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Loss of Chromosome 1p

MedGen UID:
276485
•Concept ID:
C1517972
•
Cell or Molecular Dysfunction
Synonyms: 1p Deletion; del(1p)

Definition

A cytogenetic abnormality that refers to the loss of all or part of the short arm of chromosome 1 (1p). It has been described in gliomas, meningiomas, neuroblastomas, hepatocellular carcinomas, breast carcinomas, acinar prostate adenocarcinomas, pancreatic carcinomas, and adrenal gland adenomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLoss of Chromosome 1p

Professional guidelines

PubMed

Oligodendroglioma: impact of molecular biology on its definition, diagnosis and management.
Ueki K
Neuropathology 2005 Sep;25(3):247-53. doi: 10.1111/j.1440-1789.2005.00637.x. PMID: 16193843
Successful treatment of low-grade oligodendroglial tumors with a chemotherapy regimen of procarbazine, lomustine, and vincristine.
Stege EM, Kros JM, de Bruin HG, Enting RH, van Heuvel I, Looijenga LH, van der Rijt CD, Smitt PA, van den Bent MJ
Cancer 2005 Feb 15;103(4):802-9. doi: 10.1002/cncr.20828. PMID: 15637687
Temozolomide as initial treatment for adults with low-grade oligodendrogliomas or oligoastrocytomas and correlation with chromosome 1p deletions.
Hoang-Xuan K, Capelle L, Kujas M, Taillibert S, Duffau H, Lejeune J, Polivka M, Crinière E, Marie Y, Mokhtari K, Carpentier AF, Laigle F, Simon JM, Cornu P, Broët P, Sanson M, Delattre JY
J Clin Oncol 2004 Aug 1;22(15):3133-8. doi: 10.1200/JCO.2004.10.169. PMID: 15284265

Recent clinical studies

Etiology

Oligosarcomas, IDH-mutant are distinct and aggressive.
Suwala AK, Felix M, Friedel D, Stichel D, Schrimpf D, Hinz F, Hewer E, Schweizer L, Dohmen H, Pohl U, Staszewski O, Korshunov A, Stein M, Wongsurawat T, Cheunsuacchon P, Sathornsumetee S, Koelsche C, Turner C, Le Rhun E, Mühlebner A, Schucht P, Özduman K, Ono T, Shimizu H, Prinz M, Acker T, Herold-Mende C, Kessler T, Wick W, Capper D, Wesseling P, Sahm F, von Deimling A, Hartmann C, Reuss DE
Acta Neuropathol 2022 Feb;143(2):263-281. Epub 2021 Dec 30 doi: 10.1007/s00401-021-02395-z. PMID: 34967922Free PMC Article
A molecularly integrated grade for meningioma.
Driver J, Hoffman SE, Tavakol S, Woodward E, Maury EA, Bhave V, Greenwald NF, Nassiri F, Aldape K, Zadeh G, Choudhury A, Vasudevan HN, Magill ST, Raleigh DR, Abedalthagafi M, Aizer AA, Alexander BM, Ligon KL, Reardon DA, Wen PY, Al-Mefty O, Ligon AH, Dubuc AM, Beroukhim R, Claus EB, Dunn IF, Santagata S, Bi WL
Neuro Oncol 2022 May 4;24(5):796-808. doi: 10.1093/neuonc/noab213. PMID: 34508644Free PMC Article
Grading of adult diffuse gliomas according to the 2021 WHO Classification of Tumors of the Central Nervous System.
Komori T
Lab Invest 2022 Feb;102(2):126-133. Epub 2021 Sep 9 doi: 10.1038/s41374-021-00667-6. PMID: 34504304
Adjuvant and concurrent temozolomide for 1p/19q non-co-deleted anaplastic glioma (CATNON; EORTC study 26053-22054): second interim analysis of a randomised, open-label, phase 3 study.
van den Bent MJ, Tesileanu CMS, Wick W, Sanson M, Brandes AA, Clement PM, Erridge S, Vogelbaum MA, Nowak AK, Baurain JF, Mason WP, Wheeler H, Chinot OL, Gill S, Griffin M, Rogers L, Taal W, Rudà R, Weller M, McBain C, Reijneveld J, Enting RH, Caparrotti F, Lesimple T, Clenton S, Gijtenbeek A, Lim E, Herrlinger U, Hau P, Dhermain F, de Heer I, Aldape K, Jenkins RB, Dubbink HJ, Kros JM, Wesseling P, Nuyens S, Golfinopoulos V, Gorlia T, French P, Baumert BG
Lancet Oncol 2021 Jun;22(6):813-823. Epub 2021 May 14 doi: 10.1016/S1470-2045(21)00090-5. PMID: 34000245Free PMC Article
New approaches to risk stratification for Wilms tumor.
Nelson MV, van den Heuvel-Eibrink MM, Graf N, Dome JS
Curr Opin Pediatr 2021 Feb 1;33(1):40-48. Epub 2020 Dec 29 doi: 10.1097/MOP.0000000000000988. PMID: 33394739Free PMC Article

