p230 Fusion Protein Expression

MedGen UID:: 308356
•Concept ID:: C1515676
•: Cell or Molecular Dysfunction

Synonyms:

p230 BCR-ABL1 Fusion Protein Expression; p230 BCR/ABL1 Fusion Protein Expression

Definition

Expression of a fusion protein with an apparent molecular weight of 230 kilodaltons that results from a fusion of the human genes BCR and ABL1. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVp230 Fusion Protein Expression

Molecular Genetic Variation
- Gene Abnormality
  - Deregulation of Protein and Messenger RNA Expression
    - Protein Deregulation
      - Fusion Protein Expression
        BCR-ABL1 Fusion Protein Expression
        p230 Fusion Protein Expression

Recent clinical studies

Etiology

BCR/ABL p210, p190 and p230 fusion genes in 250 Mexican patients with chronic myeloid leukaemia (CML).

Arana-Trejo RM, Ruíz Sánchez E, Ignacio-Ibarra G, Báez de la Fuente E, Garces O, Gómez Morales E, Castro Granados M, Ovilla Martínez R, Rubio-Borja ME, Solís Anaya L, Herrera P, Delgado Llamas J, Kofman S
Clin Lab Haematol 2002 Jun;24(3):145-50. doi: 10.1046/j.1365-2257.2002.00413.x. PMID: 12067277

Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases.

Quackenbush RC, Reuther GW, Miller JP, Courtney KD, Pear WS, Pendergast AM
Blood 2000 May 1;95(9):2913-21. PMID: 10779439

See all (2)

Diagnosis

Use of the «BCR/ABL - multitest» kit in the algorithm of laboratory diagnostics of oncohematological diseases: economic aspects.

Gorbenko AS, Stolyar MA, Vasiliev EV, Mikhalev MA, Bakhtina VI, Olkhovik TI, Mochalova EE, Orlova KE, Olkhovskiy IA
Klin Lab Diagn 2021 Sep 10;66(9):571-576. doi: 10.51620/0869-2084-2021-66-9-571-576. PMID: 34543537

Frequency of BCR-ABL fusion transcripts in Iranian patients with chronic myeloid leukemia.

Yaghmaie M, Ghaffari SH, Ghavamzadeh A, Alimoghaddam K, Jahani M, Mousavi SA, Irvani M, Bahar B, Bibordi I
Arch Iran Med 2008 May;11(3):247-51. PMID: 18426313

BCR/ABL p210, p190 and p230 fusion genes in 250 Mexican patients with chronic myeloid leukaemia (CML).

The Golgi-targeting sequence of the peripheral membrane protein p230.

Kjer-Nielsen L, van Vliet C, Erlich R, Toh BH, Gleeson PA
J Cell Sci 1999 Jun;112 ( Pt 11):1645-54. doi: 10.1242/jcs.112.11.1645. PMID: 10318758

P230 BCR/ABL protein may be associated with an acute leukaemia phenotype.

Haskovec C, Ponzetto C, Polák J, Maritano D, Zemanová Z, Serra A, Michalová K, Klamová H, Cermák J, Saglio G
Br J Haematol 1998 Dec;103(4):1104-8. doi: 10.1046/j.1365-2141.1998.01098.x. PMID: 9886327

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Therapy

Clonal evolution with double Ph followed by tetraploidy in imatinib-treated chronic myeloid leukemia with e19a2 transcript in transformation.

Oshikawa G, Kurosu T, Arai A, Murakami N, Miura O
Cancer Genet Cytogenet 2010 May;199(1):56-61. doi: 10.1016/j.cancergencyto.2010.01.018. PMID: 20417871

Bcr-abl-positive cells secrete angiogenic factors including matrix metalloproteinases and stimulate angiogenesis in vivo in Matrigel implants.

Janowska-Wieczorek A, Majka M, Marquez-Curtis L, Wertheim JA, Turner AR, Ratajczak MZ
Leukemia 2002 Jun;16(6):1160-6. doi: 10.1038/sj.leu.2402486. PMID: 12040448

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Prognosis

Clonal evolution with double Ph followed by tetraploidy in imatinib-treated chronic myeloid leukemia with e19a2 transcript in transformation.

Oshikawa G, Kurosu T, Arai A, Murakami N, Miura O
Cancer Genet Cytogenet 2010 May;199(1):56-61. doi: 10.1016/j.cancergencyto.2010.01.018. PMID: 20417871

Frequency of BCR-ABL fusion transcripts in Iranian patients with chronic myeloid leukemia.

Yaghmaie M, Ghaffari SH, Ghavamzadeh A, Alimoghaddam K, Jahani M, Mousavi SA, Irvani M, Bahar B, Bibordi I
Arch Iran Med 2008 May;11(3):247-51. PMID: 18426313

BCR/ABL p210, p190 and p230 fusion genes in 250 Mexican patients with chronic myeloid leukaemia (CML).

See all (3)