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Loss of Chromosome 19

MedGen UID:
276074
•Concept ID:
C1517970
•
Cell or Molecular Dysfunction
Synonym: del(19)

Definition

A cytogenetic abnormality that refers to loss of all or part of chromosome 19. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLoss of Chromosome 19

Professional guidelines

PubMed

Imaging Correlates of Adult Glioma Genotypes.
Smits M, van den Bent MJ
Radiology 2017 Aug;284(2):316-331. doi: 10.1148/radiol.2017151930. PMID: 28723281
Association of chromosome 19 to lung cancer genotypes and phenotypes.
Wang X, Zhang Y, Nilsson CL, Berven FS, Andrén PE, Carlsohn E, Horvatovich P, Malm J, Fuentes M, Végvári Á, Welinder C, Fehniger TE, Rezeli M, Edula G, Hober S, Nishimura T, Marko-Varga G
Cancer Metastasis Rev 2015 Jun;34(2):217-26. doi: 10.1007/s10555-015-9556-2. PMID: 25982285
Diagnosis and management of oligodendroglioma.
van den Bent MJ
Semin Oncol 2004 Oct;31(5):645-52. doi: 10.1053/j.seminoncol.2004.07.006. PMID: 15497117

Recent clinical studies

Etiology

DNA-methylome-assisted classification of patients with poor prognostic subventricular zone associated IDH-wildtype glioblastoma.
Adeberg S, Knoll M, Koelsche C, Bernhardt D, Schrimpf D, Sahm F, König L, Harrabi SB, Hörner-Rieber J, Verma V, Bewerunge-Hudler M, Unterberg A, Sturm D, Jungk C, Herold-Mende C, Wick W, von Deimling A, Debus J, Rieken S, Abdollahi A
Acta Neuropathol 2022 Jul;144(1):129-142. Epub 2022 Jun 4 doi: 10.1007/s00401-022-02443-2. PMID: 35660939Free PMC Article
Diagnostic test accuracy and cost-effectiveness of tests for codeletion of chromosomal arms 1p and 19q in people with glioma.
McAleenan A, Jones HE, Kernohan A, Robinson T, Schmidt L, Dawson S, Kelly C, Spencer Leal E, Faulkner CL, Palmer A, Wragg C, Jefferies S, Brandner S, Vale L, Higgins JP, Kurian KM
Cochrane Database Syst Rev 2022 Mar 2;3(3):CD013387. doi: 10.1002/14651858.CD013387.pub2. PMID: 35233774Free PMC Article
Adjuvant and concurrent temozolomide for 1p/19q non-co-deleted anaplastic glioma (CATNON; EORTC study 26053-22054): second interim analysis of a randomised, open-label, phase 3 study.
van den Bent MJ, Tesileanu CMS, Wick W, Sanson M, Brandes AA, Clement PM, Erridge S, Vogelbaum MA, Nowak AK, Baurain JF, Mason WP, Wheeler H, Chinot OL, Gill S, Griffin M, Rogers L, Taal W, Rudà R, Weller M, McBain C, Reijneveld J, Enting RH, Caparrotti F, Lesimple T, Clenton S, Gijtenbeek A, Lim E, Herrlinger U, Hau P, Dhermain F, de Heer I, Aldape K, Jenkins RB, Dubbink HJ, Kros JM, Wesseling P, Nuyens S, Golfinopoulos V, Gorlia T, French P, Baumert BG
Lancet Oncol 2021 Jun;22(6):813-823. Epub 2021 May 14 doi: 10.1016/S1470-2045(21)00090-5. PMID: 34000245Free PMC Article
Loss of heterozygosity 1p/19q and survival in glioma: a meta-analysis.
Zhao J, Ma W, Zhao H
Neuro Oncol 2014 Jan;16(1):103-12. Epub 2013 Dec 4 doi: 10.1093/neuonc/not145. PMID: 24311641Free PMC Article
A novel H101Q mutation causes PKCgamma loss in spinocerebellar ataxia type 14.
Alonso I, Costa C, Gomes A, Ferro A, Seixas AI, Silva S, Cruz VT, Coutinho P, Sequeiros J, Silveira I
J Hum Genet 2005;50(10):523-529. Epub 2005 Sep 28 doi: 10.1007/s10038-005-0287-z. PMID: 16189624