Diagnosis

Oligosarcomas, IDH-mutant are distinct and aggressive.
Suwala AK, Felix M, Friedel D, Stichel D, Schrimpf D, Hinz F, Hewer E, Schweizer L, Dohmen H, Pohl U, Staszewski O, Korshunov A, Stein M, Wongsurawat T, Cheunsuacchon P, Sathornsumetee S, Koelsche C, Turner C, Le Rhun E, Mühlebner A, Schucht P, Özduman K, Ono T, Shimizu H, Prinz M, Acker T, Herold-Mende C, Kessler T, Wick W, Capper D, Wesseling P, Sahm F, von Deimling A, Hartmann C, Reuss DE
Acta Neuropathol 2022 Feb;143(2):263-281. Epub 2021 Dec 30 doi: 10.1007/s00401-021-02395-z. PMID: 34967922Free PMC Article
Grading of adult diffuse gliomas according to the 2021 WHO Classification of Tumors of the Central Nervous System.
Komori T
Lab Invest 2022 Feb;102(2):126-133. Epub 2021 Sep 9 doi: 10.1038/s41374-021-00667-6. PMID: 34504304
Adjuvant and concurrent temozolomide for 1p/19q non-co-deleted anaplastic glioma (CATNON; EORTC study 26053-22054): second interim analysis of a randomised, open-label, phase 3 study.
van den Bent MJ, Tesileanu CMS, Wick W, Sanson M, Brandes AA, Clement PM, Erridge S, Vogelbaum MA, Nowak AK, Baurain JF, Mason WP, Wheeler H, Chinot OL, Gill S, Griffin M, Rogers L, Taal W, Rudà R, Weller M, McBain C, Reijneveld J, Enting RH, Caparrotti F, Lesimple T, Clenton S, Gijtenbeek A, Lim E, Herrlinger U, Hau P, Dhermain F, de Heer I, Aldape K, Jenkins RB, Dubbink HJ, Kros JM, Wesseling P, Nuyens S, Golfinopoulos V, Gorlia T, French P, Baumert BG
Lancet Oncol 2021 Jun;22(6):813-823. Epub 2021 May 14 doi: 10.1016/S1470-2045(21)00090-5. PMID: 34000245Free PMC Article
New approaches to risk stratification for Wilms tumor.
Nelson MV, van den Heuvel-Eibrink MM, Graf N, Dome JS
Curr Opin Pediatr 2021 Feb 1;33(1):40-48. Epub 2020 Dec 29 doi: 10.1097/MOP.0000000000000988. PMID: 33394739Free PMC Article
Biological and Genetic Features of Neuroblastoma and Their Clinical Importance.
Aygun N
Curr Pediatr Rev 2018;14(2):73-90. doi: 10.2174/1573396314666180129101627. PMID: 29380702

