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Pathogenesis of HIV Neurological Disease

MedGen UID:
275336
•Concept ID:
C1518909
•
Disease or Syndrome

Definition

The pathogenic mechanisms involved in HIV-associated neurological diseases and neurobehavioral dysfunction. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPathogenesis of HIV Neurological Disease

Professional guidelines

PubMed

HIV-1-associated neurocognitive disorder: epidemiology, pathogenesis, diagnosis, and treatment.
Eggers C, Arendt G, Hahn K, Husstedt IW, Maschke M, Neuen-Jacob E, Obermann M, Rosenkranz T, Schielke E, Straube E; German Association of Neuro-AIDS und Neuro-Infectiology (DGNANI)
J Neurol 2017 Aug;264(8):1715-1727. Epub 2017 May 31 doi: 10.1007/s00415-017-8503-2. PMID: 28567537Free PMC Article
Official American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America Clinical Practice Guidelines: Treatment of Drug-Susceptible Tuberculosis.
Nahid P, Dorman SE, Alipanah N, Barry PM, Brozek JL, Cattamanchi A, Chaisson LH, Chaisson RE, Daley CL, Grzemska M, Higashi JM, Ho CS, Hopewell PC, Keshavjee SA, Lienhardt C, Menzies R, Merrifield C, Narita M, O'Brien R, Peloquin CA, Raftery A, Saukkonen J, Schaaf HS, Sotgiu G, Starke JR, Migliori GB, Vernon A
Clin Infect Dis 2016 Oct 1;63(7):e147-e195. Epub 2016 Aug 10 doi: 10.1093/cid/ciw376. PMID: 27516382Free PMC Article
Clinical management of infectious cerebral vasculitides.
Carod Artal FJ
Expert Rev Neurother 2016;16(2):205-21. Epub 2016 Jan 19 doi: 10.1586/14737175.2015.1134321. PMID: 26689107

Recent clinical studies

Etiology

Primary neurological manifestations of HIV in children.
David JJ, Zaki SA, Shanbag P
J Infect Dev Ctries 2023 Jun 30;17(6):752-761. doi: 10.3855/jidc.17645. PMID: 37406063
Pathogenesis of age-related HIV neurodegeneration.
Mackiewicz MM, Overk C, Achim CL, Masliah E
J Neurovirol 2019 Oct;25(5):622-633. Epub 2019 Feb 21 doi: 10.1007/s13365-019-00728-z. PMID: 30790184Free PMC Article
NeuroAIDS in children.
Wilmshurst JM, Hammond CK, Donald K, Hoare J, Cohen K, Eley B
Handb Clin Neurol 2018;152:99-116. doi: 10.1016/B978-0-444-63849-6.00008-6. PMID: 29604987
HIV infection.
Deeks SG, Overbaugh J, Phillips A, Buchbinder S
Nat Rev Dis Primers 2015 Oct 1;1:15035. doi: 10.1038/nrdp.2015.35. PMID: 27188527
Updated research nosology for HIV-associated neurocognitive disorders.
Antinori A, Arendt G, Becker JT, Brew BJ, Byrd DA, Cherner M, Clifford DB, Cinque P, Epstein LG, Goodkin K, Gisslen M, Grant I, Heaton RK, Joseph J, Marder K, Marra CM, McArthur JC, Nunn M, Price RW, Pulliam L, Robertson KR, Sacktor N, Valcour V, Wojna VE
Neurology 2007 Oct 30;69(18):1789-99. Epub 2007 Oct 3 doi: 10.1212/01.WNL.0000287431.88658.8b. PMID: 17914061Free PMC Article