Diagnosis

Adjuvant and concurrent temozolomide for 1p/19q non-co-deleted anaplastic glioma (CATNON; EORTC study 26053-22054): second interim analysis of a randomised, open-label, phase 3 study.
van den Bent MJ, Tesileanu CMS, Wick W, Sanson M, Brandes AA, Clement PM, Erridge S, Vogelbaum MA, Nowak AK, Baurain JF, Mason WP, Wheeler H, Chinot OL, Gill S, Griffin M, Rogers L, Taal W, Rudà R, Weller M, McBain C, Reijneveld J, Enting RH, Caparrotti F, Lesimple T, Clenton S, Gijtenbeek A, Lim E, Herrlinger U, Hau P, Dhermain F, de Heer I, Aldape K, Jenkins RB, Dubbink HJ, Kros JM, Wesseling P, Nuyens S, Golfinopoulos V, Gorlia T, French P, Baumert BG
Lancet Oncol 2021 Jun;22(6):813-823. Epub 2021 May 14 doi: 10.1016/S1470-2045(21)00090-5. PMID: 34000245Free PMC Article
Imaging Correlates of Adult Glioma Genotypes.
Smits M, van den Bent MJ
Radiology 2017 Aug;284(2):316-331. doi: 10.1148/radiol.2017151930. PMID: 28723281
Alpha-mannosidosis.
Malm D, Nilssen Ø
Orphanet J Rare Dis 2008 Jul 23;3:21. doi: 10.1186/1750-1172-3-21. PMID: 18651971Free PMC Article
Clinicopathologic aspects of 1p/19q loss and the diagnosis of oligodendroglioma.
Aldape K, Burger PC, Perry A
Arch Pathol Lab Med 2007 Feb;131(2):242-51. doi: 10.5858/2007-131-242-CAOQLA. PMID: 17284109
Diagnosis and management of oligodendroglioma.
van den Bent MJ
Semin Oncol 2004 Oct;31(5):645-52. doi: 10.1053/j.seminoncol.2004.07.006. PMID: 15497117

Therapy

DNA-methylome-assisted classification of patients with poor prognostic subventricular zone associated IDH-wildtype glioblastoma.
Adeberg S, Knoll M, Koelsche C, Bernhardt D, Schrimpf D, Sahm F, König L, Harrabi SB, Hörner-Rieber J, Verma V, Bewerunge-Hudler M, Unterberg A, Sturm D, Jungk C, Herold-Mende C, Wick W, von Deimling A, Debus J, Rieken S, Abdollahi A
Acta Neuropathol 2022 Jul;144(1):129-142. Epub 2022 Jun 4 doi: 10.1007/s00401-022-02443-2. PMID: 35660939Free PMC Article
Adjuvant and concurrent temozolomide for 1p/19q non-co-deleted anaplastic glioma (CATNON; EORTC study 26053-22054): second interim analysis of a randomised, open-label, phase 3 study.
van den Bent MJ, Tesileanu CMS, Wick W, Sanson M, Brandes AA, Clement PM, Erridge S, Vogelbaum MA, Nowak AK, Baurain JF, Mason WP, Wheeler H, Chinot OL, Gill S, Griffin M, Rogers L, Taal W, Rudà R, Weller M, McBain C, Reijneveld J, Enting RH, Caparrotti F, Lesimple T, Clenton S, Gijtenbeek A, Lim E, Herrlinger U, Hau P, Dhermain F, de Heer I, Aldape K, Jenkins RB, Dubbink HJ, Kros JM, Wesseling P, Nuyens S, Golfinopoulos V, Gorlia T, French P, Baumert BG
Lancet Oncol 2021 Jun;22(6):813-823. Epub 2021 May 14 doi: 10.1016/S1470-2045(21)00090-5. PMID: 34000245Free PMC Article
Loss of heterozygosity 1p/19q and survival in glioma: a meta-analysis.
Zhao J, Ma W, Zhao H
Neuro Oncol 2014 Jan;16(1):103-12. Epub 2013 Dec 4 doi: 10.1093/neuonc/not145. PMID: 24311641Free PMC Article
How to use molecular markers when caring for a patient with brain cancer: 1P/19Q as a predictive and prognostic marker in the neuro-oncology clinic.
van den Bent MJ
Am Soc Clin Oncol Educ Book 2013:114-6. doi: 10.14694/EdBook_AM.2013.33.114. PMID: 23714473
Diagnosis and management of oligodendroglioma.
van den Bent MJ
Semin Oncol 2004 Oct;31(5):645-52. doi: 10.1053/j.seminoncol.2004.07.006. PMID: 15497117