Therapy

A molecularly integrated grade for meningioma.
Driver J, Hoffman SE, Tavakol S, Woodward E, Maury EA, Bhave V, Greenwald NF, Nassiri F, Aldape K, Zadeh G, Choudhury A, Vasudevan HN, Magill ST, Raleigh DR, Abedalthagafi M, Aizer AA, Alexander BM, Ligon KL, Reardon DA, Wen PY, Al-Mefty O, Ligon AH, Dubuc AM, Beroukhim R, Claus EB, Dunn IF, Santagata S, Bi WL
Neuro Oncol 2022 May 4;24(5):796-808. doi: 10.1093/neuonc/noab213. PMID: 34508644Free PMC Article
Adjuvant and concurrent temozolomide for 1p/19q non-co-deleted anaplastic glioma (CATNON; EORTC study 26053-22054): second interim analysis of a randomised, open-label, phase 3 study.
van den Bent MJ, Tesileanu CMS, Wick W, Sanson M, Brandes AA, Clement PM, Erridge S, Vogelbaum MA, Nowak AK, Baurain JF, Mason WP, Wheeler H, Chinot OL, Gill S, Griffin M, Rogers L, Taal W, Rudà R, Weller M, McBain C, Reijneveld J, Enting RH, Caparrotti F, Lesimple T, Clenton S, Gijtenbeek A, Lim E, Herrlinger U, Hau P, Dhermain F, de Heer I, Aldape K, Jenkins RB, Dubbink HJ, Kros JM, Wesseling P, Nuyens S, Golfinopoulos V, Gorlia T, French P, Baumert BG
Lancet Oncol 2021 Jun;22(6):813-823. Epub 2021 May 14 doi: 10.1016/S1470-2045(21)00090-5. PMID: 34000245Free PMC Article
Treatment of Stage IV Favorable Histology Wilms Tumor With Lung Metastases: A Report From the Children's Oncology Group AREN0533 Study.
Dix DB, Seibel NL, Chi YY, Khanna G, Gratias E, Anderson JR, Mullen EA, Geller JI, Kalapurakal JA, Paulino AC, Perlman EJ, Ehrlich PF, Malogolowkin M, Gastier-Foster JM, Wagner E, Grundy PE, Fernandez CV, Dome JS
J Clin Oncol 2018 Jun 1;36(16):1564-1570. Epub 2018 Apr 16 doi: 10.1200/JCO.2017.77.1931. PMID: 29659330Free PMC Article
Loss of heterozygosity 1p/19q and survival in glioma: a meta-analysis.
Zhao J, Ma W, Zhao H
Neuro Oncol 2014 Jan;16(1):103-12. Epub 2013 Dec 4 doi: 10.1093/neuonc/not145. PMID: 24311641Free PMC Article
Low-grade gliomas.
Ruiz J, Lesser GJ
Curr Treat Options Oncol 2009 Aug;10(3-4):231-42. Epub 2009 Apr 19 doi: 10.1007/s11864-009-0096-2. PMID: 19381819

Prognosis

Mutations of 1p genes do not consistently abrogate tumor suppressor functions in 1p-intact neuroblastoma.
Kuick CH, Tan JY, Jasmine D, Sumanty T, Ng AYJ, Venkatesh B, Chen H, Loh E, Jain S, Seow WY, Ng EHQ, Lian DWQ, Soh SY, Chang KTE, Chen ZX, Loh AHP
BMC Cancer 2022 Jun 30;22(1):717. doi: 10.1186/s12885-022-09800-0. PMID: 35768791Free PMC Article
Galectin-9/TIM-3 as a Key Regulator of Immune Response in Gliomas With Chromosome 1p/19q Codeletion.
Li G, Huang R, Fan W, Wang D, Wu F, Zeng F, Yu M, Zhai Y, Chang Y, Pan C, Jiang T, Yan W, Wang H, Zhang W
Front Immunol 2021;12:800928. Epub 2021 Dec 8 doi: 10.3389/fimmu.2021.800928. PMID: 34956239Free PMC Article
Wilms tumor: an update.
Al-Hussain T, Ali A, Akhtar M
Adv Anat Pathol 2014 May;21(3):166-73. doi: 10.1097/PAP.0000000000000017. PMID: 24713986
Low-grade gliomas.
Ruiz J, Lesser GJ
Curr Treat Options Oncol 2009 Aug;10(3-4):231-42. Epub 2009 Apr 19 doi: 10.1007/s11864-009-0096-2. PMID: 19381819
Clinicopathologic aspects of 1p/19q loss and the diagnosis of oligodendroglioma.
Aldape K, Burger PC, Perry A
Arch Pathol Lab Med 2007 Feb;131(2):242-51. doi: 10.5858/2007-131-242-CAOQLA. PMID: 17284109

