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t(8;14)(q24;q11)

MedGen UID:
308385
•Concept ID:
C1515791
•
Cell or Molecular Dysfunction

Definition

A chromosomal abnormality consisting of the translocation of 8q24 with 14q11, which juxtaposes the c-MYC gene with the gene for the T cell receptor alpha chain resulting in overexpression of c-MYC in T cells bearing the translocation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVt(8;14)(q24;q11)

Recent clinical studies

Etiology

Characteristics and therapeutic approaches for patients diagnosed with T-ALL/LBL exhibiting t(8;14)(q24;q11)/TCRA/D:MYC translocation.
Zhang X, Wang T, Zhang Y, Wang F, Chen J, Ni J, Sun R, Wei Z, Zhang G, Li W, Li J, Lu P
Leuk Lymphoma 2023 Dec;64(13):2133-2139. Epub 2023 Sep 7 doi: 10.1080/10428194.2023.2254428. PMID: 37674391
Translocation t(8;14)(q24;q11) with concurrent PTEN alterations and deletions of STIL/TAL1 and CDKN2A/B in a pediatric case of acute T-lymphoblastic leukemia: A genetic profile associated with adverse prognosis.
Skalska-Sadowska J, Dawidowska M, Szarzyńska-Zawadzka B, Jarmuż-Szymczak M, Czerwińska-Rybak J, Machowska L, Derwich K
Pediatr Blood Cancer 2017 Apr;64(4) Epub 2016 Oct 19 doi: 10.1002/pbc.26266. PMID: 27759908
Clinical and cytogenetic features of a population-based consecutive series of 285 pediatric T-cell acute lymphoblastic leukemias: rare T-cell receptor gene rearrangements are associated with poor outcome.
Karrman K, Forestier E, Heyman M, Andersen MK, Autio K, Blennow E, Borgström G, Ehrencrona H, Golovleva I, Heim S, Heinonen K, Hovland R, Johannsson JH, Kerndrup G, Nordgren A, Palmqvist L, Johansson B; Nordic Society of Pediatric Hematology, Oncology (NOPHO); Swedish Cytogenetic Leukemia Study Group (SCLSG); NOPHO Leukemia Cytogenetic Study Group (NLCSG)
Genes Chromosomes Cancer 2009 Sep;48(9):795-805. doi: 10.1002/gcc.20684. PMID: 19530250
Secondary chromosomal abnormalities in acute leukemias.
Johansson B, Mertens F, Mitelman F
Leukemia 1994 Jun;8(6):953-62. PMID: 8207990

Diagnosis

Characteristics and therapeutic approaches for patients diagnosed with T-ALL/LBL exhibiting t(8;14)(q24;q11)/TCRA/D:MYC translocation.
Zhang X, Wang T, Zhang Y, Wang F, Chen J, Ni J, Sun R, Wei Z, Zhang G, Li W, Li J, Lu P
Leuk Lymphoma 2023 Dec;64(13):2133-2139. Epub 2023 Sep 7 doi: 10.1080/10428194.2023.2254428. PMID: 37674391
Translocation t(8;14)(q24;q11) with concurrent PTEN alterations and deletions of STIL/TAL1 and CDKN2A/B in a pediatric case of acute T-lymphoblastic leukemia: A genetic profile associated with adverse prognosis.
Skalska-Sadowska J, Dawidowska M, Szarzyńska-Zawadzka B, Jarmuż-Szymczak M, Czerwińska-Rybak J, Machowska L, Derwich K
Pediatr Blood Cancer 2017 Apr;64(4) Epub 2016 Oct 19 doi: 10.1002/pbc.26266. PMID: 27759908
T-lymphoblastic lymphoma with an unusual t(8;14)(q24;q11)--case report.
Mandac I, Kolonić SO, Vrhovac R, Lasan-Trcić R, Jakelić-Pitesa J, Kardum-Skelin I
Coll Antropol 2010 Mar;34(1):265-9. PMID: 20432760
Clinical and cytogenetic features of a population-based consecutive series of 285 pediatric T-cell acute lymphoblastic leukemias: rare T-cell receptor gene rearrangements are associated with poor outcome.
Karrman K, Forestier E, Heyman M, Andersen MK, Autio K, Blennow E, Borgström G, Ehrencrona H, Golovleva I, Heim S, Heinonen K, Hovland R, Johannsson JH, Kerndrup G, Nordgren A, Palmqvist L, Johansson B; Nordic Society of Pediatric Hematology, Oncology (NOPHO); Swedish Cytogenetic Leukemia Study Group (SCLSG); NOPHO Leukemia Cytogenetic Study Group (NLCSG)
Genes Chromosomes Cancer 2009 Sep;48(9):795-805. doi: 10.1002/gcc.20684. PMID: 19530250
A t(8;14)(q24;q11) translocation in a T-cell leukemia (L1-ALL) with c-myc and TcR-alpha chain locus rearrangements.
Mathieu-Mahul D, Sigaux F, Zhu C, Bernheim A, Mauchauffe M, Daniel MT, Berger R, Larsen CJ
Int J Cancer 1986 Dec 15;38(6):835-40. doi: 10.1002/ijc.2910380609. PMID: 3466870