Prognosis

DNA-methylome-assisted classification of patients with poor prognostic subventricular zone associated IDH-wildtype glioblastoma.
Adeberg S, Knoll M, Koelsche C, Bernhardt D, Schrimpf D, Sahm F, König L, Harrabi SB, Hörner-Rieber J, Verma V, Bewerunge-Hudler M, Unterberg A, Sturm D, Jungk C, Herold-Mende C, Wick W, von Deimling A, Debus J, Rieken S, Abdollahi A
Acta Neuropathol 2022 Jul;144(1):129-142. Epub 2022 Jun 4 doi: 10.1007/s00401-022-02443-2. PMID: 35660939Free PMC Article
Imaging Correlates of Adult Glioma Genotypes.
Smits M, van den Bent MJ
Radiology 2017 Aug;284(2):316-331. doi: 10.1148/radiol.2017151930. PMID: 28723281
How to use molecular markers when caring for a patient with brain cancer: 1P/19Q as a predictive and prognostic marker in the neuro-oncology clinic.
van den Bent MJ
Am Soc Clin Oncol Educ Book 2013:114-6. doi: 10.14694/EdBook_AM.2013.33.114. PMID: 23714473
Alpha-mannosidosis.
Malm D, Nilssen Ø
Orphanet J Rare Dis 2008 Jul 23;3:21. doi: 10.1186/1750-1172-3-21. PMID: 18651971Free PMC Article
Clinicopathologic aspects of 1p/19q loss and the diagnosis of oligodendroglioma.
Aldape K, Burger PC, Perry A
Arch Pathol Lab Med 2007 Feb;131(2):242-51. doi: 10.5858/2007-131-242-CAOQLA. PMID: 17284109

Clinical prediction guides

Exploring the molecular pathogenesis, diagnosis and treatment of fibrolamellar hepatocellular carcinoma: A state of art review of the current literature.
Alshareefy Y, Shen CY, Prekash RJ
Pathol Res Pract 2023 Aug;248:154655. Epub 2023 Jun 26 doi: 10.1016/j.prp.2023.154655. PMID: 37429175
Adjuvant and concurrent temozolomide for 1p/19q non-co-deleted anaplastic glioma (CATNON; EORTC study 26053-22054): second interim analysis of a randomised, open-label, phase 3 study.
van den Bent MJ, Tesileanu CMS, Wick W, Sanson M, Brandes AA, Clement PM, Erridge S, Vogelbaum MA, Nowak AK, Baurain JF, Mason WP, Wheeler H, Chinot OL, Gill S, Griffin M, Rogers L, Taal W, Rudà R, Weller M, McBain C, Reijneveld J, Enting RH, Caparrotti F, Lesimple T, Clenton S, Gijtenbeek A, Lim E, Herrlinger U, Hau P, Dhermain F, de Heer I, Aldape K, Jenkins RB, Dubbink HJ, Kros JM, Wesseling P, Nuyens S, Golfinopoulos V, Gorlia T, French P, Baumert BG
Lancet Oncol 2021 Jun;22(6):813-823. Epub 2021 May 14 doi: 10.1016/S1470-2045(21)00090-5. PMID: 34000245Free PMC Article
DFNB68, a novel autosomal recessive non-syndromic hearing impairment locus at chromosomal region 19p13.2.
Santos RL, Hassan MJ, Sikandar S, Lee K, Ali G, Martin PE Jr, Wambangco MA, Ahmad W, Leal SM
Hum Genet 2006 Aug;120(1):85-92. Epub 2006 May 16 doi: 10.1007/s00439-006-0188-z. PMID: 16703383Free PMC Article
Familial benign hypocalciuric hypercalcemia.
Fuleihan Gel-H
J Bone Miner Res 2002 Nov;17 Suppl 2:N51-6. PMID: 12412778
A human recessive neurosensory nonsyndromic hearing impairment locus is potential homologue of murine deafness (dn) locus.
Jain PK, Fukushima K, Deshmukh D, Ramesh A, Thomas E, Lalwani AK, Kumar S, Plopis B, Skarka H, Srisailapathy CR
Hum Mol Genet 1995 Dec;4(12):2391-4. doi: 10.1093/hmg/4.12.2391. PMID: 8634715

Recent systematic reviews

Diagnostic test accuracy and cost-effectiveness of tests for codeletion of chromosomal arms 1p and 19q in people with glioma.
McAleenan A, Jones HE, Kernohan A, Robinson T, Schmidt L, Dawson S, Kelly C, Spencer Leal E, Faulkner CL, Palmer A, Wragg C, Jefferies S, Brandner S, Vale L, Higgins JP, Kurian KM
Cochrane Database Syst Rev 2022 Mar 2;3(3):CD013387. doi: 10.1002/14651858.CD013387.pub2. PMID: 35233774Free PMC Article
Diagnostic accuracy of 1p/19q codeletion tests in oligodendroglioma: A comprehensive meta-analysis based on a Cochrane systematic review.
Brandner S, McAleenan A, Jones HE, Kernohan A, Robinson T, Schmidt L, Dawson S, Kelly C, Leal ES, Faulkner CL, Palmer A, Wragg C, Jefferies S, Vale L, Higgins JPT, Kurian KM
Neuropathol Appl Neurobiol 2022 Jun;48(4):e12790. Epub 2022 Mar 3 doi: 10.1111/nan.12790. PMID: 34958131Free PMC Article

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