X
Eur J Clin Invest 2023 Jun;53(6):e13971. Epub 2023 Mar 2 doi: 10.1111/eci.13971. PMID: 36807123
Qi X, Xu L, Wang J, Yu J, Wang Y
J Gynecol Obstet Hum Reprod 2022 Sep;51(7):102424. Epub 2022 Jun 11 doi: 10.1016/j.jogoh.2022.102424. PMID: 35697250
Marmolejo DH, Wong MYZ, Bajalica-Lagercrantz S, Tischkowitz M, Balmaña J; extended ERN-GENTURIS Thematic Group 3
Eur J Med Genet 2021 Dec;64(12):104350. Epub 2021 Oct 1 doi: 10.1016/j.ejmg.2021.104350. PMID: 34606975
Konstantinopoulos PA, Norquist B, Lacchetti C, Armstrong D, Grisham RN, Goodfellow PJ, Kohn EC, Levine DA, Liu JF, Lu KH, Sparacio D, Annunziata CM
J Clin Oncol 2020 Apr 10;38(11):1222-1245. Epub 2020 Jan 27 doi: 10.1200/JCO.19.02960. PMID: 31986064Free PMC Article

Diagnosis

Mitric C, Salman L, Abrahamyan L, Kim SR, Pechlivanoglou P, Chan KKW, Gien LT, Ferguson SE
Gynecol Oncol 2023 Mar;170:133-142. Epub 2023 Jan 20 doi: 10.1016/j.ygyno.2022.12.008. PMID: 36682091
Konstantinopoulos PA, Norquist B, Lacchetti C, Armstrong D, Grisham RN, Goodfellow PJ, Kohn EC, Levine DA, Liu JF, Lu KH, Sparacio D, Annunziata CM
J Clin Oncol 2020 Apr 10;38(11):1222-1245. Epub 2020 Jan 27 doi: 10.1200/JCO.19.02960. PMID: 31986064Free PMC Article
Crane EK, Brown J
Gynecol Oncol 2018 Jun;149(3):598-604. Epub 2018 Feb 9 doi: 10.1016/j.ygyno.2018.01.035. PMID: 29429591
Perren TJ
Ann Oncol 2016 Apr;27 Suppl 1:i53-i57. doi: 10.1093/annonc/mdw087. PMID: 27141073
Xu W, Rush J, Rickett K, Coward JI
Crit Rev Oncol Hematol 2016 Jun;102:26-36. Epub 2016 Mar 19 doi: 10.1016/j.critrevonc.2016.03.015. PMID: 27083591

Therapy

Nugawela D, Gorringe KL
Int J Gynecol Cancer 2023 Jan 3;33(1):102-108. doi: 10.1136/ijgc-2022-003658. PMID: 36603894Free PMC Article
Konstantinopoulos PA, Norquist B, Lacchetti C, Armstrong D, Grisham RN, Goodfellow PJ, Kohn EC, Levine DA, Liu JF, Lu KH, Sparacio D, Annunziata CM
J Clin Oncol 2020 Apr 10;38(11):1222-1245. Epub 2020 Jan 27 doi: 10.1200/JCO.19.02960. PMID: 31986064Free PMC Article
Crane EK, Brown J
Gynecol Oncol 2018 Jun;149(3):598-604. Epub 2018 Feb 9 doi: 10.1016/j.ygyno.2018.01.035. PMID: 29429591
Perren TJ
Ann Oncol 2016 Apr;27 Suppl 1:i53-i57. doi: 10.1093/annonc/mdw087. PMID: 27141073
Harrison ML, Jameson C, Gore ME
Int J Gynecol Cancer 2008 Mar-Apr;18(2):209-14. Epub 2007 Jul 11 doi: 10.1111/j.1525-1438.2007.01022.x. PMID: 17624989