Diagnosis

Caspase cleavage of gasdermin E causes neuronal pyroptosis in HIV-associated neurocognitive disorder.
Fernandes JP, Branton WG, Cohen EA, Koopman G, Kondova I, Gelman BB, Power C
Brain 2024 Feb 1;147(2):717-734. doi: 10.1093/brain/awad375. PMID: 37931057Free PMC Article
HIV neuropathology.
Morgello S
Handb Clin Neurol 2018;152:3-19. doi: 10.1016/B978-0-444-63849-6.00002-5. PMID: 29604982
HIV-1-associated neurocognitive disorder: epidemiology, pathogenesis, diagnosis, and treatment.
Eggers C, Arendt G, Hahn K, Husstedt IW, Maschke M, Neuen-Jacob E, Obermann M, Rosenkranz T, Schielke E, Straube E; German Association of Neuro-AIDS und Neuro-Infectiology (DGNANI)
J Neurol 2017 Aug;264(8):1715-1727. Epub 2017 May 31 doi: 10.1007/s00415-017-8503-2. PMID: 28567537Free PMC Article
HIV and the spectrum of human disease.
Lucas S, Nelson AM
J Pathol 2015 Jan;235(2):229-41. doi: 10.1002/path.4449. PMID: 25251832
Updated research nosology for HIV-associated neurocognitive disorders.
Antinori A, Arendt G, Becker JT, Brew BJ, Byrd DA, Cherner M, Clifford DB, Cinque P, Epstein LG, Goodkin K, Gisslen M, Grant I, Heaton RK, Joseph J, Marder K, Marra CM, McArthur JC, Nunn M, Price RW, Pulliam L, Robertson KR, Sacktor N, Valcour V, Wojna VE
Neurology 2007 Oct 30;69(18):1789-99. Epub 2007 Oct 3 doi: 10.1212/01.WNL.0000287431.88658.8b. PMID: 17914061Free PMC Article

Therapy

Symptomatic cerebrospinal fluid escape.
Mastrangelo A, Turrini F, de Zan V, Caccia R, Gerevini S, Cinque P
AIDS 2019 Dec 1;33 Suppl 2:S159-S169. doi: 10.1097/QAD.0000000000002266. PMID: 31789816
Pathogenesis of age-related HIV neurodegeneration.
Mackiewicz MM, Overk C, Achim CL, Masliah E
J Neurovirol 2019 Oct;25(5):622-633. Epub 2019 Feb 21 doi: 10.1007/s13365-019-00728-z. PMID: 30790184Free PMC Article
HIV infection.
Deeks SG, Overbaugh J, Phillips A, Buchbinder S
Nat Rev Dis Primers 2015 Oct 1;1:15035. doi: 10.1038/nrdp.2015.35. PMID: 27188527
HIV and the spectrum of human disease.
Lucas S, Nelson AM
J Pathol 2015 Jan;235(2):229-41. doi: 10.1002/path.4449. PMID: 25251832
Primary CNS lymphoma.
Phillips EH, Fox CP, Cwynarski K
Curr Hematol Malig Rep 2014 Sep;9(3):243-53. doi: 10.1007/s11899-014-0217-2. PMID: 24969265Free PMC Article

Prognosis

The Role of Pannexin-1 Channels in HIV and NeuroHIV Pathogenesis.
Hernandez CA, Eliseo E
Cells 2022 Jul 20;11(14) doi: 10.3390/cells11142245. PMID: 35883688Free PMC Article
Neuropathogenesis of HIV and emerging therapeutic targets.
Siddiqui A, He C, Lee G, Figueroa A, Slaughter A, Robinson-Papp J
Expert Opin Ther Targets 2022 Jul;26(7):603-615. Epub 2022 Jul 18 doi: 10.1080/14728222.2022.2100253. PMID: 35815686Free PMC Article
Red and orange flags for secondary headaches in clinical practice: SNNOOP10 list.
Do TP, Remmers A, Schytz HW, Schankin C, Nelson SE, Obermann M, Hansen JM, Sinclair AJ, Gantenbein AR, Schoonman GG
Neurology 2019 Jan 15;92(3):134-144. Epub 2018 Dec 26 doi: 10.1212/WNL.0000000000006697. PMID: 30587518Free PMC Article
HIV-1-associated neurocognitive disorder: epidemiology, pathogenesis, diagnosis, and treatment.
Eggers C, Arendt G, Hahn K, Husstedt IW, Maschke M, Neuen-Jacob E, Obermann M, Rosenkranz T, Schielke E, Straube E; German Association of Neuro-AIDS und Neuro-Infectiology (DGNANI)
J Neurol 2017 Aug;264(8):1715-1727. Epub 2017 May 31 doi: 10.1007/s00415-017-8503-2. PMID: 28567537Free PMC Article
HIV and the spectrum of human disease.
Lucas S, Nelson AM
J Pathol 2015 Jan;235(2):229-41. doi: 10.1002/path.4449. PMID: 25251832

