U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RBM15-MKL1 Fusion Protein Expression

MedGen UID:
276615
•Concept ID:
C1518521
•
Cell or Molecular Dysfunction
Synonyms: OTT-MAL Fusion Protein Expression; OTT/MAL Fusion Protein Expression; RBM15-MRTFA Fusion Protein Expression; RBM15/MKL1 Fusion Protein Expression; RBM15/MRTFA Fusion Protein Expression

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRBM15-MKL1 Fusion Protein Expression

Recent clinical studies

Etiology

Prognostic impact of specific molecular profiles in pediatric acute megakaryoblastic leukemia in non-Down syndrome.
Hara Y, Shiba N, Ohki K, Tabuchi K, Yamato G, Park MJ, Tomizawa D, Kinoshita A, Shimada A, Arakawa H, Saito AM, Kiyokawa N, Tawa A, Horibe K, Taga T, Adachi S, Taki T, Hayashi Y
Genes Chromosomes Cancer 2017 May;56(5):394-404. Epub 2017 Feb 14 doi: 10.1002/gcc.22444. PMID: 28063190
NUP98/JARID1A is a novel recurrent abnormality in pediatric acute megakaryoblastic leukemia with a distinct HOX gene expression pattern.
de Rooij JD, Hollink IH, Arentsen-Peters ST, van Galen JF, Berna Beverloo H, Baruchel A, Trka J, Reinhardt D, Sonneveld E, Zimmermann M, Alonzo TA, Pieters R, Meshinchi S, van den Heuvel-Eibrink MM, Zwaan CM
Leukemia 2013 Dec;27(12):2280-8. Epub 2013 Mar 27 doi: 10.1038/leu.2013.87. PMID: 23531517

Prognosis

NUP98-BPTF gene fusion identified in primary refractory acute megakaryoblastic leukemia of infancy.
Roussy M, Bilodeau M, Jouan L, Tibout P, Laramée L, Lemyre E, Léveillé F, Tihy F, Cardin S, Sauvageau C, Couture F, Louis I, Choblet A, Patey N, Gendron P, Duval M, Teira P, Hébert J, Wilhelm BT, Choi JK, Gruber TA, Bittencourt H, Cellot S
Genes Chromosomes Cancer 2018 Jun;57(6):311-319. Epub 2018 Mar 28 doi: 10.1002/gcc.22532. PMID: 29427526
New hPSC-based human models to study pediatric Acute Megakaryoblastic Leukemia harboring the fusion oncogene RBM15-MKL1.
Ayllón V, Vogel-González M, González-Pozas F, Domingo-Reinés J, Montes R, Morales-Cacho L, Ramos-Mejía V
Stem Cell Res 2017 Mar;19:1-5. Epub 2016 Dec 19 doi: 10.1016/j.scr.2016.12.019. PMID: 28412998
Prognostic impact of specific molecular profiles in pediatric acute megakaryoblastic leukemia in non-Down syndrome.
Hara Y, Shiba N, Ohki K, Tabuchi K, Yamato G, Park MJ, Tomizawa D, Kinoshita A, Shimada A, Arakawa H, Saito AM, Kiyokawa N, Tawa A, Horibe K, Taga T, Adachi S, Taki T, Hayashi Y
Genes Chromosomes Cancer 2017 May;56(5):394-404. Epub 2017 Feb 14 doi: 10.1002/gcc.22444. PMID: 28063190
NUP98/JARID1A is a novel recurrent abnormality in pediatric acute megakaryoblastic leukemia with a distinct HOX gene expression pattern.
de Rooij JD, Hollink IH, Arentsen-Peters ST, van Galen JF, Berna Beverloo H, Baruchel A, Trka J, Reinhardt D, Sonneveld E, Zimmermann M, Alonzo TA, Pieters R, Meshinchi S, van den Heuvel-Eibrink MM, Zwaan CM
Leukemia 2013 Dec;27(12):2280-8. Epub 2013 Mar 27 doi: 10.1038/leu.2013.87. PMID: 23531517

Clinical prediction guides

OTT-MAL is a deregulated activator of serum response factor-dependent gene expression.
Descot A, Rex-Haffner M, Courtois G, Bluteau D, Menssen A, Mercher T, Bernard OA, Treisman R, Posern G
Mol Cell Biol 2008 Oct;28(20):6171-81. Epub 2008 Aug 18 doi: 10.1128/MCB.00303-08. PMID: 18710951Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...