Prognosis

Ma G, Zeng S, Zhao Y, Chi J, Wang L, Li Q, Wang J, Yao S, Zhou Q, Chen Y, Jiao X, Liu X, Yu Y, Huo Y, Li M, Peng Z, Ma D, Hu T, Gao Q
J Ovarian Res 2023 Jun 27;16(1):120. doi: 10.1186/s13048-023-01213-2. PMID: 37370173Free PMC Article
Qi X, Xu L, Wang J, Yu J, Wang Y
J Gynecol Obstet Hum Reprod 2022 Sep;51(7):102424. Epub 2022 Jun 11 doi: 10.1016/j.jogoh.2022.102424. PMID: 35697250
Hoogendam JP, Vlek CA, Witteveen PO, Verheijen R, Zweemer RP
BJOG 2017 Feb;124(3):370-378. Epub 2016 Jul 22 doi: 10.1111/1471-0528.14226. PMID: 27444115
Perren TJ
Ann Oncol 2016 Apr;27 Suppl 1:i53-i57. doi: 10.1093/annonc/mdw087. PMID: 27141073
Harrison ML, Jameson C, Gore ME
Int J Gynecol Cancer 2008 Mar-Apr;18(2):209-14. Epub 2007 Jul 11 doi: 10.1111/j.1525-1438.2007.01022.x. PMID: 17624989

Clinical prediction guides

Qi X, Xu L, Wang J, Yu J, Wang Y
J Gynecol Obstet Hum Reprod 2022 Sep;51(7):102424. Epub 2022 Jun 11 doi: 10.1016/j.jogoh.2022.102424. PMID: 35697250
Dareng EO, Tyrer JP, Barnes DR, Jones MR, Yang X, Aben KKH, Adank MA, Agata S, Andrulis IL, Anton-Culver H, Antonenkova NN, Aravantinos G, Arun BK, Augustinsson A, Balmaña J, Bandera EV, Barkardottir RB, Barrowdale D, Beckmann MW, Beeghly-Fadiel A, Benitez J, Bermisheva M, Bernardini MQ, Bjorge L, Black A, Bogdanova NV, Bonanni B, Borg A, Brenton JD, Budzilowska A, Butzow R, Buys SS, Cai H, Caligo MA, Campbell I, Cannioto R, Cassingham H, Chang-Claude J, Chanock SJ, Chen K, Chiew YE, Chung WK, Claes KBM, Colonna S; GEMO Study Collaborators; GC-HBOC Study Collaborators; EMBRACE Collaborators, Cook LS, Couch FJ, Daly MB, Dao F, Davies E, de la Hoya M, de Putter R, Dennis J, DePersia A, Devilee P, Diez O, Ding YC, Doherty JA, Domchek SM, Dörk T, du Bois A, Dürst M, Eccles DM, Eliassen HA, Engel C, Evans GD, Fasching PA, Flanagan JM, Fortner RT, Machackova E, Friedman E, Ganz PA, Garber J, Gensini F, Giles GG, Glendon G, Godwin AK, Goodman MT, Greene MH, Gronwald J; OPAL Study Group; AOCS Group, Hahnen E, Haiman CA, Håkansson N, Hamann U, Hansen TVO, Harris HR, Hartman M, Heitz F, Hildebrandt MAT, Høgdall E, Høgdall CK, Hopper JL, Huang RY, Huff C, Hulick PJ, Huntsman DG, Imyanitov EN; KConFab Investigators; HEBON Investigators, Isaacs C, Jakubowska A, James PA, Janavicius R, Jensen A, Johannsson OT, John EM, Jones ME, Kang D, Karlan BY, Karnezis A, Kelemen LE, Khusnutdinova E, Kiemeney LA, Kim BG, Kjaer SK, Komenaka I, Kupryjanczyk J, Kurian AW, Kwong A, Lambrechts D, Larson MC, Lazaro C, Le ND, Leslie G, Lester J, Lesueur F, Levine DA, Li L, Li J, Loud JT, Lu KH, Lubiński J, Mai PL, Manoukian S, Marks JR, Matsuno RK, Matsuo K, May T, McGuffog L, McLaughlin JR, McNeish IA, Mebirouk N, Menon U, Miller A, Milne RL, Minlikeeva A, Modugno F, Montagna M, Moysich KB, Munro E, Nathanson KL, Neuhausen SL, Nevanlinna H, Yie JNY, Nielsen HR, Nielsen FC, Nikitina-Zake L, Odunsi K, Offit K, Olah E, Olbrecht S, Olopade OI, Olson SH, Olsson H, Osorio A, Papi L, Park SK, Parsons MT, Pathak H, Pedersen IS, Peixoto A, Pejovic T, Perez-Segura P, Permuth JB, Peshkin B, Peterlongo P, Piskorz A, Prokofyeva D, Radice P, Rantala J, Riggan MJ, Risch HA, Rodriguez-Antona C, Ross E, Rossing MA, Runnebaum I, Sandler DP, Santamariña M, Soucy P, Schmutzler RK, Setiawan VW, Shan K, Sieh W, Simard J, Singer CF, Sokolenko AP, Song H, Southey MC, Steed H, Stoppa-Lyonnet D, Sutphen R, Swerdlow AJ, Tan YY, Teixeira MR, Teo SH, Terry KL, Terry MB; OCAC Consortium; CIMBA Consortium, Thomassen M, Thompson PJ, Thomsen LCV, Thull DL, Tischkowitz M, Titus L, Toland AE, Torres D, Trabert B, Travis R, Tung N, Tworoger SS, Valen E, van Altena AM, van der Hout AH, Van Nieuwenhuysen E, van Rensburg EJ, Vega A, Edwards DV, Vierkant RA, Wang F, Wappenschmidt B, Webb PM, Weinberg CR, Weitzel JN, Wentzensen N, White E, Whittemore AS, Winham SJ, Wolk A, Woo YL, Wu AH, Yan L, Yannoukakos D, Zavaglia KM, Zheng W, Ziogas A, Zorn KK, Kleibl Z, Easton D, Lawrenson K, DeFazio A, Sellers TA, Ramus SJ, Pearce CL, Monteiro AN, Cunningham J, Goode EL, Schildkraut JM, Berchuck A, Chenevix-Trench G, Gayther SA, Antoniou AC, Pharoah PDP
Eur J Hum Genet 2022 Mar;30(3):349-362. Epub 2022 Jan 14 doi: 10.1038/s41431-021-00987-7. PMID: 35027648Free PMC Article
Marmolejo DH, Wong MYZ, Bajalica-Lagercrantz S, Tischkowitz M, Balmaña J; extended ERN-GENTURIS Thematic Group 3
Eur J Med Genet 2021 Dec;64(12):104350. Epub 2021 Oct 1 doi: 10.1016/j.ejmg.2021.104350. PMID: 34606975
Konstantinopoulos PA, Norquist B, Lacchetti C, Armstrong D, Grisham RN, Goodfellow PJ, Kohn EC, Levine DA, Liu JF, Lu KH, Sparacio D, Annunziata CM
J Clin Oncol 2020 Apr 10;38(11):1222-1245. Epub 2020 Jan 27 doi: 10.1200/JCO.19.02960. PMID: 31986064Free PMC Article
Harrison ML, Jameson C, Gore ME
Int J Gynecol Cancer 2008 Mar-Apr;18(2):209-14. Epub 2007 Jul 11 doi: 10.1111/j.1525-1438.2007.01022.x. PMID: 17624989

