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Class II obesity

MedGen UID:
281328
•Concept ID:
C1556380
•
Finding
Synonyms: CTCAE Grade 2 Obesity; Grade 2 Obesity, CTCAE; Obesity grade 2
 
HPO: HP:0025500

Definition

Obesity with a body mass index of 35 to 39.9 kg per square meter. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClass II obesity

Professional guidelines

PubMed

Current recommendations for procedure selection in class I and II obesity developed by an expert modified Delphi consensus.
Kermansaravi M, Chiappetta S, Parmar C, Shikora SA, Prager G, LaMasters T, Ponce J, Kow L, Nimeri A, Kothari SN, Aarts E, Abbas SI, Aly A, Aminian A, Bashir A, Behrens E, Billy H, Carbajo MA, Clapp B, Chevallier JM, Cohen RV, Dargent J, Dillemans B, Faria SL, Neto MG, Garneau PY, Gawdat K, Haddad A, ElFawal MH, Higa K, Himpens J, Husain F, Hutter MM, Kasama K, Kassir R, Khan A, Khoursheed M, Kroh M, Kurian MS, Lee WJ, Loi K, Mahawar K, McBride CL, Almomani H, Melissas J, Miller K, Misra M, Musella M, Northup CJ, O'Kane M, Papasavas PK, Palermo M, Peterson RM, Peterli R, Poggi L, Pratt JSA, Alqahtani A, Ramos AC, Rheinwalt K, Ribeiro R, Rogers AM, Safadi B, Salminen P, Santoro S, Sann N, Scott JD, Shabbir A, Sogg S, Stenberg E, Suter M, Torres A, Ugale S, Vilallonga R, Wang C, Weiner R, Zundel N, Angrisani L, De Luca M
Sci Rep 2024 Feb 11;14(1):3445. doi: 10.1038/s41598-024-54141-6. PMID: 38341469Free PMC Article
Height and Growth Velocity in Children and Adolescents Undergoing Obesity Treatment: A Prospective Cohort Study.
Putri RR, Danielsson P, Marcus C, Hagman E
J Clin Endocrinol Metab 2023 Dec 21;109(1):e314-e320. doi: 10.1210/clinem/dgad419. PMID: 37453086Free PMC Article
Prevalence and Management of Adult Obesity in a Large U.S. Academic Health System.
Lumsden RH, Pagidipati NJ, Phelan MP, Chiswell K, Peterson ED
Am J Prev Med 2020 Jun;58(6):817-824. doi: 10.1016/j.amepre.2020.01.018. PMID: 32444000

