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Sinonasal Inverted Papilloma

MedGen UID:
283935
•Concept ID:
C1537102
•
Neoplastic Process
Synonyms: Inverted Schneiderian Papilloma; Sinonasal Inverted Schneiderian Papilloma

Definition

A benign neoplasm that arises from the ciliated respiratory mucosa that lines the nasal cavity or paranasal sinuses. It results from the invagination and proliferation of epithelial cells in the underlying stroma. Clinical manifestations include nasal obstruction, epistaxis, and anosmia. It has the tendency to recur and extend to adjacent structures. Inverted papillomas are occasionally associated with the development or presence of carcinomas, usually squamous cell carcinomas. [from NCI]

Professional guidelines

PubMed

DIAGNOSIS AND TREATMENT OF PATIENTS WITH SINONASAL INVERTED PAPILLOMA.
Zabolotnyi D, Zabolotna D, Zinchenko D, Tsvirinko I, Kizim Y
Georgian Med News 2020 Sep;(306):31-37. PMID: 33130642
Clinical management of emerging sinonasal malignancies.
Contrera KJ, Woody NM, Rahman M, Sindwani R, Burkey BB
Head Neck 2020 Aug;42(8):2202-2212. Epub 2020 Mar 25 doi: 10.1002/hed.26150. PMID: 32212360
Sinonasal inverted papilloma: From diagnosis to treatment.
Lisan Q, Laccourreye O, Bonfils P
Eur Ann Otorhinolaryngol Head Neck Dis 2016 Nov;133(5):337-341. Epub 2016 Apr 1 doi: 10.1016/j.anorl.2016.03.006. PMID: 27053431

Recent clinical studies

Etiology

Sinonasal inverted papilloma - malignant transformation and non-sinonasal malignancies.
Viitasalo S, Ilmarinen T, Aaltonen LM, Hagström J, Hytönen M, Hammarén-Malmi S, Pietarinen P, Järvenpää P, Kinnari T, Geneid A, Lilja M
Laryngoscope 2023 Mar;133(3):506-511. Epub 2022 Apr 5 doi: 10.1002/lary.30128. PMID: 35383941
Endoscopic Resection of Sinonasal Inverted Papilloma: Systematic Review and Meta-Analysis.
Goudakos JK, Blioskas S, Nikolaou A, Vlachtsis K, Karkos P, Markou KD
Am J Rhinol Allergy 2018 May;32(3):167-174. Epub 2018 Apr 12 doi: 10.1177/1945892418765004. PMID: 29649889
Malignant transformation of sinonasal inverted papilloma and related genetic alterations: a systematic review.
Re M, Gioacchini FM, Bajraktari A, Tomasetti M, Kaleci S, Rubini C, Bertini A, Magliulo G, Pasquini E
Eur Arch Otorhinolaryngol 2017 Aug;274(8):2991-3000. Epub 2017 Apr 21 doi: 10.1007/s00405-017-4571-2. PMID: 28432463
Sinonasal inverted papilloma: From diagnosis to treatment.
Lisan Q, Laccourreye O, Bonfils P
Eur Ann Otorhinolaryngol Head Neck Dis 2016 Nov;133(5):337-341. Epub 2016 Apr 1 doi: 10.1016/j.anorl.2016.03.006. PMID: 27053431
Sinonasal inverted papilloma: narrative review.
Anari S, Carrie S
J Laryngol Otol 2010 Jul;124(7):705-15. Epub 2010 Apr 14 doi: 10.1017/S0022215110000599. PMID: 20388243

