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Loss of Chromosome 3

MedGen UID:
276487
Concept ID:
C1517980
Cell or Molecular Dysfunction
Synonym: del(3)

Definition

A cytogenetic abnormality that refers to loss of all or part of chromosome 3. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLoss of Chromosome 3

Professional guidelines

PubMed

Damato B
Expert Rev Anticancer Ther 2006 Apr;6(4):493-506. doi: 10.1586/14737140.6.4.493. PMID: 16613538

Recent clinical studies

Etiology

Visweswaran V, Pavithran K
Curr Drug Res Rev 2022;14(2):88-95. doi: 10.2174/2589977514666220401094724. PMID: 35366789
Ottema S, Mulet-Lazaro R, Beverloo HB, Erpelinck C, van Herk S, van der Helm R, Havermans M, Grob T, Valk PJM, Bindels E, Haferlach T, Haferlach C, Smeenk L, Delwel R
Blood 2020 Jul 9;136(2):224-234. doi: 10.1182/blood.2019003701. PMID: 32219447
Mitchell TJ, Turajlic S, Rowan A, Nicol D, Farmery JHR, O'Brien T, Martincorena I, Tarpey P, Angelopoulos N, Yates LR, Butler AP, Raine K, Stewart GD, Challacombe B, Fernando A, Lopez JI, Hazell S, Chandra A, Chowdhury S, Rudman S, Soultati A, Stamp G, Fotiadis N, Pickering L, Au L, Spain L, Lynch J, Stares M, Teague J, Maura F, Wedge DC, Horswell S, Chambers T, Litchfield K, Xu H, Stewart A, Elaidi R, Oudard S, McGranahan N, Csabai I, Gore M, Futreal PA, Larkin J, Lynch AG, Szallasi Z, Swanton C, Campbell PJ; TRACERx Renal Consortium
Cell 2018 Apr 19;173(3):611-623.e17. Epub 2018 Apr 12 doi: 10.1016/j.cell.2018.02.020. PMID: 29656891Free PMC Article
Al-Hussain T, Ali A, Akhtar M
Adv Anat Pathol 2014 May;21(3):166-73. doi: 10.1097/PAP.0000000000000017. PMID: 24713986
Fujii S, Takeshima Y, Arihiro K, Kaneko M, Inai K
Hiroshima J Med Sci 1998 Sep;47(3):89-97. PMID: 9810779

Diagnosis

Kalyon S, Gökden Y, Demirel N, Erden B, Türkyılmaz A
Turk J Gastroenterol 2019 Jan;30(1):105-108. doi: 10.5152/tjg.2018.18014. PMID: 30457558Free PMC Article
Dogrusöz M, Jager MJ, Damato B
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):186-196. doi: 10.22608/APO.201734. PMID: 28399342
Brenner L, Burke K, Leduc CA, Guha S, Guo J, Chung WK
Genet Test Mol Biomarkers 2011 Jul-Aug;15(7-8):525-9. Epub 2011 Mar 27 doi: 10.1089/gtmb.2010.0277. PMID: 21438779
Croce CM, Sozzi G, Huebner K
J Clin Oncol 1999 May;17(5):1618-24. doi: 10.1200/JCO.1999.17.5.1618. PMID: 10334551
Maher ER, Kaelin WG Jr
Medicine (Baltimore) 1997 Nov;76(6):381-91. doi: 10.1097/00005792-199711000-00001. PMID: 9413424

Therapy

Wang JZ, Lin V, Toumi E, Wang K, Zhu H, Conway RM, Madigan MC, Murray M, Cherepanoff S, Zhou F, Shu W
FEBS J 2021 Nov;288(21):6226-6249. Epub 2021 May 1 doi: 10.1111/febs.15869. PMID: 33838075
Chiam PJ, Coupland SE, Kalirai H, Groenewald C, Heimann H, Damato BE
Br J Ophthalmol 2014 Jul;98(7):967-71. Epub 2014 Feb 11 doi: 10.1136/bjophthalmol-2013-304472. PMID: 24518077
Bronkhorst IH, Jager MJ
Eye (Lond) 2013 Feb;27(2):217-23. Epub 2012 Dec 14 doi: 10.1038/eye.2012.253. PMID: 23238448Free PMC Article
Oliveira CS, Alves C
Endocrinol Nutr 2011 Oct;58(8):433-42. Epub 2011 Sep 16 doi: 10.1016/j.endonu.2011.06.005. PMID: 21925981
Damato B
Expert Rev Anticancer Ther 2006 Apr;6(4):493-506. doi: 10.1586/14737140.6.4.493. PMID: 16613538

Prognosis

Dogrusöz M, Jager MJ, Damato B
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):186-196. doi: 10.22608/APO.201734. PMID: 28399342
Al-Hussain T, Ali A, Akhtar M
Adv Anat Pathol 2014 May;21(3):166-73. doi: 10.1097/PAP.0000000000000017. PMID: 24713986
Brenner L, Burke K, Leduc CA, Guha S, Guo J, Chung WK
Genet Test Mol Biomarkers 2011 Jul-Aug;15(7-8):525-9. Epub 2011 Mar 27 doi: 10.1089/gtmb.2010.0277. PMID: 21438779
Schichman SA, Lin P, Gilbrech LJ, Gray PS, Wilson CS, Sawyer JR
J Mol Diagn 2002 Nov;4(4):230-2. doi: 10.1016/S1525-1578(10)60708-8. PMID: 12411591Free PMC Article
Croce CM, Sozzi G, Huebner K
J Clin Oncol 1999 May;17(5):1618-24. doi: 10.1200/JCO.1999.17.5.1618. PMID: 10334551

Clinical prediction guides

Visweswaran V, Pavithran K
Curr Drug Res Rev 2022;14(2):88-95. doi: 10.2174/2589977514666220401094724. PMID: 35366789
Tippu Z, Au L, Turajlic S
Eur Urol Focus 2021 Jan;7(1):148-151. Epub 2020 Jan 29 doi: 10.1016/j.euf.2019.12.005. PMID: 32007485
Dogrusöz M, Jager MJ, Damato B
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):186-196. doi: 10.22608/APO.201734. PMID: 28399342
Lung ML, Choi CV, Kong H, Yuen PW, Kwong D, Sham J, Wei WI
Anticancer Res 2001 Jul-Aug;21(4B):3081-4. PMID: 11712814
Roque L, Castedo S, Clode A, Soares J
Genes Chromosomes Cancer 1993 Nov;8(3):199-203. doi: 10.1002/gcc.2870080311. PMID: 7509630

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