Recent clinical studies

Etiology

Current recommendations for procedure selection in class I and II obesity developed by an expert modified Delphi consensus.
Kermansaravi M, Chiappetta S, Parmar C, Shikora SA, Prager G, LaMasters T, Ponce J, Kow L, Nimeri A, Kothari SN, Aarts E, Abbas SI, Aly A, Aminian A, Bashir A, Behrens E, Billy H, Carbajo MA, Clapp B, Chevallier JM, Cohen RV, Dargent J, Dillemans B, Faria SL, Neto MG, Garneau PY, Gawdat K, Haddad A, ElFawal MH, Higa K, Himpens J, Husain F, Hutter MM, Kasama K, Kassir R, Khan A, Khoursheed M, Kroh M, Kurian MS, Lee WJ, Loi K, Mahawar K, McBride CL, Almomani H, Melissas J, Miller K, Misra M, Musella M, Northup CJ, O'Kane M, Papasavas PK, Palermo M, Peterson RM, Peterli R, Poggi L, Pratt JSA, Alqahtani A, Ramos AC, Rheinwalt K, Ribeiro R, Rogers AM, Safadi B, Salminen P, Santoro S, Sann N, Scott JD, Shabbir A, Sogg S, Stenberg E, Suter M, Torres A, Ugale S, Vilallonga R, Wang C, Weiner R, Zundel N, Angrisani L, De Luca M
Sci Rep 2024 Feb 11;14(1):3445. doi: 10.1038/s41598-024-54141-6. PMID: 38341469Free PMC Article
Changes in body mass index and waist circumference and heart failure in type 2 diabetes mellitus.
Zhou Y, Chai X, Yang G, Sun X, Xing Z
Front Endocrinol (Lausanne) 2023;14:1305839. Epub 2023 Dec 21 doi: 10.3389/fendo.2023.1305839. PMID: 38179309Free PMC Article
Efficacy and safety of subcutaneous semaglutide in adults with overweight or obese: a subgroup meta-analysis of randomized controlled trials.
Zhang R, Hou QC, Li BH, Deng L, Yang YM, Li TX, Yao XQ, Yang LL, Lin XL, Liao YQ, Wang L, Liu YP, Tan J, Wan ZW, Shuai P
Front Endocrinol (Lausanne) 2023;14:1132004. Epub 2023 Jun 26 doi: 10.3389/fendo.2023.1132004. PMID: 37455913Free PMC Article
Dapagliflozin for heart failure according to body mass index: the DELIVER trial.
Adamson C, Kondo T, Jhund PS, de Boer RA, Cabrera Honorio JW, Claggett B, Desai AS, Alcocer Gamba MA, Al Habeeb W, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Langkilde AM, Lindholm D, Bachus E, Litwin SE, Martinez F, Petersson M, Shah SJ, Vaduganathan M, Nguyen Vinh P, Wilderäng U, Solomon SD, McMurray JJV
Eur Heart J 2022 Nov 1;43(41):4406-4417. doi: 10.1093/eurheartj/ehac481. PMID: 36029309Free PMC Article
ASMBS pediatric metabolic and bariatric surgery guidelines, 2018.
Pratt JSA, Browne A, Browne NT, Bruzoni M, Cohen M, Desai A, Inge T, Linden BC, Mattar SG, Michalsky M, Podkameni D, Reichard KW, Stanford FC, Zeller MH, Zitsman J
Surg Obes Relat Dis 2018 Jul;14(7):882-901. Epub 2018 Mar 23 doi: 10.1016/j.soard.2018.03.019. PMID: 30077361Free PMC Article

Diagnosis

Semaglutide vs Endoscopic Sleeve Gastroplasty for Weight Loss.
Haseeb M, Chhatwal J, Xiao J, Jirapinyo P, Thompson CC
JAMA Netw Open 2024 Apr 1;7(4):e246221. doi: 10.1001/jamanetworkopen.2024.6221. PMID: 38607627Free PMC Article
UK cost-effectiveness analysis of endoscopic sleeve gastroplasty versus lifestyle modification alone for adults with class II obesity.
Kelly J, Menon V, O'Neill F, Elliot L, Combe E, Drinkwater W, Abbott S, Hayee B
Int J Obes (Lond) 2023 Nov;47(11):1161-1170. Epub 2023 Sep 6 doi: 10.1038/s41366-023-01374-6. PMID: 37674032Free PMC Article
Cost-effectiveness of endoscopic, surgical and pharmacological obesity therapies: a microsimulation and threshold analyses.
Saumoy M, Gandhi D, Buller S, Patel S, Schneider Y, Cote G, Kochman ML, Thiruvengadam NR, Sharaiha RZ
Gut 2023 Nov 24;72(12):2250-2259. doi: 10.1136/gutjnl-2023-330437. PMID: 37524445
Effects of obesity class on flat ground walking and obstacle negotiation.
Gill SV
J Musculoskelet Neuronal Interact 2019 Dec 1;19(4):448-454. PMID: 31789295Free PMC Article
ASMBS pediatric metabolic and bariatric surgery guidelines, 2018.
Pratt JSA, Browne A, Browne NT, Bruzoni M, Cohen M, Desai A, Inge T, Linden BC, Mattar SG, Michalsky M, Podkameni D, Reichard KW, Stanford FC, Zeller MH, Zitsman J
Surg Obes Relat Dis 2018 Jul;14(7):882-901. Epub 2018 Mar 23 doi: 10.1016/j.soard.2018.03.019. PMID: 30077361Free PMC Article

