ZBTB16-RARA Fusion Protein Expression

MedGen UID:: 275307
•Concept ID:: C1518796
•: Cell or Molecular Dysfunction

Synonyms:

PLZF-RARalpha Fusion Protein Expression; PLZF/RARA Fusion Protein Expression; ZBTB16/RARA Fusion Protein Expression

Definition

A fusion protein encoded by a t(15;17) translocation, which involves the human genes ZBTB16 and RARA and is characteristic of acute promyelocytic leukemia. It is a transcriptional repressor with both gain-of-function and dominant-negative properties, resulting in transcriptional repression of retinoic acid and non-retinoic acid target genes and culminating in differentiation arrest. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVZBTB16-RARA Fusion Protein Expression

Molecular Sequence Variation
- Molecular Genetic Variation
  - Gene Abnormality
    - Deregulation of Protein and Messenger RNA Expression
      - Protein Deregulation
        Fusion Protein Expression
        ZBTB16-RARA Fusion Protein Expression

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