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Pathogenesis of HIV Neurological Disease

MedGen UID:
275336
•Concept ID:
C1518909
•
Disease or Syndrome

Definition

The pathogenic mechanisms involved in HIV-associated neurological diseases and neurobehavioral dysfunction. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPathogenesis of HIV Neurological Disease

Professional guidelines

PubMed

HIV-1-associated neurocognitive disorder: epidemiology, pathogenesis, diagnosis, and treatment.
Eggers C, Arendt G, Hahn K, Husstedt IW, Maschke M, Neuen-Jacob E, Obermann M, Rosenkranz T, Schielke E, Straube E; German Association of Neuro-AIDS und Neuro-Infectiology (DGNANI)
J Neurol 2017 Aug;264(8):1715-1727. Epub 2017 May 31 doi: 10.1007/s00415-017-8503-2. PMID: 28567537Free PMC Article
HIV-associated opportunistic CNS infections: pathophysiology, diagnosis and treatment.
Bowen LN, Smith B, Reich D, Quezado M, Nath A
Nat Rev Neurol 2016 Oct 27;12(11):662-674. doi: 10.1038/nrneurol.2016.149. PMID: 27786246
Clinical management of infectious cerebral vasculitides.
Carod Artal FJ
Expert Rev Neurother 2016;16(2):205-21. Epub 2016 Jan 19 doi: 10.1586/14737175.2015.1134321. PMID: 26689107

Recent clinical studies

Etiology

Cryptococcal Antigen in Serum and Cerebrospinal Fluid for Detecting Cryptococcal Meningitis in Adults Living With Human Immunodeficiency Virus: Systematic Review and Meta-Analysis of Diagnostic Test Accuracy Studies.
Temfack E, Rim JJB, Spijker R, Loyse A, Chiller T, Pappas PG, Perfect J, Sorell TC, Harrison TS, Cohen JF, Lortholary O
Clin Infect Dis 2021 Apr 8;72(7):1268-1278. doi: 10.1093/cid/ciaa1243. PMID: 32829406Free PMC Article
Pathogenesis of age-related HIV neurodegeneration.
Mackiewicz MM, Overk C, Achim CL, Masliah E
J Neurovirol 2019 Oct;25(5):622-633. Epub 2019 Feb 21 doi: 10.1007/s13365-019-00728-z. PMID: 30790184Free PMC Article
NeuroAIDS in children.
Wilmshurst JM, Hammond CK, Donald K, Hoare J, Cohen K, Eley B
Handb Clin Neurol 2018;152:99-116. doi: 10.1016/B978-0-444-63849-6.00008-6. PMID: 29604987
HIV infection.
Deeks SG, Overbaugh J, Phillips A, Buchbinder S
Nat Rev Dis Primers 2015 Oct 1;1:15035. doi: 10.1038/nrdp.2015.35. PMID: 27188527
Primary CNS lymphoma.
Phillips EH, Fox CP, Cwynarski K
Curr Hematol Malig Rep 2014 Sep;9(3):243-53. doi: 10.1007/s11899-014-0217-2. PMID: 24969265Free PMC Article

Diagnosis

HIV neuropathology.
Morgello S
Handb Clin Neurol 2018;152:3-19. doi: 10.1016/B978-0-444-63849-6.00002-5. PMID: 29604982
HIV-1-associated neurocognitive disorder: epidemiology, pathogenesis, diagnosis, and treatment.
Eggers C, Arendt G, Hahn K, Husstedt IW, Maschke M, Neuen-Jacob E, Obermann M, Rosenkranz T, Schielke E, Straube E; German Association of Neuro-AIDS und Neuro-Infectiology (DGNANI)
J Neurol 2017 Aug;264(8):1715-1727. Epub 2017 May 31 doi: 10.1007/s00415-017-8503-2. PMID: 28567537Free PMC Article
HIV and the spectrum of human disease.
Lucas S, Nelson AM
J Pathol 2015 Jan;235(2):229-41. doi: 10.1002/path.4449. PMID: 25251832
HIV-associated neurocognitive disorder.
Clifford DB, Ances BM
Lancet Infect Dis 2013 Nov;13(11):976-86. doi: 10.1016/S1473-3099(13)70269-X. PMID: 24156898Free PMC Article
REVIEW: Neurosyphilis: A historical perspective and review.
Ghanem KG
CNS Neurosci Ther 2010 Oct;16(5):e157-68. Epub 2010 Jul 8 doi: 10.1111/j.1755-5949.2010.00183.x. PMID: 20626434Free PMC Article

Therapy

Cryptococcal Antigen in Serum and Cerebrospinal Fluid for Detecting Cryptococcal Meningitis in Adults Living With Human Immunodeficiency Virus: Systematic Review and Meta-Analysis of Diagnostic Test Accuracy Studies.
Temfack E, Rim JJB, Spijker R, Loyse A, Chiller T, Pappas PG, Perfect J, Sorell TC, Harrison TS, Cohen JF, Lortholary O
Clin Infect Dis 2021 Apr 8;72(7):1268-1278. doi: 10.1093/cid/ciaa1243. PMID: 32829406Free PMC Article
HIV infection.
Deeks SG, Overbaugh J, Phillips A, Buchbinder S
Nat Rev Dis Primers 2015 Oct 1;1:15035. doi: 10.1038/nrdp.2015.35. PMID: 27188527
Pharmacological treatments for fatigue associated with palliative care.
Mücke M; Mochamat, Cuhls H, Peuckmann-Post V, Minton O, Stone P, Radbruch L
Cochrane Database Syst Rev 2015 May 30;2015(5):CD006788. doi: 10.1002/14651858.CD006788.pub3. PMID: 26026155Free PMC Article
HIV and the spectrum of human disease.
Lucas S, Nelson AM
J Pathol 2015 Jan;235(2):229-41. doi: 10.1002/path.4449. PMID: 25251832
REVIEW: Neurosyphilis: A historical perspective and review.
Ghanem KG
CNS Neurosci Ther 2010 Oct;16(5):e157-68. Epub 2010 Jul 8 doi: 10.1111/j.1755-5949.2010.00183.x. PMID: 20626434Free PMC Article