Therapy

Current recommendations for procedure selection in class I and II obesity developed by an expert modified Delphi consensus.
Kermansaravi M, Chiappetta S, Parmar C, Shikora SA, Prager G, LaMasters T, Ponce J, Kow L, Nimeri A, Kothari SN, Aarts E, Abbas SI, Aly A, Aminian A, Bashir A, Behrens E, Billy H, Carbajo MA, Clapp B, Chevallier JM, Cohen RV, Dargent J, Dillemans B, Faria SL, Neto MG, Garneau PY, Gawdat K, Haddad A, ElFawal MH, Higa K, Himpens J, Husain F, Hutter MM, Kasama K, Kassir R, Khan A, Khoursheed M, Kroh M, Kurian MS, Lee WJ, Loi K, Mahawar K, McBride CL, Almomani H, Melissas J, Miller K, Misra M, Musella M, Northup CJ, O'Kane M, Papasavas PK, Palermo M, Peterson RM, Peterli R, Poggi L, Pratt JSA, Alqahtani A, Ramos AC, Rheinwalt K, Ribeiro R, Rogers AM, Safadi B, Salminen P, Santoro S, Sann N, Scott JD, Shabbir A, Sogg S, Stenberg E, Suter M, Torres A, Ugale S, Vilallonga R, Wang C, Weiner R, Zundel N, Angrisani L, De Luca M
Sci Rep 2024 Feb 11;14(1):3445. doi: 10.1038/s41598-024-54141-6. PMID: 38341469Free PMC Article
Changes in body mass index and waist circumference and heart failure in type 2 diabetes mellitus.
Zhou Y, Chai X, Yang G, Sun X, Xing Z
Front Endocrinol (Lausanne) 2023;14:1305839. Epub 2023 Dec 21 doi: 10.3389/fendo.2023.1305839. PMID: 38179309Free PMC Article
Efficacy and safety of subcutaneous semaglutide in adults with overweight or obese: a subgroup meta-analysis of randomized controlled trials.
Zhang R, Hou QC, Li BH, Deng L, Yang YM, Li TX, Yao XQ, Yang LL, Lin XL, Liao YQ, Wang L, Liu YP, Tan J, Wan ZW, Shuai P
Front Endocrinol (Lausanne) 2023;14:1132004. Epub 2023 Jun 26 doi: 10.3389/fendo.2023.1132004. PMID: 37455913Free PMC Article
Clinical review of subcutaneous semaglutide for obesity.
Phillips A, Clements JN
J Clin Pharm Ther 2022 Feb;47(2):184-193. Epub 2021 Dec 28 doi: 10.1111/jcpt.13574. PMID: 34964141
Obesity affects outcomes of pancreatoduodenectomy.
Zorbas K, Wu J, Reddy S, Esnaola N, Karachristos A
Pancreatology 2021 Jun;21(4):824-832. Epub 2021 Mar 4 doi: 10.1016/j.pan.2021.02.019. PMID: 33752975

Prognosis

Clinical impact of body mass index on outcomes of ischemic and hemorrhagic strokes.
Miwa K, Nakai M, Yoshimura S, Sasahara Y, Wada S, Koge J, Ishigami A, Yagita Y, Kamiyama K, Miyamoto Y, Kobayashi S, Minematsu K, Toyoda K, Koga M
Int J Stroke 2024 Oct;19(8):907-915. Epub 2024 May 6 doi: 10.1177/17474930241249370. PMID: 38651751Free PMC Article
Metabolic and Bariatric Surgery in Adolescents: For Whom, When, and How?
Janson A, Järvholm K, Sjögren L, Dahlgren J, Beamish AJ, Gronowitz E, Olbers T
Horm Res Paediatr 2023;96(6):609-619. Epub 2022 Mar 9 doi: 10.1159/000524002. PMID: 35263750
Non-alcoholic Wernicke encephalopathy: great masquerader.
Okafor C, Nimmagadda M, Soin S, Lanka L
BMJ Case Rep 2018 Dec 27;11(1) doi: 10.1136/bcr-2018-227731. PMID: 30593527Free PMC Article
Obesity and 30-Day Outcomes Following Minimally Invasive Nephrectomy.
Sperling CD, Xia L, Berger IB, Shin MH, Strother MC, Guzzo TJ
Urology 2018 Nov;121:104-111. Epub 2018 Aug 16 doi: 10.1016/j.urology.2018.08.002. PMID: 30121194
ASMBS pediatric metabolic and bariatric surgery guidelines, 2018.
Pratt JSA, Browne A, Browne NT, Bruzoni M, Cohen M, Desai A, Inge T, Linden BC, Mattar SG, Michalsky M, Podkameni D, Reichard KW, Stanford FC, Zeller MH, Zitsman J
Surg Obes Relat Dis 2018 Jul;14(7):882-901. Epub 2018 Mar 23 doi: 10.1016/j.soard.2018.03.019. PMID: 30077361Free PMC Article