Diagnosis

Sinonasal inverted papilloma - malignant transformation and non-sinonasal malignancies.
Viitasalo S, Ilmarinen T, Aaltonen LM, Hagström J, Hytönen M, Hammarén-Malmi S, Pietarinen P, Järvenpää P, Kinnari T, Geneid A, Lilja M
Laryngoscope 2023 Mar;133(3):506-511. Epub 2022 Apr 5 doi: 10.1002/lary.30128. PMID: 35383941
Decreased Expressions of CK1α and PTEN in Sinonasal Inverted Papilloma.
Liu X, Zhang XJ
Appl Immunohistochem Mol Morphol 2022 Jul 1;30(6):469-475. Epub 2022 May 17 doi: 10.1097/PAI.0000000000001034. PMID: 35588152
Risk Factors of Recurrence and Malignant Transformation of Sinonasal Inverted Papilloma.
Gamrot-Wrzoł M, Sowa P, Lisowska G, Ścierski W, Misiołek M
Biomed Res Int 2017;2017:9195163. Epub 2017 Nov 9 doi: 10.1155/2017/9195163. PMID: 29250552Free PMC Article
Sinonasal inverted papilloma: From diagnosis to treatment.
Lisan Q, Laccourreye O, Bonfils P
Eur Ann Otorhinolaryngol Head Neck Dis 2016 Nov;133(5):337-341. Epub 2016 Apr 1 doi: 10.1016/j.anorl.2016.03.006. PMID: 27053431
Imaging Features of Sinonasal Inverted Papilloma: A Pictorial Review.
Chawla A, Shenoy J, Chokkappan K, Chung R
Curr Probl Diagn Radiol 2016 Sep-Oct;45(5):347-53. Epub 2015 Nov 11 doi: 10.1067/j.cpradiol.2015.10.004. PMID: 26632214

Therapy

Sinonasal inverted papilloma recurrence rates and evaluation of current staging systems.
Mak W, Webb D, Al-Salihi S, Dadgostar A, Javer A
Rhinology 2018 Dec 1;56(4):407-414. doi: 10.4193/Rhin18.039. PMID: 30033450
Association of Krouse Classification for Sinonasal Inverted Papilloma With Recurrence: A Systematic Review and Meta-analysis.
Lisan Q, Moya-Plana A, Bonfils P
JAMA Otolaryngol Head Neck Surg 2017 Nov 1;143(11):1104-1110. doi: 10.1001/jamaoto.2017.1686. PMID: 28973390Free PMC Article
Recurrence of sinonasal inverted papilloma following surgical approach: A meta-analysis.
Kim JS, Kwon SH
Laryngoscope 2017 Jan;127(1):52-58. Epub 2016 Aug 17 doi: 10.1002/lary.26222. PMID: 27531693
Smoking and malignancy in sinonasal inverted papilloma.
Hong SL, Kim BH, Lee JH, Cho KS, Roh HJ
Laryngoscope 2013 May;123(5):1087-91. Epub 2013 Mar 11 doi: 10.1002/lary.23876. PMID: 23619620
Focal malignancy in sinonasal inverted papilloma--is postoperative radiotherapy recommendable?
Sauter A
Oral Oncol 2011 Sep;47(9):779. Epub 2011 Mar 5 doi: 10.1016/j.oraloncology.2011.02.007. PMID: 21377918

Prognosis

Clinicopathological predictors of repeated recurrence in sinonasal inverted papilloma.
Bright RR, Varghese L, Kurian R, Telugu RB, Cherian LM, Antonisamy B, Thomas M, Rupa V, Kurien R
Eur Arch Otorhinolaryngol 2023 Mar;280(3):1191-1199. Epub 2022 Aug 6 doi: 10.1007/s00405-022-07585-3. PMID: 35932314
IMP3 Immunohistochemical Expression in Inverted Papilloma and Inverted Papilloma-Associated Sinonasal Squamous Cell Carcinoma.
Hakim SA, Abd Raboh NM, Shash LS
Anal Cell Pathol (Amst) 2021;2021:6639834. Epub 2021 Feb 16 doi: 10.1155/2021/6639834. PMID: 33680717Free PMC Article
Comparison of Current Staging Systems for Sinonasal Inverted Papilloma.
Nakayama T, Tsunemi Y, Kashiwagi T, Kuboki A, Yamakawa S, Konno W, Mori A, Iimura J, Tsukidate T, Tanaka Y, Haruna SI
Am J Rhinol Allergy 2021 Jan;35(1):64-71. Epub 2020 Jun 25 doi: 10.1177/1945892420933178. PMID: 32586102
The clinical behavior of sinonasal inverted papilloma with cellular dysplasia: case series and review of the literature.
Safadi A, Yafit D, Abu-Ghanem S, Ungar OJ, Wengier A, Abergel A, Fliss DM, Koren I
Eur Arch Otorhinolaryngol 2017 Sep;274(9):3375-3382. Epub 2017 Jun 8 doi: 10.1007/s00405-017-4629-1. PMID: 28597339
Sinonasal inverted papilloma: narrative review.
Anari S, Carrie S
J Laryngol Otol 2010 Jul;124(7):705-15. Epub 2010 Apr 14 doi: 10.1017/S0022215110000599. PMID: 20388243

