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Prostatic Clear Cell Cribriform Hyperplasia

MedGen UID:
277538
•Concept ID:
C1335525
•
Pathologic Function
Synonyms: CCCH of the Prostate; Clear Cell Cribriform Hyperplasia of the Prostate; Cribriform Hyperplasia of Prostate; Cribriform Hyperplasia of the Prostate; Cribriform Prostate Hyperplasia; Prostatic CCCH; Prostatic Cribriform Hyperplasia

Definition

A rare type of prostatic hyperplasia. It is characterized by hyperplastic glandular cells with clear cytoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProstatic Clear Cell Cribriform Hyperplasia

Professional guidelines

PubMed

Treatment of benign prostatic hyperplasia with 5-alpha-reductase inhibitor: morphological changes in patients who fail to respond.
Montironi R, Valli M, Fabris G
J Clin Pathol 1996 Apr;49(4):324-8. doi: 10.1136/jcp.49.4.324. PMID: 8655710Free PMC Article

Recent clinical studies

Etiology

Histomorphological study of prostatic adenocarcinoma and its mimics.
Mahapatra QS, Mohanty P, Nanda A, Mohanty L
Indian J Pathol Microbiol 2019 Apr-Jun;62(2):251-260. doi: 10.4103/IJPM.IJPM_322_18. PMID: 30971549
Retrospective Analysis of Atypical Glands Suspicious for Carcinoma in Transurethral Resection of Prostate.
Chen S, Patil PA, Lepe M, Lombardo KA, Amin A, Matoso A
Appl Immunohistochem Mol Morphol 2018 Mar;26(3):186-191. doi: 10.1097/PAI.0000000000000407. PMID: 27299192
Precursor lesions to prostatic adenocarcinoma.
Epstein JI
Virchows Arch 2009 Jan;454(1):1-16. Epub 2008 Dec 2 doi: 10.1007/s00428-008-0707-5. PMID: 19048290
Basal cell proliferations of the prostate other than usual basal cell hyperplasia: a clinicopathologic study of 23 cases, including four carcinomas, with a proposed classification.
McKenney JK, Amin MB, Srigley JR, Jimenez RE, Ro JY, Grignon DJ, Young RH
Am J Surg Pathol 2004 Oct;28(10):1289-98. doi: 10.1097/01.pas.0000138180.95581.e1. PMID: 15371944

Diagnosis

Cribriform Lesions of the Prostate Gland.
Cai Q, Shah RB
Surg Pathol Clin 2022 Dec;15(4):591-608. Epub 2022 Oct 13 doi: 10.1016/j.path.2022.07.001. PMID: 36344177
Histomorphological study of prostatic adenocarcinoma and its mimics.
Mahapatra QS, Mohanty P, Nanda A, Mohanty L
Indian J Pathol Microbiol 2019 Apr-Jun;62(2):251-260. doi: 10.4103/IJPM.IJPM_322_18. PMID: 30971549
Pseudoneoplastic mimics of prostate and bladder carcinomas.
Hameed O, Humphrey PA
Arch Pathol Lab Med 2010 Mar;134(3):427-43. doi: 10.5858/134.3.427. PMID: 20196670
Precursor lesions to prostatic adenocarcinoma.
Epstein JI
Virchows Arch 2009 Jan;454(1):1-16. Epub 2008 Dec 2 doi: 10.1007/s00428-008-0707-5. PMID: 19048290
Clear cell cribriform hyperplasia of prostate. Report of 10 cases.
Ayala AG, Srigley JR, Ro JY, Abdul-Karim FW, Johnson DE
Am J Surg Pathol 1986 Oct;10(10):665-71. doi: 10.1097/00000478-198610000-00001. PMID: 3766845

Therapy

Treatment of benign prostatic hyperplasia with 5-alpha-reductase inhibitor: morphological changes in patients who fail to respond.
Montironi R, Valli M, Fabris G
J Clin Pathol 1996 Apr;49(4):324-8. doi: 10.1136/jcp.49.4.324. PMID: 8655710Free PMC Article

Prognosis

Retrospective Analysis of Atypical Glands Suspicious for Carcinoma in Transurethral Resection of Prostate.
Chen S, Patil PA, Lepe M, Lombardo KA, Amin A, Matoso A
Appl Immunohistochem Mol Morphol 2018 Mar;26(3):186-191. doi: 10.1097/PAI.0000000000000407. PMID: 27299192

Clinical prediction guides

Treatment of benign prostatic hyperplasia with 5-alpha-reductase inhibitor: morphological changes in patients who fail to respond.
Montironi R, Valli M, Fabris G
J Clin Pathol 1996 Apr;49(4):324-8. doi: 10.1136/jcp.49.4.324. PMID: 8655710Free PMC Article

Supplemental Content

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