Clinical prediction guides

Mutations of 1p genes do not consistently abrogate tumor suppressor functions in 1p-intact neuroblastoma.
Kuick CH, Tan JY, Jasmine D, Sumanty T, Ng AYJ, Venkatesh B, Chen H, Loh E, Jain S, Seow WY, Ng EHQ, Lian DWQ, Soh SY, Chang KTE, Chen ZX, Loh AHP
BMC Cancer 2022 Jun 30;22(1):717. doi: 10.1186/s12885-022-09800-0. PMID: 35768791Free PMC Article
Galectin-9/TIM-3 as a Key Regulator of Immune Response in Gliomas With Chromosome 1p/19q Codeletion.
Li G, Huang R, Fan W, Wang D, Wu F, Zeng F, Yu M, Zhai Y, Chang Y, Pan C, Jiang T, Yan W, Wang H, Zhang W
Front Immunol 2021;12:800928. Epub 2021 Dec 8 doi: 10.3389/fimmu.2021.800928. PMID: 34956239Free PMC Article
Adjuvant and concurrent temozolomide for 1p/19q non-co-deleted anaplastic glioma (CATNON; EORTC study 26053-22054): second interim analysis of a randomised, open-label, phase 3 study.
van den Bent MJ, Tesileanu CMS, Wick W, Sanson M, Brandes AA, Clement PM, Erridge S, Vogelbaum MA, Nowak AK, Baurain JF, Mason WP, Wheeler H, Chinot OL, Gill S, Griffin M, Rogers L, Taal W, Rudà R, Weller M, McBain C, Reijneveld J, Enting RH, Caparrotti F, Lesimple T, Clenton S, Gijtenbeek A, Lim E, Herrlinger U, Hau P, Dhermain F, de Heer I, Aldape K, Jenkins RB, Dubbink HJ, Kros JM, Wesseling P, Nuyens S, Golfinopoulos V, Gorlia T, French P, Baumert BG
Lancet Oncol 2021 Jun;22(6):813-823. Epub 2021 May 14 doi: 10.1016/S1470-2045(21)00090-5. PMID: 34000245Free PMC Article
The correlation of clinical and chromosomal alterations of benign meningiomas and their recurrences.
Och W, Szmuda T, Kulbacki K, Witek K, Sikorska B, Zakrzewska M, Springer J, Reszeć J, Parda A, Liberski PP
Neurol Neurochir Pol 2016 Nov-Dec;50(6):395-402. Epub 2016 Jul 26 doi: 10.1016/j.pjnns.2016.07.001. PMID: 27480481
Frequent loss of chromosome arm 1p DNA in parathyroid adenomas.
Cryns VL, Yi SM, Tahara H, Gaz RD, Arnold A
Genes Chromosomes Cancer 1995 May;13(1):9-17. doi: 10.1002/gcc.2870130103. PMID: 7541648

Recent systematic reviews

Diagnostic test accuracy and cost-effectiveness of tests for codeletion of chromosomal arms 1p and 19q in people with glioma.
McAleenan A, Jones HE, Kernohan A, Robinson T, Schmidt L, Dawson S, Kelly C, Spencer Leal E, Faulkner CL, Palmer A, Wragg C, Jefferies S, Brandner S, Vale L, Higgins JP, Kurian KM
Cochrane Database Syst Rev 2022 Mar 2;3(3):CD013387. doi: 10.1002/14651858.CD013387.pub2. PMID: 35233774Free PMC Article
Diagnostic accuracy of 1p/19q codeletion tests in oligodendroglioma: A comprehensive meta-analysis based on a Cochrane systematic review.
Brandner S, McAleenan A, Jones HE, Kernohan A, Robinson T, Schmidt L, Dawson S, Kelly C, Leal ES, Faulkner CL, Palmer A, Wragg C, Jefferies S, Vale L, Higgins JPT, Kurian KM
Neuropathol Appl Neurobiol 2022 Jun;48(4):e12790. Epub 2022 Mar 3 doi: 10.1111/nan.12790. PMID: 34958131Free PMC Article
Recurrence-associated chromosomal anomalies in meningiomas: Single-institution study and a systematic review with meta-analysis.
Och W, Szmuda T, Sikorska B, Springer J, Jaskólski D, Zakrzewska M, Liberski PP
Neurol Neurochir Pol 2016 Nov-Dec;50(6):439-448. Epub 2016 Aug 20 doi: 10.1016/j.pjnns.2016.08.003. PMID: 27575681
Genetic variation frequencies in Wilms' tumor: A meta-analysis and systematic review.
Deng C, Dai R, Li X, Liu F
Cancer Sci 2016 May;107(5):690-9. Epub 2016 Mar 18 doi: 10.1111/cas.12910. PMID: 26892980Free PMC Article
Management of patients with recurrence of diffuse low grade glioma: A systematic review and evidence-based clinical practice guideline.
Nahed BV, Redjal N, Brat DJ, Chi AS, Oh K, Batchelor TT, Ryken TC, Kalkanis SN, Olson JJ
J Neurooncol 2015 Dec;125(3):609-30. Epub 2015 Nov 3 doi: 10.1007/s11060-015-1910-2. PMID: 26530264

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