Recent systematic reviews

Mitric C, Salman L, Abrahamyan L, Kim SR, Pechlivanoglou P, Chan KKW, Gien LT, Ferguson SE
Gynecol Oncol 2023 Mar;170:133-142. Epub 2023 Jan 20 doi: 10.1016/j.ygyno.2022.12.008. PMID: 36682091
Konstantinopoulos PA, Norquist B, Lacchetti C, Armstrong D, Grisham RN, Goodfellow PJ, Kohn EC, Levine DA, Liu JF, Lu KH, Sparacio D, Annunziata CM
J Clin Oncol 2020 Apr 10;38(11):1222-1245. Epub 2020 Jan 27 doi: 10.1200/JCO.19.02960. PMID: 31986064Free PMC Article
Hoogendam JP, Vlek CA, Witteveen PO, Verheijen R, Zweemer RP
BJOG 2017 Feb;124(3):370-378. Epub 2016 Jul 22 doi: 10.1111/1471-0528.14226. PMID: 27444115
Shi LF, Wu Y, Li CY
Menopause 2016 Apr;23(4):417-24. doi: 10.1097/GME.0000000000000550. PMID: 26506499
Jordan SJ, Whiteman DC, Purdie DM, Green AC, Webb PM
Gynecol Oncol 2006 Dec;103(3):1122-9. Epub 2006 Sep 26 doi: 10.1016/j.ygyno.2006.08.012. PMID: 17005245

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    • PubMed
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    Curated

    • NICE, 2023
      UK NICE Clinical guideline (CG122), Ovarian cancer: recognition and initial management, 2023

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