Clinical prediction guides

Preoperative Prediction of Sinonasal Inverted Papilloma-associated Squamous Cell Carcinoma (IP-SCC).
Park MJ, Cho W, Kim JH, Chung YS, Jang YJ, Yu MS
Laryngoscope 2023 Oct;133(10):2502-2510. Epub 2023 Jan 23 doi: 10.1002/lary.30583. PMID: 36683553
Clinicopathological predictors of repeated recurrence in sinonasal inverted papilloma.
Bright RR, Varghese L, Kurian R, Telugu RB, Cherian LM, Antonisamy B, Thomas M, Rupa V, Kurien R
Eur Arch Otorhinolaryngol 2023 Mar;280(3):1191-1199. Epub 2022 Aug 6 doi: 10.1007/s00405-022-07585-3. PMID: 35932314
Comparison of Current Staging Systems for Sinonasal Inverted Papilloma.
Nakayama T, Tsunemi Y, Kashiwagi T, Kuboki A, Yamakawa S, Konno W, Mori A, Iimura J, Tsukidate T, Tanaka Y, Haruna SI
Am J Rhinol Allergy 2021 Jan;35(1):64-71. Epub 2020 Jun 25 doi: 10.1177/1945892420933178. PMID: 32586102
Clinical features of nasal and sinonasal inverted papilloma associated with malignancy.
Miyazaki T, Haku Y, Yoshizawa A, Iwanaga K, Fujiwara T, Mizuta M, Yoshida A, Satou S, Tamaki H
Auris Nasus Larynx 2018 Oct;45(5):1014-1019. Epub 2018 Mar 13 doi: 10.1016/j.anl.2018.02.009. PMID: 29548524
Sinonasal inverted papilloma: narrative review.
Anari S, Carrie S
J Laryngol Otol 2010 Jul;124(7):705-15. Epub 2010 Apr 14 doi: 10.1017/S0022215110000599. PMID: 20388243

Recent systematic reviews

Association between human papillomavirus infection and malignant transformation of sinonasal inverted papilloma: A systematic review and meta-analysis.
Ferreli F, Di Bari M, Moya-Plana A, Canzano F, Morenghi E, De Virgilio A, Mercante G, Spriano G, Colombo G
Am J Otolaryngol 2022 Nov-Dec;43(6):103614. Epub 2022 Sep 11 doi: 10.1016/j.amjoto.2022.103614. PMID: 36113312
Association Between Human Papilloma Virus Infection and Malignant Sinonasal Inverted Papilloma.
Ding R, Sun Q, Wang Y
Laryngoscope 2021 Jun;131(6):1200-1205. Epub 2020 Oct 28 doi: 10.1002/lary.29125. PMID: 33111993
Endoscopic Resection of Sinonasal Inverted Papilloma: Systematic Review and Meta-Analysis.
Goudakos JK, Blioskas S, Nikolaou A, Vlachtsis K, Karkos P, Markou KD
Am J Rhinol Allergy 2018 May;32(3):167-174. Epub 2018 Apr 12 doi: 10.1177/1945892418765004. PMID: 29649889
Association of Krouse Classification for Sinonasal Inverted Papilloma With Recurrence: A Systematic Review and Meta-analysis.
Lisan Q, Moya-Plana A, Bonfils P
JAMA Otolaryngol Head Neck Surg 2017 Nov 1;143(11):1104-1110. doi: 10.1001/jamaoto.2017.1686. PMID: 28973390Free PMC Article
Malignant transformation of sinonasal inverted papilloma and related genetic alterations: a systematic review.
Re M, Gioacchini FM, Bajraktari A, Tomasetti M, Kaleci S, Rubini C, Bertini A, Magliulo G, Pasquini E
Eur Arch Otorhinolaryngol 2017 Aug;274(8):2991-3000. Epub 2017 Apr 21 doi: 10.1007/s00405-017-4571-2. PMID: 28432463

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