Clinical prediction guides

HIV infection of non-classical cells in the brain.
Wahl A, Al-Harthi L
Retrovirology 2023 Jan 13;20(1):1. doi: 10.1186/s12977-023-00616-9. PMID: 36639783Free PMC Article
The Role of Pannexin-1 Channels in HIV and NeuroHIV Pathogenesis.
Hernandez CA, Eliseo E
Cells 2022 Jul 20;11(14) doi: 10.3390/cells11142245. PMID: 35883688Free PMC Article
Red and orange flags for secondary headaches in clinical practice: SNNOOP10 list.
Do TP, Remmers A, Schytz HW, Schankin C, Nelson SE, Obermann M, Hansen JM, Sinclair AJ, Gantenbein AR, Schoonman GG
Neurology 2019 Jan 15;92(3):134-144. Epub 2018 Dec 26 doi: 10.1212/WNL.0000000000006697. PMID: 30587518Free PMC Article
Infectious diseases causing autonomic dysfunction.
Carod-Artal FJ
Clin Auton Res 2018 Feb;28(1):67-81. Epub 2017 Jul 20 doi: 10.1007/s10286-017-0452-4. PMID: 28730326
HIV and the spectrum of human disease.
Lucas S, Nelson AM
J Pathol 2015 Jan;235(2):229-41. doi: 10.1002/path.4449. PMID: 25251832

Recent systematic reviews

Impact of Major Depressive Disorder on Comorbidities: A Systematic Literature Review.
Arnaud AM, Brister TS, Duckworth K, Foxworth P, Fulwider T, Suthoff ED, Werneburg B, Aleksanderek I, Reinhart ML
J Clin Psychiatry 2022 Oct 19;83(6) doi: 10.4088/JCP.21r14328. PMID: 36264099
Pregabalin for neuropathic pain in adults.
Derry S, Bell RF, Straube S, Wiffen PJ, Aldington D, Moore RA
Cochrane Database Syst Rev 2019 Jan 23;1(1):CD007076. doi: 10.1002/14651858.CD007076.pub3. PMID: 30673120Free PMC Article
Association of Placebo, Indomethacin, Ibuprofen, and Acetaminophen With Closure of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-analysis.
Mitra S, Florez ID, Tamayo ME, Mbuagbaw L, Vanniyasingam T, Veroniki AA, Zea AM, Zhang Y, Sadeghirad B, Thabane L
JAMA 2018 Mar 27;319(12):1221-1238. doi: 10.1001/jama.2018.1896. PMID: 29584842Free PMC Article
Topical capsaicin (high concentration) for chronic neuropathic pain in adults.
Derry S, Rice AS, Cole P, Tan T, Moore RA
Cochrane Database Syst Rev 2017 Jan 13;1(1):CD007393. doi: 10.1002/14651858.CD007393.pub4. PMID: 28085183Free PMC Article
Severe cytomegalovirus infection in apparently immunocompetent patients: a systematic review.
Rafailidis PI, Mourtzoukou EG, Varbobitis IC, Falagas ME
Virol J 2008 Mar 27;5:47. doi: 10.1186/1743-422X-5-47. PMID: 18371229Free PMC Article

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