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TAF15-NR4A3 Fusion Protein Expression

MedGen UID:
308098
•Concept ID:
C1514640
•
Cell or Molecular Dysfunction
Synonyms: RBP56-CHN Fusion Protein Expression; RBP56/CHN Fusion Protein Expression; TAF15/NR4A3 Fusion Protein Expression

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTAF15-NR4A3 Fusion Protein Expression

Recent clinical studies

Etiology

Extraskeletal myxoid chondrosarcoma: p53 and Ki-67 offer prognostic value for clinical outcome - an immunohistochemical and molecular analysis of 31 cases.
Giner F, López-Guerrero JA, Machado I, Rubio-Martínez LA, Espino M, Navarro S, Agra-Pujol C, Ferrández A, Llombart-Bosch A
Virchows Arch 2023 Feb;482(2):407-417. Epub 2022 Nov 14 doi: 10.1007/s00428-022-03453-x. PMID: 36376703

Diagnosis

Extraskeletal Myxoid Chondrosarcomas: The Uncommon Clinicopathologic Manifestations and Significance of TAF15::NR4A3 Fusion.
Huang SC, Lee JC, Hsu YC, Tsai JW, Kao YC, Hsieh TH, Chang YM, Chang KC, Wu PS, Chen PC, Chen CH, Chang CD, Lee PH, Tai HC, Liu TT, Wen MC, Li WS, Yu SC, Wang JC, Huang HY
Mod Pathol 2023 Jul;36(7):100161. Epub 2023 Mar 21 doi: 10.1016/j.modpat.2023.100161. PMID: 36948401
Keratin-positive fibrotic extraskeletal myxoid chondrosarcoma: a close mimic of myoepithelial tumour.
Sugino H, Iwata S, Satomi K, Mori T, Nobusawa S, Nagashima T, Matsushita Y, Yatabe Y, Ichimura K, Kawai A, Yoshida A
Histopathology 2023 May;82(6):937-945. Epub 2023 Feb 27 doi: 10.1111/his.14882. PMID: 36754860
Extraskeletal myxoid chondrosarcoma: A study of 17 cases focusing on the diagnostic utility of INSM1 expression and presenting rare morphological variants associated with non-EWSR1::NR4A3 fusions.
Lenz J, Klubíčková N, Ptáková N, Hájková V, Grossmann P, Šteiner P, Kinkor Z, Švajdler M, Michal M, Konečná P, Macháčová D, Hurník P, Tichý M, Tichý F, Kyllar M, Fiala L, Kavka M, Michal M
Hum Pathol 2023 Apr;134:19-29. Epub 2022 Dec 20 doi: 10.1016/j.humpath.2022.12.005. PMID: 36563884
Extraskeletal myxoid chondrosarcoma: p53 and Ki-67 offer prognostic value for clinical outcome - an immunohistochemical and molecular analysis of 31 cases.
Giner F, López-Guerrero JA, Machado I, Rubio-Martínez LA, Espino M, Navarro S, Agra-Pujol C, Ferrández A, Llombart-Bosch A
Virchows Arch 2023 Feb;482(2):407-417. Epub 2022 Nov 14 doi: 10.1007/s00428-022-03453-x. PMID: 36376703

Therapy

Activity of sunitinib in extraskeletal myxoid chondrosarcoma.
Stacchiotti S, Pantaleo MA, Astolfi A, Dagrada GP, Negri T, Dei Tos AP, Indio V, Morosi C, Gronchi A, Colombo C, Conca E, Toffolatti L, Tazzari M, Crippa F, Maestro R, Pilotti S, Casali PG
Eur J Cancer 2014 Jun;50(9):1657-64. Epub 2014 Apr 2 doi: 10.1016/j.ejca.2014.03.013. PMID: 24703573