Clinical prediction guides

Clinical impact of body mass index on outcomes of ischemic and hemorrhagic strokes.
Miwa K, Nakai M, Yoshimura S, Sasahara Y, Wada S, Koge J, Ishigami A, Yagita Y, Kamiyama K, Miyamoto Y, Kobayashi S, Minematsu K, Toyoda K, Koga M
Int J Stroke 2024 Oct;19(8):907-915. Epub 2024 May 6 doi: 10.1177/17474930241249370. PMID: 38651751Free PMC Article
Changes in body mass index and waist circumference and heart failure in type 2 diabetes mellitus.
Zhou Y, Chai X, Yang G, Sun X, Xing Z
Front Endocrinol (Lausanne) 2023;14:1305839. Epub 2023 Dec 21 doi: 10.3389/fendo.2023.1305839. PMID: 38179309Free PMC Article
Dapagliflozin for heart failure according to body mass index: the DELIVER trial.
Adamson C, Kondo T, Jhund PS, de Boer RA, Cabrera Honorio JW, Claggett B, Desai AS, Alcocer Gamba MA, Al Habeeb W, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Langkilde AM, Lindholm D, Bachus E, Litwin SE, Martinez F, Petersson M, Shah SJ, Vaduganathan M, Nguyen Vinh P, Wilderäng U, Solomon SD, McMurray JJV
Eur Heart J 2022 Nov 1;43(41):4406-4417. doi: 10.1093/eurheartj/ehac481. PMID: 36029309Free PMC Article
Effects of obesity class on flat ground walking and obstacle negotiation.
Gill SV
J Musculoskelet Neuronal Interact 2019 Dec 1;19(4):448-454. PMID: 31789295Free PMC Article
ASMBS pediatric metabolic and bariatric surgery guidelines, 2018.
Pratt JSA, Browne A, Browne NT, Bruzoni M, Cohen M, Desai A, Inge T, Linden BC, Mattar SG, Michalsky M, Podkameni D, Reichard KW, Stanford FC, Zeller MH, Zitsman J
Surg Obes Relat Dis 2018 Jul;14(7):882-901. Epub 2018 Mar 23 doi: 10.1016/j.soard.2018.03.019. PMID: 30077361Free PMC Article

Recent systematic reviews

Bariatric Surgery in Patients with Obesity and Ventricular Assist Devices Considered for Heart Transplantation: Systematic Review and Individual Participant Data Meta-analysis.
daSilva-deAbreu A, Alhafez BA, Curbelo-Pena Y, Lavie CJ, Ventura HO, Loro-Ferrer JF, Mandras SA
J Card Fail 2021 Mar;27(3):338-348. Epub 2020 Dec 25 doi: 10.1016/j.cardfail.2020.12.011. PMID: 33358959
Systematic review with meta-analysis: post-operative complications and mortality risk in liver transplant candidates with obesity.
Barone M, Viggiani MT, Losurdo G, Principi M, Leandro G, Di Leo A
Aliment Pharmacol Ther 2017 Aug;46(3):236-245. Epub 2017 May 10 doi: 10.1111/apt.14139. PMID: 28488418
Gestational weight gain in obese women by class of obesity and select maternal/newborn outcomes: A systematic review.
Faucher MA, Barger MK
Women Birth 2015 Sep;28(3):e70-9. Epub 2015 Apr 9 doi: 10.1016/j.wombi.2015.03.006. PMID: 25866207
Body mass index and colon cancer screening: a systematic review and meta-analysis.
Maruthur NM, Bolen S, Gudzune K, Brancati FL, Clark JM
Cancer Epidemiol Biomarkers Prev 2012 May;21(5):737-46. Epub 2012 Apr 4 doi: 10.1158/1055-9965.EPI-11-0826. PMID: 22492832Free PMC Article
Increasing body weight and risk of limitations in activities of daily living: a systematic review and meta-analysis.
Backholer K, Wong E, Freak-Poli R, Walls HL, Peeters A
Obes Rev 2012 May;13(5):456-68. Epub 2011 Dec 28 doi: 10.1111/j.1467-789X.2011.00970.x. PMID: 22212629

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