Prognosis

The Role of Pannexin-1 Channels in HIV and NeuroHIV Pathogenesis.
Hernandez CA, Eliseo E
Cells 2022 Jul 20;11(14) doi: 10.3390/cells11142245. PMID: 35883688Free PMC Article
Neuropathogenesis of HIV and emerging therapeutic targets.
Siddiqui A, He C, Lee G, Figueroa A, Slaughter A, Robinson-Papp J
Expert Opin Ther Targets 2022 Jul;26(7):603-615. Epub 2022 Jul 18 doi: 10.1080/14728222.2022.2100253. PMID: 35815686Free PMC Article
Red and orange flags for secondary headaches in clinical practice: SNNOOP10 list.
Do TP, Remmers A, Schytz HW, Schankin C, Nelson SE, Obermann M, Hansen JM, Sinclair AJ, Gantenbein AR, Schoonman GG
Neurology 2019 Jan 15;92(3):134-144. Epub 2018 Dec 26 doi: 10.1212/WNL.0000000000006697. PMID: 30587518Free PMC Article
HIV-1-associated neurocognitive disorder: epidemiology, pathogenesis, diagnosis, and treatment.
Eggers C, Arendt G, Hahn K, Husstedt IW, Maschke M, Neuen-Jacob E, Obermann M, Rosenkranz T, Schielke E, Straube E; German Association of Neuro-AIDS und Neuro-Infectiology (DGNANI)
J Neurol 2017 Aug;264(8):1715-1727. Epub 2017 May 31 doi: 10.1007/s00415-017-8503-2. PMID: 28567537Free PMC Article
HIV and the spectrum of human disease.
Lucas S, Nelson AM
J Pathol 2015 Jan;235(2):229-41. doi: 10.1002/path.4449. PMID: 25251832

Clinical prediction guides

The Role of Pannexin-1 Channels in HIV and NeuroHIV Pathogenesis.
Hernandez CA, Eliseo E
Cells 2022 Jul 20;11(14) doi: 10.3390/cells11142245. PMID: 35883688Free PMC Article
Proposed Linezolid Dosing Strategies to Minimize Adverse Events for Treatment of Extensively Drug-Resistant Tuberculosis.
Imperial MZ, Nedelman JR, Conradie F, Savic RM
Clin Infect Dis 2022 May 30;74(10):1736-1747. doi: 10.1093/cid/ciab699. PMID: 34604901Free PMC Article
Role of the inflammasomes in HIV-associated neuroinflammation and neurocognitive disorders.
Katuri A, Bryant J, Heredia A, Makar TK
Exp Mol Pathol 2019 Jun;108:64-72. Epub 2019 Mar 26 doi: 10.1016/j.yexmp.2019.03.008. PMID: 30922769
Red and orange flags for secondary headaches in clinical practice: SNNOOP10 list.
Do TP, Remmers A, Schytz HW, Schankin C, Nelson SE, Obermann M, Hansen JM, Sinclair AJ, Gantenbein AR, Schoonman GG
Neurology 2019 Jan 15;92(3):134-144. Epub 2018 Dec 26 doi: 10.1212/WNL.0000000000006697. PMID: 30587518Free PMC Article
HIV and the spectrum of human disease.
Lucas S, Nelson AM
J Pathol 2015 Jan;235(2):229-41. doi: 10.1002/path.4449. PMID: 25251832

Recent systematic reviews

Xpert MTB/RIF Ultra assay for tuberculosis disease and rifampicin resistance in children.
Kay AW, Ness T, Verkuijl SE, Viney K, Brands A, Masini T, González Fernández L, Eisenhut M, Detjen AK, Mandalakas AM, Steingart KR, Takwoingi Y
Cochrane Database Syst Rev 2022 Sep 6;9(9):CD013359. doi: 10.1002/14651858.CD013359.pub3. PMID: 36065889Free PMC Article
Pregabalin for neuropathic pain in adults.
Derry S, Bell RF, Straube S, Wiffen PJ, Aldington D, Moore RA
Cochrane Database Syst Rev 2019 Jan 23;1(1):CD007076. doi: 10.1002/14651858.CD007076.pub3. PMID: 30673120Free PMC Article
Association of Placebo, Indomethacin, Ibuprofen, and Acetaminophen With Closure of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-analysis.
Mitra S, Florez ID, Tamayo ME, Mbuagbaw L, Vanniyasingam T, Veroniki AA, Zea AM, Zhang Y, Sadeghirad B, Thabane L
JAMA 2018 Mar 27;319(12):1221-1238. doi: 10.1001/jama.2018.1896. PMID: 29584842Free PMC Article
Topical capsaicin (high concentration) for chronic neuropathic pain in adults.
Derry S, Rice AS, Cole P, Tan T, Moore RA
Cochrane Database Syst Rev 2017 Jan 13;1(1):CD007393. doi: 10.1002/14651858.CD007393.pub4. PMID: 28085183Free PMC Article
Severe cytomegalovirus infection in apparently immunocompetent patients: a systematic review.
Rafailidis PI, Mourtzoukou EG, Varbobitis IC, Falagas ME
Virol J 2008 Mar 27;5:47. doi: 10.1186/1743-422X-5-47. PMID: 18371229Free PMC Article

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