Prognosis

Extraskeletal Myxoid Chondrosarcomas: The Uncommon Clinicopathologic Manifestations and Significance of TAF15::NR4A3 Fusion.
Huang SC, Lee JC, Hsu YC, Tsai JW, Kao YC, Hsieh TH, Chang YM, Chang KC, Wu PS, Chen PC, Chen CH, Chang CD, Lee PH, Tai HC, Liu TT, Wen MC, Li WS, Yu SC, Wang JC, Huang HY
Mod Pathol 2023 Jul;36(7):100161. Epub 2023 Mar 21 doi: 10.1016/j.modpat.2023.100161. PMID: 36948401
Keratin-positive fibrotic extraskeletal myxoid chondrosarcoma: a close mimic of myoepithelial tumour.
Sugino H, Iwata S, Satomi K, Mori T, Nobusawa S, Nagashima T, Matsushita Y, Yatabe Y, Ichimura K, Kawai A, Yoshida A
Histopathology 2023 May;82(6):937-945. Epub 2023 Feb 27 doi: 10.1111/his.14882. PMID: 36754860
Extraskeletal myxoid chondrosarcoma: p53 and Ki-67 offer prognostic value for clinical outcome - an immunohistochemical and molecular analysis of 31 cases.
Giner F, López-Guerrero JA, Machado I, Rubio-Martínez LA, Espino M, Navarro S, Agra-Pujol C, Ferrández A, Llombart-Bosch A
Virchows Arch 2023 Feb;482(2):407-417. Epub 2022 Nov 14 doi: 10.1007/s00428-022-03453-x. PMID: 36376703
NR4A3 fusion proteins trigger an axon guidance switch that marks the difference between EWSR1 and TAF15 translocated extraskeletal myxoid chondrosarcomas.
Brenca M, Stacchiotti S, Fassetta K, Sbaraglia M, Janjusevic M, Racanelli D, Polano M, Rossi S, Brich S, Dagrada GP, Collini P, Colombo C, Gronchi A, Astolfi A, Indio V, Pantaleo MA, Picci P, Casali PG, Dei Tos AP, Pilotti S, Maestro R
J Pathol 2019 Sep;249(1):90-101. Epub 2019 May 14 doi: 10.1002/path.5284. PMID: 31020999Free PMC Article

Clinical prediction guides

Keratin-positive fibrotic extraskeletal myxoid chondrosarcoma: a close mimic of myoepithelial tumour.
Sugino H, Iwata S, Satomi K, Mori T, Nobusawa S, Nagashima T, Matsushita Y, Yatabe Y, Ichimura K, Kawai A, Yoshida A
Histopathology 2023 May;82(6):937-945. Epub 2023 Feb 27 doi: 10.1111/his.14882. PMID: 36754860
Extraskeletal myxoid chondrosarcoma: p53 and Ki-67 offer prognostic value for clinical outcome - an immunohistochemical and molecular analysis of 31 cases.
Giner F, López-Guerrero JA, Machado I, Rubio-Martínez LA, Espino M, Navarro S, Agra-Pujol C, Ferrández A, Llombart-Bosch A
Virchows Arch 2023 Feb;482(2):407-417. Epub 2022 Nov 14 doi: 10.1007/s00428-022-03453-x. PMID: 36376703
NR4A3 fusion proteins trigger an axon guidance switch that marks the difference between EWSR1 and TAF15 translocated extraskeletal myxoid chondrosarcomas.
Brenca M, Stacchiotti S, Fassetta K, Sbaraglia M, Janjusevic M, Racanelli D, Polano M, Rossi S, Brich S, Dagrada GP, Collini P, Colombo C, Gronchi A, Astolfi A, Indio V, Pantaleo MA, Picci P, Casali PG, Dei Tos AP, Pilotti S, Maestro R
J Pathol 2019 Sep;249(1):90-101. Epub 2019 May 14 doi: 10.1002/path.5284. PMID: 31020999Free PMC Article
Activity of sunitinib in extraskeletal myxoid chondrosarcoma.
Stacchiotti S, Pantaleo MA, Astolfi A, Dagrada GP, Negri T, Dei Tos AP, Indio V, Morosi C, Gronchi A, Colombo C, Conca E, Toffolatti L, Tazzari M, Crippa F, Maestro R, Pilotti S, Casali PG
Eur J Cancer 2014 Jun;50(9):1657-64. Epub 2014 Apr 2 doi: 10.1016/j.ejca.2014.03.013. PMID: 24703573

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