Prognosis

Characteristics and therapeutic approaches for patients diagnosed with T-ALL/LBL exhibiting t(8;14)(q24;q11)/TCRA/D:MYC translocation.
Zhang X, Wang T, Zhang Y, Wang F, Chen J, Ni J, Sun R, Wei Z, Zhang G, Li W, Li J, Lu P
Leuk Lymphoma 2023 Dec;64(13):2133-2139. Epub 2023 Sep 7 doi: 10.1080/10428194.2023.2254428. PMID: 37674391
Translocation t(8;14)(q24;q11) with concurrent PTEN alterations and deletions of STIL/TAL1 and CDKN2A/B in a pediatric case of acute T-lymphoblastic leukemia: A genetic profile associated with adverse prognosis.
Skalska-Sadowska J, Dawidowska M, Szarzyńska-Zawadzka B, Jarmuż-Szymczak M, Czerwińska-Rybak J, Machowska L, Derwich K
Pediatr Blood Cancer 2017 Apr;64(4) Epub 2016 Oct 19 doi: 10.1002/pbc.26266. PMID: 27759908
T-lymphoblastic lymphoma with an unusual t(8;14)(q24;q11)--case report.
Mandac I, Kolonić SO, Vrhovac R, Lasan-Trcić R, Jakelić-Pitesa J, Kardum-Skelin I
Coll Antropol 2010 Mar;34(1):265-9. PMID: 20432760
Clinical and cytogenetic features of a population-based consecutive series of 285 pediatric T-cell acute lymphoblastic leukemias: rare T-cell receptor gene rearrangements are associated with poor outcome.
Karrman K, Forestier E, Heyman M, Andersen MK, Autio K, Blennow E, Borgström G, Ehrencrona H, Golovleva I, Heim S, Heinonen K, Hovland R, Johannsson JH, Kerndrup G, Nordgren A, Palmqvist L, Johansson B; Nordic Society of Pediatric Hematology, Oncology (NOPHO); Swedish Cytogenetic Leukemia Study Group (SCLSG); NOPHO Leukemia Cytogenetic Study Group (NLCSG)
Genes Chromosomes Cancer 2009 Sep;48(9):795-805. doi: 10.1002/gcc.20684. PMID: 19530250
Pediatric leukemia/lymphoma with t(8;14)(q24;q11).
Lange BJ, Raimondi SC, Heerema N, Nowell PC, Minowada J, Steinherz PE, Arenson EB, O'Connor R, Santoli D
Leukemia 1992 Jul;6(7):613-8. PMID: 1385638

Clinical prediction guides

HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis.
Ballerini P, Blaise A, Busson-Le Coniat M, Su XY, Zucman-Rossi J, Adam M, van den Akker J, Perot C, Pellegrino B, Landman-Parker J, Douay L, Berger R, Bernard OA
Blood 2002 Aug 1;100(3):991-7. doi: 10.1182/blood-2001-11-0093. PMID: 12130513
Molecular analysis of the t(8;14)(q24;q11) chromosomal breakpoint junctions in the T-cell leukemia line MOLT-16.
Shima-Rich EA, Harden AM, McKeithan TW, Rowley JD, Diaz MO
Genes Chromosomes Cancer 1997 Dec;20(4):363-71. doi: 10.1002/(sici)1098-2264(199712)20:4<363::aid-gcc7>3.0.co;2-#. PMID: 9408752
Molecular cloning of the breakpoint junction of a human chromosomal 8;14 translocation involving the T-cell receptor alpha-chain gene and sequences on the 3' side of MYC.
McKeithan TW, Shima EA, Le Beau MM, Minowada J, Rowley JD, Diaz MO
Proc Natl Acad Sci U S A 1986 Sep;83(17):6636-40. doi: 10.1073/pnas.83.17.6636. PMID: 3529089Free PMC Article
Gene encoding the alpha chain of the T-cell receptor is moved immediately downstream of c-myc in a chromosomal 8;14 translocation in a cell line from a human T-cell leukemia.
Shima EA, Le Beau MM, McKeithan TW, Minowada J, Showe LC, Mak TW, Minden MD, Rowley JD, Diaz MO
Proc Natl Acad Sci U S A 1986 May;83(10):3439-43. doi: 10.1073/pnas.83.10.3439. PMID: 3517860Free PMC Article
A t(8;14)(q24;q11) translocation in a T-cell leukemia (L1-ALL) with c-myc and TcR-alpha chain locus rearrangements.
Mathieu-Mahul D, Sigaux F, Zhu C, Bernheim A, Mauchauffe M, Daniel MT, Berger R, Larsen CJ
Int J Cancer 1986 Dec 15;38(6):835-40. doi: 10.1002/ijc.2910380609. PMID: 3466870

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